| 1 | APC, SOHLH2
|
| Sohlh2 inhibits breast cancer cell proliferation by suppressing Wnt/β-catenin signaling pathway
|
| Zhang X, Liu R, Zhao N, Ji S, Hao C, Cui W, Zhang R, Hao J.
|
| Mol Carcinog. Jun;58(6):1008-1018. doi: 10.1002/mc.22989. Epub 2019 Mar 5. 2019
|
| 2 | APC
|
| CpG methylation of APC promoter 1A in sporadic and familial breast cancer patients.
|
| Debouki-Joudi S, Trifa F, Khabir A, Sellami-Boudawara T, Frikha M, Daoud J, Mokdad-Gargouri R.
|
| Cancer Biomark 18(2):133-141. doi: 10.3233/CBM-160005.
2017
|
| 3 | APC, RHOT1, TRAK2
|
| APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.
|
| Mills KM, Brocardo MG, Henderson BR.
|
| Mol Biol Cell 27(3):466-82. doi: 10.1091/mbc.E15-09-0632. Epub 2015 Dec 10.
2016
|
| 4 | APC
|
| APC functions at the centrosome to stimulate microtubule growth.
|
| Lui C, Ashton C, Sharma M, Brocardo MG, Henderson BR.
|
| Int J Biochem Cell Biol 70:39-47. doi: 10.1016/j.biocel.2015.10.028. Epub 2015 Nov 10.
2016
|
| 5 | APC
|
| The APC I1307K allele conveys a significant increased risk for cancer.
|
| Leshno A, Shapira S, Liberman E, Kraus S, Sror M, Harlap-Gat A, Avivi D, Galazan L, David M, Maharshak N, Moanis S, Arber N, Moshkowitz M.
|
| Int J Cancer 138(6):1361-7. doi: 10.1002/ijc.29876. Epub 2015 Oct 13.
2016
|
| 6 | APC, GSTP1, SOCS1
|
| Association of APC, GSTP1 and SOCS1 promoter methylation with the risk of hepatocellular carcinoma: a meta-analysis.
|
| Liu M, Cui LH, Li CC, Zhang L.
|
| Eur J Cancer Prev 24(6):470-83. doi: 10.1097/CEJ.0000000000000121.
2015
|
| 7 | APC, CLSS2
|
| A novel APC mutation defines a second locus for Cenani-Lenz syndrome.
|
| Patel N, Faqeih E, Anazi S, Alfawareh M, Wakil SM, Colak D, Alkuraya FS.
|
| J Med Genet 52(5):317-21. doi: 10.1136/jmedgenet-2014-102850. Epub 2015 Feb 12.
2015
|
| 8 | APC, HDD
|
| N-terminal truncation mutations of adenomatous polyposis coli are associated with primary cilia defects.
|
| Song L, Jia Y, Zhu W, Newton IP, Li Z, Li W.
|
| Int J Biochem Cell Biol 55:79-86. doi: 10.1016/j.biocel.2014.08.010. Epub 2014 Aug 21.
2014
|
| 9 | APC
|
| different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli.
|
| Schneikert J, Ruppert JG, Behrens J, Wenzel EM.
|
| PLoS One 9(4):e94413. doi: 10.1371/journal.pone.0094413. eCollection 2014.
2014
|
| 10 | APC, NRIP1
|
| RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis.
|
| Lapierre M, Bonnet S, Bascoul-Mollevi C, Ait-Arsa I, Jalaguier S, Del Rio M, Plateroti M, Roepman P, Ychou M, Pannequin J, Hollande F, Parker M, Cavailles V.
|
| J Clin Invest 124(5):1899-913. doi: 10.1172/JCI65178. Epub 2014 Mar 25.
2014
|
| 11 | APC, KRAS
|
| Dietary heme iron and the risk of colorectal cancer with specific mutations in KRAS and APC.
|
| Gilsing AM, Fransen F, de Kok TM, Goldbohm AR, Schouten LJ, de Bruïne AP, van Engeland M, van den Brandt PA, de Goeij AF, Weijenberg MP.
|
| Carcinogenesis 34(12):2757-66. doi: 10.1093/carcin/bgt290. Epub 2013 Aug 27.
2013
|
| 12 | APC, FAP
|
| APC germline mutations in families with familial adenomatous polyposis.
|
| De Queiroz Rossanese LB, De Lima Marson FA, Ribeiro JD, Coy CS, Bertuzzo CS.
|
| Oncol Rep 30(5):2081-8. doi: 10.3892/or.2013.2681. Epub 2013 Aug 21.
2013
|
| 13 | APC
|
| Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling.
|
| Li A, Chan B, Felix JC, Xing Y, Li M, Brody SL, Borok Z, Li C, Minoo P.
|
| PLoS One 8(4):e62215. doi: 10.1371/journal.pone.0062215. Print 2013.
2013
|
| 14 | APC
|
| APC binds intermediate filaments and is required for their reorganization during cell migration.
|
| Sakamoto Y, Boëda B, Etienne-Manneville S.
|
| J Cell Biol 200(3):249-58. doi: 10.1083/jcb.201206010.
2013
|
| 15 | APC
|
| APC gene hypermethylation and prostate cancer: a systematic review and meta-analysis.
|
| Chen Y, Li J, Yu X, Li S, Zhang X, Mo Z, Hu Y.
|
| Eur J Hum Genet 21(9):929-35. doi: 10.1038/ejhg.2012.281. Epub 2013 Jan 9. Review.
2013
|
| 16 | APC
|
| APC gene hypermethylation and prostate cancer: a systematic review and meta-analysis.
|
| Chen Y, Li J, Yu X, Li S, Zhang X, Mo Z, Hu Y.
|
| Eur J Hum Genet 21(9):929-35. doi: 10.1038/ejhg.2012.281. Epub 2013 Jan 9. Review.
2013
|
| 17 | APC, AXIN1, HECTD1
|
| HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction.
|
| Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, Zilberleyb I, Lee MW, Phu L, Sarkar AA, Zohn IE, Wertz IE, Kirkpatrick DS, Polakis P.
|
| J Biol Chem 288(6):3753-67. doi: 10.1074/jbc.M112.415240. Epub 2012 Dec 31.
2013
|
| 18 | AMER2, APC, MAPRE1
|
| Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
|
| Pfister AS, Hadjihannas MV, Röhrig W, Schambony A, Behrens J.
|
| J Biol Chem 287(42):35333-40. doi: 10.1074/jbc.M112.385393. Epub 2012 Aug 16.
2012
|
| 19 | APC, SMAD7, TGFBR1
|
| APC and Smad7 link TGFβ type I receptors to the microtubule system to promote cell migration.
|
| Ekman M, Mu Y, Lee SY, Edlund S, Kozakai T, Thakur N, Tran H, Qian J, Groeden J, Heldin CH, Landström M.
|
| Mol Biol Cell 23(11):2109-21. doi: 10.1091/mbc.E10-12-1000. Epub 2012 Apr 11.
2012
|
| 20 | APC
|
| Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling.
|
| Roberts DM, Pronobis MI, Poulton JS, Waldmann JD, Stephenson EM, Hanna S, Peifer M.
|
| Mol Biol Cell. 22(11):1845-63. 2011
|
| 21 | APC, CTBP2
|
| APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.
|
| Schneikert J, Brauburger K, Behrens J.
|
| Hum Mol Genet 20(18):3554-64. Epub 2011 Jun 10.
2011
|
| 22 | APC, CCNB3
|
| Proteomic identification of overexpressed adenomatous polyposis coli and cyclin B3 during endoderm differentiation from human embryonic stem cells.
|
| Lee DH, Ji YG, Chung HM, Ko JJ, Kim SK.
|
| Pancreas 40(2):271-80.
