| 1 | AP2S1, APP
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| AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice
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| Wen QX, Luo B, Xie XY, Zhou GF, Chen J, Song L, Liu Y, Xie SQ, Chen L, Li KY, Xiang XJ, Chen GJ.
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| Traffic. Jan;24(1):20-33. doi: 10.1111/tra.12874. Epub 2022 Dec 13. 2023
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| 2 | APP, GKN1
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| Role of human GKN1 on APP processing in gastric cancer.
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| Di Stadio CS, Altieri F, Minopoli G, Miselli G, Rippa E, Arcari P.
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| Biochimie Apr;135:149-153. doi: 10.1016/j.biochi.2017.02.007. Epub 2017 Feb 16 2017
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| 3 | APP, EPHA4, SORL1
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| SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.
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| Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H.
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| J Exp Med. Dec 4;214(12):3669-3685. doi: 10.1084/jem.20171413. Epub 2017 Nov 7 2017
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| 4 | APP, PIKFYVE
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| The amyloid precursor protein (APP) binds the PIKfyve complex and modulates its function.
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| Currinn H, Wassmer T.
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| Biochem Soc Trans 44(1):185-90. doi: 10.1042/BST20150179. Review. 2016
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| 5 | APP, PIKFYVE
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| APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex.
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| Currinn H, Guscott B, Balklava Z, Rothnie A, Wassmer T.
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| Cell Mol Life Sci 73(2):393-408. doi: 10.1007/s00018-015-1993-0. Epub 2015 Jul 28. 2016
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| 6 | APOE, APP
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| Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis.
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| Mattsson N, Insel PS, Palmqvist S, Stomrud E, van Westen D, Minthon L, Zetterberg H, Blennow K, Hansson O.
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| Nat Commun 7:10918. doi: 10.1038/ncomms10918.
2016
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| 7 | APP, BACE1, EGR1
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| Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of β-Secretase 1 (BACE-1) in the Brain.
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| Qin X, Wang Y, Paudel HK.
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| J Biol Chem 291(42):22276-22287. Epub 2016 Aug 30.
2016
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| 8 | APP, BACE1, SEPTiN8
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| SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
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| Kurkinen KM, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, Sarajärvi T, Gabbouj S, Kurki M, Paananen J, Koivisto AM, Rauramaa T, Leinonen V, Tanila H, Soininen H, Lucas FR, Haapasalo A, Hiltunen M.
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| J Cell Sci 129(11):2224-38. doi: 10.1242/jcs.185215. Epub 2016 Apr 15.
2016
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| 9 | ADAM10, APP, FRAXA
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| Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.
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| Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, Bagni C.
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| Neuron 87(2):382-98. doi: 10.1016/j.neuron.2015.06.032.
2015
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| 10 | APP, PIKFYVE
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| The Amyloid Precursor Protein Controls PIKfyve Function.
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| Balklava Z, Niehage C, Currinn H, Mellor L, Guscott B, Poulin G, Hoflack B, Wassmer T.
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| PLoS One 10(6):e0130485. doi: 10.1371/journal.pone.0130485. eCollection 2015. 2015
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| 11 | APP, SCN8A
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| Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.
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| Liu C, Tan FC, Xiao ZC, Dawe GS.
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| J Biol Chem 290(19):12048-57. doi: 10.1074/jbc.M114.617092. Epub 2015 Mar 12.
2015
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| 12 | APP, WASF1
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| APP intracellular domain-WAVE1 pathway reduces amyloid-β production.
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| Ceglia I, Reitz C, Gresack J, Ahn JH, Bustos V, Bleck M, Zhang X, Martin G, Simon SM, Nairn AC, Greengard P, Kim Y.
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| Nat Med 21(9):1054-9. doi: 10.1038/nm.3924. Epub 2015 Aug 17.
2015
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| 13 | APMAP, APP
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| The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain
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| Mosser S, Alattia JR, Dimitrov M, Matz A, Pascual J, Schneider BL, Fraering PC.
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| Hum Mol Genet. Jan 15;24(2):371-82. doi: 10.1093/hmg/ddu449. Epub 2014 Sep 1. 2015
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| 14 | APP, CTSB
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| Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition.
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| Cecarini V, Bonfili L, Cuccioloni M, Mozzicafreddo M, Rossi G, Keller JN, Angeletti M, Eleuteri AM.
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| Biochim Biophys Acta 1842(2):127-34. doi: 10.1016/j.bbadis.2013.11.002. Epub 2013 Nov 8.
2014
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| 15 | APP, MAP1LC3B, OPTN
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| Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome.
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| Cho MH, Cho K, Kang HJ, Jeon EY, Kim HS, Kwon HJ, Kim HM, Kim DH, Yoon SY.
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| Autophagy 10(10):1761-75. doi: 10.4161/auto.29647. Epub 2014 Jul 22.
2014
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| 16 | APP, NEUROG2
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| Neurogenin 2 mediates amyloid-β precursor protein-stimulated neurogenesis.
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| Bolós M, Hu Y, Young KM, Foa L, Small DH.
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| J Biol Chem 289(45):31253-61. doi: 10.1074/jbc.M114.581918. Epub 2014 Sep 12.
2014
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| 17 | APP, GRIA2
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| Synapto-depressive effects of amyloid beta require PICK1.
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| Alfonso S, Kessels HW, Banos CC, Chan TR, Lin ET, Kumaravel G, Scannevin RH, Rhodes KJ, Huganir R, Guckian KM, Dunah AW, Malinow R.
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| Eur J Neurosci 39(7):1225-33. doi: 10.1111/ejn.12499.
2014
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| 18 | APOE, APP
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| ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.
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| Verghese PB, Castellano JM, Garai K, Wang Y, Jiang H, Shah A, Bu G, Frieden C, Holtzman DM.
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| Proc Natl Acad Sci U S A 110(19):E1807-16. doi: 10.1073/pnas.1220484110. Epub 2013 Apr 25.
2013
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| 19 | APBB1, APP, GULP1, LRP1
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| Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).
