Citations for
1ARFGEF2, ARPHM
West syndrome, microcephaly, grey matter heterotopia and hypoplasia of corpus callosum due to a novel ARFGEF2 mutation.
Banne E, Atawneh O, Henneke M, Brockmann K, Gärtner J, Elpeleg O, Edvardson S.
J Med Genet 50(11):772-5. doi: 10.1136/jmedgenet-2013-101752. Epub 2013 Jun 28. 2013
2ARFGEF1, ARFGEF2
Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.
Le K, Li CC, Ye G, Moss J, Vaughan M.
Proc Natl Acad Sci U S A 110(34):E3162-70. doi: 10.1073/pnas.1312531110. Epub 2013 Aug 5. 2013
3ARFGEF2, ARPHM
Elaborating the phenotypic spectrum associated with mutations in ARFGEF2: case study and literature review.
Tanyalçin I, Verhelst H, Halley DJ, Vanderhasselt T, Villard L, Goizet C, Lissens W, Mancini GM, Jansen AC.
Eur J Paediatr Neurol 17(6):666-70. doi: 10.1016/j.ejpn.2013.05.002. Epub 2013 Jun 4. 2013
4ARFGEF1, ARFGEF2, GBF1
The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
Lowery J, Szul T, Styers M, Holloway Z, Oorschot V, Klumperman J, Sztul E.
J Biol Chem 288(16):11532-45. doi: 10.1074/jbc.M112.438481. Epub 2013 Feb 5. 2013
5ARFGEF2, FLNA
Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.
Zhang J, Neal J, Lian G, Hu J, Lu J, Sheen V.
J Neurosci 33(40):15735-46. doi: 10.1523/JNEUROSCI.1939-13.2013. 2013
6ARF1, ARFGEF1, ARFGEF2, ARL1
The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2.
Christis C, Munro S.
J Cell Biol 196(3):327-35. doi: 10.1083/jcb.201107115. Epub 2012 Jan 30. 2012
7ARFGEF2, FLNA
Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration.
Zhang J, Neal J, Lian G, Shi B, Ferland RJ, Sheen V.
J Neurosci 32(36):12619-29. doi: 10.1523/JNEUROSCI.1063-12.2012. 2012
8ARFGEF2
Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin β1 cycling and actin remodeling.
Shen X, Li CC, Aponte AM, Shen RF, Billings EM, Moss J, Vaughan M.
Proc Natl Acad Sci U S A 109(36):14464-9. doi: 10.1073/pnas.1211877109. Epub 2012 Aug 20. 2012
9ARFGEF2
Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation.
Lowery J, Szul T, Seetharaman J, Jian X, Su M, Forouhar F, Xiao R, Acton TB, Montelione GT, Lin H, Wright JW, Lee E, Holloway ZG, Randazzo PA, Tong L, Sztul E.
J Biol Chem 286(42):36898-906. doi: 10.1074/jbc.M111.230631. Epub 2011 Aug 2. 2011
10ARFGEF2, GOLGA8G
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (ARFGEF2): a new potential biomarker in Huntington's disease.
Lovrecic L, Slavkov I, Dzeroski S, Peterlin B.
J Int Med Res 38(5):1653-62. 2010
11ARFGEF2
Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.
Grzmil P, Enkhbaatar Z, Gundsambuu B, Oidovsambuu O, Yalcin S, Wolf S, Engel W, Neesen J.
Int J Dev Biol 54(8-9):1259-66. doi: 10.1387/ijdb.092959pg. 2010
12ARFGEF2
Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.
Grzmil P, Enkhbaatar Z, Gundsambuu B, Oidovsambuu O, Yalcin S, Wolf S, Engel W, Neesen J.
Int J Dev Biol 54(8-9):1259-66. doi: 10.1387/ijdb.092959pg. 2010
13ARFGEF1, ARFGEF2
Specific functions of BIG1 and BIG2 in endomembrane organization.
Boal F, Stephens DJ.
PLoS One 5(3):e9898. doi: 10.1371/journal.pone.0009898. 2010
14ARFGEF1, ARFGEF2
Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.
Ishizaki R, Shin HW, Mitsuhashi H, Nakayama K.
Mol Biol Cell 19(6):2650-60. doi: 10.1091/mbc.E07-10-1067. Epub 2008 Apr 16. 2008
15ARFGEF1, ARFGEF2
BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1.
Shen X, Hong MS, Moss J, Vaughan M.
Proc Natl Acad Sci U S A 104(4):1230-5. Epub 2007 Jan 16. 2007
16ARFGEF2
Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia.
Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V.
J Comp Neurol 494(3):476-84. 2006
17ARFGEF2, MYCBP
AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors.
Ishizaki R, Shin HW, Iguchi-Ariga SM, Ariga H, Nakayama K.
Genes Cells 11(8):949-59. 2006
18ARFGEF2, EXOC1, EXOC7
Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70.
Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M.
Proc Natl Acad Sci U S A 102(8):2784-9. Epub 2005 Feb 10. 2005
19ARFGEF2, ARPHM, TMSL6, ADNP, MOCS3, CZF1, ZFP64
Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex.
Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA.
Nat Genet 36(1):69-76. Epub 2003 Nov 30. 2004
20ARFGEF2
Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins.
Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K.
Biochem Biophys Res Commun 294(2):254-60. 2002
21ARFGEF2
BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors.
Pacheco-Rodriguez G, Moss J, Vaughan M.
Methods Enzymol 345:397-404. No abstract available. 2002
22ARFGEF1, ARFGEF2
Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.
Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M.
Proc Natl Acad Sci U S A 97(6):2567-72. 2000
23ARFGEF1, ARFGEF2
Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
Togawa A, et al.
J Biol Chem 274(18):12308-15. 1999