2011
|
| 23 | APC, CTNNB1, DISC1, DLG4, FZD1, GSK3B, NEUROD1, PRICKLE1, SFRP1, SYN1, WNT1, WNT3, WNT3A, WNT5A, WNT7A
|
| Emerging roles of Wnts in the adult nervous system.
|
| Inestrosa NC, Arenas E.
|
| Nat Rev Neurosci. 11(2):77-86. 2010
|
| 24 | APC, DVL1, WNT5A
|
| Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells.
|
| Matsumoto S, Fumoto K, Okamoto T, Kaibuchi K, Kikuchi A.
|
| EMBO J 29(7):1192-204. Epub 2010 Mar 11. 2010
|
| 25 | APC
|
| The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.
|
| Lane SW, Sykes SM, Al-Shahrour F, Shterental S, Paktinat M, Lo Celso C, Jesneck JL, Ebert BL, Williams DA, Gilliland DG.
|
| Blood. 115(17):3489-97. 2010
|
| 26 | APC, ARHGEF4, PPP1R9B, SPATA13
|
| Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration.
|
| Sagara M, Kawasaki Y, Iemura SI, Natsume T, Takai Y, Akiyama T.
|
| Oncogene 28(10):1357-65. Epub 2009 Jan 19.
2009
|
| 27 | APC, FAP, MAP, MUTYH
|
| APC or MUTYH mutations account for the majority of clinically well-characterized families with FAP and AFAP phenotype and patients with more than 30 adenomas.
|
| Filipe B, Baltazar C, Albuquerque C, Fragoso S, Lage P, Vitoriano I, Mão de Ferro S, Claro I, Rodrigues P, Fidalgo P, Chaves P, Cravo M, Nobre Leitão C.
|
| Clin Genet 76(3):242-55.
2009
|
| 28 | APC, RANBP2
|
| Nup358 interacts with APC and plays a role in cell polarization.
|
| Murawala P, Tripathi MM, Vyas P, Salunke A, Joseph J.
|
| J Cell Sci 122(Pt 17):3113-22. Epub 2009 Aug 4. Erratum in: J Cell Sci. 2009 Sep 1;122(Pt 17):3199.
2009
|
| 29 | APC, CCNA2
|
| Cyclin A/cdk2 regulates adenomatous polyposis coli-dependent mitotic spindle anchoring.
|
| Beamish H, de Boer L, Giles N, Stevens F, Oakes V, Gabrielli B.
|
| J Biol Chem 284(42):29015-23. doi: 10.1074/jbc.M109.042820. Epub 2009 Aug 24.
2009
|
| 30 | APC
|
| Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.
|
| Takacs CM, Baird JR, Hughes EG, Kent SS, Benchabane H, Paik R, Ahmed Y.
|
| Science 319(5861):333-6.
2008
|
| 31 | APC, BRCA1, BRCA2, CDH1, CDKN2A, MLH1, MSH2, MSH6, PMS2, PRSS1, PTEN, RB1, SPINK1, STK11, TP53
|
| Inherited susceptibility to common cancers.
|
| Foulkes WD.
|
| N Engl J Med 359(20):2143-53. No abstract available.
2008
|
| 32 | APC, ATM, EPHA3, ERBB2, ERBB4, FGFR4
|
| Somatic mutations affect key pathways in lung adenocarcinoma.
|
| Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, Cibulskis K, Sougnez C, Greulich H, Muzny DM, Morgan MB, Fulton L, Fulton RS, Zhang Q, Wendl MC, Lawrence MS, Larson DE, Chen K, Dooling DJ, Sabo A, Hawes AC, Shen H, Jhangiani SN, Lewis LR, Hall O, Zhu Y, Mathew T, Ren Y, Yao J, Scherer SE, Clerc K, Metcalf GA, Ng B, Milosavljevic A, Gonzalez-Garay ML, Osborne JR, Meyer R, Shi X, Tang Y, Koboldt DC, Lin L, Abbott R, Miner TL, Pohl C, Fewell G, Haipek C, Schmidt H, Dunford-Shore BH, Kraja A, Crosby SD, Sawyer CS, Vickery T, Sander S, Robinson J, Winckler W, Baldwin J, Chirieac LR, Dutt A, Fennell T, Hanna M, Johnson BE, Onofrio RC, Thomas RK, Tonon G, Weir BA, Zhao X, Ziaugra L, Zody MC, Giordano T, Orringer MB, Roth JA, Spitz MR, Wistuba II, Ozenberger B, Good PJ, Chang AC, Beer DG, Watson MA, Ladanyi M, Broderick S, Yoshizawa A, Travis WD, Pao W, Province MA, Weinstock GM, Varmus HE, Gabriel SB, Lander ES, Gibbs RA, Meyerson M, Wilson RK.
|
| Nature 455(7216):1069-75.
2008
|
| 33 | APC
|
| APC promoter methylation and protein expression in hepatocellular carcinoma.
|
| Csepregi A, Röcken C, Hoffmann J, Gu P, Saliger S, Müller O, Schneider-Stock R, Kutzner N, Roessner A, Malfertheiner P, Ebert MP.
|
| J Cancer Res Clin Oncol 134(5):579-89. Epub 2007 Nov 1.PMID: 17973119 2008
|
| 34 | APC
|
| Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains.
|
| Tran H, Hamada F, Schwarz-Romond T, Bienz M.
|
| Genes Dev. 22(4):528-42. 2008
|
| 35 | APC, FAP,HDD
|
| APC mutations in FAP-associated desmoid tumours are non-random but not 'just right'.
|
| Latchford A, Volikos E, Johnson V, Rogers P, Suraweera N, Tomlinson I, Phillips R, Silver A.
|
| Hum Mol Genet 16(1):78-82. Epub 2006 Nov 29. 2007
|
| 36 | APC
|
| Novel APC mutations in Czech and Slovak FAP families: clinical and genetic aspects.
|
| Stekrova J, Sulova M, Kebrdlova V, Zidkova K, Kotlas J, Ilencikova D, Vesela K, Kohoutova M.
|
| BMC Med Genet 8:16. 2007
|
| 37 | APC,MYC
|
| Myc deletion rescues Apc deficiency in the small intestine.
|
| Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR.
|
| Nature 446(7136):676-9. Epub 2007 Mar 21. 2007
|
| 38 | APC, FAP
|
| Genotype-phenotype correlations in 19 Dutch cases with APC gene deletions and a literature review.
|
| Nielsen M, Bik E, Hes FJ, Breuning MH, Vasen HF, Bakker E, Tops CM, Weiss MM.
|
| Eur J Hum Genet 15(10):1034-42. Epub 2007 Jun 13. 2007
|
| 39 | FAP, APC, MAP, MUTYH
|
| Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis.
|
| Nielsen M, Hes FJ, Nagengast FM, Weiss MM, Mathus-Vliegen EM, Morreau H, Breuning MH, Wijnen JT, Tops CM, Vasen HF.
|
| Clin Genet 71(5):427-33. 2007
|
| 40 | APC, DEL5Q
|
| Familial adenomatous polyposis in a patient with unexplained mental retardation.
|
| Heald B, Moran R, Milas M, Burke C, Eng C.
|
| Nat Clin Pract Neurol 3(12):694-700.
