1 | ARFGEF1, ARFGEF2
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| Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex.
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| Le K, Li CC, Ye G, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 110(34):E3162-70. doi: 10.1073/pnas.1312531110. Epub 2013 Aug 5.
2013
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2 | ARFGEF1, ARFGEF2, GBF1
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| The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).
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| Lowery J, Szul T, Styers M, Holloway Z, Oorschot V, Klumperman J, Sztul E.
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| J Biol Chem 288(16):11532-45. doi: 10.1074/jbc.M112.438481. Epub 2013 Feb 5.
2013
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3 | ABCA1, ARFGEF1
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| BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ATP-binding cassette transporter A-1 trafficking and function.
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| Lin S, Zhou C, Neufeld E, Wang YH, Xu SW, Lu L, Wang Y, Liu ZP, Li D, Li C, Chen S, Le K, Huang H, Liu P, Moss J, Vaughan M, Shen X.
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| Arterioscler Thromb Vasc Biol 33(2):e31-8. doi: 10.1161/ATVBAHA.112.300720. Epub 2012 Dec 6.
2013
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4 | ARF1, ARFGEF1, ARFGEF2, ARL1
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| The small G protein Arl1 directs the trans-Golgi-specific targeting of the Arf1 exchange factors BIG1 and BIG2.
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| Christis C, Munro S.
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| J Cell Biol 196(3):327-35. doi: 10.1083/jcb.201107115. Epub 2012 Jan 30. 2012
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5 | ARFGEF1, KANK1
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| Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.
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| Li CC, Kuo JC, Waterman CM, Kiyama R, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 108(48):19228-33. doi: 10.1073/pnas.1117011108. Epub 2011 Nov 14.
2011
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6 | ARFGEF1, ARFGEF2
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| Specific functions of BIG1 and BIG2 in endomembrane organization.
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| Boal F, Stephens DJ.
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| PLoS One 5(3):e9898. doi: 10.1371/journal.pone.0009898.
2010
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7 | ARFGEF1, KIF21A
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| Interaction of brefeldin A-inhibited guanine nucleotide-exchange protein (BIG) 1 and kinesin motor protein KIF21A.
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| Shen X, Meza-Carmen V, Puxeddu E, Wang G, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 105(48):18788-93. Epub 2008 Nov 19.
2008
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8 | ARFGEF1, ARFGEF2
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| Redundant roles of BIG2 and BIG1, guanine-nucleotide exchange factors for ADP-ribosylation factors in membrane traffic between the trans-Golgi network and endosomes.
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| Ishizaki R, Shin HW, Mitsuhashi H, Nakayama K.
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| Mol Biol Cell 19(6):2650-60. doi: 10.1091/mbc.E07-10-1067. Epub 2008 Apr 16.
2008
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9 | ARFGEF1, ARFGEF2
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| BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein, is required for correct glycosylation and function of integrin beta1.
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| Shen X, Hong MS, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 104(4):1230-5. Epub 2007 Jan 16. 2007
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10 | ARFGEF1, MYO9B
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| BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.
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| Saeki N, Tokuo H, Ikebe M.
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| J Biol Chem 280(11):10128-34. Epub 2005 Jan 11. 2005
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11 | ARFGEF1
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| Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
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| Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 101(9):2752-7. Epub 2004 Feb 18. 2004
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12 | ARFGEF1, ARFGEF2
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| Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.
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| Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M.
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| Proc Natl Acad Sci U S A 97(6):2567-72. 2000
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13 | ARFGEF1, ARFGEF2
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| Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
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| Togawa A, et al.
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| J Biol Chem 274(18):12308-15. 1999
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