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| Wahler A, Beyer AS, Keller IE, Schnack C, von Einem B, Pröpper C, Boeckers TM, Peltan ID, Strickland DK, Hyman BT, von Arnim CA.
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| Biochem J 450(2):333-43. doi: 10.1042/BJ20121100.
2013
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| 20 | ADAP1, APP, ELK1
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| Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction.
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| Szatmari EM, Oliveira AF, Sumner EJ, Yasuda R.
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| J Neurosci 33(12):5367-74. doi: 10.1523/JNEUROSCI.2641-12.2013. 2013
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| 21 | APP, BACE1, LRRTM3
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| LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD)
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| Lincoln S, Allen M, Cox CL, Walker LP, Malphrus K, Qiu Y, Nguyen T, Rowley C, Kouri N, Crook J, Pankratz VS, Younkin S, Younkin L, Carrasquillo M, Zou F, Abdul-Hay SO, Springer W, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Lewis JM, Dickson D, Graff-Radford NR, Petersen RC, Eckman E, Younkin SG, Ertekin-Taner N
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| PLoS One. Jun 4;8(6):e64164. doi: 10.1371/journal.pone.0064164. 2013
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| 22 | APOE, APP
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| Neurotoxicity of amyloid β-protein: synaptic and network dysfunction.
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| Mucke L, Selkoe DJ.
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| Cold Spring Harb Perspect Med 2(7):a006338. doi: 10.1101/cshperspect.a006338. Review.
2012
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| 23 | APOE, APP
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| Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.
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| Li J, Kanekiyo T, Shinohara M, Zhang Y, LaDu MJ, Xu H, Bu G.
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| J Biol Chem 287(53):44593-601. doi: 10.1074/jbc.M112.420224. Epub 2012 Nov 6.
2012
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| 24 | AOPOE, APP
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| Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.
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| Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT.
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| J Neurosci 32(43):15181-92. doi: 10.1523/JNEUROSCI.1542-12.2012.
2012
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| 25 | APOE, APP
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| Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels.
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| Lee CY, Tse W, Smith JD, Landreth GE.
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| J Biol Chem 287(3):2032-44. doi: 10.1074/jbc.M111.295451. Epub 2011 Nov 30.
2012
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| 26 | APP, CLSTN1
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| Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production.
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| Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC.
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| Hum Mol Genet 21(13):2845-54. doi: 10.1093/hmg/dds109. Epub 2012 Mar 20.
2012
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| 27 | APP, CLSTN1
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| Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.
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| Steuble M, Diep TM, Schätzle P, Ludwig A, Tagaya M, Kunz B, Sonderegger P.
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| Biol Open 1(8):761-74. doi: 10.1242/bio.20121578. Epub 2012 Jun 27.
2012
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| 28 | APP
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| A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.
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| Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jönsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K.
|
| Nature 488(7409):96-9. doi: 10.1038/nature11283.
2012
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| 29 | APP, BACE1, NFATC3
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| Aβ-induced Ca(2+) influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals.
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| Jin SM, Cho HJ, Kim YW, Hwang JY, Mook-Jung I.
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| Biochem Biophys Res Commun 425(3):649-55. doi: 10.1016/j.bbrc.2012.07.123. Epub 2012 Jul 27.
2012
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| 30 | APP, UBQLN1
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| Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.
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| El Ayadi A, Stieren ES, Barral JM, Boehning D.
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| Proc Natl Acad Sci U S A 109(33):13416-21. doi: 10.1073/pnas.1206786109. Epub 2012 Jul 30.
2012
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| 31 | APP, HAP1
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| Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.
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| Yang GZ, Yang M, Lim Y, Lu JJ, Wang TH, Qi JG, Zhong JH, Zhou XF.
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| J Neurochem 122(5):1010-22. doi: 10.1111/j.1471-4159.2012.07845.x.
2012
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| 32 | APP, PTCH1, SHH, TRI21
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| APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.
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| Trazzi S, Mitrugno VM, Valli E, Fuchs C, Rizzi S, Guidi S, Perini G, Bartesaghi R, Ciani E.
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| Hum Mol Genet 20(8):1560-73. Epub 2011 Jan 25.
2011
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| 33 | APP, CD36
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| Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta.
|
| Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti ML, Younkin L, Younkin SG, Van Nostrand WE, Cho S, Anrather J, Carlson GA, Iadecola C.
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| Proc Natl Acad Sci U S A 108(12):5063-8. Epub 2011 Mar 7.
2011
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| 34 | APP, GAS1
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| Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor protein.
|
| Chapuis J, Vingtdeux V, Campagne F, Davies P, Marambaud P.
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| Hum Mol Genet 20(10):2026-36. Epub 2011 Feb 28.
2011
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| 35 | APP, GULP1
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| GULP1 is a novel APP-interacting protein that alters APP processing.
|
| Hao Y, Perkinton MS, Chan WW, Chan HY, Miller CC, Lau KF.
|
| Biochem J 436(3):631-9. Erratum in: Biochem J. 2011 Aug 1;437(3):576. Hao, Candy Yan [corrected to Hao, Yan].
2011
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| 36 | APP, NLGN1
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| The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. Is there a role in Alzheimer's disease?
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| Dinamarca MC, Weinstein D, Monasterio O, Inestrosa NC.
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| Biochemistry 50(38):8127-37. Epub 2011 Sep 1.
2011
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| 37 | APP, CDH2
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| N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.
|
| Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A.
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| J Neurochem 119(2):354-63. doi: 10.1111/j.1471-4159.2011.07364.x. Epub 2011 Sep 20.
2011
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| 38 | APBB1, APP, LRP1
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| Phosphorylation of LRP1 regulates the interaction with Fe65.
|
| Klug W, Dietl A, Simon B, Sinning I, Wild K.
|
| FEBS Lett 585(20):3229-35. doi: 10.1016/j.febslet.2011.09.028. Epub 2011 Sep 29.