2007
|
| 41 | APC
|
| Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons.
|
| Farías GG, Vallés AS, Colombres M, Godoy JA, Toledo EM, Lukas RJ, Barrantes FJ, Inestrosa NC.
|
| J Neurosci. 27(20):5313-25. 2007
|
| 42 | APC
|
| A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer.
|
| Amos-Landgraf JM, Kwong LN, Kendziorski CM, Reichelderfer M, Torrealba J, Weichert J, Haag JD, Chen KS, Waller JL, Gould MN, Dove WF.
|
| Proc Natl Acad Sci U S A. 104(10):4036-41. 2007
|
| 43 | MUTYH, APC, FAP, FTACC
|
| MUTYH-associated polyposis: 70 of 71 patients with biallelic mutations present with an attenuated or atypical phenotype.
|
| Aretz S, Uhlhaas S, Goergens H, Siberg K, Vogel M, Pagenstecher C, Mangold E, Caspari R, Propping P, Friedl W.
|
| Int J Cancer 119(4):807-14. 2006
|
| 44 | MUTYH, APC, FAP, FTACC
|
| Prevalence of MYH germline mutations in Swiss APC mutation-negative polyposis patients.
|
| Russell AM, Zhang J, Luz J, Hutter P, Chappuis PO, Berthod CR, Maillet P, Mueller H, Heinimann K.
|
| Int J Cancer 118(8):1937-40. 2006
|
| 45 | APC
|
| Genetic inactivation of the APC gene contributes to the malignant progression of sporadic hepatocellular carcinoma: a case report.
|
| Katoh H, Shibata T, Kokubu A, Ojima H, Kosuge T, Kanai Y, Hirohashi S.
|
| Genes Chromosomes Cancer 45(11):1050-7. 2006
|
| 46 | FAP, APC, HDD
|
| Current ideas in desmoid tumours.
|
| Sturt NJ, Clark SK.
|
| Fam Cancer 5(3):275-85; discussion 287-8. Review. 2006
|
| 47 | APC, CTNNB1, WNT1, AXIN2
|
| Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis.
|
| Cho KH, Baek S, Sung MH.
|
| FEBS Lett 580(15):3665-70. Epub 2006 Jun 5. 2006
|
| 48 | APC,DEL5Q,FAP
|
| Phenotypic and molecular characterisation of a de novo 5q deletion that includes the APC gene.
|
| Ofner L, Raedle J, Windpassinger C, Schwarzbraun T, Kroisel PM, Wagner K, Petek E.
|
| J Hum Genet 51(2):141-6. Epub 2005 Dec 20. 2006
|
| 49 | APC
|
| Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development.
|
| Nadauld LD, Chidester S, Shelton DN, Rai K, Broadbent T, Sandoval IT, Peterson PW, Manos EJ, Ireland CM, Yost HJ, Jones DA.
|
| Proc Natl Acad Sci U S A. 103(36):13409-14. 2006
|
| 50 | APC,MAPRE1
|
| APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment.
|
| Green RA, Wollman R, Kaplan KB.
|
| Mol Biol Cell 16(10):4609-22. Epub 2005 Jul 19. 2005
|
| 51 | APC,MAPRE1
|
| Structural insights into the EB1-APC interaction.
|
| Honnappa S, John CM, Kostrewa D, Winkler FK, Steinmetz MO.
|
| EMBO J 24(2):261-9. Epub 2004 Dec 23. Erratum in: EMBO J. 2005 Feb 23;24(4):872. 2005
|
| 52 | APC,DEL5Q,FAP
|
| Large deletions of the APC gene in 15% of mutation-negative patients with classical polyposis (FAP): a Belgian study.
|
| Michils G, Tejpar S, Thoelen R, van Cutsem E, Vermeesch JR, Fryns JP, Legius E, Matthijs G.
|
| Hum Mutat 25(2):125-34. 2005
|
| 53 | APC
|
| Colonic tumorigenesis in BubR1 +/- Apc Min/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability.
|
| Rao, C. V., Yang, Y.-M., Swamy, M. V., Liu, T., Fang, Y., Mahmood, R., Jhanwar-Uniyal, M., Dai, W.
|
| Proc. Nat. Acad. Sci. 102: 4365-4370 2005
|
| 54 | APC
|
| Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
|
| Benzinger A, Muster N, Koch HB, Yates JR 3rd, Hermeking H.
|
| Mol Cell Proteomics. 4(6):785-95. 2005
|
| 55 | APC, GBM, HIF1A, PI3K, RB, TP53
|
| Cancer genes and the pathways they control.
|
| Vogelstein B, Kinzler KW.
|
| Nat Med 10(8):789-99. Review. 2004
|
| 56 | APC
|
| Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration.
|
| Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K.
|
| Dev Cell. 7(6):871-83. 2004
|
| 57 | APC
|
| The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.
|
| Hamada F, Bienz M.
|
| Dev Cell. 7(5):677-85. 2004
|
| 58 | APC
|
| Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function.
|
| Xing Y, Clements WK, Le Trong I, Hinds TR, Stenkamp R, Kimelman D, Xu W.
|
| Mol Cell. 15(4):523-33. 2004
|
| 59 | APC
|
| MUC1 can interact with adenomatous polyposis coli in breast cancer.
|
| Hattrup CL, Fernandez-Rodriguez J, Schroeder JA, Hansson GC, Gendler SJ.
|
| Biochem Biophys Res Commun. 316(2):364-9. 2004
|
| 60 | APC
|
| Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells.
|
| Li Q, Dashwood RH.
|
| J Biol Chem. 279(44):45669-75. 2004
|
| 61 | APC, CTNNB1
|
| The Wnt/beta-catenin pathway regulates cardiac valve formation.
|
| Hurlstone AF, Haramis AP, Wienholds E, Begthel H, Korving J, Van Eeden F, Cuppen E, Zivkovic D, Plasterk RH, Clevers H.
|
| Nature 425(6958):633-7. 2003
|
| 62 | FAP, APC
|
| Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.
|
| Crabtree M, Sieber OM, Lipton L, Hodgson SV, Lamlum H, Thomas HJ, Neale K, Phillips RK, Heinimann K, Tomlinson IP.
|
| Oncogene 22(27):4257-65. 2003
|
| 63 | APC, KRAS, TP53, FAP
|
| Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.
|
| Smith G, Carey FA, Beattie J, Wilkie MJ, Lightfoot TJ, Coxhead J, Garner RC, Steele RJ, Wolf CR.
|
| Proc Natl Acad Sci U S A 99(14):9433-8. 2002
|
| 64 | APC, BTRC, CTNNB1
|
| APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers.
|
| Gerstein AV, Almeida TA, Zhao G, Chess E, Shih IeM, Buhler K, Pienta K, Rubin MA, Vessella R, Papadopoulos N.
|
| Genes Chromosomes Cancer 34(1):9-16. 2002
|
| 65 | APC,DEL5Q,FAP
|
| Whole-gene APC deletions cause classical familial adenomatous polyposis, but not attenuated polyposis or multiple colorectal adenomas.
|
| Sieber OM, Lamlum H, Crabtree MD, Rowan AJ, Barclay E, Lipton L, Hodgson S, Thomas HJ, Neale K, Phillips RK, Farrington SM, Dunlop MG, Mueller HJ, Bisgaard ML, Bulow S, Fidalgo P, Albuquerque C, Scarano MI, Bodmer W, Tomlinson IP, Heinimann K.
|
| Proc Natl Acad Sci U S A 99(5):2954-8. Epub 2002 Feb 26. 2002
|
| 66 | APC
|
| The coiled coil region (amino acids 129-250) of the tumor suppressor protein adenomatous polyposis coli (APC). Its structure and its interaction with chromosome maintenance region 1 (Crm-1).
|
| Tickenbrock L, Cramer J, Vetter IR, Muller O.
|
| J Biol Chem. 277(35):32332-8. 2002
|
| 67 | APC
|
| Identification of a link between the tumour suppressor APC and the kinesin superfamily.
|
| Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T.
|
| Nat Cell Biol. 4(4):323-7. 2002
|
| 68 | APC
|
| Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein.
|
| Homma MK, Li D, Krebs EG, Yuasa Y, Homma Y.
|
| Proc Natl Acad Sci U S A. 99(9):5959-64. 2002
|
| 69 | APC
|
| Evidence that an interaction between EB1 and p150(Glued) is required for the formation and maintenance of a radial microtubule array anchored at the centrosome.
|
| Askham JM, Vaughan KT, Goodson HV, Morrison EE.
