Citations for
1APPL1, TRAF6
TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt.
Cheng KK, Lam KS, Wang Y, Wu D, Zhang M, Wang B, Li X, Hoo RL, Huang Z, Sweeney G, Xu A.
Biochem J 455(2):207-16. doi: 10.1042/BJ20130760. 2013
2APPL1, TRAF2
APPL1 regulates basal NF-κB activity by stabilizing NIK.
Hupalowska A, Pyrzynska B, Miaczynska M.
J Cell Sci 125(Pt 17):4090-102. doi: 10.1242/jcs.105171. Epub 2012 Jun 8. 2012
3APPL1
Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes.
Liu M, Zhou L, Wei L, Villarreal R, Yang X, Hu D, Riojas RA, Holmes BM, Langlais PR, Lee H, Dong LQ.
J Biol Chem 287(31):26087-93. doi: 10.1074/jbc.M112.372292. Epub 2012 Jun 8. 2012
4APPL1
Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion.
Han W.
Proc Natl Acad Sci U S A 109(23):8795-6. doi: 10.1073/pnas.1206730109. Epub 2012 May 21. No abstract available. 2012
5APPL1
The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.
Broussard JA, Lin WH, Majumdar D, Anderson B, Eason B, Brown CM, Webb DJ.
Mol Biol Cell 23(8):1486-99. doi: 10.1091/mbc.E11-02-0124. Epub 2012 Feb 29. 2012
6APPL1, APPL2
Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment.
Urbanska A, Sadowski L, Kalaidzidis Y, Miaczynska M.
Traffic 12(9):1227-41. doi: 10.1111/j.1600-0854.2011.01226.x. Epub 2011 Jul 3. 2011
7APPL1
Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment.
Pilecka I, Sadowski L, Kalaidzidis Y, Miaczynska M.
Exp Cell Res 317(8):1093-107. doi: 10.1016/j.yexcr.2011.02.002. Epub 2011 Feb 19. 2011
8APPL1, EGFR
Adaptor protein containing PH domain, PTB domain and leucine zipper (APPL1) regulates the protein level of EGFR by modulating its trafficking.
Lee JR, Hahn HS, Kim YH, Nguyen HH, Yang JM, Kang JS, Hahn MJ.
Biochem Biophys Res Commun 415(1):206-11. doi: 10.1016/j.bbrc.2011.10.064. Epub 2011 Oct 19. 2011
9APPL1, BOC, CDON
Cdo interacts with APPL1 and activates Akt in myoblast differentiation.
Bae GU, Lee JR, Kim BG, Han JW, Leem YE, Lee HJ, Ho SM, Hahn MJ, Kang JS.
Mol Biol Cell 21(14):2399-411. Epub 2010 May 19. 2010
10APPL1, HDAC1
Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.
Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M.
Biochem J 423(3):389-400. 2009
11APPL1, APPL2
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M.
J Biol Chem 284(27):18115-28. Epub 2009 May 11. 2009
12APPL1, AKT1
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.
Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M.
Cell 133(3):486-97. 2008
13APPL1, APPL2
Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.
Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ.
Traffic 9(2):215-29. Epub 2007 Dec 18. Erratum in: Traffic. 2008 Apr;9(4):623-4. 2008
14APPL1
The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation.
Saito T, Jones CC, Huang S, Czech MP, Pilch PF.
J Biol Chem 282(44):32280-7. Epub 2007 Sep 11. 2007
15APPL1
APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function.
Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ-Roberts CY, Hong JY, Kim RY, Liu F, Dong LQ.
Nat Cell Biol 8(5):516-23. Epub 2006 Apr 16. Erratum in: Nat Cell Biol. 2006 Jun;8(6):642. 2006
16APPL1, GIPC1, NTRK1
APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction.
Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, Miller FD, Kaplan DR.
Mol Cell Biol 26(23):8928-41. Epub 2006 Sep 25. 2006
17SSNA1, APPL1, SPG4
Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon.
Errico A, Claudiani P, D'Addio M, Rugarli EI.
Hum Mol Genet 13(18):2121-32. Epub 2004 Jul 21. 2004
18APPL1
APPL suppresses androgen receptor transactivation via potentiating Akt activity.
Yang L, Lin HK, Altuwaijri S, Xie S, Wang L, Chang C.
J Biol Chem 278(19):16820-7. Epub 2003 Mar 5. 2003
19APPL1, DCC
Mediation of the DCC apoptotic signal by DIP13 alpha.
Liu J, Yao F, Wu R, Morgan M, Thorburn A, Finley RL Jr, Chen YQ.
J Biol Chem 277(29):26281-5. 2002
20APPL1
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR.
Oncogene 18(35):4891-8 1999