Citations for
1APOE, LRP8, SFRS11
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE.
Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q.
Cell Rep. Jun 16;31(11):107713. doi: 10.1016/j.celrep.2020.107713 2020
2APOE, LRP8, SFRS11
SFRS11 Loss Leads to Aging-Associated Cognitive Decline by Modulating LRP8 and ApoE
Raihan O, Brishti A, Li Q, Zhang Q, Li D, Li X, Zhang Q, Xie Z, Li J, Zhang J, Liu Q.
Cell Rep. Jul 2;28(1):78-90.e6. doi: 10.1016/j.celrep.2019.06.002 2019
3APOE
Apolipoprotein E Gene Variants and Risk of Coronary Heart Disease: A Meta-Analysis.
Xu M, Zhao J, Zhang Y, Ma X, Dai Q, Zhi H, Wang B, Wang L.
Biomed Res Int 2016:3912175. Epub 2016 Oct 27. Review. 2016
4APOE
Identification and modification of amyloid-independent phenotypes of APOE4 mice.
DiBattista AM, Dumanis SB, Newman J, Rebeck GW.
Exp Neurol 280:97-105. doi: 10.1016/j.expneurol.2016.04.014. Epub 2016 Apr 14. 2016
5APOE
Age-Related Effects of the Apolipoprotein E Gene on Brain Function.
Matura S, Prvulovic D, Hartmann D, Scheibe M, Sepanski B, Butz M, Oertel-Knöchel V, Knöchel C, Karakaya T, Fußer F, Hattingen E, Pantel J.
J Alzheimers Dis 52(1):317-31. doi: 10.3233/JAD-150990. 2016
6APOE
Long-term episodic memory decline is associated with olfactory deficits only in carriers of ApoE-є4.
Olofsson JK, Josefsson M, Ekström I, Wilson D, Nyberg L, Nordin S, Nordin Adolfsson A, Adolfsson R, Nilsson LG, Larsson M.
Neuropsychologia 85:1-9. doi: 10.1016/j.neuropsychologia.2016.03.004. Epub 2016 Mar 5. 2016
7APOE, APP
Increased amyloidogenic APP processing in APOE ɛ4-negative individuals with cerebral β-amyloidosis.
Mattsson N, Insel PS, Palmqvist S, Stomrud E, van Westen D, Minthon L, Zetterberg H, Blennow K, Hansson O.
Nat Commun 7:10918. doi: 10.1038/ncomms10918. 2016
8APOE
Impaired Autophagy in APOE4 Astrocytes.
Simonovitch S, Schmukler E, Bespalko A, Iram T, Frenkel D, Holtzman DM, Masliah E, Michaelson DM, Pinkas-Kramarski R.
J Alzheimers Dis 51(3):915-27. doi: 10.3233/JAD-151101. 2016
9AD2, APOE
Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes.
Xu H, Perreau VM, Dent KA, Bush AI, Finkelstein DI, Adlard PA.
J Alzheimers Dis 51(2):471-87. doi: 10.3233/JAD-150797. 2016
10AD2, APOE
The role of APOE in cerebrovascular dysfunction.
Tai LM, Thomas R, Marottoli FM, Koster KP, Kanekiyo T, Morris AW, Bu G.
Acta Neuropathol 131(5):709-23. doi: 10.1007/s00401-016-1547-z. Epub 2016 Feb 16. Review. 2016
11APOE
ApoE4 upregulates the activity of mitochondria-associated ER membranes.
Tambini MD, Pera M, Kanter E, Yang H, Guardia-Laguarta C, Holtzman D, Sulzer D, Area-Gomez E, Schon EA.
EMBO Rep 17(1):27-36. doi: 10.15252/embr.201540614. Epub 2015 Nov 12. 2016
12APOE
Apolipoprotein E4 reduces evoked hippocampal acetylcholine release in adult mice.
Dolejší E, Liraz O, Rudajev V, Zimčík P, Doležal V, Michaelson DM.
J Neurochem 136(3):503-9. doi: 10.1111/jnc.13417. Epub 2015 Nov 19. 2016
13APOE, LDLR, MYLIP
The E3 ubiquitin ligase Idol controls brain LDL receptor expression, ApoE clearance, and Aβ amyloidosis.
Choi J, Gao J, Kim J, Hong C, Kim J, Tontonoz P.
Sci Transl Med 7(314):314ra184. doi: 10.1126/scitranslmed.aad1904. 2015
14APOE, KLF4
Krüppel-like factor 4 synergizes with CREB to increase the activity of apolipoprotein E gene promoter in macrophages.
