Citations for
1ARF6, ELMOD1
ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells.
Krey JF, Dumont RA, Wilmarth PA, David LL, Johnson KR, Barr-Gillespie PG.
J Neurosci 38(4):843-857. doi: 10.1523/JNEUROSCI.2658-17.2017. Epub 2017 Dec 8. 2018
2ARF6, IQSEC1
BRAG2a, a Guanine Nucleotide Exchange Factor for Arf6, Is a Component of the Dystrophin-Associated Glycoprotein Complex at the Photoreceptor Terminal.
Sakagami H, Katsumata O, Hara Y, Sasaoka T, Fukaya M.
Invest Ophthalmol Vis Sci 58(9):3795-3803. doi: 10.1167/iovs.17-21746. 2017
3ARF6, GRIN2B, IQSEC2
Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation.
Elagabani MN, Briševac D, Kintscher M, Pohle J, Köhr G, Schmitz D, Kornau HC.
J Biol Chem 291(17):9105-18. doi: 10.1074/jbc.M115.691717. Epub 2016 Feb 16. 2016
4ABCA1, ARF6
Small GTPase ARF6 Regulates Endocytic Pathway Leading to Degradation of ATP-Binding Cassette Transporter A1.
Mukhamedova N, Hoang A, Cui HL, Carmichael I, Fu Y, Bukrinsky M, Sviridov D.
Arterioscler Thromb Vasc Biol 36(12):2292-2303. Epub 2016 Oct 6. 2016
5ARF6, CYTH2
Arf6 guanine-nucleotide exchange factor cytohesin-2 regulates myelination in nerves.
Torii T, Ohno N, Miyamoto Y, Kawahara K, Saitoh Y, Nakamura K, Takashima S, Sakagami H, Tanoue A, Yamauchi J.
Biochem Biophys Res Commun iochem Biophys Res Commun. 2015 Mar 28. pii: S0006-291X(15)00579-3. doi: 10.1016/j.bbrc.2015.03.113. [Epub ahead of print] 2015
6ARF6
ADP Ribosylation Factor 6 (ARF6) Promotes Acrosomal Exocytosis by Modulating Lipid Turnover and Rab3A Activation.
Pelletán LE, Suhaiman L, Vaquer CC, Bustos MA, De Blas GA, Vitale N, Mayorga LS, Belmonte SA.
J Biol Chem 290(15):9823-41. doi: 10.1074/jbc.M114.629006. Epub 2015 Feb 20. 2015
7ARF6
ADP-ribosylation Factor 6 (ARF6) Bidirectionally Regulates Dendritic Spine Formation Depending on Neuronal Maturation and Activity.
Kim Y, Lee SE, Park J, Kim M, Lee B, Hwang D, Chang S.
J Biol Chem 290(12):7323-35. doi: 10.1074/jbc.M114.634527. Epub 2015 Jan 20. 2015
8ARF6, DNM2, PSD3, PSD4
Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis.
Okada R, Yamauchi Y, Hongu T, Funakoshi Y, Ohbayashi N, Hasegawa H, Kanaho Y.
Sci Rep 5:14919. doi: 10.1038/srep14919. 2015
9ARF6, CYTH2, RALBP1, RRAS
RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg MH, Goldfinger LE.
Biochem Biophys Res Commun 467(4):785-91. doi: 10.1016/j.bbrc.2015.10.064. Epub 2015 Oct 20. 2015
10APBB1, ARF6
FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth.
Cheung HN, Dunbar C, Mórotz GM, Cheng WH, Chan HY, Miller CC, Lau KF.
FASEB J 28(1):337-49. doi: 10.1096/fj.13-232694. Epub 2013 Sep 20. 2014
11ARF1, ARF6
Arf1 and Arf6 promote ventral actin structures formed by acute activation of protein kinase C and Src.
Caviston JP, Cohen LA, Donaldson JG.
Cytoskeleton (Hoboken) 71(6):380-94. doi: 10.1002/cm.21181. Epub 2014 Jun 26. 2014
12ARF6, CYTH2, RALBP1
The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration.
Lee S, Wurtzel JG, Goldfinger LE.
Biochem Biophys Res Commun 454(4):560-565. doi: 10.1016/j.bbrc.2014.10.114. [Epub ahead of print] 2014
13ARF6, CYTH2
Cytohesin 2/ARF6 regulates preadipocyte migration through the activation of ERK1/2.
