Citations for
1APC
CpG methylation of APC promoter 1A in sporadic and familial breast cancer patients.
Debouki-Joudi S, Trifa F, Khabir A, Sellami-Boudawara T, Frikha M, Daoud J, Mokdad-Gargouri R.
Cancer Biomark 18(2):133-141. doi: 10.3233/CBM-160005. 2017
2APC, RHOT1, TRAK2
APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.
Mills KM, Brocardo MG, Henderson BR.
Mol Biol Cell 27(3):466-82. doi: 10.1091/mbc.E15-09-0632. Epub 2015 Dec 10. 2016
3APC
APC functions at the centrosome to stimulate microtubule growth.
Lui C, Ashton C, Sharma M, Brocardo MG, Henderson BR.
Int J Biochem Cell Biol 70:39-47. doi: 10.1016/j.biocel.2015.10.028. Epub 2015 Nov 10. 2016
4APC
The APC I1307K allele conveys a significant increased risk for cancer.
Leshno A, Shapira S, Liberman E, Kraus S, Sror M, Harlap-Gat A, Avivi D, Galazan L, David M, Maharshak N, Moanis S, Arber N, Moshkowitz M.
Int J Cancer 138(6):1361-7. doi: 10.1002/ijc.29876. Epub 2015 Oct 13. 2016
5APC, GSTP1, SOCS1
Association of APC, GSTP1 and SOCS1 promoter methylation with the risk of hepatocellular carcinoma: a meta-analysis.
Liu M, Cui LH, Li CC, Zhang L.
Eur J Cancer Prev 24(6):470-83. doi: 10.1097/CEJ.0000000000000121. 2015
6APC, CLSS2
A novel APC mutation defines a second locus for Cenani-Lenz syndrome.
Patel N, Faqeih E, Anazi S, Alfawareh M, Wakil SM, Colak D, Alkuraya FS.
J Med Genet 52(5):317-21. doi: 10.1136/jmedgenet-2014-102850. Epub 2015 Feb 12. 2015
7APC, HDD
N-terminal truncation mutations of adenomatous polyposis coli are associated with primary cilia defects.
Song L, Jia Y, Zhu W, Newton IP, Li Z, Li W.
Int J Biochem Cell Biol 55:79-86. doi: 10.1016/j.biocel.2014.08.010. Epub 2014 Aug 21. 2014
8APC
different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli.
Schneikert J, Ruppert JG, Behrens J, Wenzel EM.
PLoS One 9(4):e94413. doi: 10.1371/journal.pone.0094413. eCollection 2014. 2014
9APC, NRIP1
RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis.
Lapierre M, Bonnet S, Bascoul-Mollevi C, Ait-Arsa I, Jalaguier S, Del Rio M, Plateroti M, Roepman P, Ychou M, Pannequin J, Hollande F, Parker M, Cavailles V.
J Clin Invest 124(5):1899-913. doi: 10.1172/JCI65178. Epub 2014 Mar 25. 2014
10APC, KRAS
Dietary heme iron and the risk of colorectal cancer with specific mutations in KRAS and APC.
Gilsing AM, Fransen F, de Kok TM, Goldbohm AR, Schouten LJ, de Bruïne AP, van Engeland M, van den Brandt PA, de Goeij AF, Weijenberg MP.
Carcinogenesis 34(12):2757-66. doi: 10.1093/carcin/bgt290. Epub 2013 Aug 27. 2013
11APC, FAP
APC germline mutations in families with familial adenomatous polyposis.
De Queiroz Rossanese LB, De Lima Marson FA, Ribeiro JD, Coy CS, Bertuzzo CS.
Oncol Rep 30(5):2081-8. doi: 10.3892/or.2013.2681. Epub 2013 Aug 21. 2013
12APC
Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling.
Li A, Chan B, Felix JC, Xing Y, Li M, Brody SL, Borok Z, Li C, Minoo P.
PLoS One 8(4):e62215. doi: 10.1371/journal.pone.0062215. Print 2013. 2013
13APC
APC binds intermediate filaments and is required for their reorganization during cell migration.
Sakamoto Y, Boëda B, Etienne-Manneville S.
J Cell Biol 200(3):249-58. doi: 10.1083/jcb.201206010. 2013
14APC
APC gene hypermethylation and prostate cancer: a systematic review and meta-analysis.
Chen Y, Li J, Yu X, Li S, Zhang X, Mo Z, Hu Y.
Eur J Hum Genet 21(9):929-35. doi: 10.1038/ejhg.2012.281. Epub 2013 Jan 9. Review. 2013
15APC
APC gene hypermethylation and prostate cancer: a systematic review and meta-analysis.
Chen Y, Li J, Yu X, Li S, Zhang X, Mo Z, Hu Y.
Eur J Hum Genet 21(9):929-35. doi: 10.1038/ejhg.2012.281. Epub 2013 Jan 9. Review. 2013
16APC, AXIN1, HECTD1
HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.
Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, Zilberleyb I, Lee MW, Phu L, Sarkar AA, Zohn IE, Wertz IE, Kirkpatrick DS, Polakis P.
J Biol Chem 288(6):3753-67. doi: 10.1074/jbc.M112.415240. Epub 2012 Dec 31. 2013
17AMER2, APC, MAPRE1
Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
Pfister AS, Hadjihannas MV, Röhrig W, Schambony A, Behrens J.
J Biol Chem 287(42):35333-40. doi: 10.1074/jbc.M112.385393. Epub 2012 Aug 16. 2012
18APC, SMAD7, TGFBR1
APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration.
Ekman M, Mu Y, Lee SY, Edlund S, Kozakai T, Thakur N, Tran H, Qian J, Groeden J, Heldin CH, Landström M.
Mol Biol Cell 23(11):2109-21. doi: 10.1091/mbc.E10-12-1000. Epub 2012 Apr 11. 2012
19APC
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling.
Roberts DM, Pronobis MI, Poulton JS, Waldmann JD, Stephenson EM, Hanna S, Peifer M.
Mol Biol Cell. 22(11):1845-63. 2011
20APC, CTBP2
APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.