Stavri S, Simionescu M, Kardassis D, Gafencu AV.
Biochem Biophys Res Commun 468(1-2):66-72. doi: 10.1016/j.bbrc.2015.10.163. Epub 2015 Nov 4. 2015
15APOE, PMEL
Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells.
van Niel G, Bergam P, Di Cicco A, Hurbain I, Lo Cicero A, Dingli F, Palmulli R, Fort C, Potier MC, Schurgers LJ, Loew D, Levy D, Raposo G.
Cell Rep 13(1):43-51. doi: 10.1016/j.celrep.2015.08.057. Epub 2015 Sep 17. 2015
16APOE
Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.
Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D.
Proc Natl Acad Sci U S A 112(38):11965-70. doi: 10.1073/pnas.1510011112. Epub 2015 Sep 8. 2015
17APOE, PLTP
Influence of Isoforms and Carboxyl-Terminal Truncations on the Capacity of Apolipoprotein E To Associate with and Activate Phospholipid Transfer Protein.
Dafnis I, Metso J, Zannis VI, Jauhiainen M, Chroni A.
Biochemistry 54(38):5856-66. doi: 10.1021/acs.biochem.5b00681. Epub 2015 Sep 17. 2015
18APOE
Apolipoprotein E promotes lipid accumulation and differentiation in human adipocytes.
Lasrich D, Bartelt A, Grewal T, Heeren J.
Exp Cell Res 337(1):94-102. doi: 10.1016/j.yexcr.2015.07.015. Epub 2015 Jul 19. 2015
19APOE
Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE.
Ayton S, Faux NG, Bush AI; Alzheimer's Disease Neuroimaging Initiative.
Nat Commun 6:6760. doi: 10.1038/ncomms7760. 2015
20APOE
Apolipoprotein E Inhibits Cerebrovascular Pericyte Mobility through a RhoA Protein-mediated Pathway.
Casey CS, Atagi Y, Yamazaki Y, Shinohara M, Tachibana M, Fu Y, Bu G, Kanekiyo T.
J Biol Chem 290(22):14208-17. doi: 10.1074/jbc.M114.625251. Epub 2015 Apr 22. 2015
21APOE
VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina.
Antes R, Salomon-Zimri S, Beck SC, Garcia Garrido M, Livnat T, Maharshak I, Kadar T, Seeliger M, Weinberger D, Michaelson DM.
Curr Alzheimer Res 12(4):323-34. 2015
22APOE
Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4.
Mizuguchi C, Hata M, Dhanasekaran P, Nickel M, Okuhira K, Phillips MC, Lund-Katz S, Saito H.
Biochim Biophys Acta 1841(12):1716-24. 2014
23APOE
The alternative splicing of the apolipoprotein E gene is unperturbed in the brains of Alzheimer's disease patients.
Mills JD, Sheahan PJ, Lai D, Kril JJ, Janitz M, Sutherland GT.
Mol Biol Rep 41(10):6365-76. doi: 10.1007/s11033-014-3516-8. Epub 2014 Jul 5. 2014
24APOE
APOE ε4 is associated with disproportionate progressive hippocampal atrophy in AD.
Manning EN, Barnes J, Cash DM, Bartlett JW, Leung KK, Ourselin S, Fox NC; Alzheimer's Disease NeuroImaging Initiative.
PLoS One 9(5):e97608. doi: 10.1371/journal.pone.0097608. eCollection 2014. Erratum in: PLoS One. 2014;9(7):e104482. 2014
25APOE
Apolipoprotein E in Alzheimer's disease: an update.
Yu JT, Tan L, Hardy J.
Annu Rev Neurosci 37:79-100. doi: 10.1146/annurev-neuro-071013-014300. Epub 2014 Apr 21. Review. 2014
26APOE, RNF219
Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease.
Rhinn H, Fujita R, Qiang L, Cheng R, Lee JH, Abeliovich A.
Nature 500(7460):45-50. doi: 10.1038/nature12415. Epub 2013 Jul 24. 2013
27APOE
The influence of Apolipoprotein E genotype on regional pathology in Alzheimer's disease.
Sabbagh MN, Malek-Ahmadi M, Dugger BN, Lee K, Sue LI, Serrano G, Walker DG, Davis K, Jacobson SA, Beach TG.
BMC Neurol 13:44. doi: 10.1186/1471-2377-13-44. 2013
28APOE, APP
ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions.
Verghese PB, Castellano JM, Garai K, Wang Y, Jiang H, Shah A, Bu G, Frieden C, Holtzman DM.
