| 1 | ANGPT1, NCF1
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| Angiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defense.
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| Ghosh CC, Mukherjee A, David S, Milam KE, Hunter JT, Parikh SM.
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| PLoS One 10(3):e0119577. doi: 10.1371/journal.pone.0119577.
2015
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| 2 | ANGPT1, CASP5, TEK, VEGFA
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| Effects of CASP5 gene overexpression on angiogenesis of HMEC-1 cells.
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| Li H, Li Y, Cai L, Bai B, Wang Y.
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| Int J Clin Exp Pathol 8(12):15794-800. eCollection 2015.
2015
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| 3 | ANGPT1, KDM3B
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| Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B.
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| Han A, Chae YC, Park JW, Kim KB, Kim JY, Seo SB.
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| BMB Rep MB Rep. 2014 Nov 21. pii: 2948. [Epub ahead of print]
2014
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| 4 | ANGPT1, ANGPT2
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| Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.
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| Daly C, Eichten A, Castanaro C, Pasnikowski E, Adler A, Lalani AS, Papadopoulos N, Kyle AH, Minchinton AI, Yancopoulos GD, Thurston G.
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| Cancer Res 73(1):108-18. doi: 10.1158/0008-5472.CAN-12-2064. Epub 2012 Nov 13.
2013
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| 5 | ANGPT1, ANGPT2
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| Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion: a case-control study.
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| Daponte A, Deligeoroglou E, Pournaras S, Tsezou A, Garas A, Anastasiadou F, Hadjichristodoulou C, Messinis IE.
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| Clin Chim Acta 415:145-51. doi: 10.1016/j.cca.2012.10.031. Epub 2012 Oct 22.
2013
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| 6 | ANGPT1, TEK, TIE1
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| Hypoxia reduces endothelial Ang1-induced Tie2 activity in a Tie1-dependent manner.
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| Yun JH, Lee HM, Lee EH, Park JW, Cho CH.
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| Biochem Biophys Res Commun 436(4):691-7. doi: 10.1016/j.bbrc.2013.06.018. Epub 2013 Jun 14.
2013
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| 7 | ANGPT1, ANGPT2, TEK, TIE1
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| Structural basis for angiopoietin-1-mediated signaling initiation.
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| Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA.
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| Proc Natl Acad Sci U S A 110(18):7205-10. doi: 10.1073/pnas.1216890110. Epub 2013 Apr 16.
2013
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| 8 | ANGPT1, TEK
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| Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells.
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| Ikushima YM, Arai F, Nakamura Y, Hosokawa K, Kubota Y, Hirashima M, Toyama H, Suda T.
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| Biochem Biophys Res Commun 430(1):20-5. doi: 10.1016/j.bbrc.2012.11.002. Epub 2012 Nov 10.
2013
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| 9 | ANGPT1, PLEKHG5, VEGFA
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| VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.
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| Ngok SP, Geyer R, Liu M, Kourtidis A, Agrawal S, Wu C, Seerapu HR, Lewis-Tuffin LJ, Moodie KL, Huveldt D, Marx R, Baraban JM, Storz P, Horowitz A, Anastasiadis PZ.
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| J Cell Biol Cell Biol. 2012 Dec 17. [Epub ahead of print]
2012
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| 10 | ANGPT1
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| Orchestral actions of angiopoietin-1 in vascular regeneration.
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| Koh GY.
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| Trends Mol Med rends Mol Med. 2012 Nov 22. doi:pii: S1471-4914(12)00205-5. 10.1016/j.molmed.2012.10.010. [Epub ahead of print]
2012
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| 11 | ANGPT1, VEGFA
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| Role of vascular endothelial growth factor and angiopoietin 1 in renal injury in hemolytic uremic syndrome.
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| Ohara S, Kawasaki Y, Abe Y, Watanabe M, Ono A, Suyama K, Hashimoto K, Honda T, Suzuki J, Hosoya M.
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| Am J Nephrol 36(6):516-23. doi: 10.1159/000345142. Epub 2012 Nov 17.
2012
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| 12 | ANGPT1
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| A functional variant in ANGPT1 and the risk of pregnancies with hypertensive disorders and small-for-gestational-age infants.
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| Andraweera PH, Dekker GA, Thompson SD, North RA, McCowan LM, Roberts CT; SCOPE Consortium.
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| Mol Hum Reprod 18(6):325-32. doi: 10.1093/molehr/gar081. Epub 2011 Dec 28.
2012
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| 13 | ANGPT1, TEK
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| Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells.
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| Joo HJ, Kim H, Park SW, Cho HJ, Kim HS, Lim DS, Chung HM, Kim I, Han YM, Koh GY.
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| Blood 118(8):2094-104. Epub 2011 Jun 16.
2011
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| 14 | ANGPT1, ANGPT2
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| Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis.
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| Fagiani E, Lorentz P, Kopfstein L, Christofori G.
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| Cancer Res 71(17):5717-27. Epub 2011 Jul 21.
