| 1 | APAF1, NUP107
|
| DNA damage-induced nuclear translocation of Apaf-1 is mediated by nucleoporin Nup107.
|
| Jagot-Lacoussiere L, Faye A, Bruzzoni-Giovanelli H, Villoutreix BO, Rain JC, Poyet JL.
|
| Cell Cycle 14(8):1242-51. doi: 10.1080/15384101.2015.1014148.
2015
|
| 2 | APAF1, CIAO2A
|
| FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal stromal tumors.
|
| Schwamb B, Pick R, Fernández SB, Völp K, Heering J, Dötsch V, Bösser S, Jung J, Beinoraviciute-Kellner R, Wesely J, Zörnig I, Hammerschmidt M, Nowak M, Penzel R, Zatloukal K, Joos S, Rieker RJ, Agaimy A, Söder S, Reid-Lombardo KM, Kendrick ML, Bardsley MR, Hayashi Y, Asuzu DT, Syed SA, Ordog T, Zörnig M.
|
| Int J Cancer 137(6):1318-29. doi: 10.1002/ijc.29498. Epub 2015 Mar 12.
2015
|
| 3 | APAF1, NAIP
|
| Integrity of ATP binding site is essential for effective inhibition of the intrinsic apoptosis pathway by NAIP.
|
| Karimpour S, Davoodi J, Ghahremani MH.
|
| Biochem Biophys Res Commun 407(1):158-62. Epub 2011 Mar 1.
2011
|
| 4 | APAF1
|
| Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.
|
| Reubold TF, Wohlgemuth S, Eschenburg S.
|
| Structure 19(8):1074-83.
2011
|
| 5 | APAF1
|
| APAF-1 is related to an undifferentiated state in the testicular germ cell tumor pathway.
|
| Behjati R, Kawai K, Inadome Y, Kano J, Akaza H, Noguchi M.
|
| Cancer Sci 102(1):267-74. doi: 10.1111/j.1349-7006.2010.01750.x. Epub 2010 Oct 26.
2011
|
| 6 | APAF1, UTP6
|
| Apaf1 plays a pro-survival role by regulating centrosome morphology and function.
|
| Ferraro E, Pesaresi MG, De Zio D, Cencioni MT, Gortat A, Cozzolino M, Berghella L, Salvatore AM, Oettinghaus B, Scorrano L, Pérez-Payŕ E, Cecconi F.
|
| J Cell Sci 124(Pt 20):3450-63. Epub 2011 Oct 7.
2011
|
| 7 | APAF1
|
| Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1.
|
| Sancho M, Herrera AE, Gortat A, Carbajo RJ, Pineda-Lucena A, Orzáez M, Pérez-Payá E.
|
| Hum Mol Genet 20(18):3545-53. doi: 10.1093/hmg/ddr271. Epub 2011 Jun 9.
2011
|
| 8 | APAF1
|
| Alternative cell death of Apaf1-deficient neural progenitor cells induced by withdrawal of EGF or insulin.
|
| Shiraishi H, Okamoto H, Hara H, Yoshida H.
|
| Biochim Biophys Acta 1800(3):405-15. Epub 2009 Nov 13.
2010
|
| 9 | APAF1, CASP9
|
| Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1.
|
| Zuo Y, Xiang B, Yang J, Sun X, Wang Y, Cang H, Yi J.
|
| Cell Res 19(4):449-57.
2009
|
| 10 | APAF1
|
| A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome.
|
| Reubold TF, Wohlgemuth S, Eschenburg S.
|
| J Biol Chem 284(47):32717-24. Epub 2009 Sep 30.
2009
|
| 11 | APAF1, UACA
|
| Nucling interacts with nuclear factor-kappaB, regulating its cellular distribution.
|
| Liu L, Sakai T, Tran NH, Mukai-Sakai R, Kaji R, Fukui K.
|
| FEBS J 276(5):1459-70. doi: 10.1111/j.1742-4658.2009.06888.x.
