| 1 | APPL1, TRAF2
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| APPL1 regulates basal NF-κB activity by stabilizing NIK.
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| Hupalowska A, Pyrzynska B, Miaczynska M.
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| J Cell Sci 125(Pt 17):4090-102. doi: 10.1242/jcs.105171. Epub 2012 Jun 8.
2012
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| 2 | APPL1
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| Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes.
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| Liu M, Zhou L, Wei L, Villarreal R, Yang X, Hu D, Riojas RA, Holmes BM, Langlais PR, Lee H, Dong LQ.
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| J Biol Chem 287(31):26087-93. doi: 10.1074/jbc.M112.372292. Epub 2012 Jun 8.
2012
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| 3 | APPL1
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| Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion.
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| Han W.
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| Proc Natl Acad Sci U S A 109(23):8795-6. doi: 10.1073/pnas.1206730109. Epub 2012 May 21. No abstract available.
2012
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| 4 | APPL1
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| The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.
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| Broussard JA, Lin WH, Majumdar D, Anderson B, Eason B, Brown CM, Webb DJ.
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| Mol Biol Cell 23(8):1486-99. doi: 10.1091/mbc.E11-02-0124. Epub 2012 Feb 29.
2012
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| 5 | APPL1, APPL2
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| Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment.
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| Urbanska A, Sadowski L, Kalaidzidis Y, Miaczynska M.
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| Traffic 12(9):1227-41. doi: 10.1111/j.1600-0854.2011.01226.x. Epub 2011 Jul 3.
2011
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| 6 | APPL1
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| Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment.
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| Pilecka I, Sadowski L, Kalaidzidis Y, Miaczynska M.
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| Exp Cell Res 317(8):1093-107. doi: 10.1016/j.yexcr.2011.02.002. Epub 2011 Feb 19.
2011
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| 7 | APPL1, EGFR
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| Adaptor protein containing PH domain, PTB domain and leucine zipper (APPL1) regulates the protein level of EGFR by modulating its trafficking.
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| Lee JR, Hahn HS, Kim YH, Nguyen HH, Yang JM, Kang JS, Hahn MJ.
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| Biochem Biophys Res Commun 415(1):206-11. doi: 10.1016/j.bbrc.2011.10.064. Epub 2011 Oct 19. 2011
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| 8 | APPL1, BOC, CDON
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| Cdo interacts with APPL1 and activates Akt in myoblast differentiation.
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| Bae GU, Lee JR, Kim BG, Han JW, Leem YE, Lee HJ, Ho SM, Hahn MJ, Kang JS.
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| Mol Biol Cell 21(14):2399-411. Epub 2010 May 19.
2010
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| 9 | APPL1, HDAC1
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| Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.
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| Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M.
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| Biochem J 423(3):389-400.
2009
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| 10 | APPL1, APPL2
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| Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
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| Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M.
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| J Biol Chem 284(27):18115-28. Epub 2009 May 11.
2009
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| 11 | APPL1, AKT1
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| The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.
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| Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M.
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| Cell 133(3):486-97. 2008
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| 12 | APPL1, APPL2
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| Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.
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| Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ.
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| Traffic 9(2):215-29. Epub 2007 Dec 18. Erratum in: Traffic. 2008 Apr;9(4):623-4.
2008
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| 13 | APPL1
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| The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation.
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| Saito T, Jones CC, Huang S, Czech MP, Pilch PF.
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| J Biol Chem 282(44):32280-7. Epub 2007 Sep 11.
2007
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| 14 | APPL1
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| APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function.
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| Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ-Roberts CY, Hong JY, Kim RY, Liu F, Dong LQ.
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| Nat Cell Biol 8(5):516-23. Epub 2006 Apr 16. Erratum in: Nat Cell Biol. 2006 Jun;8(6):642. 2006
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| 15 | APPL1, GIPC1, NTRK1
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| APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction.
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| Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, Miller FD, Kaplan DR.
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| Mol Cell Biol 26(23):8928-41. Epub 2006 Sep 25.
2006
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| 16 | SSNA1, APPL1, SPG4
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| Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon.
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| Errico A, Claudiani P, D'Addio M, Rugarli EI.
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| Hum Mol Genet 13(18):2121-32. Epub 2004 Jul 21. 2004
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| 17 | APPL1
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| APPL suppresses androgen receptor transactivation via potentiating Akt activity.
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| Yang L, Lin HK, Altuwaijri S, Xie S, Wang L, Chang C.
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| J Biol Chem 278(19):16820-7. Epub 2003 Mar 5. 2003
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| 18 | APPL1, DCC
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| Mediation of the DCC apoptotic signal by DIP13 alpha.
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| Liu J, Yao F, Wu R, Morgan M, Thorburn A, Finley RL Jr, Chen YQ.
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| J Biol Chem 277(29):26281-5. 2002
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| 19 | APPL1
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| Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
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| Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR.
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| Oncogene 18(35):4891-8 1999
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