Schneikert J, Brauburger K, Behrens J.
Hum Mol Genet 20(18):3554-64. Epub 2011 Jun 10. 2011
21APC, CCNB3
Proteomic identification of overexpressed adenomatous polyposis coli and cyclin B3 during endoderm differentiation from human embryonic stem cells.
Lee DH, Ji YG, Chung HM, Ko JJ, Kim SK.
Pancreas 40(2):271-80. 2011
22APC, CTNNB1, DISC1, DLG4, FZD1, GSK3B, NEUROD1, PRICKLE1, SFRP1, SYN1, WNT1, WNT3, WNT3A, WNT5A, WNT7A
Emerging roles of Wnts in the adult nervous system.
Inestrosa NC, Arenas E.
Nat Rev Neurosci. 11(2):77-86. 2010
23APC, DVL1, WNT5A
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells.
Matsumoto S, Fumoto K, Okamoto T, Kaibuchi K, Kikuchi A.
EMBO J 29(7):1192-204. Epub 2010 Mar 11. 2010
24APC
The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.
Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DG.
Blood. 115(17):3489-97. 2010
25APC, ARHGEF4, PPP1R9B, SPATA13
Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.
Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T.
Oncogene 28(10):1357-65. Epub 2009 Jan 19. 2009
26APC, FAP, MAP, MUTYH
APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas.
Filipe B, Baltazar C, Albuquerque C, Fragoso S, Lage P, Vitoriano I, Mão de Ferro S, Claro I, Rodrigues P, Fidalgo P, Chaves P, Cravo M, Nobre Leitão C.
Clin Genet 76(3):242-55. 2009
27APC, RANBP2
Nup358 interacts with APC and plays a role in cell polarization.
Murawala P, Tripathi MM, Vyas P, Salunke A, Joseph J.
J Cell Sci 122(Pt 17):3113-22. Epub 2009 Aug 4. Erratum in: J Cell Sci. 2009 Sep 1;122(Pt 17):3199. 2009
28APC, CCNA2
Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring.
Beamish H, de Boer L, Giles N, Stevens F, Oakes V, Gabrielli B.
J Biol Chem 284(42):29015-23. doi: 10.1074/jbc.M109.042820. Epub 2009 Aug 24. 2009
29APC
Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.
Takacs CM, Baird JR, Hughes EG, Kent SS, Benchabane H, Paik R, Ahmed Y.
Science 319(5861):333-6. 2008
30APC, BRCA1, BRCA2, CDH1, CDKN2A, MLH1, MSH2, MSH6, PMS2, PRSS1, PTEN, RB1, SPINK1, STK11, TP53
Inherited susceptibility to common cancers.
Foulkes WD.
N Engl J Med 359(20):2143-53. No abstract available. 2008
31APC, ATM, EPHA3, ERBB2, ERBB4, FGFR4
Somatic mutations affect key pathways in lung adenocarcinoma.
Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK.
Nature 455(7216):1069-75. 2008
32APC
APC promoter methylation and protein expression in hepatocellular carcinoma.
Csepregi A, Röcken C, Hoffmann J, Gu P, Saliger S, Müller O, Schneider-Stock R, Kutzner N, Roessner A, Malfertheiner P, Ebert MP.
J Cancer Res Clin Oncol 134(5):579-89. Epub 2007 Nov 1.PMID: 17973119 2008
33APC
Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.
Tran H, Hamada F, Schwarz-Romond T, Bienz M.
Genes Dev. 22(4):528-42. 2008
34APC, FAP,HDD
APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.
Latchford A, Volikos E, Johnson V, Rogers P, Suraweera N, Tomlinson I, Phillips R, Silver A.
Hum Mol Genet 16(1):78-82. Epub 2006 Nov 29. 2007
35APC
Novel APC mutations in Czech and Slovak FAP families: clinical and genetic aspects.
Stekrova J, Sulova M, Kebrdlova V, Zidkova K, Kotlas J, Ilencikova D, Vesela K, Kohoutova M.
BMC Med Genet 8:16. 2007
36APC,MYC
Myc deletion rescues Apc deficiency in the small intestine.
Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR.
Nature 446(7136):676-9. Epub 2007 Mar 21. 2007
37APC, FAP
Genotype-phenotype correlations in 19 Dutch cases with APC gene deletions and a literature review.
Nielsen M, Bik E, Hes FJ, Breuning MH, Vasen HF, Bakker E, Tops CM, Weiss MM.
Eur J Hum Genet 15(10):1034-42. Epub 2007 Jun 13. 2007
38FAP, APC, MAP, MUTYH
Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis.
Nielsen M, Hes FJ, Nagengast FM, Weiss MM, Mathus-Vliegen EM, Morreau H, Breuning MH, Wijnen JT, Tops CM, Vasen HF.
Clin Genet 71(5):427-33. 2007
39APC, DEL5Q
Familial adenomatous polyposis in a patient with unexplained mental retardation.
Heald B, Moran R, Milas M, Burke C, Eng C.
Nat Clin Pract Neurol 3(12):694-700. 2007
40APC
Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons.
Farías GG, Vallés AS, Colombres M, Godoy JA, Toledo EM, Lukas RJ, Barrantes FJ, Inestrosa NC.
J Neurosci. 27(20):5313-25. 2007
41APC
A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer.
Amos-Landgraf JM, Kwong LN, Kendziorski CM, Reichelderfer M, Torrealba J, Weichert J, Haag JD, Chen KS, Waller JL, Gould MN, Dove WF.
Proc Natl Acad Sci U S A. 104(10):4036-41. 2007
42MUTYH, APC, FAP, FTACC
MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype.
Aretz S, Uhlhaas S, Goergens H, Siberg K, Vogel M, Pagenstecher C, Mangold E, Caspari R, Propping P, Friedl W.
Int J Cancer 119(4):807-14. 2006
43MUTYH, APC, FAP, FTACC
Prevalence of MYH germline mutations in Swiss APC mutation-negative polyposis patients.
Russell AM, Zhang J, Luz J, Hutter P, Chappuis PO, Berthod CR, Maillet P, Mueller H, Heinimann K.