2011
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| 39 | APP, NTRK1
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| APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.
|
| Matrone C, Barbagallo AP, La Rosa LR, Florenzano F, Ciotti MT, Mercanti D, Chao MV, Calissano P, D'Adamio L.
|
| J Neurosci 31(33):11756-61. doi: 10.1523/JNEUROSCI.1960-11.2011.
2011
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| 40 | APP, TFRC
|
| Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
|
| Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI.
|
| Cell 142(6):857-67. 2010
|
| 41 | APBB1, APP, LRP2
|
| Megalin interacts with APP and the intracellular adapter protein FE65 in neurons.
|
| Alvira-Botero X, Pérez-Gonzalez R, Spuch C, Vargas T, Antequera D, Garzón M, Bermejo-Pareja F, Carro E.
|
| Mol Cell Neurosci 45(3):306-15. Epub 2010 Jul 14.
2010
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| 42 | APP, NSG1
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| Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.
|
| Norstrom EM, Zhang C, Tanzi R, Sisodia SS.
|
| J Neurosci 30(46):15677-85. doi: 10.1523/JNEUROSCI.4464-10.2010.
2010
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| 43 | APP, iAPP
|
| Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction.
|
| Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, Guilhaus M, Ittner LM, Eckert A, Götz J.
|
| Proteomics 10(8):1621-33. doi: 10.1002/pmic.200900651.
2010
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| 44 | AD1, APP
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| A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.
|
| Di Fede G, Catania M, Morbin M, Rossi G, Suardi S, Mazzoleni G, Merlin M, Giovagnoli AR, Prioni S, Erbetta A, Falcone C, Gobbi M, Colombo L, Bastone A, Beeg M, Manzoni C, Francescucci B, Spagnoli A, Cantù L, Del Favero E, Levy E, Salmona M, Tagliavini F.
|
| Science 323(5920):1473-7. 2009
|
| 45 | APP, IGF2R, PACS1, SORCS1, SORCS2, SORCS3, SORL1, SORT1
|
| VPS10P-domain receptors - regulators of neuronal viability and function.
|
| Willnow TE, Petersen CM, Nykjaer A.
|
| Nat Rev Neurosci. 9(12):899-909. 2009
|
| 46 | APP
|
| APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
|
| Nikolaev A, McLaughlin T, O'Leary DD, Tessier-Lavigne M.
|
| Nature 457(7232):981-9. 2009
|
| 47 | APP
|
| Selective vulnerability in Alzheimer's disease: amyloid precursor protein and p75-NTR interaction.
|
| Fombonne, J.; Rabizadeh, S.; Banwait, S.; Mehlen, P.; Bredesen, D. E.
|
| Ann. Neurol. 65: 294-303 2009
|
| 48 | APBB1, APP, CNTN2
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| A TAG1-APP signalling pathway through Fe65 negatively modulates neurogenesis.
|
| Ma QH, Futagawa T, Yang WL, Jiang XD, Zeng L, Takeda Y, Xu RX, Bagnard D, Schachner M, Furley AJ, Karagogeos D, Watanabe K, Dawe GS, Xiao ZC.
|
| Nat Cell Biol 10(3):283-94. Epub 2008 Feb 17. Erratum in: Nat Cell Biol. 2008 Apr;10(4):497.
2008
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| 49 | AD1, AD2, AD24, AD3, AD4, APOE, APP, PSEN1, PSEN2
|
| Genome-wide association studies in Alzheimer disease.
|
| Waring SC, Rosenberg RN.
|
| Arch Neurol 65(3):329-34. Review. 2008
|
| 50 | APP, BACE1, BACE2
|
| Protein expression of BACE1, BACE2 and APP in Down syndrome brains.
|
| Cheon MS, Dierssen M, Kim SH, Lubec G.
|
| Amino Acids 35(2):339-43. Epub 2007 Dec 29.
2008
|
| 51 | APP, CCR2
|
| Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.
|
| El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD.
|
| Nat Med 13(4):432-8. Epub 2007 Mar 11. 2007
|
| 52 | APP
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| Variations in the APP gene promoter region and risk of Alzheimer disease.
|
| Guyant-Maréchal L, Rovelet-Lecrux A, Goumidi L, Cousin E, Hannequin D, Raux G, Penet C, Ricard S, Macé S, Amouyel P, Deleuze JF, Frebourg T, Brice A, Lambert JC, Campion D.
|
| Neurology 68(9):684-7.
2007
|
| 53 | APP, MME
|
| Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.
|
| Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ.
|
| Am J Pathol 171(1):241-51.
2007
|
| 54 | APP
|
| Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease.
|
| Theuns J, Brouwers N, Engelborghs S, Sleegers K, Bogaerts V, Corsmit E, De Pooter T, van Duijn CM, De Deyn PP, Van Broeckhoven C.
|
| Am J Hum Genet 78(6):936-46. Epub 2006 Apr 10. 2006
|
| 55 | APP, AD1
|
| APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.
|
| Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, Vital A, Dumanchin C, Feuillette S, Brice A, Vercelletto M, Dubas F, Frebourg T, Campion D.
|
| Nat Genet 38(1):24-6. Epub 2005 Dec 20. 2006
|
| 56 | UBE3A, SUMO1, APP
|
| Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processes.
|
| Baron CA, Tepper CG, Liu SY, Davis RR, Wang NJ, Schanen NC, Gregg JP.
|
| Hum Mol Genet 15(6):853-69. Epub 2006 Jan 30. 2006
|
| 57 | APP, AD1
|
| Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment.
|
| Theuns J, Marjaux E, Vandenbulcke M, Van Laere K, Kumar-Singh S, Bormans G, Brouwers N, Van den Broeck M, Vennekens K, Corsmit E, Cruts M, De Strooper B, Van Broeckhoven C, Vandenberghe R.
|
| Hum Mutat 27(9):888-96. 2006
|
| 58 | AD1,APP
|
| APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy.
|
| Sleegers K, Brouwers N, Gijselinck I, Theuns J, Goossens D, Wauters J, Del-Favero J, Cruts M, van Duijn CM, Van Broeckhoven C.