Davies JC, Tamaddon-Jahromi S, Jannoo R, Kanamarlapudi V.
Biochem Pharmacol 92(4):651-60. doi: 10.1016/j.bcp.2014.09.023. Epub 2014 Oct 20. 2014
14ARF6, PSD3
Exchange factor EFA6R requires C-terminal targeting to the plasma membrane to promote cytoskeletal rearrangement through the activation of ADP-ribosylation factor 6 (ARF6).
Kanamarlapudi V.
J Biol Chem 289(48):33378-90. doi: 10.1074/jbc.M113.534156. Epub 2014 Oct 8. 2014
15ARF6, MAPK8IP3, SPAG9
JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis.
Tuvshintugs B, Sato T, Enkhtuya R, Yamashita K, Yoshioka K.
Genes Cells 19(9):692-703. doi: 10.1111/gtc.12170. Epub 2014 Aug 6. 2014
16ARF6, EDN1, EDNRA
ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes.
Davies JC, Bain SC, Kanamarlapudi V.
Biochem Pharmacol 90(4):406-13. doi: 10.1016/j.bcp.2014.06.012. Epub 2014 Jun 20. 2014
17ARF6, ARHGAP24
ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbing.
Kawaguchi K, Saito K, Asami H, Ohta Y.
J Biol Chem 289(14):9675-82. doi: 10.1074/jbc.M113.546051. Epub 2014 Feb 13. 2014
18ARF6, PSD, SNX1
EFA6A, a guanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth.
Fukaya M, Fukushima D, Hara Y, Sakagami H.
J Neurochem 129(1):21-36. doi: 10.1111/jnc.12524. Epub 2013 Nov 22. 2014
19ARF6, PSD
EFA6 controls Arf1 and Arf6 activation through a negative feedback loop.
Padovani D, Folly-Klan M, Labarde A, Boulakirba S, Campanacci V, Franco M, Zeghouf M, Cherfils J.
Proc Natl Acad Sci U S A 111(34):12378-83. doi: 10.1073/pnas.1409832111. Epub 2014 Aug 11. 2014
20ARF6, TICAM1, TICAM2
The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling.
Van Acker T, Eyckerman S, Vande Walle L, Gerlo S, Goethals M, Lamkanfi M, Bovijn C, Tavernier J, Peelman F.
J Biol Chem 289(3):1364-76. doi: 10.1074/jbc.M113.499194. Epub 2013 Dec 2. 2014
21ARAP2, ARF6, RAC1
ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology.
Chen PW, Jian X, Yoon HY, Randazzo PA.
J Biol Chem 288(8):5849-60. doi: 10.1074/jbc.M112.415778. Epub 2013 Jan 7. 2013
22ARF6, PSD
EFA6 activates Arf6 and participates in its targeting to the Flemming body during cytokinesis.
Ueda T, Hanai A, Takei T, Kubo K, Ohgi M, Sakagami H, Takahashi S, Shin HW, Nakayama K.
FEBS Lett 587(11):1617-23. doi: 10.1016/j.febslet.2013.03.042. Epub 2013 Apr 18. 2013
23ARF6
ARF6 regulates neuron differentiation through glucosylceramide synthase.
Li L, Stĺhlman M, Rutberg M, Hĺversen L, Fogelstrand P, Andersson L, Levin M, Borén J.
PLoS One 8(3):e60118. doi: 10.1371/journal.pone.0060118. Epub 2013 Mar 28. 2013
24ARF6, CYTH1
Signaling through Arf6 guanine-nucleotide exchange factor cytohesin-1 regulates migration in Schwann cells.
Miyamoto Y, Torii T, Nakamura K, Takashima S, Sanbe A, Tanoue A, Yamauchi J.
Cell Signal 25(6):1379-87. doi: 10.1016/j.cellsig.2013.03.008. Epub 2013 Mar 19. 2013
25ARF6, RAB35
Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration.
Allaire PD, Seyed Sadr M, Chaineau M, Seyed Sadr E, Konefal S, Fotouhi M, Maret D, Ritter B, Del Maestro RF, McPherson PS.
J Cell Sci 126(Pt 3):722-31. doi: 10.1242/jcs.112375. Epub 2012 Dec 21. 2013
26ARF6, RAB8A, SYTL1, TBC1D10A
EPI64 interacts with Slp1/JFC1 to coordinate Rab8a and Arf6 membrane trafficking.