Int J Cancer 118(8):1937-40. 2006
44APC
Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report.
Katoh H, Shibata T, Kokubu A, Ojima H, Kosuge T, Kanai Y, Hirohashi S.
Genes Chromosomes Cancer 45(11):1050-7. 2006
45FAP, APC, HDD
Current ideas in desmoid tumours.
Sturt NJ, Clark SK.
Fam Cancer 5(3):275-85; discussion 287-8. Review. 2006
46APC, CTNNB1, WNT1, AXIN2
Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis.
Cho KH, Baek S, Sung MH.
FEBS Lett 580(15):3665-70. Epub 2006 Jun 5. 2006
47APC,DEL5Q,FAP
Phenotypic and molecular characterisation of a de novo 5q deletion that includes the APC gene.
Ofner L, Raedle J, Windpassinger C, Schwarzbraun T, Kroisel PM, Wagner K, Petek E.
J Hum Genet 51(2):141-6. Epub 2005 Dec 20. 2006
48APC
Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development.
Nadauld LD, Chidester S, Shelton DN, Rai K, Broadbent T, Sandoval IT, Peterson PW, Manos EJ, Ireland CM, Yost HJ, Jones DA.
Proc Natl Acad Sci U S A. 103(36):13409-14. 2006
49APC,MAPRE1
APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.
Green RA, Wollman R, Kaplan KB.
Mol Biol Cell 16(10):4609-22. Epub 2005 Jul 19. 2005
50APC,MAPRE1
Structural insights into the EB1-APC interaction.
Honnappa S, John CM, Kostrewa D, Winkler FK, Steinmetz MO.
EMBO J 24(2):261-9. Epub 2004 Dec 23. Erratum in: EMBO J. 2005 Feb 23;24(4):872. 2005
51APC,DEL5Q,FAP
Large deletions of the APC gene in 15% of mutation-negative patients with classical polyposis (FAP): a Belgian study.
Michils G, Tejpar S, Thoelen R, van Cutsem E, Vermeesch JR, Fryns JP, Legius E, Matthijs G.
Hum Mutat 25(2):125-34. 2005
52APC
Colonic tumorigenesis in BubR1 +/- Apc Min/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability.
Rao, C. V., Yang, Y.-M., Swamy, M. V., Liu, T., Fang, Y., Mahmood, R., Jhanwar-Uniyal, M., Dai, W.
Proc. Nat. Acad. Sci. 102: 4365-4370 2005
53APC
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
Benzinger A, Muster N, Koch HB, Yates JR 3rd, Hermeking H.
Mol Cell Proteomics. 4(6):785-95. 2005
54APC, GBM, HIF1A, PI3K, RB, TP53
Cancer genes and the pathways they control.
Vogelstein B, Kinzler KW.
Nat Med 10(8):789-99. Review. 2004
55APC
Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.
Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K.
Dev Cell. 7(6):871-83. 2004
56APC
The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.
Hamada F, Bienz M.
Dev Cell. 7(5):677-85. 2004
57APC
Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function.
Xing Y, Clements WK, Le Trong I, Hinds TR, Stenkamp R, Kimelman D, Xu W.
Mol Cell. 15(4):523-33. 2004
58APC
MUC1 can interact with adenomatous polyposis coli in breast cancer.
Hattrup CL, Fernandez-Rodriguez J, Schroeder JA, Hansson GC, Gendler SJ.
Biochem Biophys Res Commun. 316(2):364-9. 2004
59APC
Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.
Li Q, Dashwood RH.
J Biol Chem. 279(44):45669-75. 2004
60APC, CTNNB1
The Wnt/beta-catenin pathway regulates cardiac valve formation.
Hurlstone AF, Haramis AP, Wienholds E, Begthel H, Korving J, Van Eeden F, Cuppen E, Zivkovic D, Plasterk RH, Clevers H.
Nature 425(6958):633-7. 2003
61FAP, APC
Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.
Crabtree M, Sieber OM, Lipton L, Hodgson SV, Lamlum H, Thomas HJ, Neale K, Phillips RK, Heinimann K, Tomlinson IP.
Oncogene 22(27):4257-65. 2003
62APC, KRAS, TP53, FAP
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.
Smith G, Carey FA, Beattie J, Wilkie MJ, Lightfoot TJ, Coxhead J, Garner RC, Steele RJ, Wolf CR.
Proc Natl Acad Sci U S A 99(14):9433-8. 2002
63APC, BTRC, CTNNB1
APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers.
Gerstein AV, Almeida TA, Zhao G, Chess E, Shih IeM, Buhler K, Pienta K, Rubin MA, Vessella R, Papadopoulos N.
Genes Chromosomes Cancer 34(1):9-16. 2002
64APC,DEL5Q,FAP
Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or multiple colorectal adenomas.
Sieber OM, Lamlum H, Crabtree MD, Rowan AJ, Barclay E, Lipton L, Hodgson S, Thomas HJ, Neale K, Phillips RK, Farrington SM, Dunlop MG, Mueller HJ, Bisgaard ML, Bulow S, Fidalgo P, Albuquerque C, Scarano MI, Bodmer W, Tomlinson IP, Heinimann K.
Proc Natl Acad Sci U S A 99(5):2954-8. Epub 2002 Feb 26. 2002
65APC
The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1).
Tickenbrock L, Cramer J, Vetter IR, Muller O.
J Biol Chem. 277(35):32332-8. 2002
66APC
Identification of a link between the tumour suppressor APC and the kinesin superfamily.
Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T.
Nat Cell Biol. 4(4):323-7. 2002
67APC
Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein.
Homma MK, Li D, Krebs EG, Yuasa Y, Homma Y.
Proc Natl Acad Sci U S A. 99(9):5959-64. 2002
68APC
Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome.
Askham JM, Vaughan KT, Goodson HV, Morrison EE.
Mol Biol Cell. 13(10):3627-45. 2002
69APC, FAP
Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
Abraham SC, Wu TT, Klimstra DS, Finn LS, Lee JH, Yeo CJ, Cameron JL, Hruban RH.
Am J Pathol 159(5):1619-27. 2001
70APC
A role for the Adenomatous Polyposis Coli protein in chromosome segregation.
Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Näthke IS.
Nat Cell Biol. 3(4):429-32. 2001
71APC
Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.
Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N.
Mol Cell. 7(5):927-36. 2001
72APC
ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.
Galea MA, Eleftheriou A, Henderson BR.
J Biol Chem. 276(49):45833-9. 2001
73APC
Mutations in the APC tumour suppressor gene cause chromosomal instability.
Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, Gaspar C, van Es JH, Breukel C, Wiegant J, Giles RH, Clevers H.
Nat Cell Biol. 3(4):433-8. 2001
74APC
Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor.
Lal, G., Ash, C., Hay, K., Redston, M., Kwong, E., Hancock, B., Mak, T., Kargman, S., Evans, J. F., Gallinger, S.
Cancer Res. 61: 6131-6136 2001
75APC
Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation.
Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS.
Curr Biol. 11(1):44-9. 2001
76APC, FAP
Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5(q22q23.3) in the father.
Hastings RJ, Svennevik EC, Setterfield B, Wells D, Delhanty JD, Mackinnon H.
J Med Genet 37(2):141-5. No abstract available. 2000
77APC, FAP
Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposis
Su LK, Steinbach G, Sawyer JC, Hindi M, Ward PA, Lynch PM.
Hum Genet 106:101-107 2000
78APC, FAP
APC mutations are sufficient for the growth of early colorectal adenomas.
Lamlum H, Papadopoulou A, Ilyas M, Rowan A, Gillet C, Hanby A, Talbot I, Bodmer W, Tomlinson I.
Proc Natl Acad Sci U S A 97(5):2225-8. 2000
79APC, FAP
APC mutations in sporadic colorectal tumors: A mutational hotspot and interdependence of the two hits.
Rowan AJ, Lamlum H, Ilyas M, Wheeler J, Straub J, Papadopoulou A, Bicknell D, Bodmer WF, Tomlinson IP.
Proc Natl Acad Sci U S A 97(7):3352-7. 2000
80APC, ARHGEF4
Asef, a link between the tumor suppressor APC and G-protein signaling.
Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O, Akiyama T.
Science 289(5482):1194-7. 2000
81APC
A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor.
Couture J, Mitri A, Lagace R, Smits R, Berk T, Bouchard HL, Fodde R, Alman B, Bapat B.
Clin Genet 57(3):205-12. 2000
82APC, FAP
Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.
Su LK, Barnes CJ, Yao W, Qi Y, Lynch PM, Steinbach G.
Am J Hum Genet 67(3):582-90. 2000
83APC
Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q.
Lamlum H, Al Tassan N, Jaeger E, Frayling I, Sieber O, Reza FB, Eckert M, Rowan A, Barclay E, Atkin W, Williams C, Gilbert J, Cheadle J, Bell J, Houlston R, Bodmer W, Sampson J, Tomlinson I.
Hum Mol Genet 9(15):2215-21. 2000
84APC
Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.
von Kries JP, Winbeck G, Asbrand C, Schwarz-Romond T, Sochnikova N, Dell'Oro A, Behrens J, Birchmeier W.
Nat Struct Biol. 7(9):800-7. 2000
85APC
The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain.
Erdmann KS, Kuhlmann J, Lessmann V, Herrmann L, Eulenburg V, Müller O, Heumann R.
Oncogene. 19(34):3894-901. 2000
86APC
GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.
Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A.
Oncogene. 19(4):537-45. 2000
87APC, FAP
Molecular analysis of the APC gene in 205 families : extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition.
Wallis YL, Morton DG, McKeown CM, Macdonald F.
J Med Genet 36 : 14-20. 1999
88APC, FAP
Familial adenomatous polyposis associated with multiple adrenal adenomas in a patient with a rare 3' APC mutation.
Kartheuser A, Walon C, West S, Breukel C, Detry R, Gribomont AC, Hamzehloei T, Hoang P, Maiter D, Pringot J, Rahier J, Khan PM, Curtis A, Burn J, Fodde R, Verellen-Dumoulin C.
J Med Genet 36 : 65-67. 1999
89APC, CTNNB1, FAP
Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas.
Mann B, et al.
Proc Natl Acad Sci U S A 96 : 1603-1608. 1999
90APC
Hereditary Desmoid Disease in a Family with a Germline Alu I Repeat Mutation of the APC Gene.
Halling KC, et al.
Hum Hered 49(2):97-102. 1999
91APC, CTNNB1, FAP
Germline mutations are frequent in the APC gene but absent in the beta-catenin gene in familial adenomatous polyposis patients.
Cao X, et al.
Genes Chromosomes Cancer 25(4):396-8. 1999
92APC, FAP
Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis.
Dihlmann S, et al.
Cancer Res 59(8):1857-60. 1999
93APC, FAP
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
Lamlum H, et al.
Nat Med 5(9):1071-5 1999
94APC, FAP
Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.
Gryfe R, et al.
Am J Hum Genet 64(2):378-84 1999
95APC, CTNNB1, FAP
Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.
Miyaki M, Iijima T, Kimura J, Yasuno M, Mori T, Hayashi Y, Koike M, Shitara N, Iwama T, Kuroki T.
Cancer Res 59(18):4506-9 1999
96APC, RP1
EB/RP gene family encodes tubulin binding proteins.
Juwana JP, Henderikx P, Mischo A, Wadle A, Fadle N, Gerlach K, Arends JW, Hoogenboom H, Pfreundschuh M, Renner C.
Int J Cancer. 81(2):275-84. 1999
97APC
Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM.
Science. 283(5410):2089-91. 1999
98APC, FAP
Genotype-phenotype correlations in attenuated adenomatous polyposis coli.
Soravia C, et al.
Am J Hum Genet 62 : 1290-1301. 1998
99APC, AXIN1, CTNNB1, GSK3B
Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.
Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T.
Genes Cells 3 : 395-403. 1998
100APC, FAP
The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.
Frayling IM, et al.
Proc Natl Acad Sci U S A 95 : 10722-10727. 1998
101APC, BRCA1, DPP4, MLH1, MSH2, MSH6, NF1, PMS2, RB1, TP53, VHL, WT1, FAP
Tumour suppressor gene mutations in humans and mice : parallels and contrasts.