Proc Natl Acad Sci U S A 110(19):E1807-16. doi: 10.1073/pnas.1220484110. Epub 2013 Apr 25. 2013
29APOE
Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex.
Rodriguez GA, Burns MP, Weeber EJ, Rebeck GW.
Learn Mem 20(5):256-66. doi: 10.1101/lm.030031.112. 2013
30APOE
Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development.
Jain S, Yoon SY, Leung L, Knoferle J, Huang Y.
PLoS One 8(3):e59478. doi: 10.1371/journal.pone.0059478. Epub 2013 Mar 19. 2013
31APOE
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy.
Liu CC, Kanekiyo T, Xu H, Bu G.
Nat Rev Neurol 9(2):106-18. doi: 10.1038/nrneurol.2012.263. Epub 2013 Jan 8. Erratum in: Nat Rev Neurol. 2013. doi: 10.1038/nmeurol.2013.32. Li 2013
32APOE
Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia.
Ossenkoppele R, van der Flier WM, Zwan MD, Adriaanse SF, Boellaard R, Windhorst AD, Barkhof F, Lammertsma AA, Scheltens P, van Berckel BN.
Neurology 80(4):359-65. doi: 10.1212/WNL.0b013e31827f0889. Epub 2012 Dec 19. 2013
33APOE, COMT
Role of the apolipoprotein E and catechol-O-methyltransferase genes in prospective and retrospective memory traits.
Dongés B, Haupt LM, Lea RA, Chan RC, Shum DH, Griffiths LR.
Gene 506(1):135-40. doi: 10.1016/j.gene.2012.06.067. Epub 2012 Jul 3. 2012
34APOE, APP
Neurotoxicity of amyloid β-protein: synaptic and network dysfunction.
Mucke L, Selkoe DJ.
Cold Spring Harb Perspect Med 2(7):a006338. doi: 10.1101/cshperspect.a006338. Review. 2012
35APOE
Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice.
Leung L, Andrews-Zwilling Y, Yoon SY, Jain S, Ring K, Dai J, Wang MM, Tong L, Walker D, Huang Y.
PLoS One 7(12):e53569. doi: 10.1371/journal.pone.0053569. Epub 2012 Dec 31. 2012
36APOE, APP
Differential regulation of amyloid-β endocytic trafficking and lysosomal degradation by apolipoprotein E isoforms.
Li J, Kanekiyo T, Shinohara M, Zhang Y, LaDu MJ, Xu H, Bu G.
J Biol Chem 287(53):44593-601. doi: 10.1074/jbc.M112.420224. Epub 2012 Nov 6. 2012
37APOE
Effects of APOE on brain white matter microstructure in healthy adults.
Westlye LT, Reinvang I, Rootwelt H, Espeseth T.
Neurology 79(19):1961-9. doi: 10.1212/WNL.0b013e3182735c9c. Epub 2012 Oct 24. 2012
38APOE
APOE genotype in the diagnosis of Alzheimer's disease in patients with cognitive impairment.
Sun X, Nicholas J, Walker A, Wagner MT, Bachman D.
Am J Alzheimers Dis Other Demen 27(5):315-20. doi: 10.1177/1533317512452037. 2012
39APOE
Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease.
Frieden C, Garai K.
Proc Natl Acad Sci U S A 109(23):8913-8. doi: 10.1073/pnas.1207022109. Epub 2012 May 21. Erratum in: Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13130. 2012
40APOE
ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.
Annema W, Dikkers A, Freark de Boer J, Gautier T, Rensen PC, Rader DJ, Tietge UJ.
J Lipid Res 53(5):929-40. doi: 10.1194/jlr.M020743. Epub 2012 Mar 1. 2012
41APOE, APP
Apolipoprotein E promotes β-amyloid trafficking and degradation by modulating microglial cholesterol levels.
Lee CY, Tse W, Smith JD, Landreth GE.
J Biol Chem 287(3):2032-44. doi: 10.1074/jbc.M111.295451. Epub 2011 Nov 30. 2012
42APOE, CR1
A coding variant in CR1 interacts with APOE-ε4 to influence cognitive decline.
Keenan BT, Shulman JM, Chibnik LB, Raj T, Tran D, Sabuncu MR; Alzheimer's Disease Neuroimaging Initiative, Allen AN, Corneveaux JJ, Hardy JA, Huentelman MJ, Lemere CA, Myers AJ, Nicholson-Weller A, Reiman EM, Evans DA, Bennett DA, De Jager PL.