|
| Brain 129(Pt 11):2977-83. Epub 2006 Aug 18. 2006
|
| 59 | AD1,APP
|
| Phenotype associated with APP duplication in five families.
|
| Cabrejo L, Guyant-Marechal L, Laquerriere A, Vercelletto M, De la Fourniere F, Thomas-Anterion C, Verny C, Letournel F, Pasquier F, Vital A, Checler F, Frebourg T, Campion D, Hannequin D.
|
| Brain 129(Pt 11):2966-76. Epub 2006 Sep 7. 2006
|
| 60 | APP,CRYAB
|
| alphaB-crystallin competes with Alzheimer's disease beta-amyloid peptide for peptide-peptide interactions and induces oxidation of Abeta-Met35.
|
| Narayanan S, Kamps B, Boelens WC, Reif B.
|
| FEBS Lett 580(25):5941-6. Epub 2006 Oct 5. 2006
|
| 61 | APP, MAPT
|
| Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease.
|
| Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease.
|
| Proc Natl Acad Sci U S A. 103(6):1953-8. 2006
|
| 62 | APP, SORL1
|
| Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
|
| Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, McKinstry WJ, Parker MW, Masters CL, Hyman BT, Cappai R, Willnow TE.
|
| Biochemistry. 45(8):2618-28. 2006
|
| 63 | APP
|
| A specific amyloid-beta protein assembly in the brain impairs memory.
|
| Lesne, S.; Koh, M. T.; Kotilinek, L.; Kayed, R.; Glabe, C. G.; Yang, A.; Gallagher, M.; Ashe, K. H.
|
| Nature 440: 352-357 2006
|
| 64 | APP
|
| NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease.
|
| Colton CA, Vitek MP, Wink DA, Xu Q, Cantillana V, Previti ML, Van Nostrand WE, Weinberg JB, Dawson H.
|
| Proc Natl Acad Sci U S A. 103(34):12867-72. 2006
|
| 65 | APP
|
| The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
|
| Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP.
|
| Nature 440(7083):528-34 2006
|
| 66 | AD1, AD24, AD3, APP, PSEN1
|
| Molecular diagnosis of autosomal dominant early onset Alzheimer's disease: an update.
|
| Raux G, Guyant-Marechal L, Martin C, Bou J, Penet C, Brice A, Hannequin D, Frebourg T, Campion D.
|
| J Med Genet 42(10):793-5. Epub 2005 Jul 20. 2005
|
| 67 | APP, APLP2
|
| Protease nexin-2/amyloid beta-protein precursor limits cerebral thrombosis.
|
| Xu F, Davis J, Miao J, Previti ML, Romanov G, Ziegler K, Van Nostrand WE.
|
| Proc Natl Acad Sci U S A 102(50):18135-40. Epub 2005 Dec 5. 2005
|
| 68 | COL25A1, APP
|
| Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site.
|
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| J Biol Chem 280(2):1007-15. Epub 2004 Nov 1. 2005
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| 69 | APP, HCHWAD
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| A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy.
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| Obici L, Demarchi A, de Rosa G, Bellotti V, Marciano S, Donadei S, Arbustini E, Palladini G, Diegoli M, Genovese E, Ferrari G, Coverlizza S, Merlini G.
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| Ann Neurol 58(4):639-44.
2005
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| 70 | APP
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| Homo- and heterodimerization of APP family members promotes intercellular adhesion.
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| Soba P, Eggert S, Wagner K, Zentgraf H, Siehl K, Kreger S, Löwer A, Langer A, Merdes G, Paro R, Masters CL, Müller U, Kins S, Beyreuther K.
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| EMBO J. 24(20):3624-34. 2005
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| 71 | APP
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| The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice.
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| LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G.
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| Nat Genet. 9(1):21-30. 2005
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| 72 | APP
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| Brain estrogen deficiency accelerates A-beta plaque formation in an Alzheimer's disease animal model.
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| Yue, X.; Lu, M.; Lancaster, T.; Cao, P.; Honda, S.-I.; Staufenbiel, M.; Harada, N.; Zhong, Z.; Shen, Y.; Li, R.
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| Proc. Nat. Acad. Sci. 102: 19198-19203 2005
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| 73 | APP
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| Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin.
|
| Grimm, M. O. W.; Grimm, H. S.; Patzold, A. J.; Zinser, E. G.; Halonen, R.; Duering, M.; Tschape, J.-A.; De Strooper, B.; Muller, U.; Shen, J.; Hartmann, T.
|
| Nature Cell Biol. 7: 1118-1123 2005
|
| 74 | APP
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| Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue.
|
| Kaneko I, Yamada N, Sakuraba Y, Kamenosono M, Tutumi S.
|
| J Neurochem. 68(1):437-9. 2005
|
| 75 | APP, HCHWAD
|
| Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.
|
| Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman ML, Staufenbiel M, Mathews PM, Jucker M.
|
| Nat Neurosci 7(9):954-60. Epub 2004 Aug 15.
2004
|
| 76 | APP
|
| The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.
|
| Cam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Li Y, Bu G.
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| J Biol Chem. 279(28):29639-46. 2004
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| 77 | APP
|
| Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage.
|
| Ho A, Südhof TC.
|
| Proc Natl Acad Sci U S A. 101(8):2548-53. 2004
|
| 78 | APP
|
| Alzheimer's disease-associated amyloid beta interacts with the human serine protease HtrA2/Omi.
|
| Park HJ, Seong YM, Choi JY, Kang S, Rhim H.
|
| Neurosci Lett. 357(1):63-7. 2004
|
| 79 | APP
|
| Dissecting the pathological effects of human A-beta-40 and A-beta-42 in Drosophila: a potential model for Alzheimer's disease.
|
| Iijima, K.; Liu, H.-P.; Chiang, A.-S.; Hearn, S. A.; Konsolaki, M.; Zhong, Y.