|
| Mol Biol Cell. 13(10):3627-45. 2002
|
| 70 | APC, FAP
|
| Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
|
| Abraham SC, Wu TT, Klimstra DS, Finn LS, Lee JH, Yeo CJ, Cameron JL, Hruban RH.
|
| Am J Pathol 159(5):1619-27. 2001
|
| 71 | APC
|
| A role for the Adenomatous Polyposis Coli protein in chromosome segregation.
|
| Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Näthke IS.
|
| Nat Cell Biol. 3(4):429-32. 2001
|
| 72 | APC
|
| Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein.
|
| Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N.
|
| Mol Cell. 7(5):927-36. 2001
|
| 73 | APC
|
| ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.
|
| Galea MA, Eleftheriou A, Henderson BR.
|
| J Biol Chem. 276(49):45833-9. 2001
|
| 74 | APC
|
| Mutations in the APC tumour suppressor gene cause chromosomal instability.
|
| Fodde R, Kuipers J, Rosenberg C, Smits R, Kielman M, Gaspar C, van Es JH, Breukel C, Wiegant J, Giles RH, Clevers H.
|
| Nat Cell Biol. 3(4):433-8. 2001
|
| 75 | APC
|
| Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor.
|
| Lal, G., Ash, C., Hay, K., Redston, M., Kwong, E., Hancock, B., Mak, T., Kargman, S., Evans, J. F., Gallinger, S.
|
| Cancer Res. 61: 6131-6136 2001
|
| 76 | APC
|
| Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation.
|
| Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS.
|
| Curr Biol. 11(1):44-9. 2001
|
| 77 | APC, FAP
|
| Deletion and duplication of the adenomatous polyposis coli gene resulting from an interchromosomal insertion involving 5(q22q23.3) in the father.
|
| Hastings RJ, Svennevik EC, Setterfield B, Wells D, Delhanty JD, Mackinnon H.
|
| J Med Genet 37(2):141-5. No abstract available. 2000
|
| 78 | APC, FAP
|
| Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposis
|
| Su LK, Steinbach G, Sawyer JC, Hindi M, Ward PA, Lynch PM.
|
| Hum Genet 106:101-107 2000
|
| 79 | APC, FAP
|
| APC mutations are sufficient for the growth of early colorectal adenomas.
|
| Lamlum H, Papadopoulou A, Ilyas M, Rowan A, Gillet C, Hanby A, Talbot I, Bodmer W, Tomlinson I.
|
| Proc Natl Acad Sci U S A 97(5):2225-8. 2000
|
| 80 | APC, FAP
|
| APC mutations in sporadic colorectal tumors: A mutational hotspot and interdependence of the two hits.
|
| Rowan AJ, Lamlum H, Ilyas M, Wheeler J, Straub J, Papadopoulou A, Bicknell D, Bodmer WF, Tomlinson IP.
|
| Proc Natl Acad Sci U S A 97(7):3352-7. 2000
|
| 81 | APC, ARHGEF4
|
| Asef, a link between the tumor suppressor APC and G-protein signaling.
|
| Kawasaki Y, Senda T, Ishidate T, Koyama R, Morishita T, Iwayama Y, Higuchi O, Akiyama T.
|
| Science 289(5482):1194-7. 2000
|
| 82 | APC
|
| A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor.
|
| Couture J, Mitri A, Lagace R, Smits R, Berk T, Bouchard HL, Fodde R, Alman B, Bapat B.
|
| Clin Genet 57(3):205-12. 2000
|
| 83 | APC, FAP
|
| Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis.
|
| Su LK, Barnes CJ, Yao W, Qi Y, Lynch PM, Steinbach G.
|
| Am J Hum Genet 67(3):582-90. 2000
|
| 84 | APC
|
| Germline APC variants in patients with multiple colorectal adenomas, with evidence for the particular importance of E1317Q.
|
| Lamlum H, Al Tassan N, Jaeger E, Frayling I, Sieber O, Reza FB, Eckert M, Rowan A, Barclay E, Atkin W, Williams C, Gilbert J, Cheadle J, Bell J, Houlston R, Bodmer W, Sampson J, Tomlinson I.
|
| Hum Mol Genet 9(15):2215-21. 2000
|
| 85 | APC
|
| Hot spots in beta-catenin for interactions with LEF-1, conductin and APC.
|
| von Kries JP, Winbeck G, Asbrand C, Schwarz-Romond T, Sochnikova N, Dell'Oro A, Behrens J, Birchmeier W.
|
| Nat Struct Biol. 7(9):800-7. 2000
|
| 86 | APC
|
| The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain.
|
| Erdmann KS, Kuhlmann J, Lessmann V, Herrmann L, Eulenburg V, Müller O, Heumann R.
|
| Oncogene. 19(34):3894-901. 2000
|
| 87 | APC
|
| GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin.
|
| Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A.
|
| Oncogene. 19(4):537-45. 2000
|
| 88 | APC, FAP
|
| Molecular analysis of the APC gene in 205 families : extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition.
|
| Wallis YL, Morton DG, McKeown CM, Macdonald F.
|
| J Med Genet 36 : 14-20. 1999
|
| 89 | APC, FAP
|
| Familial adenomatous polyposis associated with multiple adrenal adenomas in a patient with a rare 3' APC mutation.
|
| Kartheuser A, Walon C, West S, Breukel C, Detry R, Gribomont AC, Hamzehloei T, Hoang P, Maiter D, Pringot J, Rahier J, Khan PM, Curtis A, Burn J, Fodde R, Verellen-Dumoulin C.
|
| J Med Genet 36 : 65-67. 1999
|
| 90 | APC, CTNNB1, FAP
|
| Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas.
|
| Mann B, et al.
|
| Proc Natl Acad Sci U S A 96 : 1603-1608. 1999
|
| 91 | APC
|
| Hereditary Desmoid Disease in a Family with a Germline Alu I Repeat Mutation of the APC Gene.
|
| Halling KC, et al.
|
| Hum Hered 49(2):97-102. 1999
|
| 92 | APC, CTNNB1, FAP
|
| Germline mutations are frequent in the APC gene but absent in the beta-catenin gene in familial adenomatous polyposis patients.
|
| Cao X, et al.
|
| Genes Chromosomes Cancer 25(4):396-8. 1999
|
| 93 | APC, FAP
|
| Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis.
|
| Dihlmann S, et al.
|
| Cancer Res 59(8):1857-60. 1999
|
| 94 | APC, FAP
|
| The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
|
| Lamlum H, et al.
|
| Nat Med 5(9):1071-5 1999
|
| 95 | APC, FAP
|
| Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism.
|
| Gryfe R, et al.
|
| Am J Hum Genet 64(2):378-84 1999
|
| 96 | APC, CTNNB1, FAP
|
| Frequent mutation of beta-catenin and APC genes in primary colorectal tumors from patients with hereditary nonpolyposis colorectal cancer.
|
| Miyaki M, Iijima T, Kimura J, Yasuno M, Mori T, Hayashi Y, Koike M, Shitara N, Iwama T, Kuroki T.
|
| Cancer Res 59(18):4506-9 1999
|
| 97 | APC, RP1
|
| EB/RP gene family encodes tubulin binding proteins.
|
| Juwana JP, Henderikx P, Mischo A, Wadle A, Fadle N, Gerlach K, Arends JW, Hoogenboom H, Pfreundschuh M, Renner C.
|
| Int J Cancer. 81(2):275-84. 1999
|
| 98 | APC
|
| Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.
|
| Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM.
|
| Science. 283(5410):2089-91. 1999
|
| 99 | APC, FAP
|
| Genotype-phenotype correlations in attenuated adenomatous polyposis coli.
|
| Soravia C, et al.
|
| Am J Hum Genet 62 : 1290-1301. 1998
|
| 100 | APC, AXIN1, CTNNB1, GSK3B
|
| Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.
|
| Nakamura T, Hamada F, Ishidate T, Anai K, Kawahara K, Toyoshima K, Akiyama T.
