| 1 | ANGPTL4, LPL
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| Mapping the sites of the lipoprotein lipase (LPL)-angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition.
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| Gutgsell AR, Ghodge SV, Bowers AA, Neher SB.
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| J Biol Chem. Feb 22;294(8):2678-2689. doi: 10.1074/jbc.RA118.005932. Epub 2018 Dec 27 2019
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| 2 | ANGPTL3, ANGPTL3, ANGPTL4, LPL
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| On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity.
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| Kovrov O, Kristensen KK, Larsson E, Ploug M, Olivecrona G.
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| J Lipid Res. Apr;60(4):783-793. doi: 10.1194/jlr.M088807. Epub 2019 Jan 27 2019
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| 3 | ANGPTL4, LPL, PCSK1
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| Angiopoietin-like 4 promotes the intracellular cleavage of lipoprotein lipase by PCSK3/furin in adipocytes.
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| Dijk W, Ruppert PMM, Oost LJ, Kersten S.
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| J Biol Chem. Sep 7;293(36):14134-14145. doi: 10.1074/jbc.RA118.002426. Epub 2018 Jul 18 2018
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| 4 | ANGPTL4, FTO
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| Loss of FTO in adipose tissue decreases Angptl4 translation and alters triglyceride metabolism.
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| Wang CY, Shie SS, Wen MS, Hung KC, Hsieh IC, Yeh TS, Wu D.
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| Sci Signal 8(407):ra127. doi: 10.1126/scisignal.aab3357.
2015
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| 5 | ANGPTL4
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| Angiopoietin-like 4 (ANGPTL4) promotes angiogenesis in tendon and is increased in cyclically loaded tendon fibroblasts.
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| Mousavizadeh R, Scott A, Lu A, Ardekani GS, Behzad H, Lundgreen K, Ghaffari M, McCormack RG, Duronio V.
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| J Physiol Physiol. 2015 Dec 16. doi: 10.1113/JP271752. [Epub ahead of print]
2015
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| 6 | ANGPTL4
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| ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure.
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| Dijk W, Heine M, Vergnes L, Boon MR, Schaart G, Hesselink MK, Reue K, van Marken Lichtenbelt WD, Olivecrona G, Rensen PC, Heeren J, Kersten S.
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| Elife 4. pii: e08428. doi: 10.7554/eLife.08428.
2015
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| 7 | ANGPTL4, GPIHBP1, LPL
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| Angiopoietin-like 4 Modifies the Interactions between Lipoprotein Lipase and Its Endothelial Cell Transporter GPIHBP1.
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| Chi X, Shetty SK, Shows HW, Hjelmaas AJ, Malcolm EK, Davies BS.
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| J Biol Chem 290(19):11865-77. doi: 10.1074/jbc.M114.623769. Epub 2015 Mar 25. 2015
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| 8 | ANGPTL4, LPL
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| Lipoprotein lipase and angiopoietin-like 4 - Cardiomyocyte secretory proteins that regulate metabolism during diabetic heart disease.
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| Puthanveetil P, Wan A, Rodrigues B.
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| Crit Rev Clin Lab Sci. 52(3):138-49. doi: 10.3109/10408363.2014.997931. Epub 2015 Jan 19 2015
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| 9 | ANGPTL4
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| Angiopoietin-like protein 4 significantly predicts future cardiovascular events in coronary patients.
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| Muendlein A, Saely CH, Leiherer A, Fraunberger P, Kinz E, Rein P, Vonbank A, Zanolin D, Malin C, Drexel H.
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| Atherosclerosis 237(2):632-8. doi: 10.1016/j.atherosclerosis.2014.10.028. Epub 2014 Oct 22.
2014
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| 10 | ANGPTL4
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| Angiopoietin-like 4, a protein strongly induced during sebocyte differentiation, regulates sebaceous lipogenesis but is dispensable for sebaceous gland function in vivo.
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| Dahlhoff M, Camera E, Picardo M, Zouboulis CC, Schneider MR.
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| J Dermatol Sci 75(2):148-50. doi: 10.1016/j.jdermsci.2014.04.008. Epub 2014 May 9. No abstract available.
2014
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| 11 | ANGPTL4
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| Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise.
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| Catoire M, Alex S, Paraskevopulos N, Mattijssen F, Evers-van Gogh I, Schaart G, Jeppesen J, Kneppers A, Mensink M, Voshol PJ, Olivecrona G, Tan NS, Hesselink MK, Berbée JF, Rensen PC, Kalkhoven E, Schrauwen P, Kersten S.