Hokanson DE, Bretscher AP.
Mol Biol Cell 23(4):701-15. doi: 10.1091/mbc.E11-06-0521. Epub 2012 Jan 4. 2012
27ARF6, MICALL1, RAB35
MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.
Rahajeng J, Giridharan SS, Cai B, Naslavsky N, Caplan S.
Traffic 13(1):82-93. doi: 10.1111/j.1600-0854.2011.01294.x. Epub 2011 Oct 24. 2012
28ARF6, P2RY1, P2RY12
ARF6-dependent regulation of P2Y receptor traffic and function in human platelets.
Kanamarlapudi V, Owens SE, Saha K, Pope RJ, Mundell SJ.
PLoS One 7(8):e43532. doi: 10.1371/journal.pone.0043532. Epub 2012 Aug 16. 2012
29ARAP1, ARF5, ARF6
ARAP1 regulates the ring size of circular dorsal ruffles through Arf1 and Arf5.
Hasegawa J, Tsujita K, Takenawa T, Itoh T.
Mol Biol Cell 23(13):2481-9. doi: 10.1091/mbc.E12-01-0017. Epub 2012 May 9. 2012
30ARF4, ARF5, ARF6, IQSEC1
BRAG2/GEP100/IQSec1 interacts with clathrin and regulates α5β1 integrin endocytosis through activation of ADP ribosylation factor 5 (Arf5).
Moravec R, Conger KK, D'Souza R, Allison AB, Casanova JE.
J Biol Chem 287(37):31138-47. doi: 10.1074/jbc.M112.383117. Epub 2012 Jul 19. 2012
31ACAP1, ARF6
ARF6 directs axon transport and traffic of integrins and regulates axon growth in adult DRG neurons.
Eva R, Crisp S, Marland JR, Norman JC, Kanamarlapudi V, ffrench-Constant C, Fawcett JW.
J Neurosci 32(30):10352-64. 2012
32ACAP1, ARF6, USP6
The oncogenic TBC domain protein USP6/TRE17 regulates cell migration and cytokinesis.
Rueckert C, Haucke V.
Biol Cell 104(1):22-33. doi: 10.1111/boc.201100108. Epub 2011 Dec 1. 2012
33ARF6, CYTH3, GRASP
Grp1-associated scaffold protein (GRASP) is a regulator of the ADP ribosylation factor 6 (Arf6)-dependent membrane trafficking pathway.
Venkataraman A, Nevrivy DJ, Filtz TM, Leid M.
Cell Biol Int 36(12):1115-28. doi: 10.1042/CBI20120221. 2012
34ARF6, PLCB3
Inhibition of cell migration by PITENINs: the role of ARF6.
Miao B, Skidan I, Yang J, You Z, Fu X, Famulok M, Schaffhausen B, Torchilin V, Yuan J, Degterev A.
Oncogene 31(39):4317-32. doi: 10.1038/onc.2011.593. 2012
35ARF6, LHCGR
ARF6 activated by the LHCG receptor through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalization and signaling.
Kanamarlapudi V, Thompson A, Kelly E, López Bernal A.
J Biol Chem 287(24):20443-55. doi: 10.1074/jbc.M112.362087. Epub 2012 Apr 20. 2012
36ARF6, CYTH2, MYD88
Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability.
Zhu W, London NR, Gibson CC, Davis CT, Tong Z, Sorensen LK, Shi DS, Guo J, Smith MC, Grossmann AH, Thomas KR, Li DY.
Nature 492(7428):252-5. doi: 10.1038/nature11603. Epub 2012 Nov 11. 2012
37ARF6, ASAP1, IQSEC1
GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.
Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, Hirose M, Menju T, Morishige M, Manabe T, Toda Y, Ishida S, Sabe H.
PLoS One 6(8):e23359. doi: 10.1371/journal.pone.0023359. Epub 2011 Aug 15. 2011
38ACAP2, ARF6, RAB35
Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcγR-mediated phagocytosis.
Egami Y, Fukuda M, Araki N.
J Cell Sci 124(Pt 21):3557-67. doi: 10.1242/jcs.083881. Epub 2011 Nov 1. 2011
39ARF6, ASAP1, ASAP2, ASAP3
The structure of an Arf-ArfGAP complex reveals a Ca2+ regulatory mechanism.
