| 1 | APELA, APLN
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| Elabela and Apelin actions in healthy and pathological pregnancies.
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| Eberlé D, Marousez L, Hanssens S, Knauf C, Breton C, Deruelle P, Lesage J.
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| Cytokine Growth Factor Rev 46:45-53. doi: 10.1016/j.cytogfr.2019.03.003. Epub 2019 Mar 16. Review.
2019
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| 2 | APELA, APLN
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| Apelin and Elabela/Toddler; double ligands for APJ/Apelin receptor in heart development, physiology, and pathology.
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| Kuba K, Sato T, Imai Y, Yamaguchi T.
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| Peptides 111:62-70. doi: 10.1016/j.peptides.2018.04.011. Epub 2018 Apr 21. Review.
2019
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| 3 | APELA, APLN, GPR25
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| The orphan G protein-coupled receptor 25 (GPR25) is activated by Apelin and Apela in non-mammalian vertebrates.
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| Zhang J, Wan Y, Fang C, Chen J, Ouyang W, Li J, Wang Y.
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| Biochem Biophys Res Commun 501(2):408-414. doi: 10.1016/j.bbrc.2018.04.229. Epub 2018 May 11.
2018
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| 4 | APLN, APLNR
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| Effect of the spinal apelin‑APJ system on the pathogenesis of chronic constriction injury‑induced neuropathic pain in rats.
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| Xiong Q, He W, Wang H, Zhou J, Zhang Y, He J, Yang C, Zhang B.
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| Mol Med Rep 16(2):1223-1231. doi: 10.3892/mmr.2017.6734. Epub 2017 Jun 9.
2017
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| 5 | APELA, APLN, APLNR
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| Structural Basis for Apelin Control of the Human Apelin Receptor.
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| Ma Y, Yue Y, Ma Y, Zhang Q, Zhou Q, Song Y, Shen Y, Li X, Ma X, Li C, Hanson MA, Han GW, Sickmier EA, Swaminath G, Zhao S, Stevens RC, Hu LA, Zhong W, Zhang M, Xu F.
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| Structure 25(6):858-866.e4. doi: 10.1016/j.str.2017.04.008. Epub 2017 May 18.
2017
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| 6 | APLN
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| Hypoxic Exercise Training Promotes apelin/APJ Expression in Skeletal Muscles of High Fat Diet-Induced Obese Mice.
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| Ji W, Gong L, Wang J, He H, Zhang Y.
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| Protein Pept Lett 24(1):64-70. doi: 10.2174/0929866524666161111111726.
2017
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| 7 | APELA, APLN
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| Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.
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| Perjés Á, Kilpiö T, Ulvila J, Magga J, Alakoski T, Szabó Z, Vainio L, Halmetoja E, Vuolteenaho O, Petäjä-Repo U, Szokodi I, Kerkelä R.
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| Basic Res Cardiol 111(1):2. doi: 10.1007/s00395-015-0521-6. Epub 2015 Nov 26.
2016
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| 8 | APLN, APLNR
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| Apelin (APLN) and Apelin Receptor (APLNR) in Human Ovary: Expression, Signaling, and Regulation of Steroidogenesis in Primary Human Luteinized Granulosa Cells.
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| Roche J, Ramé C, Reverchon M, Mellouk N, Cornuau M, Guerif F, Froment P, Dupont J.
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| Biol Reprod 95(5):104. Epub 2016 Sep 28.
2016
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| 9 | APLN, APLNR
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| Hypoxia induces the proliferation of endothelial progenitor cells via upregulation of Apelin/APLNR/MAPK signaling.
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| Zhang J, Liu Q, Fang Z, Hu X, Huang F, Tang L, Zhou S.
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| Mol Med Rep 13(2):1801-6. doi: 10.3892/mmr.2015.4691. Epub 2015 Dec 17.
2016
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| 10 | APLN, APLNR
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| New structural insights into the apelin receptor: identification of key residues for apelin binding.
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| Gerbier R, Leroux V, Couvineau P, Alvear-Perez R, Maigret B, Llorens-Cortes C, Iturrioz X.