Hum Mol Genet 21(10):2377-88. doi: 10.1093/hmg/dds054. Epub 2012 Feb 17. 2012
43APOE
Structural differences between apoE3 and apoE4 may be useful in developing therapeutic agents for Alzheimer's disease.
Frieden C, Garai K.
Proc Natl Acad Sci U S A 109(23):8913-8. doi: 10.1073/pnas.1207022109. Epub 2012 May 21. Erratum in: Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13130. 2012
44APOE
Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.
Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.
J Biol Chem 286(7):5215-21. Epub 2010 Nov 30. 2011
45APOE
ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice.
Murphy AJ, Akhtari M, Tolani S, Pagler T, Bijl N, Kuo CL, Wang M, Sanson M, Abramowicz S, Welch C, Bochem AE, Kuivenhoven JA, Yvan-Charvet L, Tall AR.
J Clin Invest 121(10):4138-49. doi: 10.1172/JCI57559. 2011
46APOE
ApoE is required for maintenance of the dentate gyrus neural progenitor pool.
Yang CP, Gilley JA, Zhang G, Kernie SG.
Development 138(20):4351-62. doi: 10.1242/dev.065540. Epub 2011 Aug 31. 2011
47ABCA1, APOE
A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression.
Zhao Y, Chen X, Yang H, Zhou L, Okoro EU, Guo Z.
PLoS One 6(7):e21453. doi: 10.1371/journal.pone.0021453. Epub 2011 Jul 11. 2011
48APOE
Molecular basis for the differences in lipid and lipoprotein binding properties of human apolipoproteins E3 and E4.
Nguyen D, Dhanasekaran P, Nickel M, Nakatani R, Saito H, Phillips MC, Lund-Katz S.
Biochemistry 49(51):10881-9. Epub 2010 Dec 3. 2010
49APOE
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y.
J Neurosci 30(41):13707-17. doi: 10.1523/JNEUROSCI.4040-10.2010. 2010
50APOE, ARMD1, ARMD2, ARMD3, ARMD7, ARMD8, ARMDA, ARMDC, ARMS2, C2, C3, CFB, CFH, HTRA1
Multilocus analysis of age-related macular degeneration.
Bergeron-Sawitzke J, Gold B, Olsh A, Schlotterbeck S, Lemon K, Visvanathan K, Allikmets R, Dean M.
Eur J Hum Genet ur J Hum Genet. 2009 Mar 4. [Epub ahead of print] 2009
51APOC1, APOE, NECTIN2, TOMM40
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.
Takei N, Miyashita A, Tsukie T, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kimura H, Kakita A, Takahashi H, Tsuji S, Kanazawa I, Ihara Y, Odani S, Kuwano R; Japanese Genetic Study Consortium for Alzheimer Disease.
Genomics 93(5):441-8. Epub 2009 Feb 3. 2009
52APOE
Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene.
Fritsche LG, Freitag-Wolf S, Bettecken T, Meitinger T, Keilhauer CN, Krawczak M, Weber BH.
Hum Mutat 30(7):1048-53.PMID: 19384966 2009
53APOE, COMT, DAO, DRD1, DRD2, DRD4, DTNBP1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SCZD23, SLC6A4, TP53, TPH1
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L.
Nat Genet 40(7):827-34. 2008
54AD1, AD2, AD24, AD3, AD4, APOE, APP, PSEN1, PSEN2
Genome-wide association studies in Alzheimer disease.
Waring SC, Rosenberg RN.
Arch Neurol 65(3):329-34. Review. 2008
55APOE, LPL
Subsets of SNPs define rare genotype classes that predict ischemic heart disease.
Frikke-Schmidt R, Sing CF, Nordestgaard BG, Steffensen R, Tybjaerg-Hansen A.
Hum Genet 120(6):865-877. Epub 2006 Sep 28. 2007
56ACE, APOE, CHRNB2, CST3, ESR1, GAPDHS, IDE, MTHFR, NCSTN, PRNP, PSEN1, TF, TFAM, TNF
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE.
Nat Genet 39(1):17-23. 2007
57APOA1, APOA2, APOB, APOC1, APOC2, APOC3, APOE, CLU
Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expression.
Li CM, Clark ME, Chimento MF, Curcio CA.
Invest Ophthalmol Vis Sci 47(7):3119-28. 2006
58APOE
Relations of APOE promoter polymorphisms to LDL cholesterol and markers of subclinical atherosclerosis in young adults.
Viiri LE, Raitakari OT, Huhtala H, KŠhšnen M, Rontu R, Juonala M, Hutri-KŠhšnen N, Marniemi J, Viikari JS, Karhunen PJ, LehtimŠki T.