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| Proc Natl Acad Sci U S A. 101: 6623-6628, 2004. 2004
|
| 80 | APP
|
| Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression.
|
| Krezowski, J.; Knudson, D.; Ebeling, C.; Pitstick, R.; Giri, R. K.; Schenk, D.; Westaway, D.; Younkin, L.; Younkin, S. G.; Ashe, K. H.; Carlson, G. A.
|
| Hum. Molec. Genet. 13: 1989-1997 2004
|
| 81 | APP
|
| Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease.
|
| Reddy PH, McWeeney S, Park BS, Manczak M, Gutala RV, Partovi D, Jung Y, Yau V, Searles R, Mori M, Quinn J.
|
| Hum. Molec. Genet. 13(12):1225-40. 2004
|
| 82 | APP
|
| A phosphorylated, carboxy-terminal fragment of beta-amyloid precursor protein localizes to the splicing factor compartment.
|
| Muresan Z, Muresan V.
|
| Hum Mol Genet. 13(5):475-88. 2004
|
| 83 | APP
|
| Platelet amyloid precursor protein abnormalities in mild cognitive impairment predict conversion to dementia of Alzheimer type: a 2-year follow-up study.
|
| Borroni B, Colciaghi F, Caltagirone C, Rozzini L, Broglio L, Cattabeni F, Di Luca M, Padovani A.
|
| Arch Neurol 60(12):1740-4. 2003
|
| 84 | MMP2, APP
|
| Identification of a region of beta-amyloid precursor protein essential for its gelatinase A inhibitory activity.
|
| Higashi S, Miyazaki K.
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| J Biol Chem 278(16):14020-8. Epub 2003 Feb 13. 2003
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| 85 | APP
|
| Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639.
|
| Tang K, Wang C, Shen C, Sheng S, Ravid R, Jing N.
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| Eur J Neurosci 18(1):102-8. 2003
|
| 86 | NCSTN, APP, PSEN1
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| Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane.
|
| Pasternak SH, Bagshaw RD, Guiral M, Zhang S, Ackerley CA, Pak BJ, Callahan JW, Mahuran DJ.
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| J Biol Chem 278(29):26687-94. Epub 2003 May 7. 2003
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| 87 | ETS2, APP
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| The chromosome 21 transcription factor ETS2 transactivates the beta-APP promoter: implications for Down syndrome.
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| Wolvetang EW, Bradfield OM, Tymms M, Zavarsek S, Hatzistavrou T, Kola I, Hertzog PJ.
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| Biochim Biophys Acta 1628(2):105-10. 2003
|
| 88 | APP, TGFB1
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| A direct interaction between transforming growth factor (TGF)-betas and amyloid-beta protein affects fibrillogenesis in a TGF-beta receptor-independent manner.
|
| Mousseau DD, Chapelsky S, De Crescenzo G, Kirkitadze MD, Magoon J, Inoue S, Teplow DB, O'Connor-McCourt MD.
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| J Biol Chem. 278(40):38715-22. 2003
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| 89 | APBB2, APBB3, APP
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| Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.
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| Chang Y, Tesco G, Jeong WJ, Lindsley L, Eckman EA, Eckman CB, Tanzi RE, Guénette SY.
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| J Biol Chem 278(51):51100-7. Epub 2003 Oct 3. 2003
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| 90 | APP, LRP1
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| Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.
|
| Mettenburg JM, Webb DJ, Gonias SL.
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| J Biol Chem 277(15):13338-45. 2002
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| 91 | APP, SHC3
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| Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
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| Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L.
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| J Biol Chem 277(19):16798-804. Epub 2002 Mar 04. 2002
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| 92 | APP
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| Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide.
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| Cottingham MG, Hollinshead MS, Vaux DJ.
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| Biochemistry. 41(46):13539-47. 2002
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| 93 | APP
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| Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.
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| Russo C, Dolcini V, Salis S, Venezia V, Violani E, Carlo P, Zambrano N, Russo T, Schettini G.
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| Ann N Y Acad Sci. 973:323-33. 2002
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| 94 | APP
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| Evidence for binding of the ectodomain of amyloid precursor protein 695 and activated high molecular weight kininogen.
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| Das A, Smalheiser NR, Markaryan A, Kaplan A.
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| Biochim Biophys Acta. 1571(3):225-38. 2002
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| 95 | APP
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| Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).
|
| Scheinfeld MH, Roncarati R, Vito P, Lopez PA, Abdallah M, D'Adamio L.
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| J Biol Chem. 277(5):3767-75 2002
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| 96 | APP
|
| The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.
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| Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L.
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| Proc Natl Acad Sci U S A. 99(10):7102-7. 2002
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| 97 | APP
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| Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha-7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins.
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| Dineley, K. T.; Xia, X.; Bui, D.; Sweatt, J. D.; Zheng, H.
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| J. Biol. Chem. 277: 22768-22780 2002
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| 98 | APP
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| Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism.
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| Taru, H.; Kirino, Y.; Suzuki, T.
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| J. Biol. Chem. 277: 27567-27574 2002
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| 99 | APP, PSEN1, PSEN2
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| Presenilin, Notch, and the genesis and treatment of Alzheimer's disease.
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| Selkoe DJ.
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| Proc Natl Acad Sci U S A 98(20):11039-41. 2001
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| 100 | APP, NAE1
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| A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60.
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| Cao X, Sudhof TC.
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| Science 293(5527):115-20. 2001
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| 101 | APP, TM2D2, TM2D3
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| beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module.
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| Kajkowski EM, Lo CF, Ning X, Walker S, Sofia HJ, Wang W, Edris W, ChandaP, Wagner E, Vile S, Ryan K, McHendry-Rinde B, Smith SC, Wood A, Rhodes KJ,Kennedy JD, Bard J, Jacobsen JS, Ozenberger BA.
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| J Biol Chem 276(22):18748-56. Epub 2001 Feb 20. 2001
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| 102 | APP, HCHWAD
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| Dementia in hereditary cerebral hemorrhage with amyloidosis-Dutch type is associated with cerebral amyloid angiopathy but is independent of plaques and neurofibrillary tangles.
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| Natté R, Maat-Schieman ML, Haan J, Bornebroek M, Roos RA, van Duinen SG.
