| 1 | APPL1
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| APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes.
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| Jiang X, Zhou Y, Wu KK, Chen Z, Xu A, Cheng KK.
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| Diabetologia 60(3):464-474. doi: 10.1007/s00125-016-4185-z. Epub 2016 Dec 23.
2017
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| 2 | APPL1
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| APPL1-Mediating Leptin Signaling Contributes to Proliferation and Migration of Cancer Cells.
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| Ding Y, Cao Y, Wang B, Wang L, Zhang Y, Zhang D, Chen X, Li M, Wang C.
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| PLoS One 11(11):e0166172. doi: 10.1371/journal.pone.0166172. eCollection 2016.
2016
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| 3 | APPL1, PRKCZ
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| APPL1 promotes glucose uptake in response to mechanical stretch via the PKCζ-non-muscle myosin IIa pathway in C2C12 myotubes.
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| Saito T, Okada S, Shimoda Y, Tagaya Y, Osaki A, Yamada E, Shibusawa R, Nakajima Y, Ozawa A, Satoh T, Mori M, Yamada M.
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| Cell Signal 28(11):1694-702. doi: 10.1016/j.cellsig.2016.07.010. Epub 2016 Jul 28.
2016
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| 4 | APPL1, APPL2, TGFBR1
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| APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain.
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| Song J, Mu Y, Li C, Bergh A, Miaczynska M, Heldin CH, Landström M.
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| Oncotarget 7(1):279-92. doi: 10.18632/oncotarget.6346.
2016
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| 5 | APPL1
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| Loss-of-Function Mutations in APPL1 in Familial Diabetes Mellitus.
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| Prudente S, Jungtrakoon P, Marucci A, Ludovico O, Buranasupkajorn P, Mazza T, Hastings T, Milano T, Morini E, Mercuri L, Bailetti D, Mendonca C, Alberico F, Basile G, Romani M, Miccinilli E, Pizzuti A, Carella M, Barbetti F, Pascarella S, Marchetti P, Trischitta V, Di Paola R, Doria A.
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| Am J Hum Genet 97(1):177-85. doi: 10.1016/j.ajhg.2015.05.011. Epub 2015 Jun 11.
2015
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| 6 | APPL1, EEA1
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| APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments.
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| Kalaidzidis I, Miaczynska M, Brewińska-Olchowik M, Hupalowska A, Ferguson C, Parton RG, Kalaidzidis Y, Zerial M.
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| J Cell Biol 211(1):123-44. doi: 10.1083/jcb.201311117.
2015
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| 7 | APPL1
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| APPL1 acts as a protective factor against podocytes injury in high glucose environment.
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| Ji Z, Hu Z, Xu Y.
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| Int J Clin Exp Pathol 8(6):6764-71. eCollection 2015.
2015
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| 8 | APPL1, DVL2, JUN
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| APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription.
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| Banach-Orlowska M, Szymanska E, Miaczynska M.
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| FEBS Lett 589(4):532-9. doi: 10.1016/j.febslet.2015.01.022. Epub 2015 Jan 23.
2015
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| 9 | APPL1, INSR, IRS1, IRS2
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| APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor.
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| Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, White MF, Liu F, Dong LQ.
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| Cell Rep 7(4):1227-38. doi: 10.1016/j.celrep.2014.04.006. Epub 2014 May 10.
2014
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| 10 | APPL1, TRAF6
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| TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt.
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| Cheng KK, Lam KS, Wang Y, Wu D, Zhang M, Wang B, Li X, Hoo RL, Huang Z, Sweeney G, Xu A.
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| Biochem J 455(2):207-16. doi: 10.1042/BJ20130760.
2013
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| 11 | APPL1
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| APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction.
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| Park M, Wu D, Park T, Choi CS, Li RK, Cheng KK, Xu A, Sweeney G.
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| Am J Physiol Endocrinol Metab 305(7):E795-804. doi: 10.1152/ajpendo.00257.2013. Epub 2013 Aug 6.
2013
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| 12 | APPL1
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| Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function.
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| Wang C, Li X, Mu K, Li L, Wang S, Zhu Y, Zhang M, Ryu J, Xie Z, Shi D, Zhang WJ, Dong LQ, Jia W.
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| Diabetologia 56(9):1999-2009. doi: 10.1007/s00125-013-2971-4. Epub 2013 Jun 22.
2013
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| 13 | APPL1, TRAF2
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| APPL1 regulates basal NF-κB activity by stabilizing NIK.
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| Hupalowska A, Pyrzynska B, Miaczynska M.
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| J Cell Sci 125(Pt 17):4090-102. doi: 10.1242/jcs.105171. Epub 2012 Jun 8.
2012
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| 14 | APPL1
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| Phosphorylation of adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain, and leucine zipper motif 1 (APPL1) at Ser430 mediates endoplasmic reticulum (ER) stress-induced insulin resistance in hepatocytes.
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| Liu M, Zhou L, Wei L, Villarreal R, Yang X, Hu D, Riojas RA, Holmes BM, Langlais PR, Lee H, Dong LQ.
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| J Biol Chem 287(31):26087-93. doi: 10.1074/jbc.M112.372292. Epub 2012 Jun 8.