J Lipid Res 47(6):1298-306. Epub 2006 Mar 9. 2006
59APOE, USF1
USF1 and dyslipidemias: converging evidence for a functional intronic variant.
Naukkarinen J, Gentile M, Soro-Paavonen A, Saarela J, Koistinen HA, Pajukanta P, Taskinen MR, Peltonen L.
Hum Mol Genet 14(17):2595-605. Epub 2005 Aug 2. 2005
60APOE
Sense and antisense transcripts of the apolipoprotein E gene in normal and ApoE knockout mice, their expression after spinal cord injury and corresponding human transcripts.
Seitz A, Gourevitch D, Zhang XM, Clark L, Chen P, Kragol M, Levenkova N, Rux J, Samulewicz S, Heber-Katz E.
Hum Mol Genet 14(18):2661-70. Epub 2005 Aug 9. 2005
61APOE
Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism.
Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J.
Proc Natl Acad Sci U S A 102(23):8299-302. Epub 2005 Jun 2. 2005
62SBHD, APOE
Variable expressivity of the clinical and biochemical phenotype associated with the apolipoprotein E p.Leu149del mutation.
Faivre L, Saugier-Veber P, Pais de Barros JP, Verges B, Couret B, Lorcerie B, Thauvin C, Charbonnier F, Huet F, Gambert P, Frebourg T, Duvillard L.
Eur J Hum Genet 13(11):1186-91. 2005
63APOE, SLOS
Maternal apo E genotype is a modifier of the Smith-Lemli-Opitz syndrome.
Witsch-Baumgartner M, Gruber M, Kraft HG, Rossi M, Clayton P, Giros M, Haas D, Kelley RI, Krajewska-Walasek M, Utermann G.
J Med Genet 41(8):577-84. 2004
64APOE
Apolipoprotein E in schizophrenia: A French association study and meta-analysis.
Schurhoff F, Krebs MO, Szoke A, Loze JY, Goldberger C, Quignon V, Tignol J, Rouillon F, Laplanche JL, Leboyer M.
Am J Med Genet 119B(1):18-23. 2003
65APOE
Characterization of the heparin binding sites in human apolipoprotein E.
Saito H, Dhanasekaran P, Nguyen D, Baldwin F, Weisgraber KH, Wehrli S, Phillips MC, Lund-Katz S.
J Biol Chem 278(17):14782-7. Epub 2003 Feb 14. 2003
66APOE
Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.
Heijmans BT, Slagboom PE, Gussekloo J, Droog S, Lagaay AM, Kluft C, Knook DL, Westendorp RG.
Am J Med Genet 107(3):201-8. 2002
67APOE, MYOC
Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene.
Copin B, Brezin AP, Valtot F, Dascotte JC, Bechetoille A, Garchon HJ.
Am J Hum Genet 70(6):1575-81. 2002
68APOE,FTDP17
Apolipoprotein E gene in frontotemporal dementia: an association study and meta-analysis.
Verpillat P, Camuzat A, Hannequin D, Thomas-Anterion C, Puel M, Belliard S, Dubois B, Didic M, Lacomblez L, Moreaud O, Golfier V, Campion D, Brice A, Clerget-Darpoux F.
Eur J Hum Genet 10(7):399-405. 2002
69APOE, NR1H3, APOC1, APOC2, APOC4
Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA.
J Biol Chem 277(35):31900-8. 2002
70APOE
Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease.
Carrieri G, BonafŽ M, De Luca M, Rose G, Varcasia O, Bruni A, Maletta R, Nacmias B, Sorbi S, Corsonello F, Feraco E, Andreev KF, Yashin AI, Franceschi C, De Benedictis G.
Hum Genet 108 : 194-198. 2001
71AD2, APOE
Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease.
Lambert JC, Mann D, Goumidi L, Harris J, Amouyel P, Iwatsubo T, Lendon C, Chartier-Harlin MC.
Lancet 357 : 608. 2001
72APOE, ZIC1, ZIC2
Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter.
Salero E, Perez-Sen R, Aruga J, Gimenez C, Zafra F.
J Biol Chem 276(3):1881-8. 2001
73APOE
Independent association of an APOE gene promoter polymorphism with increased risk of myocardial infarction and decreased APOE plasma concentrations-the ECTIM study.
Lambert JC, Brousseau T, Defosse V, Evans A, Arveiler D, Ruidavets JB, Haas B, Cambou JP, Luc G, Ducimetiere P, Cambien F, Chartier-Harlin MC, Amouyel P.
Hum Mol Genet 9(1):57-61 2000
74APOE
Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage.