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| Ann Neurol 50(6):765-72.
2001
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| 103 | ABL1, APP
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| The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene.
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| Zambrano N, Bruni P, Minopoli G, Mosca R, Molino D, Russo C, Schettini G, Sudol M, Russo T.
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| J Biol Chem. 276(23):19787-92. 2001
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| 104 | APP, CALR
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| Calreticulin functions as a molecular chaperone for the beta-amyloid precursor protein.
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| Johnson RJ, Xiao G, Shanmugaratnam J, Fine RE.
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| Neurobiol Aging. 22(3):387-95. 2001
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| 105 | APP
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| Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function.
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| Ohsawa I, Takamura C, Kohsaka S.
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| J Neurochem. 76(5):1411-20. 2001
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| 106 | APP
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| Entactin-induced inhibition of human amyloid beta-protein fibril formation in vitro.
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| Kiuchi Y, Isobe Y, Fukushima K.
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| Neurosci Lett. 305(2):119-22. 2001
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| 107 | APP
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| Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP
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| Lewis, J.; Dickson, D. W.; Lin, W.-L.; Chisholm, L.; Corral, A.; Jones, G.; Yen, S.-H.; Sahara, N.; Skipper, L.; Yager, D.; Eckman, C.; Hardy, J.; Hutton, M.; McGowan, E.
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| Science 293: 1487-1491 2001
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| 108 | APP
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| Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP.
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| Kamal A, Almenar-Queralt A, LeBlanc JF, Roberts EA, Goldstein LS.
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| Nature 414(6864):643-8 2001
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| 109 | APP
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| A transcriptionally active complex of APP with Fe65 and histone acetyltransferase Tip60.
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| Cao, X.; Sudhof, T. C.
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| Science 293: 115-120 2001
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| 110 | APP, PRNP, PSEN1, PSEN2
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| High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes.
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| Finckh U, Muller-Thomsen T, Mann U, Eggers C, Marksteiner J, Meins W, Binetti G, Alberici A, Hock C, Nitsch RM, Gal A.
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| Am J Hum Genet 66(1):110-7. 2000
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| 111 | APP
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| Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
|
| Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Lofgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C.
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| Hum Mol Genet 9(18):2589-98. 2000
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| 112 | APP, NCSTN, PSEN1
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| Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
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| Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P.
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| Nature 407(6800):48-54. 2000
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| 113 | APP, KLC1
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| Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.
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| Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS.
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| Neuron. 28(2):449-59. 2000
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| 114 | APP
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| Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.
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| Lefterov IM, Koldamova RP, Lazo JS.
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| FASEB J. 14(12):1837-47. 2000
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| 115 | APP, PSEN1
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| Inhibiting amyloid precursor protein C-terminal cleavage promotes an interaction with presenilin 1.
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| Verdile G, Martins RN, Duthie M, Holmes E, St George-Hyslop PH, Fraser PE.
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| J Biol Chem. 275(27):20794-8. 2000
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| 116 | APP, CHRNA7
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| beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.
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| Wang HY, Lee DH, D'Andrea MR, Peterson PA, Shank RP, Reitz AB.
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| J Biol Chem. 275(8):5626-32. 2000
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| 117 | APP
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| Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
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| Takahashi M, Doré S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim SH, Thinakaran G, Sisodia SS, Snyder SH.
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| Neuron. 28(2):461-73. 2000
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| 118 | APP, AD1
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| Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new val-715 --> met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.
|
| Ancolio K, et al.
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| Proc Natl Acad Sci U S A 96(7):4119-24. 1999
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| 119 | APBA2, APP
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| Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.
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| Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T.
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| J Biol Chem 274(4):2243-54. 1999
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| 120 | APBA3, APP
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| X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein.
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| Tanahashi H, Tabira T.
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| Biochem Biophys Res Commun 255(3):663-7. 1999
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| 121 | AD1, APP
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| Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter.
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| Querfurth HW, et al.
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| Gene 232(1):125-41. 1999
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| 122 | APBB3, APP
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| Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.
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| Tanahashi H, Tabira T.
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| Neurosci Lett 261(3):143-6. 1999
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| 123 | APP
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| Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.
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| Homayouni R, Rice DS, Sheldon M, Curran T.
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| J Neurosci. 19(17):7507-15. 1999
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| 124 | APP
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| Binding of gelsolin, a secretory protein, to amyloid beta-protein.
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| Chauhan VP, Ray I, Chauhan A, Wisniewski HM.
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| Biochem Biophys Res Commun. 258(2):241-6. 1999
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| 125 | APP
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| Binding of amyloid beta-peptide to mitochondrial hydroxyacyl-CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in Alzheimer's disease.
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| Oppermann UC, Salim S, Tjernberg LO, Terenius L, Jörnvall H.
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| FEBS Lett. 451(3):238-42. 1999
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| 126 | AD1, APP
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| Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-Gly mutation.
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| 127 | APP, AD1
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| The role of A beta 42 in Alzheimer's disease.
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| J Physiol Paris 92(3-4):289-92. Review. 1998
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| 128 | APP
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| PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein
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| Proc Natl Acad Sci U S A. 95(25):14745-50. 1998
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| 129 | APP
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| Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
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| Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, Sisodia SS, Wang R, Greengard P, Gandy S.
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| Nat Med. 4(4):447-51. 1998
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| 130 | APP
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| Nucleic Acids Res 25 : 1802-1808. 1997
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| 131 | APP, GRIK1, SOD1, DEL21QD, DEL21QT
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| High-resolution physical mapping of a 6.7-Mb YAC contig spanning a region critical for the monosomy 21 phenotype in 21q21.3-q22.1.
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| Orti R, Megarbane A, Maunoury C, Van Broeckhoven C, Sinet PM, Delabar JM.
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| 132 | AD1, APP
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| A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43).
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| Eckman CB, Mehta ND, Crook R, Perez-tur J, Prihar G, Pfeiffer E, Graff-Radford N, Hinder P, Yager D, Zenk B, Refolo LM, Prada CM, Younkin SG, Hutton M, Hardy J.
