| 1 | APEX1, PRDX1
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| Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression.
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| Nassour H, Wang Z, Saad A, Papaluca A, Brosseau N, Affar el B, Alaoui-Jamali MA, Ramotar D.
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| Sci Rep 6:29389. doi: 10.1038/srep29389.
2016
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| 2 | APEX1, POT1, TERF2
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| Essential role for mammalian apurinic/apyrimidinic (AP) endonuclease Ape1/Ref-1 in telomere maintenance.
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| Madlener S, Ströbel T, Vose S, Saydam O, Price BD, Demple B, Saydam N.
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| Proc Natl Acad Sci U S A 110(44):17844-9. doi: 10.1073/pnas.1304784110. Epub 2013 Oct 14.
2013
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| 3 | APEX1
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| Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.
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| Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G.
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| Mol Biol Cell 23(20):4079-96. doi: 10.1091/mbc.E12-04-0299. Epub 2012 Aug 23.
2012
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| 4 | APEX1
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| Nuclear depletion of apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) is an indicator of energy disruption in neurons.
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| Singh S, Englander EW.
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| Free Radic Biol Med 53(9):1782-90. doi: 10.1016/j.freeradbiomed.2012.07.025. Epub 2012 Jul 27.
2012
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| 5 | APEX1, CYP11B2
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| APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans.
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| McManus F, Sands W, Diver L, MacKenzie SM, Fraser R, Davies E, Connell JM.
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| Circ Res 111(2):212-9. doi: 10.1161/CIRCRESAHA.111.262931. Epub 2012 May 31.
2012
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| 6 | APEX1
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| Characterization of the redox activity and disulfide bond formation in apurinic/apyrimidinic endonuclease.
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| Luo M, Zhang J, He H, Su D, Chen Q, Gross ML, Kelley MR, Georgiadis MM.
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| Biochemistry 51(2):695-705. doi: 10.1021/bi201034z. Epub 2012 Jan 4.
2012
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| 7 | APEX1
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| APE1/Ref-1 role in redox signaling: translational applications of targeting the redox function of the DNA repair/redox protein APE1/Ref-1.
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| Kelley MR, Georgiadis MM, Fishel ML.
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| Curr Mol Pharmacol 5(1):36-53. Review.
2012
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| 8 | ABCB1, APEX1, YBX1
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| Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1.
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| Sengupta S, Mantha AK, Mitra S, Bhakat KK.
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| Oncogene 30(4):482-93. Epub 2010 Sep 20.
2011
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| 9 | APEX1
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| Characterization of the endoribonuclease active site of human apurinic/apyrimidinic endonuclease 1.
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| Kim WC, Berquist BR, Chohan M, Uy C, Wilson DM 3rd, Lee CH.
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| J Mol Biol 411(5):960-71. doi: 10.1016/j.jmb.2011.06.050. Epub 2011 Jul 6.
2011
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| 10 | APEX1
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| Impact of APE1/Ref-1 redox inhibition on pancreatic tumor growth.
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| Fishel ML, Jiang Y, Rajeshkumar NV, Scandura G, Sinn AL, He Y, Shen C, Jones DR, Pollok KE, Ivan M, Maitra A, Kelley MR.
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| Mol Cancer Ther 10(9):1698-708. doi: 10.1158/1535-7163.MCT-11-0107. Epub 2011 Jun 23.
2011
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| 11 | APEX1
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| Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo.
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| Jiang A, Gao H, Kelley MR, Qiao X.
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| Vision Res 51(1):93-100. doi: 10.1016/j.visres.2010.10.008. Epub 2010 Oct 14.
2011
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| 12 | APEX1
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| Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer.
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| Kuasne H, Rodrigues IS, Losi-Guembarovski R, Reis MB, Fuganti PE, Gregório EP, Libos Junior F, Matsuda HM, Rodrigues MA, Kishima MO, Cólus IM.
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| Mol Biol Rep 38(3):1585-91. doi: 10.1007/s11033-010-0267-z. Epub 2010 Sep 18.
2011
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| 13 | APEX1, SIRT1
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| SIRT1 deacetylates APE1 and regulates cellular base excision repair.
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| Yamamori T, DeRicco J, Naqvi A, Hoffman TA, Mattagajasingh I, Kasuno K, Jung SB, Kim CS, Irani K.
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| Nucleic Acids Res 38(3):832-45. Epub 2009 Nov 24.
2010
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| 14 | APEX1
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| Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1.
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| Li M, Zhong Z, Zhu J, Xiang D, Dai N, Cao X, Qing Y, Yang Z, Xie J, Li Z, Baugh L, Wang G, Wang D.
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| J Biol Chem 285(20):14871-81. Epub 2010 Mar 15.PMID: 20231292 2010
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| 15 | APEX1
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| Subcellular localization of apurinic endonuclease 1 promotes lung tumor aggressiveness via NF-kappaB activation.
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| Wu HH, Cheng YW, Chang JT, Wu TC, Liu WS, Chen CY, Lee H.
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| Oncogene 29(30):4330-40. doi: 10.1038/onc.2010.178. Epub 2010 May 24.
2010
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| 16 | APEX1
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| APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.
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| Vascotto C, Fantini D, Romanello M, Cesaratto L, Deganuto M, Leonardi A, Radicella JP, Kelley MR, D'Ambrosio C, Scaloni A, Quadrifoglio F, Tell G.
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| Mol Cell Biol. 29(7):1834-54 2009
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| 17 | APEX1, APTX, PARP1
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| Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.