O'Donnell HC, Rosand J, Knudsen KA, Furie KL, Segal AZ, Chiu RI, Ikeda D, Greenberg SM.
N Engl J Med 342(4):240-5 2000
75APOC-E@, APOC1, APOC4, APOE, KLK11, KLK8, NECTIN2
Analysis of Association at Single Nucleotide Polymorphisms in the APOE Region.
Martin ER, Gilbert JR, Lai EH, Riley J, Rogala AR, Slotterbeck BD, Sipe CA, Grubber JM, Warren LL, Conneally PM, Saunders AM, Schmechel DE, Purvis I, Pericak-Vance MA, Roses AD, Vance JM.
Genomics 63(1):7-12. 2000
76APOE
The number of trait loci in late-onset Alzheimer disease.
Warwick Daw E, Payami H, Nemens EJ, Nochlin D, Bird TD, Schellenberg GD, Wijsman EM.
Am J Hum Genet 66(1):196-204. 2000
77AD2, APOE
APOE promoter polymorphisms do not confer independent risk for Alzheimer's disease in a French population.
Zurutuza L, Verpillat P, Raux G, Hannequin D, Puel M, Belliard S, Michon A, Pothin Y, Camuzat A, Penet C, Martin C, Brice A, Campion D, Clerget-Darpoux F, Frebourg T.
Eur J Hum Genet 8(9):713-6. 2000
78AD2, APOE
Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele.
Vidal R, Calero M, Piccardo P, Farlow MR, Unverzagt FW, Mendez E, Jimenez-Huete A, Beavis R, Gallo G, Gomez-Tortosa E, Ghiso J, Hyman BT, Frangione B, Ghetti B.
Acta Neuropathol (Berl) 100(1):1-12. 2000
79APOE, AD2
A novel mutation in the apolipoprotein E gene (APOE*4 Pittsburgh) is associated with the risk of late-onset Alzheimer's disease.
Kamboh MI, et al.
Neurosci Lett 263(2-3):129-32. 1999
80APOE, NRP1, SEMA3A
Association of the APOE epsilon4 allele with disease activity in multiple sclerosis.
Evangelou N, et al.
J Neurol Neurosurg Psychiatry 67(2):203-5 1999
81APOE
Relation of genetic polymorphisms of apolipoprotein E, angiotensin converting enzyme, apolipoprotein B-100, and glycoprotein IIIa and early-onset coronary heart disease.
Nassar BA, Dunn J, Title LM, O'Neill BJ, Kirkland SA, Zayed E, Bata IR, Cantrill RC, Johnstone J, Dempsey GI, Tan MH, Breckenridge WC, Johnstone DE.
Clin Biochem 32(4):275-82 1999
82AD2, APOE
A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.
Bullido MJ, Artiga MJ, Recuero M, Sastre I, Garcia MA, Aldudo J, Lendon C, Han SW, Morris JC, Frank A, Vazquez J, Goate A, Valdivieso F.
Nat Genet 18(1):69-71. 1998
83AD2, APOE
A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.
Lambert JC, Pasquier F, Cottel D, Frigard B, Amouyel P, Chartier-Harlin MC.
Hum Mol Genet 7(3):533-40. 1998
84AD2, APOE
ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families.
Houlden H, Crook R, Backhovens H, Prihar G, Baker M, Hutton M, Rossor M, Martin JJ, Van Broeckhoven C, Hardy J.
Am J Med Genet 81(1):117-21. 1998
85APOE
Genetic association of apolipoprotein E with age-related macular degeneration.
Klaver CCW, et al.
Am J Hum Genet 63 : 200-206. 1998
86AD2, APOE
Apolipoprotein E epsilon4 allele and familial aggregation of Alzheimer disease.
Martinez M, et al.
Arch Neurol 55 : 810-816. 1998
87AD2, APOE
The -491A/T apolipoprotein E promoter polymorphism association with Alzheimer's disease : independent risk and linkage disequilibrium with the known APOE polymorphism.
Town T, et al.
Neurosci Lett 252 : 95-98. 1998
88AD2, APOE
Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.
Artiga MJ, et al.
Hum Mol Genet 7 : 1887-1892. 1998
89APOE
A 4-Mb high-density single nucleotide polymorphism-based map around human APOE.
Lai E, et al.
Genomics 54 : 31-38. 1998
90APOE
The epsilon4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration.
Souied EH, et al.
Am J Ophthalmol 125 : 353-359. 1998
91AD2, APOE
Apolipoprotein E and Alzheimer disease : genotype-specific risks by age and sex.