2011
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| 15 | ANGPT1, IQGAP1
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| Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense.
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| David S, Ghosh CC, Mukherjee A, Parikh SM.
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| Arterioscler Thromb Vasc Biol 31(11):2643-52. doi: 10.1161/ATVBAHA.111.233189.
2011
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| 16 | ANGPT1
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| Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation.
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| Fuxe J, Tabruyn S, Colton K, Zaid H, Adams A, Baluk P, Lashnits E, Morisada T, Le T, O'Brien S, Epstein DM, Koh GY, McDonald DM.
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| Am J Pathol 178(6):2897-909. doi: 10.1016/j.ajpath.2011.02.008. Epub 2011 May 6.
2011
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| 17 | ANGPT1, TEK
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| Angiopoietin-1/Tie2 signal augments basal Notch signal controlling vascular quiescence by inducing delta-like 4 expression through AKT-mediated activation of beta-catenin.
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| Zhang J, Fukuhara S, Sako K, Takenouchi T, Kitani H, Kume T, Koh GY, Mochizuki N.
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| J Biol Chem 286(10):8055-66. doi: 10.1074/jbc.M110.192641. Epub 2011 Jan 6.
2011
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| 18 | ANGPT1
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| Serum angiopoietin-1 level is increased in patients with Behçet's disease.
|
| Choe JY, Park SH, Kim SK.
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| Joint Bone Spine 77(4):340-4. doi: 10.1016/j.jbspin.2010.01.014. Epub 2010 May 14.
2010
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| 19 | ANGPT1
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| The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem/progenitor cells.
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| Rosa AI, Gonçalves J, Cortes L, Bernardino L, Malva JO, Agasse F.
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| J Neurosci 30(13):4573-84. doi: 10.1523/JNEUROSCI.5597-09.2010.
2010
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| 20 | ANGPT1, ANGPT2, TEK, TIE1
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| Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands.
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| Seegar TC, Eller B, Tzvetkova-Robev D, Kolev MV, Henderson SC, Nikolov DB, Barton WA.
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| Mol Cell 37(5):643-55. doi: 10.1016/j.molcel.2010.02.007.
2010
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| 21 | ANGPT1
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| COMP-Ang1 ameliorates leukocyte adhesion and reinforces endothelial tight junctions during endotoxemia.
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| Hwang JA, Lee EH, Lee SD, Park JB, Jeon BH, Cho CH.
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| Biochem Biophys Res Commun 381(4):592-6. Epub 2009 Feb 24.
2009
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| 22 | ANGPT1, ANGPT2, TEK
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| Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.
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| Yuan HT, Khankin EV, Karumanchi SA, Parikh SM.
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| Mol Cell Biol 29(8):2011-22. Epub 2009 Feb 17. Erratum in: Mol Cell Biol. 2009 Jun;29(12):3451.
2009
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| 23 | ANGPT1, TJP, TJP2
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| Angiopoietin-1 reduces vascular endothelial growth factor-induced brain endothelial permeability via upregulation of ZO-2.
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| Lee SW, Kim WJ, Jun HO, Choi YK, Kim KW.
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| Int J Mol Med 23(2):279-84. 2009
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| 24 | ANGPT1
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| Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway.
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| Bai Y, Cui M, Meng Z, Shen L, He Q, Zhang X, Chen F, Xiao J.
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| Biochem Biophys Res Commun 378(2):296-301. Epub 2008 Nov 24.
2009
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| 25 | ANGPT1, TEK
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| Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters.
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| Martin V, Xu J, Pabbisetty SK, Alonso MM, Liu D, Lee OH, Gumin J, Bhat KP, Colman H, Lang FF, Fueyo J, Gomez-Manzano C.
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| Oncogene 28(24):2358-63. Epub 2009 May 4.
2009
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| 26 | ANGPT1, ANGPT2, TEK, TIE1
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| The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placenta.
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| Seval Y, Sati L, Celik-Ozenci C, Taskin O, Demir R.
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| Placenta 29(9):809-15. doi: 10.1016/j.placenta.2008.06.009.
2008
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| 27 | TEK, ANGPT1, ANGPT2
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| Angiopoietin-1, angiopoietin-2 and tie-2 in the coronary circulation of patients with and without coronary collateral vessels.
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| Mitsuma W, Kodama M, Hirono S, Ito M, Ramadan MM, Tanaka K, Hoyano M, Saigawa T, Kashimura T, Fuse K, Okura Y, Aizawa Y.
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| Circ J 71(3):343-7. 2007
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| 28 | ANGPT1, ANGPT2
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| Admission angiopoietin levels in children with septic shock.
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| Giuliano JS Jr, Lahni PM, Harmon K, Wong HR, Doughty LA, Carcillo JA, Zingarelli B, Sukhatme VP, Parikh SM, Wheeler DS.
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| Shock 28(6):650-654.