Ismail SA, Vetter IR, Sot B, Wittinghofer A.
Cell 141(5):812-21 2010
40ARF6
ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis.
Schweitzer JK, Sedgwick AE, D'Souza-Schorey C.
Semin Cell Dev Biol emin Cell Dev Biol. 2010 Sep 15. [Epub ahead of print]PMID: 20837153 2010
41ARF6
Molecular cloning, chromosomal localization and expression pattern of porcine ADP-ribosylation factor(Arf) gene family.
Zhang R, Lei T, Qi Y, Lei P, Chen Z, Chen X, Yang Z.
Anim Sci J 81(4):425-31.PMID: 20662810 2010
42ARF6
ADP-ribosylation factor 6 regulates mammalian myoblast fusion through phospholipase D1 and phosphatidylinositol 4,5-bisphosphate signaling pathways.
Bach AS, Enjalbert S, Comunale F, Bodin S, Vitale N, Charrasse S, Gauthier-Rouvičre C.
Mol Biol Cell 21(14):2412-24. Epub 2010 May 26.PMID: 20505075 2010
43ARF6, MAPK8IP3, SPAG9
The scaffold protein JIP3 functions as a downstream effector of the small GTPase ARF6 to regulate neurite morphogenesis of cortical neurons.
Suzuki A, Arikawa C, Kuwahara Y, Itoh K, Watanabe M, Watanabe H, Suzuki T, Funakoshi Y, Hasegawa H, Kanaho Y.
FEBS Lett 584(13):2801-6. Epub 2010 May 21.PMID: 20493856 2010
44ARF6, VEZT
Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons.
Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H.
Neurosci Res 67(2):126-36. Epub 2010 Feb 24. 2010
45ARF6, ARL4D, ARP6, CYTH2
Valproic acid-inducible Arl4D and cytohesin-2/ARNO, acting through the downstream Arf6, regulate neurite outgrowth in N1E-115 cells.
Yamauchi J, Miyamoto Y, Torii T, Mizutani R, Nakamura K, Sanbe A, Koide H, Kusakawa S, Tanoue A.
Exp Cell Res 315(12):2043-52. Epub 2009 Mar 25.PMID: 19327349 2009
46ARF6
Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation.
Li M, Wang J, Ng SS, Chan CY, He ML, Yu F, Lai L, Shi C, Chen Y, Yew DT, Kung HF, Lin MC.
Cancer 115(21):4959-72.PMID: 19642173 2009
47ARF6
ARF6 Interacts with JIP4 to control a motor switch mechanism regulating endosome traffic in cytokinesis.
Montagnac G, Sibarita JB, Loubéry S, Daviet L, Romao M, Raposo G, Chavrier P.
Curr Biol 19(3):184-95.PMID: 19211056 2009
48ARF6, ASAP1, IQSEC1
The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.
Sabe H, Hashimoto S, Morishige M, Ogawa E, Hashimoto A, Nam JM, Miura K, Yano H, Onodera Y.
Traffic 10(8):982-93. doi: 10.1111/j.1600-0854.2009.00917.x. Epub 2009 Apr 21. Review. 2009
49ARF6, PSD
Localization of EFA6A, a guanine nucleotide exchange factor for ARF6, in spermatogenic cells of testes of adult mice.
Suzuki R, Saino-Saito S, Sakagami H, Toshimori K, Abe H, Kondo H.
J Mol Histol 40(1):77-80. doi: 10.1007/s10735-008-9207-9. Epub 2008 Dec 16. 2009
50IQSEC1, ARF6
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.
Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, Hirose M, Wei S, Hashimoto A, Yamada A, Yano H, Mazaki Y, Kodama H, Nio Y, Manabe T, Wada H, Kobayashi H, Sabe H.
Nat Cell Biol 10(1):85-92. Epub 2007 Dec 16. 2008
51ARF1, ARF6
Arf family GTP loading is activated by, and generates, positive membrane curvature.
Lundmark R, Doherty GJ, Vallis Y, Peter BJ, McMahon HT.
Biochem J 414(2):189-94. 2008
52ARF6, PSD
Predominant localization of EFA6A, a guanine nucleotide exchange factor for ARF6, at the perisynaptic photoreceptor processes.
Katsumata O, Honma T, Sanda M, Kamata A, Takeda S, Kondo H, Sakagami H.