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| FASEB J 29(1):314-22. doi: 10.1096/fj.14-256339. Epub 2014 Oct 30.
2015
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| 11 | APLN
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| Apelin attenuates oxidative stress in human adipocytes.
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| Than A, Zhang X, Leow MK, Poh CL, Chong SK, Chen P.
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| J Biol Chem 289(6):3763-74. doi: 10.1074/jbc.M113.526210. Epub 2013 Dec 20.
2014
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| 12 | APLN, ATF4
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| Apelin is transcriptionally regulated by ER stress-induced ATF4 expression via a p38 MAPK-dependent pathway.
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| Jeong K, Oh Y, Kim SJ, Kim H, Park KC, Kim SS, Ha J, Kang I, Choe W.
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| Apoptosis 19(9):1399-410. doi: 10.1007/s10495-014-1013-0.
2014
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| 13 | APLN, APLNR
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| Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling.
|
| Chen X, Bai B, Tian Y, Du H, Chen J.
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| J Biol Chem 289(45):31173-87. doi: 10.1074/jbc.M114.574020. Epub 2014 Sep 30.
2014
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| 14 | APLN, APLNR
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| Apelin and its receptor APJ in cardiovascular diseases.
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| Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK.
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| Clin Chim Acta 428:1-8. doi: 10.1016/j.cca.2013.09.001. Epub 2013 Sep 18. Review.
2014
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| 15 | APLN, EGR1, SPP1
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| Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
|
| Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ.
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| Biochem Biophys Res Commun 439(2):235-40. doi: 10.1016/j.bbrc.2013.08.051. Epub 2013 Aug 22.
2013
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| 16 | APLN
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| Apelin-13 regulates proliferation, migration and survival of retinal Müller cells under hypoxia.
|
| Lu Q, Jiang YR, Qian J, Tao Y.
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| Diabetes Res Clin Pract 99(2):158-67. doi: 10.1016/j.diabres.2012.09.045. Epub 2013 Jan 15.
2013
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| 17 | APLN
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| Apelin-13 induces proliferation, migration, and collagen I mRNA expression in human RPE cells via PI3K/Akt and MEK/Erk signaling pathways.
|
| Qin D, Zheng XX, Jiang YR.
|
| Mol Vis 19:2227-36. eCollection 2013.
2013
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| 18 | ACE2, APLN
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| Apelin is a positive regulator of ACE2 in failing hearts.
|
| Sato T, Suzuki T, Watanabe H, Kadowaki A, Fukamizu A, Liu PP, Kimura A, Ito H, Penninger JM, Imai Y, Kuba K.
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| J Clin Invest 123(12):5203-11. doi: 10.1172/JCI69608. Epub 2013 Nov 1.
2013
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| 19 | APLN
|
| Apelin ameliorates TNF-α-induced reduction of glycogen synthesis in the hepatocytes through G protein-coupled receptor APJ.
|
| Chu J, Zhang H, Huang X, Lin Y, Shen T, Chen B, Man Y, Wang S, Li J.
|
| PLoS One 8(2):e57231. doi: 10.1371/journal.pone.0057231. Epub 2013 Feb 21.
2013
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| 20 | APLN
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| Inhibition of apelin expression by BMP signaling in endothelial cells.
|
| Poirier O, Ciumas M, Eyries M, Montagne K, Nadaud S, Soubrier F.
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| Am J Physiol Cell Physiol 303(11):C1139-45. doi: 10.1152/ajpcell.00168.2012. Epub 2012 Aug 15.
2012
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| 21 | APLN
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| Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
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| Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P.
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| Mol Cell Endocrinol 362(1-2):227-41. doi: 10.1016/j.mce.2012.07.002. Epub 2012 Jul 26.
2012
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| 22 | APLN
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| APELIN promotes hematopoiesis from human embryonic stem cells.
|
| Yu QC, Hirst CE, Costa M, Ng ES, Schiesser JV, Gertow K, Stanley EG, Elefanty AG.
