| 1 | ANO1, TMEM147
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| Genome-wide analysis identifies gallstone-susceptibility loci including genes regulating gastrointestinal motility
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| Fairfield CJ, Drake TM, Pius R, Bretherick AD, Campbell A, Clark DW, Fallowfield JA, Hayward C, Henderson NC, Iakovliev A, Joshi PK, Mills NL, Porteous DJ, Ramachandran P, Semple RK, Shaw CA, Sudlow CLW, Timmers PRHJ, Wilson JF, Wigmore SJ, Spiliopoulou A, Harrison EM.
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| Hepatology May;75(5):1081-1094. doi: 10.1002/hep.32199. Epub 2021 Dec 10. 2022
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| 2 | ANO1
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| Recent advances in TMEM16A: Structure, function, and disease.
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| Ji Q, Guo S, Wang X, Pang C, Zhan Y, Chen Y, An H.
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| J Cell Physiol Cell Physiol. 2018 Dec 4. doi: 10.1002/jcp.27865. [Epub ahead of print] Review.
2018
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| 3 | ANO1, TRPV1
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| Involvement of TRPV1-ANO1 Interactions in Pain-Enhancing Mechanisms.
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| Takayama Y, Tominaga M.
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| Adv Exp Med Biol 1099:29-36. doi: 10.1007/978-981-13-1756-9_3.
2018
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| 4 | ANO1
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| Nephron-specific knockout of TMEM16A leads to reduced number of glomeruli and albuminuria.
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| Schenk LK, Buchholz B, Henke SF, Michgehl U, Daniel C, Amann K, Kunzelmann K, Pavenstädt HJ.
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| Am J Physiol Renal Physiol m J Physiol Renal Physiol. 2018 Aug 29. doi: 10.1152/ajprenal.00638.2017. [Epub ahead of print]
2018
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| 5 | ANO1
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| Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1).
|
| De Jesús-Pérez JJ, Cruz-Rangel S, Espino-Saldaña ÁE, Martínez-Torres A, Qu Z, Hartzell HC, Corral-Fernandez NE, Pérez-Cornejo P, Arreola J.
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| Biochim Biophys Acta Mol Cell Biol Lipids 1863(3):299-312. doi: 10.1016/j.bbalip.2017.12.009. Epub 2017 Dec 22.
2018
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| 6 | ANO1, ESYT1
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| A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.
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| Lérias JR, Pinto MC, Botelho HM, Awatade NT, Quaresma MC, Silva IAL, Wanitchakool P, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD.
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| Biochim Biophys Acta Mol Cell Res 1865(2):421-431. doi: 10.1016/j.bbamcr.2017.11.009. Epub 2017 Nov 15.
2018
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| 7 | ANO1
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| TMEM16A/ANO1 Inhibits Apoptosis Via Downregulation of Bim Expression.
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| Godse NR, Khan N, Yochum ZA, Gomez-Casal R, Kemp C, Shiwarski DJ, Seethala RS, Kulich S, Seshadri M, Burns TF, Duvvuri U.
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| Clin Cancer Res 23(23):7324-7332. doi: 10.1158/1078-0432.CCR-17-1561. Epub 2017 Sep 12.
2017
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| 8 | ANO1
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| ANO1 inhibits cardiac fibrosis after myocardial infraction via TGF-β/smad3 pathway.
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| Gao Y, Zhang YM, Qian LJ, Chu M, Hong J, Xu D.
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| Sci Rep 7(1):2355. doi: 10.1038/s41598-017-02585-4.
2017
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| 9 | ANO1, CLCA1
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| Modulation of TMEM16A channel activity by the von Willebrand factor type A (VWA) domain of the calcium-activated chloride channel regulator 1 (CLCA1).
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| Sala-Rabanal M, Yurtsever Z, Berry KN, Nichols CG, Brett TJ.
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| J Biol Chem 292(22):9164-9174. doi: 10.1074/jbc.M117.788232. Epub 2017 Apr 18.
2017
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| 10 | ANO1
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| EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.
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| Strege PR, Gibbons SJ, Mazzone A, Bernard CE, Beyder A, Farrugia G.
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| Am J Physiol Gastrointest Liver Physiol 312(6):G572-G579. doi: 10.1152/ajpgi.00429.2016. Epub 2017 Mar 23.