|
| Genes Cells 3 : 395-403. 1998
|
| 101 | APC, FAP
|
| The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.
|
| Frayling IM, et al.
|
| Proc Natl Acad Sci U S A 95 : 10722-10727. 1998
|
| 102 | APC, BRCA1, DPP4, MLH1, MSH2, MSH6, NF1, PMS2, RB1, TP53, VHL, WT1, FAP
|
| Tumour suppressor gene mutations in humans and mice : parallels and contrasts.
|
| Hooper ML.
|
| EMBO J 17(23):6783-9. 1998
|
| 103 | APC, FAP
|
| Alleles of APC modulate the frequency and classes of mutations that lead to colon polyps.
|
| Spirio LN, et al.
|
| Nat Genet 20 : 385-388. 1998
|
| 104 | APC, KRAS1P, FAP
|
| [Analysis of genetic disorders of cancer of the rectum : differences in relation to cancer of the colon].
|
| Rebischung C, Laurent-Puig P, Gerard JP, Thomas G, Hamelin R.
|
| Gastroenterol Clin Biol 22 : 679-687. 1998
|
| 105 | APC
|
| Novel protein isoforms of the APC tumor suppressor in neural tissue.
|
| Pyles RB, Santoro IM, Groden J, Parysek LM.
|
| Oncogene 16(1):77-82. 1998
|
| 106 | APC, ATG12, CDO1, FER, MCC, RN28SL, SEMA4DL, TSG5A, ZRSR1
|
| Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer.
|
| Ueno K, Kumagai T, Kijima T, Kishimoto T, Hosoe S.
|
| Hum Genet 102(1):63-8. 1998
|
| 107 | APC
|
| Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.
|
| Takaku, K., Oshima, M., Miyoshi, H., Matsui, M., Seldin, M. F., Taketo, M. M.
|
| Cell. 92: 645-656 1998
|
| 108 | APC, CDC20, MAD1L1
|
| The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.
|
| Fang G, Yu H, Kirschner MW.
|
| Genes Dev. 12(12):1871-83. 1998
|
| 109 | APC, FAP
|
| Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis : 67 germline mutations identified by DGGE, PTT, and Southern analysis.
|
| Van der Luijt RB, et al.
|
| Hum Mutat 9 : 7-16. 1997
|
| 110 | APC, CTNNB1, LEF1, FAP
|
| Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.
|
| Morin PJ, et al.
|
| Science 275 : 1787-1790. 1997
|
| 111 | APC, CTNNB1, TCF7L2, FAP
|
| Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
|
| Korinek V, et al.
|
| Science 275 : 1784-1787. 1997
|
| 112 | APC, FAP
|
| Characterization of 19 novel and six recurring APC mutations in Italian adenomatous polyposis patients, using two different mutation detection techniques.
|
| Gismondi V, et al.
|
| Hum Mutat 9 : 370-373. 1997
|
| 113 | APC, DLG3, DLG4, MPP1
|
| Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein.
|
| Makino K, Kuwahara H, Masuko N, Nishiyama Y, Morisaki T, Sasaki J, Nakao M, Kuwano A, Nakata M, Ushio Y, Saya H.
|
| Oncogene 14(20):2425-33. 1997
|
| 114 | APC, FAP
|
| Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.
|
| Laken SJ, Petersen GM, Gruber SB, Oddoux C, Ostrer H, Giardiello FM, Hamilton SR, Hampel H, Markowitz A, Klimstra D, Jhanwar S, Winawer S, Offit K, Luce MC, Kinzler KW, Vogelstein B.
|
| Nat Genet 17(1):79-83. 1997
|
| 115 | APC, FAP
|
| Novel germline mutations in the APC gene and their phenotypic spectrum in familial adenomatous polyposis kindreds.
|
| Walon C, Kartheuser A, Michils G, Smaers M, Lannoy N, Ngounou P, Mertens G, Verellen-Dumoulin C.
|
| Hum Genet 100(5-6):601-5. 1997
|
| 116 | APC
|
| Alternative splicing of the APC gene and its association with terminal differentiation.
|
| Santoro IM, Groden J.
|
| Cancer Res 57(3):488-94. 1997
|
| 117 | APC, DLG4, DLGAP1, DLGAP2, PSD95
|
| DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95.
|
| Satoh K, Yanai H, Senda T, Kohu K, Nakamura T, Okumura N, Matsumine A, Kobayashi S, Toyoshima K, Akiyama T.
|
| Genes Cells. 2(6):415-24 1997
|
| 118 | APC, FAP
|
| Familial adenomatous polyposis : a submicroscopic deletion at the APC locus in a family with mentally normal patients.
|
| Mandl M, et al.
|
| Hum Genet 97 : 204-208. 1996
|
| 119 | APC
|
| Germline APC mutation (Gln1317) in a cancer-prone family that does not result in familial adenomatous polyposis.
|
| White S, et al.
|
| Genes Chromosomes Cancer 15 : 122-128. 1996
|
| 120 | APC
|
| Familial adenomatous polyposis in a 5 year old child : a clinical, pathological, and molecular genetic study.
|
| Distante S, et al.
|
| J Med Genet 33 : 157-160. 1996
|
| 121 | APC, FAP
|
| Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein.
|
| Friedl W, et al.
|
| Hum Genet 97 : 579-584. 1996
|
| 122 | APC, TP53, FAP
|
| Database of mutations in the p53 and APC tumor suppressor genes designedto facilitate molecular epidemiological analyses.
|
| de Vries EMG, et al.
|
| Hum Mutat 7 : 202-213. 1996
|
| 123 | APC, FAP
|
| Correlation between the development of extracolonic manifestations in FAP patients and mutations beyond codon 1403 in the APC gene.
|
| Dobbie Z, et al.
|
| J Med Genet 33 : 274-280. 1996
|
| 124 | APC, CHRPE
|
| A novel deletion at codon 441 of the APC gene associated with ophthalmic lesions (CHRPE) in a South African family.
|
| Grobbelaar JJ, et al.
|
| J Med Genet 33 : 384-386. 1996
|
| 125 | APC
|
| Long-range physical map and deletion characterization of the 1100-kb Notl restriction fragment harboring the APC gene.
|
| Thliveris A, et al.
|
| Genomics 34 : 268-270. 1996
|
| 126 | APC, FAP
|
| Identification of a novel single base insertion in the adenomatous polyposis coli gene.
|
| Kotze MJ, et al.
|
| Hum Mutat 7 : 68-69. 1996
|
| 127 | APC, FAP
|
| APC mutations in colorectal tumors with mismatch repair deficiency.
|
| Huang J, et al.
|
| Proc Natl Acad Sci U S A 93 : 9049-9054. 1996
|
| 128 | APC
|
| Multiple products in the protein truncation test due to alternative splicing in the adenomatous polyposis coli (APC) gene.
|
| Bala S, et al.
|
| Hum Genet 98 : 528-533. 1996
|
| 129 | APC, FAP
|
| Germline mutations in the 3' part of APC exon 15 do not result in truncated proteins and are associated with attenuated adenomatous polyposis coli.
|
| Van der Luijt RB, et al.
|
| Hum Genet 98 : 727-734. 1996
|
| 130 | APC, FAP
|
| Three novel APC gene mutations in Portuguese FAP kindreds.
|
| Marshall B, et al.
|
| Hum Mutat 8 : 395. 1996
|
| 131 | APC
|
| Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation.
|
| Scott RJ, et al.
|
| Hum Mol Genet 5 : 1921-1924. 1996
|
| 132 | APC, FAP
|
| Mutation detection in exons 1-14 of the adenomatous polyposis coli gene : identification of an alternatively spliced transcript.
|
| Hamzehloei T, et al.
|
| Mol Cell Probes 10 : 379-385. 1996
|
| 133 | APC, TSG5A, FAP
|
| APC gene mutations and allelic losses in sporadic ampullary tumours : evidence of genetic difference from tumours associated with familial adenomatous polyposis.