2009
|
| 12 | APAF1
|
| PHAPI, CAS, and Hsp70 promote apoptosome formation by preventing Apaf-1 aggregation and enhancing nucleotide exchange on Apaf-1.
|
| Kim HE, Jiang X, Du F, Wang X.
|
| Mol Cell 30(2):239-47.
2008
|
| 13 | APAF1
|
| Loss of APAF-1 expression is associated with tumour progression and adverse prognosis in colorectal cancer.
|
| Zlobec I, Minoo P, Baker K, Haegert D, Khetani K, Tornillo L, Terracciano L, Jass JR, Lugli A.
|
| Eur J Cancer 43(6):1101-7. Epub 2007 Mar 12.
2007
|
| 14 | APAF1
|
| Nonapoptotic role for Apaf-1 in the DNA damage checkpoint.
|
| Zermati Y, Mouhamad S, Stergiou L, Besse B, Galluzzi L, Boehrer S, Pauleau AL, Rosselli F, D'Amelio M, Amendola R, Castedo M, Hengartner M, Soria JC, Cecconi F, Kroemer G.
|
| Mol Cell 28(4):624-37.
2007
|
| 15 | APAF1
|
| Reduced expression of Apaf-1 in colorectal adenocarcinoma correlates with tumor progression and aggressive phenotype.
|
| Paik SS, Jang KS, Song YS, Jang SH, Min KW, Han HX, Na W, Lee KH, Choi D, Jang SJ.
|
| Ann Surg Oncol 14(12):3453-9. Epub 2007 Sep 20.
2007
|
| 16 | APAF1
|
| Requirement of Apaf-1 for mitochondrial events and the cleavage or activation of all procaspases during genotoxic stress-induced apoptosis.
|
| Franklin EE, Robertson JD.
|
| Biochem J 405(1):115-22.
2007
|
| 17 | APAF1
|
| Apaf-1 Deficiency Causes Chromosomal Instability.
|
| Mouhamad S, Galluzzi L, Zermati Y, Castedo M, Kroemer G.
|
| Cell Cycle 6(24):3103-3107. Epub 2007 Sep 14.PMID: 18073531 2007
|
| 18 | APAF1, UTP6
|
| Positive regulation of apoptosis by HCA66, a new Apaf-1 interacting protein, and its putative role in the physiopathology of NF1 microdeletion syndrome patients.
|
| Piddubnyak V, Rigou P, Michel L, Rain JC, Geneste O, Wolkenstein P, Vidaud D, Hickman JA, Mauviel A, Poyet JL.
|
| Cell Death Differ 14(6):1222-33. Epub 2007 Mar 23.
2007
|
| 19 | APAF1
|
| Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance.
|
| Campioni M, Santini D, Tonini G, Murace R, Dragonetti E, Spugnini EP, Baldi A.
|
| Exp Dermatol 14(11):811-8. Review.
2005
|
| 20 | APAF1, CASP9, APIP
|
| Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein.
|
| Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK.
|
| J Biol Chem 279(38):39942-50. Epub 2004 Jul 15. 2004
|
| 21 | APAF1, UACA
|
| Nucling recruits Apaf-1/pro-caspase-9 complex for the induction of stress-induced apoptosis.
|
| Sakai T, Liu L, Teng X, Mukai-Sakai R, Shimada H, Kaji R, Mitani T, Matsumoto M, Toida K, Ishimura K, Shishido Y, Mak TW, Fukui K.
|
| J Biol Chem 279(39):41131-40.
