Citations for
1AGTR1, APLNR
Stretch-Induced Biased Signaling in Angiotensin II Type 1 and Apelin Receptors for the Mediation of Cardiac Contractility and Hypertrophy.
Seo K, Parikh VN, Ashley EA.
Front Physiol 11:181. doi: 10.3389/fphys.2020.00181. eCollection 2020. Review. 2020
2APLNR
The Apelin/APJ System in Psychosis and Neuropathy.
Lv SY, Chen WD, Wang YD.
Front Pharmacol 11:320. doi: 10.3389/fphar.2020.00320. eCollection 2020. Review. 2020
3APELA, APLNR
The Elabela-APJ axis: a promising therapeutic target for heart failure.
Ma Z, Song JJ, Martin S, Yang XC, Zhong JC.
Heart Fail Rev eart Fail Rev. 2020 Apr 20. doi: 10.1007/s10741-020-09957-5. [Epub ahead of print] Review. 2020
4ADRA1A, APLNR
Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction.
Nagano K, Kwon C, Ishida J, Hashimoto T, Kim JD, Kishikawa N, Murao M, Kimura K, Kasuya Y, Kimura S, Chen YC, Tsuchimochi H, Shirai M, Pearson JT, Fukamizu A.
J Biochem 166(5):383-392. doi: 10.1093/jb/mvz071. 2019
5APLNR
Apelin and apelin receptor expression in renal cell carcinoma.
Tolkach Y, Ellinger J, Kremer A, Esser L, Müller SC, Stephan C, Jung K, Toma M, Kristiansen G, Hauser S.
Br J Cancer 120(6):633-639. doi: 10.1038/s41416-019-0396-7. Epub 2019 Feb 20. 2019
6APLNR
Apelin receptor (Aplnr) signaling promotes fibroblast migration.
Doğan A.
Tissue Cell 56:98-106. doi: 10.1016/j.tice.2019.01.003. Epub 2019 Jan 17. 2019
7APLNR
Function and regulation of apelin/APJ system in digestive physiology and pathology.
Huang Z, Luo X, Liu M, Chen L.
J Cell Physiol 234(6):7796-7810. doi: 10.1002/jcp.27720. Epub 2018 Nov 2. Review. 2019
8APELA, APLNR
Apela/Elabela/Toddler: New perspectives in molecular mechanism of heart failure.
Sunjaya AP, Sunjaya AF, Ferdinal F.
Glob Cardiol Sci Pract 2019(2):e201915. doi: 10.21542/gcsp.2019.15. Review. 2019
9APLNR
Apelin/APJ system: A novel promising target for anti-aging intervention.
Zhou Q, Chen L, Tang M, Guo Y, Li L.
Clin Chim Acta 487:233-240. doi: 10.1016/j.cca.2018.10.011. Epub 2018 Oct 5. Review. 2018
10APLNR
Apelin/APJ system: A critical regulator of vascular smooth muscle cell.
Luo X, Liu J, Zhou H, Chen L.
J Cell Physiol 233(7):5180-5188. doi: 10.1002/jcp.26339. Epub 2018 Jan 23. Review. 2018
11APLN, APLNR
Effect of the spinal apelin‑APJ system on the pathogenesis of chronic constriction injury‑induced neuropathic pain in rats.
Xiong Q, He W, Wang H, Zhou J, Zhang Y, He J, Yang C, Zhang B.
Mol Med Rep 16(2):1223-1231. doi: 10.3892/mmr.2017.6734. Epub 2017 Jun 9. 2017
12APELA, APLN, APLNR
Structural Basis for Apelin Control of the Human Apelin Receptor.
Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F.
Structure 25(6):858-866.e4. doi: 10.1016/j.str.2017.04.008. Epub 2017 May 18. 2017
13ACE, APELA, APLNR
ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.
Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K.
Cardiovasc Res 113(7):760-769. doi: 10.1093/cvr/cvx061. 2017
14APLNR
The mechanosensitive APJ internalization via clathrin-mediated endocytosis: A new molecular mechanism of cardiac hypertrophy.
He L, Chen L, Li L.
Med Hypotheses 90:6-10. doi: 10.1016/j.mehy.2016.02.017. Epub 2016 Feb 27. 2016
15APLN, APLNR
Apelin (APLN) and Apelin Receptor (APLNR) in Human Ovary: Expression, Signaling, and Regulation of Steroidogenesis in Primary Human Luteinized Granulosa Cells.
Roche J, Ramé C, Reverchon M, Mellouk N, Cornuau M, Guerif F, Froment P, Dupont J.
Biol Reprod 95(5):104. Epub 2016 Sep 28. 2016
16APLN, APLNR
Hypoxia induces the proliferation of endothelial progenitor cells via upregulation of Apelin/APLNR/MAPK signaling.
Zhang J, Liu Q, Fang Z, Hu X, Huang F, Tang L, Zhou S.