|
| Achille A, et al.
|
| Int J Cancer 68 : 305-312. 1996
|
| 134 | APC
|
| The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.
|
| NŠthke IS, et al.
|
| J Cell Biol 134 : 165-179. 1996
|
| 135 | APC, GSK3B
|
| Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.
|
| Rubinfeld B, Albert I, Porfiri E, Fiol C, Munemitsu S, Polakis P.
|
| Science 272 : 1023-1026. 1996
|
| 136 | APC, HDD
|
| Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene.
|
| Eccles DM, van der Luijt R, Breukel C, Bullman H, Bunyan D, Fisher A, Barber J, du Boulay C, Primrose J, Burn J, Fodde R.
|
| Am J Hum Genet 59(6):1193-201. 1996
|
| 137 | APC, CHRPE, FAP
|
| Congenital hypertrophy of the retinal pigment epithelium in familial adenomatous polyposis. Novel criteria of assessment and correlations with constitutional adenomatous polyposis coli gene mutations.
|
| Valanzano R, Cama A, Volpe R, Curia MC, Mencucci R, Palmirotta R, Battista P, Ficari F, Mariani-Costantini R, Tonelli F.
|
| Cancer 78(11):2400-10.PMID: 8941012 [PubMed - indexed for MEDLINE] 1996
|
| 138 | APC
|
| Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).
|
| Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF, Taketo MM.
|
| Cell. 87(5):803-9. 1996
|
| 139 | APC, FAP
|
| Multiplex PCR analysis and genotype-phenotype correlations of frequent APC mutations.
|
| Cama A, et al.
|
| Hum Mutat 5 : 144-152. 1995
|
| 140 | APC
|
| A novel coding exon of the human adenomatous polyposis coli gene.
|
| Sulekova Z, et al.
|
| Hum Genet 96 : 469-471. 1995
|
| 141 | APC, CHRPE, FAP
|
| Severe Gardner syndrome in families with mutations restricted to a specific region of the APC gene.
|
| Davies DR, et al.
|
| Am J Hum Genet 57 : 1151-1158. 1995
|
| 142 | APC, FAP
|
| Attenuated familial adenomatous polyposis (AFAP).
|
| Lynch HT, et al.
|
| Cancer 76 : 2427-2433. 1995
|
| 143 | APC, FAP
|
| Molecular genetic analysis of exons 1 to 6 of the APC gene in non-polyposis familial colorectal cancer.
|
| Joyce JA, et al.
|
| Clin Genet 48 : 299-303. 1995
|
| 144 | APC, FAP
|
| Familial adenomatous polyposis : desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444.
|
| Caspari R, et al.
|
| Hum Mol Genet 4 : 337-340. 1995
|
| 145 | APC, MLH1, MHS2, PMS2, FAP
|
| The molecular basis of Turcot's syndrome.
|
| Hamilton SR, et al.
|
| N Engl J Med 332 : 839-847. 1995
|
| 146 | APC, FAP
|
| Haplotype comparison in fresh mutation cases of adenomatous polyposis coli due to deletion AAAGA at codon 1309.
|
| Delhanty JDA, et al.
|
| Ann Hum Genet 59 : 39-42. 1995
|
| 147 | APC, FAP
|
| Molecular, cytogenetic, and phenotypic studies of a constitutional reciprocal translocation t(5;10)(q22;q25) responsible for familial adenomatous polyposis in a Dutch pedigree.
|
| Van der Luijt RB, et al.
|
| Genes Chromosomes Cancer 13 : 192-202. 1995
|
| 148 | APC, FAP
|
| Rapid detection of rare variants and common polymorphisms in the APC gene by PCR-SSCP for presymptomatic diagnosis and showing allele loss.
|
| Gayther SA, et al.
|
| J Med Genet 32 : 568-571. 1995
|
| 149 | APC, FAP
|
| Evidence for a novel exon in the coding region of the adenomatous polyposis coli (APC) gene.
|
| Xia L, et al.
|
| Genomics 28 : 589-591. 1995
|
| 150 | APC, MAPRE1
|
| APC binds to the novel protein EB1.
|
| Su LK, Burrell M, Hill DE, Gyuris J, Brent R, Wiltshire R, Trent J, Vogelstein B, Kinzler KW.
|
| Cancer Res 55(14):2972-7 1995
|
| 151 | APC
|
| The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.
|
| Rubinfeld B, Souza B, Albert I, Munemitsu S, Polakis P.
|
| J Biol Chem. 270(10):5549-55. 1995
|
| 152 | APC
|
| Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
|
| Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., Taketo, M.
|
| Proc. Nat. Acad. Sci. 92: 4482-4486 1995
|
| 153 | APC, FAP
|
| Exon eight APC mutations account for a disproportionate number of familial adenomatous polyposis families.
|
| Koorey DJ, et al.
|
| Hum Mutat 3 : 12-18. 1994
|
| 154 | APC, TSG5A, FAP
|
| Mutation in a splice-donor site of the APC gene in a family with polyposis and late age of colonic cancer death.
|
| Varesco L, et al.
|
| Hum Genet 93 : 281-286. 1994
|
| 155 | APC, FAP
|
| Frequency of common and novel inactivating APC mutations in 202 families with familial adenomatous polyposis.
|
| Mandl M, et al.
|
| Hum Mol Genet 3 : 181-184. 1994
|
| 156 | APC, FAP
|
| Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli.
|
| Gayther SA, et al.
|
| Hum Mol Genet 3 : 53-56. 1994
|
| 157 | APC, TSG5A, FAP
|
| Frequent polymorphism in exon 15 of the adenomatous polyposis coli gene.
|
| Davies SM, et al.
|
| Hum Genet 93 : 329-330. 1994
|
| 158 | APC
|
| Rapid detection of translation-terminating mutations at the adenomatous polyposis coli (APC) gene by direct protein truncation test.
|
| Van der Luijt R, et al.
|
| Genomics 20 : 1-4. 1994
|
| 159 | APC, FAP
|
| Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion.
|
| Barber JCK, et al.
|
| J Med Genet 31 : 312-316. 1994
|
| 160 | APC
|
| Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region.
|
| Jorde LB, et al.
|
| Am J Hum Genet 54 : 884-898. 1994
|
| 161 | APC, FAP
|
| A somatic mutation in the adenomatous polyposis coli (APC) gene in peripheral blood cells - implications for predictive diagnosis.
|
| Mandl M, et al.
|
| Hum Mol Genet 3 : 1009-1011. 1994
|
| 162 | APC, FAP, FAP
|
| Four novel germ-line mutations in the APC gene detected by heteroduplex analysis.
|
| Hamzehloei T, et al.
|
| Hum Mol Genet 3 : 1023-1024. 1994
|
| 163 | APC, FAP
|
| Identification of a novel germline mutation in a FAP family.
|
| Gebert JF, et al.
|
| Hum Mol Genet 3 : 1167-1168. 1994
|
| 164 | APC, FAP
|
| Four novel mutations of the APC (adenomatous polyposis coli) gene in FAP patients.
|
| Stella A, et al.
|
| Hum Mol Genet 3 : 1687-1688. 1994
|
| 165 | APC, FAP
|
| Eleven novel germline mutations in the adenomatous polyposis coli (APC) gene.
|
| Paffenholz R, et al.
|
| Hum Mol Genet 3 : 1703-1704. 1994
|
| 166 | APC, FAP
|
| APC mutation associated with late onset of familial adenomatous polyposis.
|
| Smith-Ravin J, et al.
|
| J Med Genet 31 : 888-890. 1994
|
| 167 | APC, FAP
|
| Characterization of two novel adenomatous polyposis coli (APC) gene mutations in patients with familial adenomatous polyposis (FAP).
|
| Bapat B, et al.