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| Hum Mol Genet 6(12):2087-9. 1997
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| 133 | APP, PSEN1, PSEN2
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| 134 | APP, PSEN2
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| Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein.
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| Weidemann A, Paliga K, Durrwang U, Czech C, Evin G, Masters CL, Beyreuther K.
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| Nat Med 3(3):328-32. 1997
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| 135 | APP
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| Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC.
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| Jensen PH, Hojrup P, Hager H, Nielsen MS, Jacobsen L, Olesen OF, Gliemann J, Jakes R.
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| 136 | APP, AD1
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| 138 | APP, AGER
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| RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease.
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| 139 | APP, NAE1
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| 140 | APP
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| The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
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| The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
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| Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.
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| The upstream promoter of the beta-amyloid precursor protein gene (APP) shows differential patterns of methylation in human brain.
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| 155 | APP
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| Intraneuronal compartments of the amyloid precursor protein.
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| J Neurosci 13(7):3112-23 1993
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| 156 | APP, GAPDH
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| Rat brain glyceraldehyde-3-phosphate dehydrogenase interacts with the recombinant cytoplasmic domain of Alzheimer's beta-amyloid precursor protein.
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| Schulze H, Schuler A, Stüber D, Döbeli H, Langen H, Huber G.
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| J Neurochem. 60(5):1915-22. 1993
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| 157 | APP
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| Long-distance restriction mapping of the proximal long arm of human chromosome 21 with Not I linking clones.
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| Ichikawa H, et al.
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| Proc Natl Acad Sci U S A 89 : 23-27. 1992
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| 158 | APP
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| Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease : identification of a further family with APP717 Val-Ile.
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| Fidani L, et al.
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| Hum Mol Genet 1 : 165-168. 1992
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| 159 | APP
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| Presenile dementia and cerebral haemorrhage linked to a mutation at codon-692 of the beta-amyloid precursor protein gene.
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| Hendriks L, et al.
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| Nat Genet 1 : 218-221. 1992
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| 160 | APP
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| Mutation in codon-713 of the beta-amyloid precursor protein gene presenting with schizophrenia.
|
| Jones CT, et al.
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| Nat Genet 1 : 306-308. 1992
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| 161 | APP
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| A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
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| Mullan M, et al.
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| Nat Genet 1 : 345-347. 1992
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| 162 | APP
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| A novel but non-pathogenic mutation in exon 4 of the human amyloid precursor protein (APP) gene.
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| Vaula G, et al.
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| Neurosci Lett 144 : 46-48. 1992
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| 163 | APP, AD1
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| Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the beta-amyloid precursor protein gene.
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| Karlinsky H, et al.
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| Neurology 42 : 1445-1453. 1992
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| 164 | APP
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| Improved direct sequencing of Alzheimer's amyloid precursor protein (APP) exons 16 and 17.
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| Adroer R, et al.
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| Neurosci Lett 141 : 69-71. 1992
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| 165 | APP
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| Characterization of Alzheimer amyloid precursor protein transcripts in platelets and megakarocytes.
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| Neurosci Lett 138 : 229-232. 1992
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| 166 | AD1, AD2, APP
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| Molecular classification of Alzheimer's disease.
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| Hardy J, et al.
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| Lancet 337 : 1342-1343. 1991
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| 167 | APP
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| Mononucleotide repeat polymorphism in the APP gene.
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| Mant R, et al.
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| Nucleic Acids Res 19 : 4572. 1991
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| 168 | APP
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| APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease.
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| Schellenberg GD, et al.
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| Am J Hum Genet 49 : 511-517. 1991
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| 169 | APP
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| DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type).
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| Bakker E, et al.
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| Am J Hum Genet 49 : 518-521. 1991
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| 170 | APP
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| The 717val-Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.
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| Yoshioka K, et al.
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| Biochem Biophys Res Commun 178 : 1141-1146. 1991
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| 171 | APP
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| Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.
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| Chartier-Harlin MC, et al.
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| Nature 353 : 844-846. 1991
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| 172 | APP
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| Screening for the beta-amyloid precursor protein mutation (APP717: Val-Ile) in extended pedigrees with early onset Alzheimer's disease.
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| Chartier-Harlin MC, et al.
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| Neurosci Lett 129 : 134-135. 1991
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| 173 | APP
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| A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease.
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| Murrell J, et al.
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| Science 254 : 97-99. 1991
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| 174 | AD1, APP
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| Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
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| Goate A, et al.
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| Nature 349 : 704-706. 1991
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| 175 | AD1, APP
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| Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.
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| van Duijn CM, et al.
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| Lancet 337 : 978. 1991
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| 176 | AD1, APP
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| Mis-sense mutation Val-Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
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| Naruse S, et al.
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| Lancet 337 : 978-979. 1991
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| 177 | APP
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| Protease nexin-2/amyloid beta-protein precursor in blood is a platelet-specific protein.
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| Van Nostrand WE, et al.
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| Biochem Biophys Res Commun 175 : 15-21. 1991
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| 178 | APP
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| Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein.
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| Van Nostrand WE, et al.
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| Science 248 : 745-748. 1990
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| 179 | APP
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| Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.
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| Levy E, et al.
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| Science 248 : 1124-1126. 1990
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| 180 | APP
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| Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch).
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| Van Broeckhoven C, et al.
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| Science 248 : 1120-1122. 1990
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| 181 | APP
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| Genomic organization of the human amyloid beta-protein precursor gene.
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| Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y.
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| Gene 87(2):257-63. 1990
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| 182 | APP, HCHWAD
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| Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.
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| Levy E, Carman MD, Fernandez-Madrid IJ, Power MD, Lieberburg I, van Duinen SG, Bots GT, Luyendijk W, Frangione B.
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| Science 248(4959):1124-6.
1990
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| 183 | APP
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| Alpha 1-antichymotrypsin is associated solely with amyloid deposits containing the beta-protein. Amyloid and cell localization of alpha 1-antichymotrypsin.
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| Abraham CR, Shirahama T, Potter H.