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| Blood 119(26):6243-54. doi: 10.1182/blood-2011-12-396093. Epub 2012 May 18.
2012
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| 23 | APLN, OPRK1
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| Heterodimerization of human apelin and kappa opioid receptors: roles in signal transduction.
|
| Li Y, Chen J, Bai B, Du H, Liu Y, Liu H.
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| Cell Signal 24(5):991-1001. doi: 10.1016/j.cellsig.2011.12.012. Epub 2011 Dec 20.
2012
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| 24 | APLN
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| Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis.
|
| Kasai A, Kinjo T, Ishihara R, Sakai I, Ishimaru Y, Yoshioka Y, Yamamuro A, Ishige K, Ito Y, Maeda S.
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| PLoS One 6(8):e23968. doi: 10.1371/journal.pone.0023968. Epub 2011 Aug 24.
2011
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| 25 | APLN
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| Lower serum apelin levels in women with polycystic ovary syndrome.
|
| Chang CY, Tsai YC, Lee CH, Chan TF, Wang SH, Su JH.
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| Fertil Steril 95(8):2520-3.e1-2. doi: 10.1016/j.fertnstert.2011.04.044. Epub 2011 May 14.
2011
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| 26 | APLN, APLNR
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| The apelinergic system in the developing lung: expression and signaling.
|
| Piairo P, Moura RS, Nogueira-Silva C, Correia-Pinto J.
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| Peptides 32(12):2474-83. doi: 10.1016/j.peptides.2011.10.010. Epub 2011 Oct 12.
2011
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| 27 | APL, APLN, APLNR
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| Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans.
|
| Dray C, Debard C, Jager J, Disse E, Daviaud D, Martin P, Attané C, Wanecq E, Guigné C, Bost F, Tanti JF, Laville M, Vidal H, Valet P, Castan-Laurell I.
|
| Am J Physiol Endocrinol Metab 298(6):E1161-9. Epub 2010 Mar 16.PMID: 20233941 2010
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| 28 | ACE2, APLN
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| Apelin and ACE2 in cardiovascular disease.
|
| Kalea AZ, Batlle D.
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| Curr Opin Investig Drugs 11(3):273-82. Review. 2010
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| 29 | APLN
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| Structural insight into G-protein coupled receptor binding by apelin.
|
| Langelaan DN, Bebbington EM, Reddy T, Rainey JK.
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| Biochemistry 48(3):537-48.PMID: 19123778 2009
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| 30 | APLN, APLNR
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| Apelin and its receptor APJ in human aortic valve stenosis.
|
| Peltonen T, Näpänkangas J, Vuolteenaho O, Ohtonen P, Soini Y, Juvonen T, Satta J, Ruskoaho H, Taskinen P.
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| J Heart Valve Dis 18(6):644-52.PMID: 20099713 2009
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| 31 | APLN, APLNR
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| Abnormal fluid homeostasis in apelin receptor knockout mice.
|
| Roberts EM, Newson MJ, Pope GR, Landgraf R, Lolait SJ, O'Carroll AM.
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| J Endocrinol 202(3):453-62. Epub 2009 Jul 3.PMID: 19578099 2009
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| 32 | APLN
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| A putative role for apelin in the etiology of obesity.
|
| Rayalam S, Della-Fera MA, Krieg PA, Cox CM, Robins A, Baile CA.
|
| Biochem Biophys Res Commun 368(3):815-9. Epub 2008 Feb 12. Review. 2008
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| 33 | APLN
|
| The hepatic apelin system: a new therapeutic target for liver disease.
|
| Principe A, Melgar-Lesmes P, Fernández-Varo G, del Arbol LR, Ros J, Morales-Ruiz M, Bernardi M, Arroyo V, Jiménez W.
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| Hepatology 48(4):1193-201.PMID: 1881663 2008
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| 34 | APLN
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| Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus.
|
| Erdem G, Dogru T, Tasci I, Sonmez A, Tapan S.