2017
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| 11 | ANO1
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| TMEM16A Contributes to Endothelial Dysfunction by Facilitating Nox2 NADPH Oxidase-Derived Reactive Oxygen Species Generation in Hypertension.
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| Ma MM, Gao M, Guo KM, Wang M, Li XY, Zeng XL, Sun L, Lv XF, Du YH, Wang GL, Zhou JG, Guan YY.
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| Hypertension 69(5):892-901. doi: 10.1161/HYPERTENSIONAHA.116.08874. Epub 2017 Mar 20.
2017
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| 12 | ANO1, CYBB
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| TMEM16A Contributes to Endothelial Dysfunction by Facilitating Nox2 NADPH Oxidase-Derived Reactive Oxygen Species Generation in Hypertension.
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| Ma MM, Gao M, Guo KM, Wang M, Li XY, Zeng XL, Sun L, Lv XF, Du YH, Wang GL, Zhou JG, Guan YY.
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| Hypertension 69(5):892-901. doi: 10.1161/HYPERTENSIONAHA.116.08874. Epub 2017 Mar 20.
2017
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| 13 | ANO1, ANO10, ANO4, ANO6, ORAI1
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| Differential effects of anoctamins on intracellular calcium signals.
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| Cabrita I, Benedetto R, Fonseca A, Wanitchakool P, Sirianant L, Skryabin BV, Schenk LK, Pavenstädt H, Schreiber R, Kunzelmann K.
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| FASEB J. May;31(5):2123-2134. doi: 10.1096/fj.201600797RR. Epub 2017 Feb 9. 2017
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| 14 | ANO1, ANO10, ANO6
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| Expression of anoctamins in retinal pigment epithelium (RPE).
|
| Schreiber R, Kunzelmann K.
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| Pflugers Arch 468(11-12):1921-1929. Epub 2016 Nov 7.
2016
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| 15 | ANO1, ANO2
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| Intermolecular Interactions in the TMEM16A Dimer Controlling Channel Activity.
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| Scudieri P, Musante I, Gianotti A, Moran O, Galietta LJ.
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| Sci Rep 6:38788. doi: 10.1038/srep38788.
2016
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| 16 | ANO1
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| Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells.
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| Guan L, Song Y, Gao J, Gao J, Wang K.
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| Oncotarget 7(48):78619-78630. doi: 10.18632/oncotarget.12524.
2016
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| 17 | ANO1, COPB1
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| Surface expression of the Anoctamin-1 (ANO1) channel is suppressed by protein-protein interactions with β-COP.
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| Lee YS, Bae Y, Park N, Yoo JC, Cho CH, Ryoo K, Hwang EM, Park JY.
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| Biochem Biophys Res Commun 475(2):216-22. doi: 10.1016/j.bbrc.2016.05.077. Epub 2016 May 17.
2016
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| 18 | ANO1
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| The Ca2+-activated Cl- channel Ano1 controls microvilli length and membrane surface area in the oocyte.
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| Courjaret R, Hodeify R, Hubrack S, Ibrahim A, Dib M, Daas S, Machaca K.
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| J Cell Sci 129(13):2548-58. doi: 10.1242/jcs.188367. Epub 2016 May 12.
2016
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| 19 | ANO1, ANO2
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| Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.
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| Zhang W, Schmelzeisen S, Parthier D, Frings S, Möhrlen F.
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| PLoS One 10(11):e0142160. doi: 10.1371/journal.pone.0142160. eCollection 2015.
2015
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| 20 | ANO1
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| A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2.
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| Strege PR, Bernard CE, Mazzone A, Linden DR, Beyder A, Gibbons SJ, Farrugia G.
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| Am J Physiol Gastrointest Liver Physiol 309(9):G743-9. doi: 10.1152/ajpgi.00074.2015. Epub 2015 Sep 10.
2015
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| 21 | ANO1, CLCA1
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| Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells.
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| Sala-Rabanal M, Yurtsever Z, Nichols CG, Brett TJ.
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| Elife 4. doi: 10.7554/eLife.05875.
2015
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| 22 | ANO1, ANO6
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| Functional swapping between transmembrane proteins TMEM16A and TMEM16F.
|
| Suzuki T, Suzuki J, Nagata S.