Brain Res 1234:44-9. doi: 10.1016/j.brainres.2008.07.093. Epub 2008 Aug 3. 2008
53ARF6, CYTH2
The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network.
Bouschet T, Martin S, Kanamarlapudi V, Mundell S, Henley JM.
J Cell Sci 120(Pt 15):2489-97. Epub 2007 Jul 10. 2007
54ARF6, RAB11FIP3
Molecular characterization of Rab11-FIP3 binding to ARF GTPases.
Schonteich E, Pilli M, Simon GC, Matern HT, Junutula JR, Sentz D, Holmes RK, Prekeris R.
Eur J Cell Biol 86(8):417-31. Epub 2007 Jul 12. 2007
55ACAP1, ARF6, GULP1
Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP.
Ma Z, Nie Z, Luo R, Casanova JE, Ravichandran KS.
Curr Biol 17(8):722-7. Epub 2007 Mar 29. 2007
56ARF6, ASAP1
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.
Hashimoto S, Hirose M, Hashimoto A, Morishige M, Yamada A, Hosaka H, Akagi K, Ogawa E, Oneyama C, Agatsuma T, Okada M, Kobayashi H, Wada H, Nakano H, Ikegami T, Nakagawa A, Sabe H.
Proc Natl Acad Sci U S A 103(18):7036-41. Epub 2006 Apr 24. 2006
57ARF6
ARF6 and EFA6A regulate the development and maintenance of dendritic spines.
Choi S, Ko J, Lee JR, Lee HW, Kim K, Chung HS, Kim H, Kim E.
J Neurosci 26(18):4811-9. 2006
58ARF6, PSD
ARF6 and EFA6A regulate the development and maintenance of dendritic spines.
Choi S, Ko J, Lee JR, Lee HW, Kim K, Chung HS, Kim H, Kim E.
J Neurosci 26(18):4811-9. 2006
59ARF6
Sequence, genomic organization, and expression of the human ADP-ribosylation factor 6 (ARF6) gene: a class III ARF.
Lebeda RA, Johnson SK, Stewart MI, Haun RS.
DNA Cell Biol 22(11):737-41. 2003
60ARF1, ARF5, ARF6
Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3.
Austin C, Boehm M, Tooze SA.
Biochemistry 41(14):4669-77. 2002
61ARF6
An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.
Palacios F, Price L, Schweitzer J, Collard JG, D'Souza-Schorey C.
EMBO J 20(17):4973-86. 2001
62ARF5,ARF6,RAB11FIP3
Arfophilin is a common target of both class II and class III ADP-ribosylation factors.
Shin OH, Couvillon AD, Exton JH.
Biochemistry 40(36):10846-52. 2001
63ACAP1, ACAP2, ARF6, ASAP1, ASAP2
ACAPs are arf6 GTPase-activating proteins that function in the cell periphery.
Jackson TR, Brown FD, Nie Z, Miura K, Foroni L, Sun J, Hsu VW, Donaldson JG, Randazzo PA.
J Cell Biol 151(3):627-38. 2000
64ARF6
ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA.
Boshans RL, Szanto S, van Aelst L, D'Souza-Schorey C.
Mol Cell Biol 20(10):3685-94. 2000
65ARF6, PIP5K1A
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation.
Honda A, Nogami M, Yokozeki T, Yamazaki M, Nakamura H, Watanabe H, Kawamoto K, Nakayama K, Morris AJ, Frohman MA, Kanaho Y.
Cell 99(5):521-32 1999
66ARF1, ARF3, ARF4, ARF5, ARF6
The role of ARF and Rab GTPases in membrane transport.
Chavrier P, Goud B.
Curr Opin Cell Biol 11(4):466-75. Review. 1999
67ARF1, ARF4, ARF3, ARL4D, ARF5, ARF6
Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6).
Hosaka M, et al.
J Biochem (Tokyo) 120(4):813-9. 1996
68ARF1, ARF3, ARF4, ARF5, ARF6
Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells.
Tsuchiya M, Price SR, Tsai SC, Moss J, Vaughan M.
J Biol Chem 266(5):2772-7 1991
69ARF1, ARF3, ARF4, ARF5, ARF6
ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein.
Serafini T, Orci L, Amherdt M, Brunner M, Kahn RA, Rothman JE.
Cell 67(2):239-53. 1991