Bickebšller H, et al.
Am J Hum Genet 60 : 439-446. 1997
92AD2, APOE
The absence of an apolipoprotein epsilon4 allele is associated with a more aggressive form of Alzheimer's disease.
Stern Y, Brandt J, Albert M, Jacobs DM, Liu X, Bell K, Marder K, Sano M, Albert S, Del-Castillo Castenada C, Bylsma F, Tycko B, Mayeux R.
Ann Neurol 41(5):615-20. 1997
93AD2, APOE
Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.
Bales KR, Verina T, Dodel RC, Du Y, Altstiel L, Bender M, Hyslop P, Johnstone EM, Little SP, Cummins DJ, Piccardo P, Ghetti B, Paul SM.
Nat Genet 17(3):263-4. 1997
94APOC-E@, APOC1, APOC2, APOC4, APOE
Two hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene cluster.
Allan CM, Taylor S, Taylor JM.
J Biol Chem 272(46):29113-9. 1997
95APOE, AD2
Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample.
Jarvik GP, et al.
Am J Hum Genet 58 : 191-200. 1996
96APOE
A 10-bp deletion in the apolipoprotein epsilon gene causing apolipoprotein E deficiency and severe type III hyperlipoproteinemia.
Feussner G, et al.
Am J Hum Genet 58 : 281-291. 1996
97AD2, APOE
Association of apolipoprotein E epsilon4 allele with bulbar-onset motor neuron disease.
Al-Chalabi A, et al.
Lancet 347 : 159-160. 1996
98AD2, APOE
Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotien E epsilon4.
Rao VS, et al.
Am J Hum Genet 59 : 664-675. 1996
99APOE
Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.
Schupf N, et al.
Ann Neurol 40 : 799-801. 1996
100APOE, AD2
Lack of an association between apolipoprotein E epsilon4 and Alzheimer's disease in elderly Nigerians.
Osuntokun BO, et al.
Ann Neurol 38 : 463-465. 1995
101AD2, APOE
Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein.
Polvikoski T, et al.
N Engl J Med 333 : 1242-1247. 1995
102APOC1, APOE, AD2
A closely linked gene to apolipoprotein E may serve as an additonal riskfactor for Alzheimer's disease.
Poduslo SE, et al.
Neurosci Lett 201 : 81-83. 1995
103APOE, NIDDM6
Increased frequency of apolipoprotein epsilon2 allele in non-insulin dependent diabetic (NIDDM) patients with nephropathy.
Eto M, et al.
Clin Genet 48 : 288-292. 1995
104LCR-APOC-E@, APOC1, APOE
Structure of the hepatic control region of the human apolipoprotein E/C-I gene locus.
Dang Q, Walker D, Taylor S, Allan C, Chin P, Fan J, Taylor J.
J Biol Chem 270(38):22577-85 1995
105APOE, AD2
Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease.
Liddell M, et al.
J Med Genet 31 : 197-200. 1994
106APOE, AD2
Apolipoprotein E, epsilon4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease : analysis of the 19q13.2 chromosomal region.
Chartier-Harlin MC, et al.
Hum Mol Genet 3 : 569-574. 1994
107APOC-E@, AD2, APOC1, APOC2, APOE
The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease.
Yu CE, et al.
Am J Hum Genet 54 : 631-642. 1994
108APOE, AD2
The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease.
Amouyel P, et al.
Lancet 344 : 1315-1318. 1994
109APOE
Plasma lipoproteins in familial dysbetalipoproteinemia associated with apolipoproteins E2 (Arg158-Cys), E3-Leiden and E2(Lys146-Gln), and effects of treatment with simvastatin.
Zhao SP, et al.
Arterioscler Thromb 14 : 1705-1716. 1994
110APOE
Characterization of five new mutants in the carboxyl-terminal domain of human apolipoprotein E : no cosegregation with severe hyperlipidemia.
van den Maagdenberg AMJM, et al.
Am J Hum Genet 52 : 937-946. 1993
111APOE, AD2
Linkage of late-onset Alzheimer's disease with apolipoprotein E type 4 on chromosome 19.
Borgaonkar DS, et al.
Lancet 342 : 625. 1993
112APOE, AD3
Apolipoprotein E epsilon4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases.
Saunders AM, et al.
Lancet 342 : 710-711. 1993
113APOE, AD3
Apolipoprotein E polymorphism and Alzheimer's disease.
Poirier J, et al.