Mol Med Rep 13(2):1801-6. doi: 10.3892/mmr.2015.4691. Epub 2015 Dec 17. 2016
17APELA, APLNR
Apela Regulates Fluid Homeostasis by Binding to the APJ Receptor to Activate Gi Signaling.
Deng C, Chen H, Yang N, Feng Y, Hsueh AJ.
J Biol Chem 290(30):18261-8. doi: 10.1074/jbc.M115.648238. Epub 2015 May 20. 2015
18APLN, APLNR
New structural insights into the apelin receptor: identification of key residues for apelin binding.
Gerbier R, Leroux V, Couvineau P, Alvear-Perez R, Maigret B, Llorens-Cortes C, Iturrioz X.
FASEB J 29(1):314-22. doi: 10.1096/fj.14-256339. Epub 2014 Oct 30. 2015
19APLNR, BDKRB1
Heterodimerization of human apelin and bradykinin 1 receptors: novel signal transduction characteristics.
Bai B, Liu L, Zhang N, Wang C, Jiang Y, Chen J.
Cell Signal 26(7):1549-59. doi: 10.1016/j.cellsig.2014.03.022. Epub 2014 Mar 29. 2014
20APLN, APLNR
Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling.
Chen X, Bai B, Tian Y, Du H, Chen J.
J Biol Chem 289(45):31173-87. doi: 10.1074/jbc.M114.574020. Epub 2014 Sep 30. 2014
21APLN, APLNR
Apelin and its receptor APJ in cardiovascular diseases.
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK.
Clin Chim Acta 428:1-8. doi: 10.1016/j.cca.2013.09.001. Epub 2013 Sep 18. Review. 2014
22APLNR, CER1, SMARCD3
The G-protein-coupled receptor APJ is expressed in the second heart field and regulates Cerberus-Baf60c axis in embryonic stem cell cardiomyogenesis.
D'Aniello C, Fiorenzano A, Iaconis S, Liguori GL, Andolfi G, Cobellis G, Fico A, Minchiotti G.
Cardiovasc Res 100(1):95-104. doi: 10.1093/cvr/cvt166. Epub 2013 Jun 19. 2013
23APLNR
APJ acts as a dual receptor in cardiac hypertrophy.
Scimia MC, Hurtado C, Ray S, Metzler S, Wei K, Wang J, Woods CE, Purcell NH, Catalucci D, Akasaka T, Bueno OF, Vlasuk GP, Kaliman P, Bodmer R, Smith LH, Ashley E, Mercola M, Brown JH, Ruiz-Lozano P.
Nature 488(7411):394-8. doi: 10.1038/nature11263. 2012
24APLN, APLNR
The apelinergic system in the developing lung: expression and signaling.
Piairo P, Moura RS, Nogueira-Silva C, Correia-Pinto J.
Peptides 32(12):2474-83. doi: 10.1016/j.peptides.2011.10.010. Epub 2011 Oct 12. 2011
25APL, APLN, APLNR
Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans.
Dray C, Debard C, Jager J, Disse E, Daviaud D, Martin P, Attané C, Wanecq E, Guigné C, Bost F, Tanti JF, Laville M, Vidal H, Valet P, Castan-Laurell I.
Am J Physiol Endocrinol Metab 298(6):E1161-9. Epub 2010 Mar 16.PMID: 20233941 2010
26APLN, APLNR
Apelin and its receptor APJ in human aortic valve stenosis.
Peltonen T, Näpänkangas J, Vuolteenaho O, Ohtonen P, Soini Y, Juvonen T, Satta J, Ruskoaho H, Taskinen P.
J Heart Valve Dis 18(6):644-52.PMID: 20099713 2009
27APLN, APLNR
Abnormal fluid homeostasis in apelin receptor knockout mice.
Roberts EM, Newson MJ, Pope GR, Landgraf R, Lolait SJ, O'Carroll AM.
J Endocrinol 202(3):453-62. Epub 2009 Jul 3.PMID: 19578099 2009
28APLNR
Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction.
Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M.
Hum Mol Genet 16(6):630-9. Epub 2007 Feb 19. 2007
29APLN, APLNR
Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure.
Foldes G, Horkay F, Szokodi I, Vuolteenaho O, Ilves M, Lindstedt KA, Mayranpaa M, Sarman B, Seres L, Skoumal R, Lako-Futo Z, deChatel R, Ruskoaho H, Toth M.
Biochem Biophys Res Commun 308(3):480-5. 2003
30APLN, APLNR
Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction.
Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R, Ben-Dor A, Fenster B, Yang E, King JY, Fowler M, Robbins R, Johnson FL, Bruhn L, McDonagh T, Dargie H, Yakhini Z, Tsao PS, Quertermous T.
Circulation 108(12):1432-9. Epub 2003 Sep 8. 2003
31APLN, APLNR
Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin.
Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, Lawrie KW, Hervieu G, Riley G, Bolaky JE, Herrity NC, Murdock P, Darker JG.
J Neurochem 84(5):1162-72.PMID: 12603839 2003
32APLNR
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11.
O'Dowd BF, et al.
Gene 136 : 355-360. 1993