2012
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| 15 | APPL1
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| Dual functions of adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) in insulin signaling and insulin secretion.
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| Han W.
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| Proc Natl Acad Sci U S A 109(23):8795-6. doi: 10.1073/pnas.1206730109. Epub 2012 May 21. No abstract available.
2012
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| 16 | APPL1
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| The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.
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| Broussard JA, Lin WH, Majumdar D, Anderson B, Eason B, Brown CM, Webb DJ.
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| Mol Biol Cell 23(8):1486-99. doi: 10.1091/mbc.E11-02-0124. Epub 2012 Feb 29.
2012
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| 17 | APPL1
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| APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice.
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| Cheng KK, Lam KS, Wu D, Wang Y, Sweeney G, Hoo RL, Zhang J, Xu A.
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| Proc Natl Acad Sci U S A 109(23):8919-24. doi: 10.1073/pnas.1202435109. Epub 2012 May 7.
2012
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| 18 | APPL1, APPL2
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| Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment.
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| Urbanska A, Sadowski L, Kalaidzidis Y, Miaczynska M.
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| Traffic 12(9):1227-41. doi: 10.1111/j.1600-0854.2011.01226.x. Epub 2011 Jul 3.
2011
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| 19 | APPL1
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| Recruitment of APPL1 to ubiquitin-rich aggresomes in response to proteasomal impairment.
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| Pilecka I, Sadowski L, Kalaidzidis Y, Miaczynska M.
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| Exp Cell Res 317(8):1093-107. doi: 10.1016/j.yexcr.2011.02.002. Epub 2011 Feb 19.
2011
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| 20 | APPL1, EGFR
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| Adaptor protein containing PH domain, PTB domain and leucine zipper (APPL1) regulates the protein level of EGFR by modulating its trafficking.
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| Lee JR, Hahn HS, Kim YH, Nguyen HH, Yang JM, Kang JS, Hahn MJ.
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| Biochem Biophys Res Commun 415(1):206-11. doi: 10.1016/j.bbrc.2011.10.064. Epub 2011 Oct 19. 2011
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| 21 | APPL1, BOC, CDON
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| Cdo interacts with APPL1 and activates Akt in myoblast differentiation.
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| Bae GU, Lee JR, Kim BG, Han JW, Leem YE, Lee HJ, Ho SM, Hahn MJ, Kang JS.
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| Mol Biol Cell 21(14):2399-411. Epub 2010 May 19.
2010
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| 22 | APPL1, HDAC1
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| Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex.
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| Banach-Orlowska M, Pilecka I, Torun A, Pyrzynska B, Miaczynska M.
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| Biochem J 423(3):389-400.
2009
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| 23 | APPL1, APPL2
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| Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription.
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| Rashid S, Pilecka I, Torun A, Olchowik M, Bielinska B, Miaczynska M.
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| J Biol Chem 284(27):18115-28. Epub 2009 May 11.
2009
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| 24 | APPL1, AKT1
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| The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.
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| Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M.
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| Cell 133(3):486-97. 2008
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| 25 | APPL1, APPL2
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| Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides.
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| Chial HJ, Wu R, Ustach CV, McPhail LC, Mobley WC, Chen YQ.
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| Traffic 9(2):215-29. Epub 2007 Dec 18. Erratum in: Traffic. 2008 Apr;9(4):623-4.
2008
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| 26 | APPL1
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| The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation.
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| Saito T, Jones CC, Huang S, Czech MP, Pilch PF.
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| J Biol Chem 282(44):32280-7. Epub 2007 Sep 11.
2007
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| 27 | APPL1
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| APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function.
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| Mao X, Kikani CK, Riojas RA, Langlais P, Wang L, Ramos FJ, Fang Q, Christ-Roberts CY, Hong JY, Kim RY, Liu F, Dong LQ.
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| Nat Cell Biol 8(5):516-23. Epub 2006 Apr 16. Erratum in: Nat Cell Biol. 2006 Jun;8(6):642. 2006
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| 28 | APPL1, GIPC1, NTRK1
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| APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction.
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| Lin DC, Quevedo C, Brewer NE, Bell A, Testa JR, Grimes ML, Miller FD, Kaplan DR.
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| Mol Cell Biol 26(23):8928-41. Epub 2006 Sep 25.
2006
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| 29 | SSNA1, APPL1, SPG4
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| Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon.
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| Errico A, Claudiani P, D'Addio M, Rugarli EI.
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| Hum Mol Genet 13(18):2121-32. Epub 2004 Jul 21. 2004
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| 30 | APPL1
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| APPL suppresses androgen receptor transactivation via potentiating Akt activity.
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| Yang L, Lin HK, Altuwaijri S, Xie S, Wang L, Chang C.
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| J Biol Chem 278(19):16820-7. Epub 2003 Mar 5. 2003
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| 31 | APPL1, DCC
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| Mediation of the DCC apoptotic signal by DIP13 alpha.
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| Liu J, Yao F, Wu R, Morgan M, Thorburn A, Finley RL Jr, Chen YQ.
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| J Biol Chem 277(29):26281-5. 2002
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| 32 | APPL1
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| Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2.
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| Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR.
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| Oncogene 18(35):4891-8 1999
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