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| J Biol Chem 289(11):7438-47. doi: 10.1074/jbc.M113.542324. Epub 2014 Jan 28.
2014
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| 23 | ANO1
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| Inhibition of TMEM16A expression suppresses growth and invasion in human colorectal cancer cells.
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| Sui Y, Sun M, Wu F, Yang L, Di W, Zhang G, Zhong L, Ma Z, Zheng J, Fang X, Ma T.
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| PLoS One 9(12):e115443. doi: 10.1371/journal.pone.0115443. eCollection 2014.
2014
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| 24 | ANO1, ANO2
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| Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels.
|
| Yang T, Hendrickson WA, Colecraft HM.
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| Proc Natl Acad Sci U S A 111(51):18213-8. doi: 10.1073/pnas.1420984111. Epub 2014 Dec 8.
2014
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| 25 | ANO1
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| Anoctamin-1/TMEM16A is the major apical iodide channel of the thyrocyte.
|
| Twyffels L, Strickaert A, Virreira M, Massart C, Van Sande J, Wauquier C, Beauwens R, Dumont JE, Galietta LJ, Boom A, Kruys V.
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| Am J Physiol Cell Physiol 307(12):C1102-12. doi: 10.1152/ajpcell.00126.2014. Epub 2014 Oct 8.
2014
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| 26 | ANO1
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| TMEM16A is a Ca(2+) -activated Cl(-) channel expressed in the renal collecting duct.
|
| Svenningsen P, Nielsen MR, Marcussen N, Walter S, Jensen BL.
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| Acta Physiol (Oxf) 212(2):166-74. doi: 10.1111/apha.12323. Epub 2014 Jun 26.
2014
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| 27 | ANO1
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| The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis.
|
| Ruppersburg CC, Hartzell HC.
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| Mol Biol Cell 25(11):1793-807. doi: 10.1091/mbc.E13-10-0599. Epub 2014 Apr 2.
2014
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| 28 | ANO1, ANO6
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| TMEM16F (Anoctamin 6), an anion channel of delayed Ca(2+) activation.
|
| Grubb S, Poulsen KA, Juul CA, Kyed T, Klausen TK, Larsen EH, Hoffmann EK.
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| J Gen Physiol 141(5):585-600. doi: 10.1085/jgp.201210861.
2013
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| 29 | ANO1, ANO2, ANO6
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| TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel.
|
| Shimizu T, Iehara T, Sato K, Fujii T, Sakai H, Okada Y.
|
| Am J Physiol Cell Physiol 304(8):C748-59. doi: 10.1152/ajpcell.00228.2012. Epub 2013 Feb 20.
2013
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| 30 | ANO1
|
| Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels.
|
| Terashima H, Picollo A, Accardi A.
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| Proc Natl Acad Sci U S A 110(48):19354-9. doi: 10.1073/pnas.1312014110. Epub 2013 Oct 28.
2013
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| 31 | ANO1
|
| Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network.
|
| Perez-Cornejo P, Gokhale A, Duran C, Cui Y, Xiao Q, Hartzell HC, Faundez V.
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| Proc Natl Acad Sci U S A 109(26):10376-81. doi: 10.1073/pnas.1200174109. Epub 2012 Jun 8.
2012
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| 32 | ANO1, SLC4A4
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| Expression of TMEM16A and SLC4A4 in human pancreatic islets.
|
| Hanzu FA, Gasa R, Bulur N, Lybaert P, Gomis R, Malaisse WJ, Beauwens R, Sener A.
|
| Cell Physiol Biochem 29(1-2):61-4. doi: 10.1159/000337587. Epub 2012 Mar 1.
2012
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| 33 | ANO1, ANO2, ANO4, ANO6, ANO7
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| Anoctamins are a family of Ca2+-activated Cl- channels.
|
| Tian Y, Schreiber R, Kunzelmann K.
|
| J Cell Sci. Nov 1;125(Pt 21):4991-8. doi: 10.1242/jcs.109553. Epub 2012 Sep 3. 2012
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| 34 | ANO1, CLCA4
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| Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.
|
| Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR.
|
| Proc Natl Acad Sci U S A 109(40):16354-9. doi: 10.1073/pnas.1214596109. Epub 2012 Sep 17.