|
| Hum Mutat 4 : 253-256. 1994
|
| 168 | APC, FAP
|
| Mutations of the adenomatous polyposis coli gene in the mutation cluster region : comparison of human pancreatic and colorectal cancers.
|
| Yashima K, et al.
|
| Int J Cancer 59 : 43-47. 1994
|
| 169 | APC, CTNNB1, CTNND1, JUP, KPNA3, ARVCF, CTNND2, KPNA2, PKP4, PKP1, PKP2, SPAG6
|
| A repeating amino acid motif shared by proteins with diverse cellular roles.
|
| Peifer M, et al.
|
| Cell 76(5):789-91. No abstract available 1994
|
| 170 | APC
|
| Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation.
|
| Shibata T, Gotoh M, Ochiai A, Hirohashi S.
|
| Biochem Biophys Res Commun. 203(1):519-22. 1994
|
| 171 | APC
|
| A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.
|
| Fodde, R., Edelmann, W., Yang, K., van Leeuwen, C., Carlson, C., Renault, B., Breukel, C., Alt, E., Lipkin, M., Meera Khan, P., Kucherlapati, R.
|
| Proc. Nat. Acad. Sci. 91: 8969-8973 1994
|
| 172 | APC, FAP
|
| Mutations of the APC (adenomatous polyposis coli) gene.
|
| Nagase H, et al.
|
| Hum Mutat 2 : 425-434. 1993
|
| 173 | APC, FAP
|
| Molecular diagnosis of familial adenomatous polyposis.
|
| Powell SM, et al.
|
| N Engl J Med 329 : 1982-1987. 1993
|
| 174 | CHRPE, APC, FAP
|
| Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients.
|
| Olschwang S, et al.
|
| Cell 75 : 959-968. 1993
|
| 175 | APC, FAP
|
| Alleles of the APC gene : an attenuated form of familial polyposis.
|
| Spirio L, et al.
|
| Cell 75 : 951-957. 1993
|
| 176 | APC
|
| Association of the APC gene product with beta-catenin.
|
| Rubinfeld B, et al.
|
| Science 262 : 1731-1734. 1993
|
| 177 | APC, FAP
|
| A novel mutation of the APC (adenomatous polyposis coli) gene in a familial adenomatous polyposis (FAP) patient and presymptomatic diagnosis using PCR.
|
| Ichii S, et al.
|
| Hum Mol Genet 2 : 597. 1993
|
| 178 | APC, FAP
|
| Presymptomatic direct detection of adenomatous polyposis coli (APC) gene mutations in familial adenomatous polyposis.
|
| Petersen GM, et al.
|
| Hum Genet 91 : 307-311. 1993
|
| 179 | APC, FAP
|
| Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis.
|
| Paul P, et al.
|
| Hum Mol Genet 2 : 925-931. 1993
|
| 180 | APC, FAP
|
| Mutational analysis of patients with adenomatous polyposis : identical inactivating mutations in unrelated individuals.
|
| Groden J, et al.
|
| Am J Hum Genet 52 : 263-272. 1993
|
| 181 | APC
|
| Germ-line mutations in the first 14 exons of the adenomatous polyposis coli (APC) gene.
|
| Olschwang S, et al.
|
| Am J Hum Genet 52 : 273-279. 1993
|
| 182 | APC, FAP
|
| The APC (adenomatous polyposis coli) gene : a novel mutation in an FAP patient and a DdeI polymorphism in the 5' noncoding region.
|
| Mori T, et al.
|
| Hum Mutat 2 : 240-243. 1993
|
| 183 | APC, FAP
|
| Linkage studies in Italian families with familial adenomatous polyposis.
|
| Mareni C, et al.
|
| Hum Genet 90 : 545-550. 1993
|
| 184 | APC
|
| Association of the APC tumor suppressor protein with catenins.
|
| Su LK, et al.
|
| Science 262 : 1734-1737. 1993
|
| 185 | APC
|
| Apc(Min), a mutation in the murine Apc gene, predisposes to mammary carcinomas and focal alveolar hyperplasias.
|
| Moser, A. R., Mattes, E. M., Dove, W. F., Lindstrom, M. J., Haag, J. D., Gould, M. N.
|
| Proc. Nat. Acad. Sci. 90: 8977-8981 1993
|
| 186 | APC, FAP
|
| Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer.
|
| Miki Y, et al.
|
| Cancer Res 52 : 643-645. 1992
|
| 187 | APC
|
| Two intragenic polymorphisms of the APC-gene detected by PCR and enzymatic digestion.
|
| Kraus C, et al.
|
| Hum Genet 88 : 705-706. 1992
|
| 188 | APC
|
| Detection by DGGE of a new polymorphism closely linked to the adenomatous polyposis coli region.
|
| Olschwang S, et al.
|
| Hum Genet 88 : 658-660. 1992
|
| 189 | APC, FAP
|
| Phenotypic, cytogenetic, and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis.
|
| Lindgren V, et al.
|
| Am J Hum Genet 50 : 988-997. 1992
|
| 190 | APC, FAP
|
| Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
|
| Miyoshi Y, et al.
|
| Proc Natl Acad Sci U S A 89 : 4452-4456. 1992
|
| 191 | TSG5A, APC, MCC
|
| Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.
|
| Boynton RF, et al.
|
| Proc Natl Acad Sci U S A 89 : 3385-3388. 1992
|
| 192 | APC, FAP
|
| Familial adenomatous polyposis : identification of a new frameshift mutation of the APC gene in an Italian family.
|
| Stella A, et al.
|
| Biochem Biophys Res Commun 184 : 1357-1363. 1992
|
| 193 | APC
|
| Two MspI polymorphisms within the APC gene.
|
| Cottrell S, et al.
|
| Hum Mol Genet 1 : 352. 1992
|
| 194 | APC
|
| Eight novel inactiving germ line mutations at the APC gene identified by denaturing gradient gel electrophoresis.
|
| Fodde R, et al.
|
| Genomics 13 : 1162-1168. 1992
|
| 195 | APC, MCC, FAP
|
| Evidence that the MCC-APC gene region in 5q21 is not the site for susceptibility to hereditary nonpolyposis colorectal carcinoma.
|
| PeltomŠki P, et al.
|
| Cancer Res 52 : 4530-4533. 1992
|
| 196 | APC
|
| Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
|
| Cottrell S, et al.
|
| Lancet 340 : 626-630. 1992
|
| 197 | APC, FAP
|
| Linkage of a variant or attenuated form of adenomatous polyposis coli to the adenomatous polyposis coli (APC) locus.
|
| Spirio L, et al.
|
| Am J Hum Genet 51 : 92-100. 1992
|
| 198 | APC
|
| Frequent polymorphism in the 13th exon of the adenomatous polyposis coli gene.
|
| Olschwang S, et al.
|
| Hum Genet 90 : 161-163. 1992
|
| 199 | APC, FAP
|
| An intrachromosomal insertion causing 5q22 deletion and familial adenomatous polyposis coli in two generations.
|
| Cross I, et al.
|
| J Med Genet 29 : 175-179. 1992
|
| 200 | APC, DIHBD, FAP
|
| Two cases of 5q deletions in patients with familial adenomatous polyposis : possible link with Caroli's disease.
|
| Hodgson SV, et al.
|
| J Med Genet 30 : 369-375. 1992
|
| 201 | APC, MCC
|
| Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancer.
|
| D'Amico D, et al.
|
| Cancer Res 52 : 1996-1999. 1992
|
| 202 | RB1, TP53, MCC, APC, TSG5A, TSG13A, TSG17A
|
| Loss of heterozygosity affecting the p53, Rb, and mcc/apc tumor suppressor gene loci in dysplastic and cancerous ulcerative colitis.
|
| Greenwald BD, et al.
|
| Cancer Res 52 : 741-745. 1992
|
| 203 | APC, FAP
|
| Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP).
|
| Ichii S, et al.
|
| Hum Mol Genet 1 : 387-390. 1992
|
| 204 | APC
|
| Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.