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| Proc Natl Acad Sci U S A 111(11):E1043-52. doi: 10.1073/pnas.1400889111. Epub 2014 Mar 3.
2014
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| 12 | ANGPTL4, FOXO1, NR3C1
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| Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.
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| Kuo T, Chen TC, Yan S, Foo F, Ching C, McQueen A, Wang JC.
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| J Lipid Res 55(5):919-28. doi: 10.1194/jlr.M047860. Epub 2014 Feb 24.
2014
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| 13 | ANGPTL4
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| Involvement of angiopoietin-like 4 in matrix remodeling during chondrogenic differentiation of mesenchymal stem cells.
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| Mathieu M, Iampietro M, Chuchana P, Guérit D, Djouad F, Noël D, Jorgensen C.
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| J Biol Chem 289(12):8402-12. doi: 10.1074/jbc.M113.539825. Epub 2014 Feb 6.
2014
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| 14 | ANGPTL4
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| ANGPTL4 is produced by entero-endocrine cells in the human intestinal tract.
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| Alex S, Lichtenstein L, Dijk W, Mensink RP, Tan NS, Kersten S.
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| Histochem Cell Biol 141(4):383-91. doi: 10.1007/s00418-013-1157-y. Epub 2013 Oct 19.
2014
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| 15 | ANGPTL4
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| ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis.
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| Okochi-Takada E, Hattori N, Tsukamoto T, Miyamoto K, Ando T, Ito S, Yamamura Y, Wakabayashi M, Nobeyama Y, Ushijima T.
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| Oncogene 33(17):2273-8. doi: 10.1038/onc.2013.174. Epub 2013 May 20.
2014
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| 16 | ANGPTL4, PPARD
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| Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion.
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| Adhikary T, Brandt DT, Kaddatz K, Stockert J, Naruhn S, Meissner W, Finkernagel F, Obert J, Lieber S, Scharfe M, Jarek M, Toth PM, Scheer F, Diederich WE, Reinartz S, Grosse R, Müller-Brüsselbach S, Müller R.
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| Oncogene 32(44):5241-52. doi: 10.1038/onc.2012.549. Epub 2012 Dec 3.
2013
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| 17 | ANGPTL4
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| Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4.
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| Xin X, Rodrigues M, Umapathi M, Kashiwabuchi F, Ma T, Babapoor-Farrokhran S, Wang S, Hu J, Bhutto I, Welsbie DS, Duh EJ, Handa JT, Eberhart CG, Lutty G, Semenza GL, Montaner S, Sodhi A.
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| Proc Natl Acad Sci U S A 110(36):E3425-34. doi: 10.1073/pnas.1217091110. Epub 2013 Aug 19.
2013
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| 18 | ANGPTL4
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| Angiopoietin-like protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells.
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| Yokouchi H, Eto K, Nishimura W, Takeda N, Kaburagi Y, Yamamoto S, Yasuda K.
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| Acta Ophthalmol 91(4):e289-97. doi: 10.1111/aos.12097. Epub 2013 Feb 7.
2013
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| 19 | ANGPTL4, PPARD
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| Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes.
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| Robciuc MR, Skrobuk P, Anisimov A, Olkkonen VM, Alitalo K, Eckel RH, Koistinen HA, Jauhiainen M, Ehnholm C.
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| PLoS One 7(10):e46212. doi: 10.1371/journal.pone.0046212. Epub 2012 Oct 4.
2012
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| 20 | ANGPTL4
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| Fatty acids bind tightly to the N-terminal domain of angiopoietin-like protein 4 and modulate its interaction with lipoprotein lipase.
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| Robal T, Larsson M, Martin M, Olivecrona G, Lookene A.
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| J Biol Chem 287(35):29739-52. doi: 10.1074/jbc.M111.303529. Epub 2012 Jul 7.
2012
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| 21 | ANGPTL4
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| Angiopoietin like protein 4 expression is decreased in activated macrophages.
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| Feingold KR, Shigenaga JK, Cross AS, Moser A, Grunfeld C.
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| Biochem Biophys Res Commun 421(3):612-5. doi: 10.1016/j.bbrc.2012.04.055. Epub 2012 Apr 19.
2012
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| 22 | ANGPTL4, ANGPTL5
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| Angptl4 maintains in vivo repopulation capacity of CD34+ human cord blood cells.
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| Blank U, Ehrnström B, Heinz N, Nilsson E, Brun A, Baum C, Schiedlmeier B, Karlsson S.