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| Harris JL, Jakob B, Taucher-Scholz G, Dianov GL, Becherel OJ, Lavin MF.
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| Hum Mol Genet 18(21):4102-17. Epub 2009 Jul 30.PMID: 19643912 2009
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| 18 | SMN1, SOD1, HFE, APEX1, ANG
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| Genetics of sporadic amyotrophic lateral sclerosis.
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| Schymick JC, Talbot K, Traynor BJ.
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| Hum Mol Genet 16 Spec No 2:R233-42. 2007
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| 19 | APEX1
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| Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein
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| Mitra S, Izumi T, Boldogh I, Bhakat KK, Chattopadhyay R, Szczesny B.
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| DNA Repair (Amst). 6(4):461-9 2007
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| 20 | APEX1
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| Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells
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| Chattopadhyay, R., L. Wiederhold, B. Szczesny, I. Boldogh, T. K. Hazra, T.
Izumi, and S. Mitra
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| Nucleic Acids Res. 34:2067–2076 2006
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| 21 | APEX1
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| Molecular and biological roles of Ape1 protein in mammalian base excision repair.
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| Demple B, Sung JS.
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| DNA Repair (Amst) 4(12):1442-9. Epub 2005 Sep 30. Review. 2005
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| 22 | APEX1
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| Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair
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| Raffoul JJ, Cabelof DC, Nakamura J, Meira LB, Friedberg EC, Heydari AR.
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| J Biol Chem. 279(18):18425-33 2004
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| 23 | APEX1
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| Specific stimulation of human apurinic/apyrimidinic endonuclease by heat shock protein 70.
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| Mendez F, Sandigursky M, Kureekattil RP, Kenny MK, Franklin WA, Bases R.
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| DNA Repair (Amst) 2(3):259-71. 2003
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| 24 | APEX1, FEN1
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| AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair.
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| Ranalli TA, Tom S, Bambara RA.
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| J Biol Chem 277(44):41715-24. 2002
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| 25 | APEX1, APEX2
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| Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III.
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| Hadi MZ, Ginalski K, Nguyen LH, Wilson DM 3rd.
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| J Mol Biol 316(3):853-66. 2002
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| 26 | APEX1
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| An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3-prime mispaired DNA
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| Chou, K.-M.; Cheng, Y.-C.
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| Nature 415: 655-659 2002
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| 27 | APEX1
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| Altered post-translational modification of redox factor 1 protein in human uterine smooth muscle tumors
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| Orii, A.; Masutani, H.; Nikaido, T.; Zhai, Y.-L.; Kato, K.; Kariya, M.; Konishi, I.; Yodoi, J.; Fujii, S.
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| J. Clin. Endocr. Metab. 87: 3754-3759 2002
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| 28 | APEX1, XRCC1
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| XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions.
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| Vidal AE, Boiteux S, Hickson ID, Radicella JP.
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| EMBO J 20(22):6530-9. 2001
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| 29 | APEX1
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| Functional characterization of ape1 variants identified in the human population.
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| Hadi MZ, Coleman MA, Fidelis K, Mohrenweiser HW, Wilson III DM.
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| Nucleic Acids Res 28(20):3871-9. 2000
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| 30 | APEX1
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| Mapping the protein-DNA interface and the metal-binding site of the major human apurinic/apyrimidinic endonuclease.
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| Nguyen LH, Barsky D, Erzberger JP, Wilson DM 3rd.
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| J Mol Biol 298(3):447-59. 2000
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| 31 | APEX1
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| Human APE/Ref-1 protein.
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| Fritz G.
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| Int J Biochem Cell Biol 32(9):925-9. Review. 2000
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| 32 | APEX1
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| Molecular genetic analysis of the APEX nuclease gene in amyotrophic lateral sclerosis.
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| Hayward C, et al.
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| Neurology 52(9):1899-901. 1999
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| 33 | APEX1
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| Identification of redox/repair protein Ref-1 as a potent activator of p53
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| Jayaraman, L.; Murthy, K. G. K.; Zhu, C.; Curran, T.; Xanthoudakis, S.; Prives, C.
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| Genes Dev. 11: 558-570 1997
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| 34 | APEX1
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| Negative regulation of the major human AP-endonuclease, a multifunctional protein
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| Izumi, T.; Henner, D.; Mitra, S.
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| Biochemistry 35: 14679-14683 1996
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| 35 | APEX1, Ref-1
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| The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
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| Xanthoudakis, S.; Smeyne, R. J.; Wallace, J. D.; Curran, T.
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| Proc. Nat. Acad. Sci 93: 8919-8923 1996
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| 36 | APEX1
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| Structure, promoter analysis and chromosomal assignment of the human APEX gene.
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| Akiyama K, et al.
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| Biochim Biophys Acta 1219 : 15-25. 1994
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| 37 | APEX1
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| Structure of the human DNA repair gene HAP1 and its localisation to chromosome 14q11.2-12.
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| Robson CN, et al.
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| Nucleic Acids Res 20 : 4417-4421. 1992
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| 38 | APEX1
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| Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 14q11.2-12).
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| Harrison L, et al.
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| Hum Mol Genet 1 : 677-680. 1992
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| 39 | APEX1
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| The human gene for apurinic/apyrimidinic endonuclease (HAP1) : sequence and localization to chromosome 14 band q12.
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| Zhao B, et al.
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| Nucleic Acids Res 20 : 4097-4098. 1992
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| 40 | APEX1
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| Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease : definition of a family of DNA repair enzymes.
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| Demple B, et al.
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| Proc Natl Acad Sci U S A 88 : 11450-11454. 1991
|