1 | ARFGEF2, ARPHM
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| West syndrome, microcephaly, grey matter heterotopia and hypoplasia of corpus callosum due to a novel ARFGEF2 mutation.
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| Banne E, Atawneh O, Henneke M, Brockmann K, Gärtner J, Elpeleg O, Edvardson S.
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| J Med Genet 50(11):772-5. doi: 10.1136/jmedgenet-2013-101752. Epub 2013 Jun 28.
2013
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2 | ARFGEF1, ARFGEF2
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| Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.
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| Le K, Li CC, Ye G, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 110(34):E3162-70. doi: 10.1073/pnas.1312531110. Epub 2013 Aug 5.
2013
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3 | ARFGEF2, ARPHM
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| Elaborating the phenotypic spectrum associated with mutations in ARFGEF2: case study and literature review.
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| Tanyalçin I, Verhelst H, Halley DJ, Vanderhasselt T, Villard L, Goizet C, Lissens W, Mancini GM, Jansen AC.
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| Eur J Paediatr Neurol 17(6):666-70. doi: 10.1016/j.ejpn.2013.05.002. Epub 2013 Jun 4.
2013
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4 | ARFGEF1, ARFGEF2, GBF1
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| The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
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| Lowery J, Szul T, Styers M, Holloway Z, Oorschot V, Klumperman J, Sztul E.
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| J Biol Chem 288(16):11532-45. doi: 10.1074/jbc.M112.438481. Epub 2013 Feb 5.
2013
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5 | ARFGEF2, FLNA
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| Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.
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| Zhang J, Neal J, Lian G, Hu J, Lu J, Sheen V.
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| J Neurosci 33(40):15735-46. doi: 10.1523/JNEUROSCI.1939-13.2013.
2013
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6 | ARF1, ARFGEF1, ARFGEF2, ARL1
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| The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2.
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| Christis C, Munro S.
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| J Cell Biol 196(3):327-35. doi: 10.1083/jcb.201107115. Epub 2012 Jan 30. 2012
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7 | ARFGEF2, FLNA
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| Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration.
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| Zhang J, Neal J, Lian G, Shi B, Ferland RJ, Sheen V.
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| J Neurosci 32(36):12619-29. doi: 10.1523/JNEUROSCI.1063-12.2012.
2012
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8 | ARFGEF2
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| Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin β1 cycling and actin remodeling.
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| Shen X, Li CC, Aponte AM, Shen RF, Billings EM, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 109(36):14464-9. doi: 10.1073/pnas.1211877109. Epub 2012 Aug 20.
2012
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9 | ARFGEF2
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| Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation.
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| Lowery J, Szul T, Seetharaman J, Jian X, Su M, Forouhar F, Xiao R, Acton TB, Montelione GT, Lin H, Wright JW, Lee E, Holloway ZG, Randazzo PA, Tong L, Sztul E.
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| J Biol Chem 286(42):36898-906. doi: 10.1074/jbc.M111.230631. Epub 2011 Aug 2.
2011
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10 | ARFGEF2, GOLGA8G
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| ADP-ribosylation factor guanine nucleotide-exchange factor 2 (ARFGEF2): a new potential biomarker in Huntington's disease.
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| Lovrecic L, Slavkov I, Dzeroski S, Peterlin B.
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| J Int Med Res 38(5):1653-62.
2010
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11 | ARFGEF2
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| Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.
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| Grzmil P, Enkhbaatar Z, Gundsambuu B, Oidovsambuu O, Yalcin S, Wolf S, Engel W, Neesen J.
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| Int J Dev Biol 54(8-9):1259-66. doi: 10.1387/ijdb.092959pg.
2010
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12 | ARFGEF2
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| Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.
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| Grzmil P, Enkhbaatar Z, Gundsambuu B, Oidovsambuu O, Yalcin S, Wolf S, Engel W, Neesen J.
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| Int J Dev Biol 54(8-9):1259-66. doi: 10.1387/ijdb.092959pg.
2010
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13 | ARFGEF1, ARFGEF2
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| Specific functions of BIG1 and BIG2 in endomembrane organization.
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| Boal F, Stephens DJ.
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| PLoS One 5(3):e9898. doi: 10.1371/journal.pone.0009898.
2010
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14 | ARFGEF1, ARFGEF2
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| Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.
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| Ishizaki R, Shin HW, Mitsuhashi H, Nakayama K.
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| Mol Biol Cell 19(6):2650-60. doi: 10.1091/mbc.E07-10-1067. Epub 2008 Apr 16.
2008
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15 | ARFGEF1, ARFGEF2
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| BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1.
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| Shen X, Hong MS, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 104(4):1230-5. Epub 2007 Jan 16. 2007
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16 | ARFGEF2
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| Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia.
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| Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V.
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| J Comp Neurol 494(3):476-84. 2006
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17 | ARFGEF2, MYCBP
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| AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.
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| Ishizaki R, Shin HW, Iguchi-Ariga SM, Ariga H, Nakayama K.
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| Genes Cells 11(8):949-59. 2006
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18 | ARFGEF2, EXOC1, EXOC7
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| Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70.
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| Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 102(8):2784-9. Epub 2005 Feb 10. 2005
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19 | ARFGEF2, ARPHM, TMSL6, ADNP, MOCS3, CZF1, ZFP64
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| Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex.
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| Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA.
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| Nat Genet 36(1):69-76. Epub 2003 Nov 30. 2004
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20 | ARFGEF2
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| Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins.
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| Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K.
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| Biochem Biophys Res Commun 294(2):254-60. 2002
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21 | ARFGEF2
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| BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors.
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| Pacheco-Rodriguez G, Moss J, Vaughan M.
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| Methods Enzymol 345:397-404. No abstract available. 2002
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22 | ARFGEF1, ARFGEF2
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| Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.
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| Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 97(6):2567-72. 2000
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23 | ARFGEF1, ARFGEF2
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| Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
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| Togawa A, et al.
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| J Biol Chem 274(18):12308-15. 1999
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