Hooper ML.
EMBO J 17(23):6783-9. 1998
102APC, FAP
Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps.
Spirio LN, et al.
Nat Genet 20 : 385-388. 1998
103APC, KRAS1P, FAP
[Analysis of genetic disorders of cancer of the rectum : differences in relation to cancer of the colon].
Rebischung C, Laurent-Puig P, Gerard JP, Thomas G, Hamelin R.
Gastroenterol Clin Biol 22 : 679-687. 1998
104APC
Novel protein isoforms of the APC tumor suppressor in neural tissue.
Pyles RB, Santoro IM, Groden J, Parysek LM.
Oncogene 16(1):77-82. 1998
105APC, ATG12, CDO1, FER, MCC, RN28SL, SEMA4DL, TSG5A, ZRSR1
Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer.
Ueno K, Kumagai T, Kijima T, Kishimoto T, Hosoe S.
Hum Genet 102(1):63-8. 1998
106APC
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.
Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M. F., Taketo, M. M.
Cell. 92: 645-656 1998
107APC, CDC20, MAD1L1
The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.
Fang G, Yu H, Kirschner MW.
Genes Dev. 12(12):1871-83. 1998
108APC, FAP
Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis : 67 germline mutations identified by DGGE, PTT, and Southern analysis.
Van der Luijt RB, et al.
Hum Mutat 9 : 7-16. 1997
109APC, CTNNB1, LEF1, FAP
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
Morin PJ, et al.
Science 275 : 1787-1790. 1997
110APC, CTNNB1, TCF7L2, FAP
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
Korinek V, et al.
Science 275 : 1784-1787. 1997
111APC, FAP
Characterization of 19 novel and six recurring APC mutations in Italian adenomatous polyposis patients, using two different mutation detection techniques.
Gismondi V, et al.
Hum Mutat 9 : 370-373. 1997
112APC, DLG3, DLG4, MPP1
Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.
Makino K, Kuwahara H, Masuko N, Nishiyama Y, Morisaki T, Sasaki J, Nakao M, Kuwano A, Nakata M, Ushio Y, Saya H.
Oncogene 14(20):2425-33. 1997
113APC, FAP
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
Laken SJ, Petersen GM, Gruber SB, Oddoux C, Ostrer H, Giardiello FM, Hamilton SR, Hampel H, Markowitz A, Klimstra D, Jhanwar S, Winawer S, Offit K, Luce MC, Kinzler KW, Vogelstein B.
Nat Genet 17(1):79-83. 1997
114APC, FAP
Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds.
Walon C, Kartheuser A, Michils G, Smaers M, Lannoy N, Ngounou P, Mertens G, Verellen-Dumoulin C.
Hum Genet 100(5-6):601-5. 1997
115APC
Alternative splicing of the APC gene and its association with terminal differentiation.
Santoro IM, Groden J.
Cancer Res 57(3):488-94. 1997
116APC, DLG4, DLGAP1, DLGAP2, PSD95
DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.
Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, Matsumine A, Kobayashi S, Toyoshima K, Akiyama T.
Genes Cells. 2(6):415-24 1997
117APC, FAP
Familial adenomatous polyposis : a submicroscopic deletion at the APC locus in a family with mentally normal patients.
Mandl M, et al.
Hum Genet 97 : 204-208. 1996
118APC
Germline APC mutation (Gln1317) in a cancer-prone family that does not result in familial adenomatous polyposis.
White S, et al.
Genes Chromosomes Cancer 15 : 122-128. 1996
119APC
Familial adenomatous polyposis in a 5 year old child : a clinical, pathological, and molecular genetic study.
Distante S, et al.
J Med Genet 33 : 157-160. 1996
120APC, FAP
Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein.
Friedl W, et al.
Hum Genet 97 : 579-584. 1996
121APC, TP53, FAP
Database of mutations in the p53 and APC tumor suppressor genes designedto facilitate molecular epidemiological analyses.
de Vries EMG, et al.
Hum Mutat 7 : 202-213. 1996
122APC, FAP
Correlation between the development of extracolonic manifestations in FAP patients and mutations beyond codon 1403 in the APC gene.
Dobbie Z, et al.
J Med Genet 33 : 274-280. 1996
123APC, CHRPE
A novel deletion at codon 441 of the APC gene associated with ophthalmic lesions (CHRPE) in a South African family.
Grobbelaar JJ, et al.
J Med Genet 33 : 384-386. 1996
124APC
Long-range physical map and deletion characterization of the 1100-kb Notl restriction fragment harboring the APC gene.
Thliveris A, et al.
Genomics 34 : 268-270. 1996
125APC, FAP
Identification of a novel single base insertion in the adenomatous polyposis coli gene.
Kotze MJ, et al.
Hum Mutat 7 : 68-69. 1996
126APC, FAP
APC mutations in colorectal tumors with mismatch repair deficiency.
Huang J, et al.
Proc Natl Acad Sci U S A 93 : 9049-9054. 1996
127APC
Multiple products in the protein truncation test due to alternative splicing in the adenomatous polyposis coli (APC) gene.
Bala S, et al.
Hum Genet 98 : 528-533. 1996
128APC, FAP
Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli.
Van der Luijt RB, et al.
Hum Genet 98 : 727-734. 1996
129APC, FAP
Three novel APC gene mutations in Portuguese FAP kindreds.
Marshall B, et al.
Hum Mutat 8 : 395. 1996
130APC
Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation.
Scott RJ, et al.
Hum Mol Genet 5 : 1921-1924. 1996
131APC, FAP
Mutation detection in exons 1-14 of the adenomatous polyposis coli gene : identification of an alternatively spliced transcript.
Hamzehloei T, et al.
Mol Cell Probes 10 : 379-385. 1996
132APC, TSG5A, FAP
APC gene mutations and allelic losses in sporadic ampullary tumours : evidence of genetic difference from tumours associated with familial adenomatous polyposis.
Achille A, et al.
Int J Cancer 68 : 305-312. 1996
133APC
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.
NŠthke IS, et al.