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| Eur J Haematol 89(3):198-205. doi: 10.1111/j.1600-0609.2012.01812.x. Epub 2012 Jun 20.
2012
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| 23 | ANGPTL4, ZHX3
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| Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome.
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| Clement LC, Avila-Casado C, Macé C, Soria E, Bakker WW, Kersten S, Chugh SS.
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| Nat Med 17(1):117-22. Epub 2010 Dec 12. 2011
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| 24 | ANGPTL4
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| Proteolytic processing of angiopoietin-like protein 4 by proprotein convertases modulates its inhibitory effects on lipoprotein lipase activity.
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| Lei X, Shi F, Basu D, Huq A, Routhier S, Day R, Jin W.
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| J Biol Chem 286(18):15747-56. Epub 2011 Mar 12.
2011
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| 25 | ANGPTL4
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| Expression of angiopoietin-like 4 (ANGPTL4) in human colorectal cancer: ANGPTL4 promotes venous invasion and distant metastasis.
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| Nakayama T, Hirakawa H, Shibata K, Nazneen A, Abe K, Nagayasu T, Taguchi T.
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| Oncol Rep 25(4):929-35. doi: 10.3892/or.2011.1176. Epub 2011 Feb 9.
2011
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| 26 | ANGPTL4
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| ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression.
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| Kim SH, Park YY, Kim SW, Lee JS, Wang D, DuBois RN.
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| Cancer Res 71(22):7010-20. doi: 10.1158/0008-5472.CAN-11-1262. Epub 2011 Sep 21.
2011
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| 27 | ANGPTL3, ANGPTL4, ANGPTL6
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| Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases.
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| Kadomatsu T, Tabata M, Oike Y.
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| FEBS J 278(4):559-64. doi: 10.1111/j.1742-4658.2010.07979.x. Epub 2010 Dec 23. Review.
2011
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| 28 | ANGPTL4
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| Angiopoietin-like 4 interacts with integrins beta1 and beta5 to modulate keratinocyte migration.
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| Goh YY, Pal M, Chong HC, Zhu P, Tan MJ, Punugu L, Lam CR, Yau YH, Tan CK, Huang RL, Tan SM, Tang MB, Ding JL, Kersten S, Tan NS.
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| Am J Pathol 177(6):2791-803. Epub 2010 Oct 15.
2010
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| 29 | ANGPTL4
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| Angiopoietin-like 4 interacts with matrix proteins to modulate wound healing.
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| Goh YY, Pal M, Chong HC, Zhu P, Tan MJ, Punugu L, Tan CK, Huang RL, Sze SK, Tang MB, Ding JL, Kersten S, Tan NS.
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| J Biol Chem 285(43):32999-3009. Epub 2010 Aug 21.
2010
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| 30 | ANGPTL3, ANGPTL4, ANGPTL5
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| Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events.
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| Miida T, Hirayama S.
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| Curr Opin Lipidol 21(1):70-5. doi: 10.1097/MOL.0b013e328333269e. Review.
2010
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| 31 | ANGPTL4
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| Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis.
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| Adachi H, Fujiwara Y, Kondo T, Nishikawa T, Ogawa R, Matsumura T, Ishii N, Nagai R, Miyata K, Tabata M, Motoshima H, Furukawa N, Tsuruzoe K, Kawashima J, Takeya M, Yamashita S, Koh GY, Nagy A, Suda T, Oike Y, Araki E.
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| Biochem Biophys Res Commun 379(4):806-11. Epub 2008 Dec 16.
2009
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| 32 | ANGPTL4
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| Genetic variation in ANGPTL4 provides insights into protein processing and function.
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| Yin W, Romeo S, Chang S, Grishin NV, Hobbs HH, Cohen JC.
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| J Biol Chem 284(19):13213-22. Epub 2009 Mar 7.
2009
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| 33 | ANGPTL3, ANGPTL4
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| The angiopoietin-like proteins ANGPTL3 and ANGPTL4 inhibit lipoprotein lipase activity through distinct mechanisms.
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| Shan L, Yu XC, Liu Z, Hu Y, Sturgis LT, Miranda ML, Liu Q.
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| J Biol Chem 284(3):1419-24. Epub 2008 Nov 21.
2009
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| 34 | ANGPTL3, ANGPTL4
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| Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL).
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| Lee EC, Desai U, Gololobov G, Hong S, Feng X, Yu XC, Gay J, Wilganowski N, Gao C, Du LL, Chen J, Hu Y, Zhao S, Kirkpatrick L, Schneider M, Zambrowicz BP, Landes G, Powell DR, Sonnenburg WK.