2012
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| 35 | ANO1
|
| Inhibition of cell proliferation by a selective inhibitor of the Ca(2+)-activated Cl(-) channel, Ano1.
|
| Mazzone A, Eisenman ST, Strege PR, Yao Z, Ordog T, Gibbons SJ, Farrugia G.
|
| Biochem Biophys Res Commun 427(2):248-53. doi: 10.1016/j.bbrc.2012.09.022. Epub 2012 Sep 17.
2012
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| 36 | ANO1, CFTR, IL8
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| Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia.
|
| Veit G, Bossard F, Goepp J, Verkman AS, Galietta LJ, Hanrahan JW, Lukacs GL.
|
| Mol Biol Cell 23(21):4188-202. doi: 10.1091/mbc.E12-06-0424. Epub 2012 Sep 12.
2012
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| 37 | ANO1, GPR39
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| GPR39 is coupled to TMEM16A in intestinal fibroblast-like cells.
|
| Zeng F, Wind N, McClenaghan C, Verkuyl JM, Watson RP, Nash MS.
|
| PLoS One 7(10):e47686. doi: 10.1371/journal.pone.0047686. Epub 2012 Oct 25.
2012
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| 38 | ANO1
|
| Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A.
|
| Sheridan JT, Worthington EN, Yu K, Gabriel SE, Hartzell HC, Tarran R.
|
| J Biol Chem 286(2):1381-8. Epub 2010 Nov 5.
2011
|
| 39 | ANO1
|
| Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium.
|
| Dutta AK, Khimji AK, Kresge C, Bugde A, Dougherty M, Esser V, Ueno Y, Glaser SS, Alpini G, Rockey DC, Feranchak AP.
|
| J Biol Chem 286(1):766-76. Epub 2010 Nov 1.
2011
|
| 40 | ANO1
|
| TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
|
| Namkung W, Phuan PW, Verkman AS.
|
| J Biol Chem 286(3):2365-74. Epub 2010 Nov 17.
2011
|
| 41 | ANO1
|
| Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop.
|
| Xiao Q, Yu K, Perez-Cornejo P, Cui Y, Arreola J, Hartzell HC.
|
| Proc Natl Acad Sci U S A 108(21):8891-6. Epub 2011 May 9.
2011
|
| 42 | ANO1, CFTR
|
| CFTR and TMEM16A are separate but functionally related Cl- channels.
|
| Ousingsawat J, Kongsuphol P, Schreiber R, Kunzelmann K.
|
| Cell Physiol Biochem 28(4):715-24. doi: 10.1159/000335765. Epub 2011 Dec 14.
2011
|
| 43 | ANO1, ANO10, ANO2, ANO3, ANO4, ANO5, ANO6, ANO7, ANO8, ANO9
|
| Expression and function of epithelial anoctamins.
|
| Schreiber R, Uliyakina I, Kongsuphol P, Warth R, Mirza M, Martins JR, Kunzelmann K.
|
| J Biol Chem 285(10):7838-45. Epub 2010 Jan 7.PMID: 20056604 2010
|
| 44 | ANO1, ANO10, ANO2, ANO3, ANO4, ANO5, ANO6, ANO7, ANO8, ANO9, SCAR10
|
| Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia.
|
| Vermeer S, Hoischen A, Meijer RP, Gilissen C, Neveling K, Wieskamp N, de Brouwer A, Koenig M, Anheim M, Assoum M, Drouot N, Todorovic S, Milic-Rasic V, Lochmüller H, Stevanin G, Goizet C, David A, Durr A, Brice A, Kremer B, van de Warrenburg BP, Schijvenaars MM, Heister A, Kwint M, Arts P, van der Wijst J, Veltman J, Kamsteeg EJ, Scheffer H, Knoers N.
|
| Am J Hum Genet 87(6):813-9. Epub 2010 Nov 18.PMID: 21092923 2010
|
| 45 | ANO1, ANO6, SCOTS
|
| Calcium-dependent phospholipid scrambling by TMEM16F.
|
| Suzuki J, Umeda M, Sims PJ, Nagata S.
|
| Nature 468(7325):834-8. Epub 2010 Nov 24. 2010
|
| 46 | ANO1
|
| Regulation of TMEM16A chloride channel properties by alternative splicing.
|
| Ferrera L, Caputo A, Ubby I, Bussani E, Zegarra-Moran O, Ravazzolo R, Pagani F, Galietta LJ.
|
| J Biol Chem 284(48):33360-8. Epub 2009 Oct 9.