J Cell Biol 134 : 165-179. 1996
134APC, GSK3B
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.
Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P.
Science 272 : 1023-1026. 1996
135APC, HDD
Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene.
Eccles DM, van der Luijt R, Breukel C, Bullman H, Bunyan D, Fisher A, Barber J, du Boulay C, Primrose J, Burn J, Fodde R.
Am J Hum Genet 59(6):1193-201. 1996
136APC, CHRPE, FAP
Congenital hypertrophy of the retinal pigment epithelium in familial adenomatous polyposis. Novel criteria of assessment and correlations with constitutional adenomatous polyposis coli gene mutations.
Valanzano R, Cama A, Volpe R, Curia MC, Mencucci R, Palmirotta R, Battista P, Ficari F, Mariani-Costantini R, Tonelli F.
Cancer 78(11):2400-10.PMID: 8941012 [PubMed - indexed for MEDLINE] 1996
137APC
Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF, Taketo MM.
Cell. 87(5):803-9. 1996
138APC, FAP
Multiplex PCR analysis and genotype-phenotype correlations of frequent APC mutations.
Cama A, et al.
Hum Mutat 5 : 144-152. 1995
139APC
A novel coding exon of the human adenomatous polyposis coli gene.
Sulekova Z, et al.
Hum Genet 96 : 469-471. 1995
140APC, CHRPE, FAP
Severe Gardner syndrome in families with mutations restricted to a specific region of the APC gene.
Davies DR, et al.
Am J Hum Genet 57 : 1151-1158. 1995
141APC, FAP
Attenuated familial adenomatous polyposis (AFAP).
Lynch HT, et al.
Cancer 76 : 2427-2433. 1995
142APC, FAP
Molecular genetic analysis of exons 1 to 6 of the APC gene in non-polyposis familial colorectal cancer.
Joyce JA, et al.
Clin Genet 48 : 299-303. 1995
143APC, FAP
Familial adenomatous polyposis : desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444.
Caspari R, et al.
Hum Mol Genet 4 : 337-340. 1995
144APC, MLH1, MHS2, PMS2, FAP
The molecular basis of Turcot's syndrome.
Hamilton SR, et al.
N Engl J Med 332 : 839-847. 1995
145APC, FAP
Haplotype comparison in fresh mutation cases of adenomatous polyposis coli due to deletion AAAGA at codon 1309.
Delhanty JDA, et al.
Ann Hum Genet 59 : 39-42. 1995
146APC, FAP
Molecular, cytogenetic, and phenotypic studies of a constitutional reciprocal translocation t(5;10)(q22;q25) responsible for familial adenomatous polyposis in a Dutch pedigree.
Van der Luijt RB, et al.
Genes Chromosomes Cancer 13 : 192-202. 1995
147APC, FAP
Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.
Gayther SA, et al.
J Med Genet 32 : 568-571. 1995
148APC, FAP
Evidence for a novel exon in the coding region of the adenomatous polyposis coli (APC) gene.
Xia L, et al.
Genomics 28 : 589-591. 1995
149APC, MAPRE1
APC binds to the novel protein EB1.
Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW.
Cancer Res 55(14):2972-7 1995
150APC
The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.
Rubinfeld B, Souza B, Albert I, Munemitsu S, Polakis P.
J Biol Chem. 270(10):5549-55. 1995
151APC
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., Taketo, M.
Proc. Nat. Acad. Sci. 92: 4482-4486 1995
152APC, FAP
Exon eight APC mutations account for a disproportionate number of familial adenomatous polyposis families.
Koorey DJ, et al.
Hum Mutat 3 : 12-18. 1994
153APC, TSG5A, FAP
Mutation in a splice-donor site of the APC gene in a family with polyposis and late age of colonic cancer death.
Varesco L, et al.
Hum Genet 93 : 281-286. 1994
154APC, FAP
Frequency of common and novel inactivating APC mutations in 202 families with familial adenomatous polyposis.
Mandl M, et al.
Hum Mol Genet 3 : 181-184. 1994
155APC, FAP
Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli.
Gayther SA, et al.
Hum Mol Genet 3 : 53-56. 1994
156APC, TSG5A, FAP
Frequent polymorphism in exon 15 of the adenomatous polyposis coli gene.
Davies SM, et al.
Hum Genet 93 : 329-330. 1994
157APC
Rapid detection of translation-terminating mutations at the adenomatous polyposis coli (APC) gene by direct protein truncation test.
Van der Luijt R, et al.
Genomics 20 : 1-4. 1994
158APC, FAP
Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion.
Barber JCK, et al.
J Med Genet 31 : 312-316. 1994
159APC
Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.
Jorde LB, et al.
Am J Hum Genet 54 : 884-898. 1994
160APC, FAP
A somatic mutation in the adenomatous polyposis coli (APC) gene in peripheral blood cells - implications for predictive diagnosis.
Mandl M, et al.
Hum Mol Genet 3 : 1009-1011. 1994
161APC, FAP, FAP
Four novel germ-line mutations in the APC gene detected by heteroduplex analysis.
Hamzehloei T, et al.
Hum Mol Genet 3 : 1023-1024. 1994
162APC, FAP
Identification of a novel germline mutation in a FAP family.
Gebert JF, et al.
Hum Mol Genet 3 : 1167-1168. 1994
163APC, FAP
Four novel mutations of the APC (adenomatous polyposis coli) gene in FAP patients.
Stella A, et al.
Hum Mol Genet 3 : 1687-1688. 1994
164APC, FAP
Eleven novel germline mutations in the adenomatous polyposis coli (APC) gene.
Paffenholz R, et al.
Hum Mol Genet 3 : 1703-1704. 1994
165APC, FAP
APC mutation associated with late onset of familial adenomatous polyposis.
Smith-Ravin J, et al.
J Med Genet 31 : 888-890. 1994
166APC, FAP
Characterization of two novel adenomatous polyposis coli (APC) gene mutations in patients with familial adenomatous polyposis (FAP).
Bapat B, et al.
Hum Mutat 4 : 253-256. 1994
167APC, FAP
Mutations of the adenomatous polyposis coli gene in the mutation cluster region : comparison of human pancreatic and colorectal cancers.