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| Exp Clin Endocrinol Diabetes 116(5):289-92.PMID: 18484561 2008
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| 35 | APLN
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| Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemia-reperfusion injury.
|
| Simpkin JC, Yellon DM, Davidson SM, Lim SY, Wynne AM, Smith CC.
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| Basic Res Cardiol 102(6):518-28. Epub 2007 Aug 13.PMID: 17694254 2007
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| 36 | APLN
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| Apelin is a potent activator of tumour neoangiogenesis.
|
| Sorli SC, Le Gonidec S, Knibiehler B, Audigier Y.
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| Oncogene 26(55):7692-9. Epub 2007 Jun 11.PMID: 17563744 2007
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| 37 | APLN
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| Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells.
|
| Hashimoto T, Kihara M, Ishida J, Imai N, Yoshida S, Toya Y, Fukamizu A, Kitamura H, Umemura S.
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| Arterioscler Thromb Vasc Biol 26(6):1267-72. Epub 2006 Mar 23. 2006
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| 38 | APLN
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| Apelin, a newly identified adipokine up-regulated by insulin and obesity.
|
| Boucher J, Masri B, Daviaud D, Gesta S, Guigne C, Mazzucotelli A, Castan-Laurell I, Tack I, Knibiehler B, Carpene C, Audigier Y, Saulnier-Blache JS, Valet P.
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| Endocrinology 146(4):1764-71. Epub 2005 Jan 27. 2005
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| 39 | APLN
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| Apelin, a new enteric peptide: localization in the gastrointestinal tract, ontogeny, and stimulation of gastric cell proliferation and of cholecystokinin secretion.
|
| Wang G, Anini Y, Wei W, Qi X, OCarroll AM, Mochizuki T, Wang HQ, Hellmich MR, Englander EW, Greeley GH Jr.
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| Endocrinology 145(3):1342-8. Epub 2003 Dec 11. 2004
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| 40 | APLN
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| Apelin is a novel angiogenic factor in retinal endothelial cells.
|
| Kasai A, Shintani N, Oda M, Kakuda M, Hashimoto H, Matsuda T, Hinuma S, Baba A.
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| Biochem Biophys Res Commun 325(2):395-400. 2004
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| 41 | APLN, APLNR
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| Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure.
|
| Foldes G, Horkay F, Szokodi I, Vuolteenaho O, Ilves M, Lindstedt KA, Mayranpaa M, Sarman B, Seres L, Skoumal R, Lako-Futo Z, deChatel R, Ruskoaho H, Toth M.
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| Biochem Biophys Res Commun 308(3):480-5. 2003
|
| 42 | APLN, APLNR
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| Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction.
|
| Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R, Ben-Dor A, Fenster B, Yang E, King JY, Fowler M, Robbins R, Johnson FL, Bruhn L, McDonagh T, Dargie H, Yakhini Z, Tsao PS, Quertermous T.
|
| Circulation 108(12):1432-9. Epub 2003 Sep 8. 2003
|
| 43 | APLN, APLNR
|
| Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin.
|
| Medhurst AD, Jennings CA, Robbins MJ, Davis RP, Ellis C, Winborn KY, Lawrie KW, Hervieu G, Riley G, Bolaky JE, Herrity NC, Murdock P, Darker JG.
|
| J Neurochem 84(5):1162-72.PMID: 12603839 2003
|
| 44 | APLN
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| Molecular properties of apelin: tissue distribution and receptor binding.
|
| Kawamata Y, Habata Y, Fukusumi S, Hosoya M, Fujii R, Hinuma S, Nishizawa N, Kitada C, Onda H, Nishimura O, Fujino M.
|
| Biochim Biophys Acta 1538(2-3):162-71. 2001
|
| 45 | APLN
|
| Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum.
|
| Habata Y, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, Kitada C, Nishizawa N, Murosaki S, Kurokawa T, Onda H, Tatemoto K, Fujino M.
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| Biochim Biophys Acta 1452(1):25-35. 1999
|
| 46 | APLN
|
| Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.
|
| Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H, Fujino M.
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| Biochem Biophys Res Commun 251(2):471-6. 1998
|