2009
|
| 47 | ANO1
|
| TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A.
|
| Almaça J, Tian Y, Aldehni F, Ousingsawat J, Kongsuphol P, Rock JR, Harfe BD, Schreiber R, Kunzelmann K.
|
| J Biol Chem 284(42):28571-8. Epub 2009 Aug 4.PMID: 19654323 2009
|
| 48 | ANO1
|
| Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport.
|
| Ousingsawat J, Martins JR, Schreiber R, Rock JR, Harfe BD, Kunzelmann K.
|
| J Biol Chem 284(42):28698-703. Epub 2009 Aug 13.PMID: 19679661 2009
|
| 49 | ANO1, ANO2
|
| Studies on expression and function of the TMEM16A calcium-activated chloride channel.
|
| Huang F, Rock JR, Harfe BD, Cheng T, Huang X, Jan YN, Jan LY.
|
| Proc Natl Acad Sci U S A 106(50):21413-8. Epub 2009 Nov 24.PMID: 19965375 2009
|
| 50 | ANO1, ANO10, ANO3, ANO6, ANO8
|
| Expression patterns of the Tmem16 gene family during cephalic development in the mouse.
|
| Gritli-Linde A, Vaziri Sani F, Rock JR, Hallberg K, Iribarne D, Harfe BD, Linde A.
|
| Gene Expr Patterns 9(3):178-91. Epub 2008 Nov 25.PMID: 19059364 2009
|
| 51 | ANO1, ANO10, ANO2, ANO3, ANO4, ANO5, ANO6, ANO7, ANO8, ANO9, BEST1
|
| Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions.
|
| Kunzelmann K, Kongsuphol P, Aldehni F, Tian Y, Ousingsawat J, Warth R, Schreiber R.
|
| Cell Calcium 46(4):233-41. Epub 2009 Sep 26. Review.PMID: 19783045 2009
|
| 52 | ANO1
|
| Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.
|
| Schroeder BC, Cheng T, Jan YN, Jan LY.
|
| Cell 134(6):1019-29.
2008
|
| 53 | ANO1, ANO10, ANO2, ANO3, ANO4, ANO5, ANO6, ANO7, ANO8, ANO9
|
| Expression of TMEM16 paralogs during murine embryogenesis.
|
| Rock JR, Harfe BD.
|
| Dev Dyn 237(9):2566-74.
2008
|
| 54 | ANO1
|
| TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity.
|
| Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, Pfeffer U, Ravazzolo R, Zegarra-Moran O, Galietta LJ.
|
| Science 322(5901):590-4. Epub 2008 Sep 4.
2008
|
| 55 | ANO1
|
| TMEM16A confers receptor-activated calcium-dependent chloride conductance.
|
| Yang YD, Cho H, Koo JY, Tak MH, Cho Y, Shim WS, Park SP, Lee J, Lee B, Kim BM, Raouf R, Shin YK, Oh U.
|
| Nature 455(7217):1210-5 2008
|
| 56 | ANO1, C11orf78, FADD, FGF3
|
| SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma.
|
| Gregory-Evans CY, Moosajee M, Hodges MD, Mackay DS, Game L, Vargesson N, Bloch-Zupan A, Ruschendorf F, Santos-Pinto L, Wackens G, Gregory-Evans K.
|
| Hum Mol Genet 16(20):3482-93. Epub 2007 Jul 25. 2007
|
| 57 | ANO1, ANO10, ANO2, ANO3, ANO4, ANO5, ANO6, ANO7, ANO8, ANO9
|
| Identification and characterization of TMEM16E and TMEM16F genes in silico.
|
| Katoh M, Katoh M.
|
| Int J Oncol 24(5):1345-9.
2004
|
| 58 | ANO1, ANO2, ANO3, ANO4, ANO9
|
| FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products.
|
| Katoh M, Katoh M.
|
| Int J Oncol 22(6):1375-81. 2003
|