Lancet 342 : 697-699. 1993
114APOE
Heterozygosity for apolipoprotein E-4Philadelphia (GLU13-Lys, Arg145-Cys) is associated with incomplete dominance of type III hyperlipoproteinemia.
Lohse P, et al.
J Biol Chem 267 : 13642-13646. 1992
115APOE, CSF1R
Increased apolipoprotein E and c-fms gene expression without elevated interleukin 1 or 6 mRNA levels indicates selective activation of macrophage functions in advanced human atheroma.
Salomon RN, et al.
Proc Natl Acad Sci U S A 89 : 2814-2818. 1992
116APOE
Apolipoprotein E1 Lys-146--Glu with type III hyperlipoproteinemia.
Moriyama K, et al.
Biochim Biophys Acta 1128 : 58-64. 1992
117APOE
Apolipoprotein E-4Philadelphia (Glu13 - Lys, Arg145 - Cys). Homozygosity for two rare point mutations in the apolipoprotein E gene combined with severe type III hyperlipoproteinemia.
Lohse P, et al.
J Biol Chem 266 : 10479-10484. 1991
118APOE
Familial dysbetalipoproteinemia associated with apolipoprotein E3-Leiden in an extended multigeneration pedigree.
de Knijff P, et al.
J Clin Invest 88 : 643-655. 1991
119APOE
Apolipoprotein E genotyping by one-stage PCR.
Wenham PR, et al.
Lancet 337 : 1158-1159. 1991
120APOE
Apolipoprotein E polymorphism determined by restriction enzyme analysis of DNA amplified by polymerase chain reaction : convenient alternative to phenotyping by isoelectric focusing.
Kontula K, et al.
Clin Chem 36 : 2087-2092. 1990
121APOC-E@, APOC4, APOE
Long-range restriction map of a region of human chromosome 19 containing the apolipoprotein genes, a CLL-associated translocation breakpoint, and two polymorphic MluI sites.
Shaw DJ, et al.
Hum Genet 83 : 71-74. 1989
122APOE, APOC2
Apolipoprotein (apo) E genotypes by polymerase chain reaction and allele-specific oligonucleotide probes : no detectable linkage disequilibrium between apo E and apo CII.
Houlston RS, et al.
Hum Genet 83 : 364-368. 1989
123APOE
A common restriction fragment length polymorphism of the human apolipoprotein E gene and its relationship to type III hyperlipidaemia.
Klasen EC, et al.
Hum Genet 75 : 244-247. 1987
124APOE
The molecular basis of a familial ApoE deficiency. An acceptor splice site mutation in the third intron of the deficient apoE gene.
Cladaras C, Hadzopoulou-Cladaras M, Felber BK, Pavlakis G, Zannis VI.
J Biol Chem 262 : 2310-2315. 1987
125APOC1, APOC2, APOE, C3, LDLR, PEPD, GPI
Regional mapping of human chromosome 19 : Organisation of genes for plasma lipid transport (APOC1,-C2, and -E and LDLR) and the genes C3, PEPD, and GPI.
Lusis AJ, et al.
Proc Natl Acad Sci U S A 83 : 3929-3933. 1986
126APOE
Apolipoprotein E3-Leiden. A new variant of human apolipoprotein E associated with familial type III hyperlipoproteinemia.
Havekes L, de Wit E, Leuven JG, Klasen E, Utermann G, Weber W, Beisiegel U.
Hum Genet 73 : 157-163. 1986
127APOC1, APOE, APOC1P1
There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4kb from the gene for apo E.
Davison PJ, et al.
Biochem Biophys Res Commun 136 : 876-884. 1986
128APOC1, APOC2, APOE, ERCC1, LDLR
A somatic cell hybrid panel for chromosome 19 : localization of known genes and RFLP's and orientation of the linkage group.
Brook JD, et al.
(HGM8) Cytogenet Cell Genet 40 : 590-591. 1985
129APOE
Isolation, characterization, and mapping to chromosome 19 of the human apolipoprotein E gene.
Das HK, et al.
J Biol Chem 260 : 6240-6247. 1985
130APOE
The locus for apolipoprotein E (apoE) is close to the Lutheran (LU) blood group locus on chromosome 19.
Gedde-Dahl T, et al.
Hum Genet 67 : 178-182. 1984
131C3, PEPD, GPI, APOE
Mapping studies with peptidase D (PEPD).
Ball S, et al.
(HGM7) Cytogenet Cell Genet 37 : 411-412. 1984
132APOE
Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects.
Rall SC Jr, Weisgraber KH, Innerarity TL, Mahley RW.
Proc Natl Acad Sci U S A 79 : 4696-4700. 1982