Yashima K, et al.
Int J Cancer 59 : 43-47. 1994
168APC, CTNNB1, CTNND1, JUP, KPNA3, ARVCF, CTNND2, KPNA2, PKP4, PKP1, PKP2, SPAG6
A repeating amino acid motif shared by proteins with diverse cellular roles.
Peifer M, et al.
Cell 76(5):789-91. No abstract available 1994
169APC
Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation.
Shibata T, Gotoh M, Ochiai A, Hirohashi S.
Biochem Biophys Res Commun. 203(1):519-22. 1994
170APC
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.
Fodde, R., Edelmann, W., Yang, K., van Leeuwen, C., Carlson, C., Renault, B., Breukel, C., Alt, E., Lipkin, M., Meera Khan, P., Kucherlapati, R.
Proc. Nat. Acad. Sci. 91: 8969-8973 1994
171APC, FAP
Mutations of the APC (adenomatous polyposis coli) gene.
Nagase H, et al.
Hum Mutat 2 : 425-434. 1993
172APC, FAP
Molecular diagnosis of familial adenomatous polyposis.
Powell SM, et al.
N Engl J Med 329 : 1982-1987. 1993
173CHRPE, APC, FAP
Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients.
Olschwang S, et al.
Cell 75 : 959-968. 1993
174APC, FAP
Alleles of the APC gene : an attenuated form of familial polyposis.
Spirio L, et al.
Cell 75 : 951-957. 1993
175APC
Association of the APC gene product with beta-catenin.
Rubinfeld B, et al.
Science 262 : 1731-1734. 1993
176APC, FAP
A novel mutation of the APC (adenomatous polyposis coli) gene in a familial adenomatous polyposis (FAP) patient and presymptomatic diagnosis using PCR.
Ichii S, et al.
Hum Mol Genet 2 : 597. 1993
177APC, FAP
Presymptomatic direct detection of adenomatous polyposis coli (APC) gene mutations in familial adenomatous polyposis.
Petersen GM, et al.
Hum Genet 91 : 307-311. 1993
178APC, FAP
Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis.
Paul P, et al.
Hum Mol Genet 2 : 925-931. 1993
179APC, FAP
Mutational analysis of patients with adenomatous polyposis : identical inactivating mutations in unrelated individuals.
Groden J, et al.
Am J Hum Genet 52 : 263-272. 1993
180APC
Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.
Olschwang S, et al.
Am J Hum Genet 52 : 273-279. 1993
181APC, FAP
The APC (adenomatous polyposis coli) gene : a novel mutation in an FAP patient and a DdeI polymorphism in the 5' noncoding region.
Mori T, et al.
Hum Mutat 2 : 240-243. 1993
182APC, FAP
Linkage studies in Italian families with familial adenomatous polyposis.
Mareni C, et al.
Hum Genet 90 : 545-550. 1993
183APC
Association of the APC tumor suppressor protein with catenins.
Su LK, et al.
Science 262 : 1734-1737. 1993
184APC
Apc(Min), a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.
Moser, A. R., Mattes, E. M., Dove, W. F., Lindstrom, M. J., Haag, J. D., Gould, M. N.
Proc. Nat. Acad. Sci. 90: 8977-8981 1993
185APC, FAP
Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.
Miki Y, et al.
Cancer Res 52 : 643-645. 1992
186APC
Two intragenic polymorphisms of the APC-gene detected by PCR and enzymatic digestion.
Kraus C, et al.
Hum Genet 88 : 705-706. 1992
187APC
Detection by DGGE of a new polymorphism closely linked to the adenomatous polyposis coli region.
Olschwang S, et al.
Hum Genet 88 : 658-660. 1992
188APC, FAP
Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis.
Lindgren V, et al.
Am J Hum Genet 50 : 988-997. 1992
189APC, FAP
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
Miyoshi Y, et al.
Proc Natl Acad Sci U S A 89 : 4452-4456. 1992
190TSG5A, APC, MCC
Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.
Boynton RF, et al.
Proc Natl Acad Sci U S A 89 : 3385-3388. 1992
191APC, FAP
Familial adenomatous polyposis : identification of a new frameshift mutation of the APC gene in an Italian family.
Stella A, et al.
Biochem Biophys Res Commun 184 : 1357-1363. 1992
192APC
Two MspI polymorphisms within the APC gene.
Cottrell S, et al.
Hum Mol Genet 1 : 352. 1992
193APC
Eight novel inactiving germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis.
Fodde R, et al.
Genomics 13 : 1162-1168. 1992
194APC, MCC, FAP
Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma.
PeltomŠki P, et al.
Cancer Res 52 : 4530-4533. 1992
195APC
Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
Cottrell S, et al.
Lancet 340 : 626-630. 1992
196APC, FAP
Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.
Spirio L, et al.
Am J Hum Genet 51 : 92-100. 1992
197APC
Frequent polymorphism in the 13th exon of the adenomatous polyposis coli gene.
Olschwang S, et al.
Hum Genet 90 : 161-163. 1992
198APC, FAP
An intrachromosomal insertion causing 5q22 deletion and familial adenomatous polyposis coli in two generations.
Cross I, et al.
J Med Genet 29 : 175-179. 1992
199APC, DIHBD, FAP
Two cases of 5q deletions in patients with familial adenomatous polyposis : possible link with Caroli's disease.
Hodgson SV, et al.
J Med Genet 30 : 369-375. 1992
200APC, MCC
Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer.
D'Amico D, et al.
Cancer Res 52 : 1996-1999. 1992
201RB1, TP53, MCC, APC, TSG5A, TSG13A, TSG17A
Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis.
Greenwald BD, et al.
Cancer Res 52 : 741-745. 1992
202APC, FAP
Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP).
Ichii S, et al.
Hum Mol Genet 1 : 387-390. 1992
203APC
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.
Su, L.-K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A., Dove, W. F.
Science 256: 668-670 1992
204APC, FAP
Identification and characterization of the familial adenomatous polyposis coli gene.
Groden J, et al.