|
| Su, L.-K., Kinzler, K. W., Vogelstein, B., Preisinger, A. C., Moser, A. R., Luongo, C., Gould, K. A., Dove, W. F.
|
| Science 256: 668-670 1992
|
| 205 | APC, FAP
|
| Identification and characterization of the familial adenomatous polyposis coli gene.
|
| Groden J, et al.
|
| Cell 66 : 589-600. 1991
|
| 206 | APC
|
| Characterization and mapping of microdissected genomic clones from the adenomatous polyposis coli (APC) region.
|
| Hampton G, et al.
|
| Genomics 11 : 247-251. 1991
|
| 207 | APC, FAP
|
| Linkage analysis in adenomatous polyposis coli: the use of four closely linked DNA probes in 20 UK families.
|
| Cachon-Gonzalez MB, et al.
|
| J Med Genet 28 : 681-685. 1991
|
| 208 | APC
|
| A CA repeat 30-70 KB downstream from the adenomatous polyposis coli (APC) gene.
|
| Spirio L, et al.
|
| Nucleic Acids Res 19 : 6348. 1991
|
| 209 | APC, D5S299, FAP
|
| CA repeat polymorphism at the D5S299 locus linked to adenomatous polyposis coli (APC).
|
| van Leeuwen C, et al.
|
| Nucleic Acids Res 19 : 5805. 1991
|
| 210 | APC
|
| SspI polymorphism in sequence encoding 3' untranslated region of the APC gene.
|
| Heighway J, et al.
|
| Nucleic Acids Res 19 : 6966. 1991
|
| 211 | APC
|
| Fine mapping of probes in the adenomatous polyposis coli region of chromosome 5 by in situ hybridization.
|
| Williams SV, et al.
|
| Genes Chromosomes Cancer 3 : 382-389. 1991
|
| 212 | APC, FAP
|
| Gardner syndrome in a boy with interstitial deletion of the long arm of chromosome 5.
|
| Kobayashi T, et al.
|
| Am J Med Genet 41 : 460-463. 1991
|
| 213 | APC
|
| Regional mapping of 22 microclones around the adenomatous polyposis coli (APC) locus on chromosome 5q.
|
| Hampton GM, et al.
|
| Hum Genet 88 : 112-114. 1991
|
| 214 | APC, D5S71, FAP
|
| A new deletion polymorphism at D5S71 raises the linkage information on adenomatous polyposis coli : implications for presymptomatic diagnosis.
|
| Tops CMJ, et al.
|
| Hum Genet 86 : 365-368. 1991
|
| 215 | APC, D5S141, MCC, SRP19, REEP5
|
| Identification of FAP locus genes from chromosome 5q21.
|
| Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, Smith KJ,Preisinger AC, Hedge P, McKechnie D, et al.
|
| Science 253(5020):661-5. 1991
|
| 216 | SRP19, APC, REEP5, FAP
|
| Identification of deletion mutations and three new genes at the familial polyposis locus.
|
| Joslyn G, Carlson M, Thliveris A, Albertsen H, Gelbert L, Samowitz W,Groden J, Stevens J, Spirio L, Robertson M, et al.
|
| Cell 66(3):601-13. 1991
|
| 217 | APC, FAP, REEP5, SLC25A46
|
| Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.
|
| Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P.
|
| Science 253(5020):665-9. 1991
|
| 218 | APC, FAP
|
| Genetic analysis of an inherited predisposition to colon cancer in a family with a variable number of adenomatous polyps.
|
| Leppert M, et al.
|
| N Engl J Med 322 : 904-908. 1990
|
| 219 | APC, FAP
|
| A constitutional 5q23 deletion.
|
| Rivera H, et al.
|
| J Med Genet 27 : 267-268. 1990
|
| 220 | APC, FAP
|
| Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5.
|
| Dunlop MG, et al.
|
| Am J Hum Genet 47 : 982-987. 1990
|
| 221 | APC, FAP
|
| Deletion of chromosome 5q and familial adenomatous polyposis.
|
| Hockey KA, Mulcahy MT, Montgomery P, Levitt S.
|
| J Med Genet 26 : 61-68. 1989
|
| 222 | APC, FAP
|
| Linkage analysis in familial adenomatous polyposis : order of C11P11 (D5S71) and pi227 (D5S37) loci at the apc gene.
|
| Dunlop MG, Steel CM, Wyllie AH, Bird CC, Evans HJ.
|
| Genomics 5 : 350-353. 1989
|
| 223 | APC, FAP
|
| Presymptomatic diagnosis of familial adenomatous polyposis by bridging DNA markers.
|
| Tops CMJ, et al.
|
| Lancet II : 1361-1363. 1989
|
| 224 | APC, D5S120, FAP
|
| High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-q22.
|
| Ashton-Rickardt PG, et al.
|
| Oncogene 4 : 1169-1174. 1989
|
| 225 | APC, D5S81, D5S82, D5S83, D5S84, D5S85, D5S86, FAP
|
| Localization of the genetic defect in familial adenomatous polyposis within a small region of chromosome 5.
|
| Nakamura Y, Lathrop M, Leppert M, Dobbs M, Wasmuth J, Wolff E, Carlson M, Fujimoto E, Krapcho K, Sears T, et al.
|
| Am J Hum Genet 43 : 638-644. 1988
|
| 226 | APC, CHRPE, FAP
|
| A genetic study of Gardner syndrome and congenital hypertrophy of the retinal pigment epithelium.
|
| Lyons LA, et al.
|
| Am J Hum Genet 42 : 290-296. 1988
|
| 227 | APC, FAP
|
| Chromosome 5 allele loss at the glucocorticoid receptor locus in human colorectal carcinomas.
|
| Wildrick DM, et al.
|
| Biochem Biophys Res Commun 150 : 591-598. 1988
|
| 228 | APC, D5S37, D5S71, FAP
|
| Close linkage of a highly polymorphic marker (D5S37) to familial adenomatous polyposis (FAP) and confirmation of FAP localization on chromosome 5q21-q22.
|
| Meera Khan P, et al.
|
| Hum Genet 79 : 183-185. 1988
|
| 229 | APC, D5S71, FAP
|
| Localization of the gene for familial adenomatous polyposis on chromosome 5.
|
| Bodmer WF, Bailey CJ, Bodmer J, Bussey HJ, Ellis A, Gorman P, Lucibello FC, Murday VA, Rider SH, Scambler P, et al.
|
| Nature 328 : 614-616. 1987
|
| 230 | APC, D5S43, FAP
|
| Chromosome 5 allele loss in human colorectal carcinomas.
|
| Solomon E, Voss R, Hall V, Bodmer WF, Jass JR, Jeffreys AJ, Lucibello FC, Patel I, Rider SH.
|
| Nature 328 : 616-619. 1987
|
| 231 | APC, D5S21, D5S22, D5S39, D5S70, D5S71, D5S74, D5S76, D5S78, FAP
|
| The gene for familial polyposis coli maps to the long arm of chromosome 5.
|
| Leppert M, et al.
|
| Science 238 : 1411-1413. 1987
|
| 232 | APC, FAP
|
| Gardner syndrome in a man with an interstitial deletion of 5q.
|
| Herrera L, et al.
|
| Am J Med Genet 25 : 473-476. 1986
|
| 233 | APC
|
| Cytogenetic findings in a large bowel adenocarcinoma.
|
| Ferti-Passantonopoulou A, et al.
|
| Cancer Genet Cytogenet 21 : 361-364. 1986
|
| 234 | APC, FAP
|
| The Gardner syndrome. Significance of ocular features.
|
| Lewis RA, et al.
|
| Ophthalmology 91 : 916-925. 1984
|
| 235 | APC
|
| Hypertrophy of the retinal pigment epithelium associated with Gardner's syndrome.
|
| Blair NP, et al.
|
| Am J Ophthalmol 90 : 661-667. 1980
|