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| J Biol Chem 284(20):13735-45. Epub 2009 Mar 23.
2009
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| 35 | ANGPTL4, NR3C1
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| Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism.
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| Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV Jr, Wang JC.
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| J Biol Chem 284(38):25593-601. Epub 2009 Jul 23.PMID: 19628874 2009
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| 36 | ANGPTL4
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| Hypoxia upregulates the expression of angiopoietin-like-4 in human articular chondrocytes: role of angiopoietin-like-4 in the expression of matrix metalloproteinases and cartilage degradation.
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| Murata M, Yudo K, Nakamura H, Chiba J, Okamoto K, Suematsu N, Nishioka K, Beppu M, Inoue K, Kato T, Masuko K.
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| J Orthop Res 27(1):50-7.
2009
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| 37 | ANGPTL3, ANGPTL4, ANGPTL5
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| Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.
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| Romeo S, Yin W, Kozlitina J, Pennacchio LA, Boerwinkle E, Hobbs HH, Cohen JC.
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| J Clin Invest 119(1):70-9. doi: 10.1172/JCI37118. Epub 2008 Dec 15.
2009
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| 38 | ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL5, ANGPTL7
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| Ontogeny of angiopoietin-like protein 1, 2, 3, 4, 5, and 7 genes during chick embryonic development.
|
| Niki D, Katsu K, Yokouchi Y.
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| Dev Growth Differ 51(9):821-32. doi: 10.1111/j.1440-169X.2009.01145.x.
2009
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| 39 | ANGPTL4
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| Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4.
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| Yang YH, Wang Y, Lam KS, Yau MH, Cheng KK, Zhang J, Zhu W, Wu D, Xu A.
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| Arterioscler Thromb Vasc Biol 28(5):835-40. Epub 2008 Mar 13.
2008
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| 40 | ANGPTL3, ANGPTL4, ANGPTL6
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| The role of angiopoietin-like proteins in angiogenesis and metabolism.
|
| Hato T, Tabata M, Oike Y.
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| Trends Cardiovasc Med 18(1):6-14. doi: 10.1016/j.tcm.2007.10.003. Review.
2008
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| 41 | ANGPTL4
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| Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL.
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| Romeo S, Pennacchio LA, Fu Y, Boerwinkle E, Tybjaerg-Hansen A, Hobbs HH, Cohen JC.
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| Nat Genet 39(4):513-6. Epub 2007 Feb 25. 2007
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| 42 | ANGPTL4
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| Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness.
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| Galaup A, Cazes A, Le Jan S, Philippe J, Connault E, Le Coz E, Mekid H, Mir LM, Opolon P, Corvol P, Monnot C, Germain S.
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| Proc Natl Acad Sci U S A 103(49):18721-6. Epub 2006 Nov 27. 2006
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| 43 | ANGPTL4
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| Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice.
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| Xu A, Lam MC, Chan KW, Wang Y, Zhang J, Hoo RL, Xu JY, Chen B, Chow WS, Tso AW, Lam KS.
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| Proc Natl Acad Sci U S A 102(17):6086-91. Epub 2005 Apr 18. 2005
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| 44 | ANGPTL4
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| Genes that mediate breast cancer metastasis to lung.
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| Minn AJ, Gupta GP, Siegel PM, Bos PD, Shu W, Giri DD, Viale A, Olshen AB, Gerald WL, Massague J.
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| Nature 436(7050):518-24. 2005
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| 45 | ANGPTL4
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| Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma.
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| Le Jan S, Amy C, Cazes A, Monnot C, Lamande N, Favier J, Philippe J, Sibony M, Gasc JM, Corvol P, Germain S.
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| Am J Pathol 162(5):1521-8. 2003
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| 46 | ANGPTL4, FLNC, HAND1, HRASLS, LOX
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| Identification of silencing of nine genes in human gastric cancers.
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| Kaneda A, Kaminishi M, Yanagihara K, Sugimura T, Ushijima T.
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| Cancer Res 62(22):6645-50. 2002
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| 47 | ANGPTL4
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| Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation.
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| Yoon JC, Chickering TW, Rosen ED, Dussault B, Qin Y, Soukas A, Friedman JM, Holmes WE, Spiegelman BM.
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| Mol Cell Biol 20(14):5343-9. 2000
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| 48 | ANGPTL4
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| Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis.
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| Kim I, Kim HG, Kim H, Kim HH, Park SK, Uhm CS, Lee ZH, Koh GY.
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| Biochem J 346 Pt 3:603-10. 2000
|