Cell 66 : 589-600. 1991
205APC
Characterization and mapping of microdissected genomic clones from the adenomatous polyposis coli (APC) region.
Hampton G, et al.
Genomics 11 : 247-251. 1991
206APC, FAP
Linkage analysis in adenomatous polyposis coli: the use of four closely linked DNA probes in 20 UK families.
Cachon-Gonzalez MB, et al.
J Med Genet 28 : 681-685. 1991
207APC
A CA repeat 30-70 KB downstream from the adenomatous polyposis coli (APC) gene.
Spirio L, et al.
Nucleic Acids Res 19 : 6348. 1991
208APC, D5S299, FAP
CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC).
van Leeuwen C, et al.
Nucleic Acids Res 19 : 5805. 1991
209APC
SspI polymorphism in sequence encoding 3' untranslated region of the APC gene.
Heighway J, et al.
Nucleic Acids Res 19 : 6966. 1991
210APC
Fine mapping of probes in the adenomatous polyposis coli region of chromosome 5 by in situ hybridization.
Williams SV, et al.
Genes Chromosomes Cancer 3 : 382-389. 1991
211APC, FAP
Gardner syndrome in a boy with interstitial deletion of the long arm of chromosome 5.
Kobayashi T, et al.
Am J Med Genet 41 : 460-463. 1991
212APC
Regional mapping of 22 microclones around the adenomatous polyposis coli (APC) locus on chromosome 5q.
Hampton GM, et al.
Hum Genet 88 : 112-114. 1991
213APC, D5S71, FAP
A new deletion polymorphism at D5S71 raises the linkage information on adenomatous polyposis coli : implications for presymptomatic diagnosis.
Tops CMJ, et al.
Hum Genet 86 : 365-368. 1991
214APC, D5S141, MCC, SRP19, REEP5
Identification of FAP locus genes from chromosome 5q21.
Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, Smith KJ,Preisinger AC, Hedge P, McKechnie D, et al.
Science 253(5020):661-5. 1991
215SRP19, APC, REEP5, FAP
Identification of deletion mutations and three new genes at the familial polyposis locus.
Joslyn G, Carlson M, Thliveris A, Albertsen H, Gelbert L, Samowitz W,Groden J, Stevens J, Spirio L, Robertson M, et al.
Cell 66(3):601-13. 1991
216APC, FAP, REEP5, SLC25A46
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.
Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P.
Science 253(5020):665-9. 1991
217APC, FAP
Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps.
Leppert M, et al.
N Engl J Med 322 : 904-908. 1990
218APC, FAP
A constitutional 5q23 deletion.
Rivera H, et al.
J Med Genet 27 : 267-268. 1990
219APC, FAP
Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5.
Dunlop MG, et al.
Am J Hum Genet 47 : 982-987. 1990
220APC, FAP
Deletion of chromosome 5q and familial adenomatous polyposis.
Hockey KA, Mulcahy MT, Montgomery P, Levitt S.
J Med Genet 26 : 61-68. 1989
221APC, FAP
Linkage analysis in familial adenomatous polyposis : order of C11P11 (D5S71) and pi227 (D5S37) loci at the apc gene.
Dunlop MG, Steel CM, Wyllie AH, Bird CC, Evans HJ.
Genomics 5 : 350-353. 1989
222APC, FAP
Presymptomatic diagnosis of familial adenomatous polyposis by bridging DNA markers.
Tops CMJ, et al.
Lancet II : 1361-1363. 1989
223APC, D5S120, FAP
High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-q22.
Ashton-Rickardt PG, et al.
Oncogene 4 : 1169-1174. 1989
224APC, D5S81, D5S82, D5S83, D5S84, D5S85, D5S86, FAP
Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5.
Nakamura Y, Lathrop M, Leppert M, Dobbs M, Wasmuth J, Wolff E, Carlson M, Fujimoto E, Krapcho K, Sears T, et al.
Am J Hum Genet 43 : 638-644. 1988
225APC, CHRPE, FAP
A genetic study of Gardner syndrome and congenital hypertrophy of the retinal pigment epithelium.
Lyons LA, et al.
Am J Hum Genet 42 : 290-296. 1988
226APC, FAP
Chromosome 5 allele loss at the glucocorticoid receptor locus in human colorectal carcinomas.
Wildrick DM, et al.
Biochem Biophys Res Commun 150 : 591-598. 1988
227APC, D5S37, D5S71, FAP
Close linkage of a highly polymorphic marker (D5S37) to familial adenomatous polyposis (FAP) and confirmation of FAP localization on chromosome 5q21-q22.
Meera Khan P, et al.
Hum Genet 79 : 183-185. 1988
228APC, D5S71, FAP
Localization of the gene for familial adenomatous polyposis on chromosome 5.
Bodmer WF, Bailey CJ, Bodmer J, Bussey HJ, Ellis A, Gorman P, Lucibello FC, Murday VA, Rider SH, Scambler P, et al.
Nature 328 : 614-616. 1987
229APC, D5S43, FAP
Chromosome 5 allele loss in human colorectal carcinomas.
Solomon E, Voss R, Hall V, Bodmer WF, Jass JR, Jeffreys AJ, Lucibello FC, Patel I, Rider SH.
Nature 328 : 616-619. 1987
230APC, D5S21, D5S22, D5S39, D5S70, D5S71, D5S74, D5S76, D5S78, FAP
The gene for familial polyposis coli maps to the long arm of chromosome 5.
Leppert M, et al.
Science 238 : 1411-1413. 1987
231APC, FAP
Gardner syndrome in a man with an interstitial deletion of 5q.
Herrera L, et al.
Am J Med Genet 25 : 473-476. 1986
232APC
Cytogenetic findings in a large bowel adenocarcinoma.
Ferti-Passantonopoulou A, et al.
Cancer Genet Cytogenet 21 : 361-364. 1986
233APC, FAP
The Gardner syndrome. Significance of ocular features.
Lewis RA, et al.
Ophthalmology 91 : 916-925. 1984
234APC
Hypertrophy of the retinal pigment epithelium associated with Gardner's syndrome.
Blair NP, et al.
Am J Ophthalmol 90 : 661-667. 1980