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| Neurobiol Aging. 11(2):123-9. 1990
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| 184 | APP
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| Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor.
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| Van Nostrand WE, et al.
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| Nature 341 : 546-549. 1989
|
| 185 | APP
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| Mapping of the gene encoding the §-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21.
|
| Patterson D, Gardiner K, Kao FT, Tanzi R, Watkins P, Gusella JF.
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| Proc Natl Acad Sci U S A 85 : 8266-8270. 1988
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| 186 | APP
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| Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein.
|
| Schubert D, Schroeder R, LaCorbiere M, Saitoh T, Cole G.
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| Science 241 : 223-226. 1988
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| 187 | APP
|
| Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
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| Tanzi RE, et al.
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| Nature 331 : 528-530. 1988
|
| 188 | APP
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| Fine mapping of an Alzheimer disease-associated gene encoding beta-amyloid protein.
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| Jenkins EC, et al.
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| Biochem Biophys Res Commun 151 : 1-8. 1988
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| 189 | APP
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| A high frequency NcoI RFLP detected in the Alzheimer amyloid peptide gene.
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| Wu Y, et al.
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| Nucleic Acids Res 16 : 1647. 1988
|
| 190 | APP, D21S11, D21S60, GART, SOD1
|
| Irradiation-reduced human chromosome 21 hybrids.
|
| Graw S, et al.
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| Somat Cell Mol Genet 14 : 233-242. 1988
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| 191 | AD1, APP
|
| Chromosome 21 physical map : familial Alzheimer-linked DNA sequences cluster in a probable hot spot of recombination.
|
| Pulst SM, et al.
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| Am J Hum Genet 43 : A156. 1988
|
| 192 | APP
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| EcoT14I RFLP found at the human amyloid beta protein gene locus.
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| Taylor JE, et al.
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| Nucleic Acids Res 16 : 6259. 1988
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| 193 | APP
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| Human amyloid beta protein gene locus : HaeIII RFLP.
|
| Taylor JE, et al.
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| Nucleic Acids Res 16 : 7217. 1988
|
| 194 | APP
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| A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors.
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| Ponte P, et al.
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| Nature 331(6156):525-7 1988
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| 195 | AD1, APP
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| Genetic linkage analysis of the Alzheimer's associated amyloid beta protein gene with familial Alzheimer's disease and chromosome 21.
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| Tanzi R, et al.
|
| (HGM9) Cytogenet Cell Genet 46 : 703. 1987
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| 196 | APP
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| Hereditary cerebral hemorrhage with amyloidosis in patients of Dutch origin is related to Alzheimer disease.
|
| van Duinen SG, et al.
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| Proc Natl Acad Sci U S A 84 : 5991-5994. 1987
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| 197 | APP
|
| Sublocalization of the gene for the precursor of Alzheimer's disease amyloid A4 protein on chromosome 21.
|
| Zabel BU, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 725. 1987
|
| 198 | AD1, APP
|
| Localization of amyloid § protein messenger RNA in brains from patients with Alzheimer's disease.
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| Bahmanyar S, et al.
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| Science 237 : 77-80. 1987
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| 199 | APP
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| Chromosome 21q21 sublocalisation of gene encoding beta-amyloid peptide in cerebral vessels and neutrinic (senile) plaques of people with Alzheimer disease and Down syndrome.
|
| Robakis NK, et al.
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| Lancet I : 384-385. 1987
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| 200 | APP
|
| Conservation of brain amyloid protein in aged mammals and humans with Alzheimer's disease.
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| Selkoe DJ, et al.
|
| Science 235 : 873-877. 1987
|
| 201 | APP
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| In situ hybridization of the §-amyloid protein (APP) cDNA to the vicinity of the interface of 21q21 and q22 in normal and Alzheimer's disease individuals.
|
| Blanquet V, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 582. 1987
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| 202 | APP
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| Beta amyloid gene duplication in Alzheimer's disease and karyotypically normal Down syndrome.
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| Delabar JM, et al.
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| Science 235 : 1390-1392. 1987
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| 203 | APP
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| Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.
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| Goldgaber D, et al.
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| Science 235 : 877-880. 1987
|
| 204 | APP
|
| The mouse homolog of the human amyloid beta protein (AD-AP) gene is located on the distal end of mouse chromosome 16 : further extension of the homology between human chromosome 21 and mouse chromosome 16.
|
| Lovett M, et al.
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| Biochem Biophys Res Commun 144 : 1069-1075. 1987
|
| 205 | APP
|
| Identification of a frequent DNA polymorphism for the A4-amyloid gene.
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| Horsthemke B, et al.
|
| (HGM9) Cytogenet Cell Genet 46 : 630. 1987
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| 206 | APP
|
| The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
|
| Kang J, et al.
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| Nature 325 : 733-736. 1987
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| 207 | APP
|
| Molecular cloning and characterization of cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.
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| Robakis NK, et al.
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| Proc Natl Acad Sci U S A 84 : 4190-4194. 1987
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| 208 | APP
|
| The beta amyloid protein (AD-AP) cDNA hybridizes in normal and Alzheimer individuals near the interface of 21q21 and q22.1.
|
| Blanquet V, et al.
|
| Ann Genet 30 : 68-69. 1987
|
| 209 | APP
|
| A new TaqI polymorphism detected by the cDNA encoding amyloid beta protein of Alzheimer's disease.
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| David F, et al.
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| Nucleic Acids Res 15 : 9103. 1987
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| 210 | APP
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| A HindIII polymorphism detected by the cDNA encoding amyloid beta protein of Alzheimer's disease.
|
| Sasaki H, et al.
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| Nucleic Acids Res 15 : 6309. 1987
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| 211 | APP, AD1
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| Beta-amyloid gene is not present in three copies in autopsy-validated Alzheimer's disease.
|
| Warren AC, et al.
|
| Genomics 1 : 307-312. 1987
|
| 212 | APP, AD1
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| Rearrangement of chromosome 21 in Alzheimer's disease.
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| Delabar JM, et al.
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| Ann Genet 29 : 226-228. 1986
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