2004
|
| 22 | TSG12C, APAF1
|
| Frequent LOH at chromosome 12q22-23 and Apaf-1 inactivation in glioblastoma.
|
| Watanabe T, Hirota Y, Arakawa Y, Fujisawa H, Tachibana O, Hasegawa M, Yamashita J, Hayashi Y.
|
| Brain Pathol 13(4):431-9. 2003
|
| 23 | CASP9, APAF1
|
| Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN.
|
| Teitz T, Wei T, Liu D, Valentine V, Valentine M, Grenet J, Lahti JM, Kidd VJ.
|
| Oncogene 21(12):1848-58. 2002
|
| 24 | APAF1
|
| Inactivation of the apoptosis effector Apaf-1 in malignant melanoma.
|
| Soengas MS, Capodieci P, Polsky D, Mora J, Esteller M, Opitz-Araya X, McCombie R, Herman JG, Gerald WL, Lazebnik YA, Cordon-Cardo C, Lowe SW.
|
| Nature 409(6817):207-11. 2001
|
| 25 | APAF1
|
| APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.
|
| Robles AI, Bemmels NA, Foraker AB, Harris CC.
|
| Cancer Res 61(18):6660-4. 2001
|
| 26 | APAF1
|
| Genetic analysis of the APAF1 gene in male germ cell tumors.
|
| Bala S, Oliver H, Renault B, Montgomery K, Dutta S, Rao P, Houldsworth J, Kucherlapati R, Wang X, Chaganti RS, Murty VV.
|
| Genes Chromosomes Cancer 28(3):258-68. 2000
|
| 27 | APAF1, CAD, AIFM1
|
| Apoptosis. A cellular poison cupboard.
|
| Earnshaw WC.
|
| Nature 397 : 387-389. 1999
|
| 28 | APAF1
|
| Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia.
|
| Krajewski S, et al.
|
| Proc Natl Acad Sci U S A 96(10):5752-7 1999
|
| 29 | APAF1, CASP9
|
| Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation.
|
| Saleh A, et al.
|
| J Biol Chem 274(25):17941-5 1999
|
| 30 | APAF1, CASP9
|
| Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.
|
| Hu Y, et al.
|
| EMBO J 18(13):3586-95 1999
|
| 31 | APAF1
|
| Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1.
|
| Moriishi K, et al.
|
| Proc Natl Acad Sci U S A 96(17):9683-8 1999
|
| 32 | APAF1
|
| Assignment(1) of apoptotic protease activating factor-1 gene (APAF1) to human chromosome band 12q23 by fluorescence in situ hybridization.
|
| Kim H, Jung YK, Kwon YK, Park SH.
|
| Cytogenet Cell Genet 87(3-4):252-253. 1999
|
| 33 | APAF1, NOD1
|
| Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB.
|
| Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS.
|
| J Biol Chem 274(19):12955-8. 1999
|
| 34 | APAF1, CASP9
|
| An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9.
|
| Zou H, Li Y, Liu X, Wang X.
|
| J Biol Chem 274(17):11549-56. 1999
|
| 35 | APAF1, CASP9
|
| Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.
|
| Srinivasula SM, et al.
|
| Mol Cell 1(7):949-57 1998
|
| 36 | APAF1
|
| Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.
|
| Zou H, Henzel WJ, Liu X, Lutschg A, Wang X.
|
| Cell 90(3):405-13. 1997
|
| 37 | ADCY6, AP5Z1, APAF1, ATG2A, ATMIN, BSN, CACNA1G, CCNA1, CCP110, CCP110, CHD5, DENND4B, FEM1B, FLRT2, GPRASP1, HISPPD1, HSPA12A, HSPG2, KIAA0408, LKAP, LRRTM2, MBNL1, MTSS1, NEDD4, NUP58, PJA2, PREPL, RNMT, RRP8, SEC14L5, SGSM2, SH3PXD2A, SMG1, SRGAP2, TOGARAM1, TTI1, ZBTB24, ZHX3, ZMYM4, ZNF264, ZSCAN12, ZZEF1
|
| Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.
|
| Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A,Kotani H, Nomura N, Ohara O.
|
| DNA Res 4(5):307-13. 1997
|