2007
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| 29 | XLKD1, FIGF, VEGFC, PROX1, FLT4, LCP2, ANGPT1, ANGPTL1, ANGPT4, TEK, EFNB2, FOXC2, PDPN
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| Lymphangiogenesis in development and human disease.
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| Alitalo K, Tammela T, Petrova TV.
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| Nature 438(7070):946-53. Review. 2005
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| 30 | ANGPT1
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| Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma.
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| Torimura T, Ueno T, Kin M, Harada R, Taniguchi E, Nakamura T, Sakata R, Hashimoto O, Sakamoto M, Kumashiro R, Sata M, Nakashima O, Yano H, Kojiro M.
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| J Hepatol 40(5):799-807. 2004
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| 31 | ELF3, ANGPT1
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| ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation.
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| Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravallese EM, Oettgen P.
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| J Biol Chem 279(13):12794-803. Epub 2004 Jan 8. 2004
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| 32 | ANGPT1,FOXO1
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| Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1).
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| Daly C, Wong V, Burova E, Wei Y, Zabski S, Griffiths J, Lai KM, Lin HC, Ioffe E, Yancopoulos GD, Rudge JS.
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| Genes Dev 18(9):1060-71. 2004
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| 33 | ANGPT1
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| Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha.
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| Gravallese EM, Pettit AR, Lee R, Madore R, Manning C, Tsay A, Gaspar J, Goldring MB, Goldring SR, Oettgen P.
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| Ann Rheum Dis 62(2):100-7. 2003
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| 34 | ANGPT1, ANGPT2, TEK
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| Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma.
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| Mitsuhashi N, Shimizu H, Ohtsuka M, Wakabayashi Y, Ito H, Kimura F, Yoshidome H, Kato A, Nukui Y, Miyazaki M.
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| Hepatology 37(5):1105-13. 2003
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| 35 | TEK, ANGPT1, PLD1
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| Localization of Tie2 and phospholipase D in endothelial caveolae is involved in angiopoietin-1-induced MEK/ERK phosphorylation and migration in endothelial cells.
|
| Yoon MJ, Cho CH, Lee CS, Jang IH, Ryu SH, Koh GY.
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| Biochem Biophys Res Commun 308(1):101-5. 2003
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| 36 | ANGPT1
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| Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells.
|
| Kim I, Oh JL, Ryu YS, So JN, Sessa WC, Walsh K, Koh GY.
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| FASEB J 16(1):126-8. 2002
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| 37 | ANGPT1
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| Down-regulation of angiopoietin-1 expression in menorrhagia.
|
| Hewett P, Nijjar S, Shams M, Morgan S, Gupta J, Ahmed A.
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| Am J Pathol 160(3):773-80. 2002
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| 38 | ANGPT1
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| Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1.
|
| Tian S, Hayes AJ, Metheny-Barlow LJ, Li LY.
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| Br J Cancer 86(4):645-51. 2002
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| 39 | ANGPT1, ANGPT2
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| Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2.
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| Geva E, Ginzinger DG, Zaloudek CJ, Moore DH, Byrne A, Jaffe RB.
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| J Clin Endocrinol Metab 87(9):4213-24. 2002
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| 40 | ANGPT1, TEK
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| Human podocytes express angiopoietin 1, a potential regulator of glomerular vascular endothelial growth factor.
|
| Satchell SC, Harper SJ, Tooke JE, Kerjaschki D, Saleem MA, Mathieson PW.
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| J Am Soc Nephrol 13(2):544-50. 2002
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| 41 | ANGPT1, ANGPT2, TEK
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| Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer.
|
| Hata K, Udagawa J, Fujiwaki R, Nakayama K, Otani H, Miyazaki K.
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| Oncology 62(4):340-8. 2002
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| 42 | ANGPT1, ANGPT2, ANGPT4
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| Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2.
|
| Ward EG, Grosios K, Markham AF, Jones PF.
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| Cytogenet Cell Genet 94(3-4):147-54. 2001
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| 43 | ANGPT1, HNF1A
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| Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.
|
| Wang H, Antinozzi PA, Hagenfeldt KA, Maechler P, Wollheim CB.
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| EMBO J 19(16):4257-64. 2000
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| 44 | ANGPT1, ANGPT2, TEK
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| Angiogenesis in the human corpus luteum: localization and changes in angiopoietins, tie-2, and vascular endothelial growth factor messenger ribonucleic acid.
|
| Wulff C, Wilson H, Largue P, Duncan WC, Armstrong DG, Fraser HM.
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| J Clin Endocrinol Metab 85(11):4302-9. 2000
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| 45 | ANGPT1, ANGPT2, ANGPT4
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| Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping.
|
| Grosios K, et al.
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| Cytogenet Cell Genet 84(1-2):118-20. No abstract available 1999
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| 46 | ANGPT1, ANGPT2
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| Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2) : regional localization of the human genes to 8q22.3-q23 and 8p23.
|
| Cheung AH, et al.
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| Genomics 48 : 389-391. 1998
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| 47 | ANGPT1, ANGPT2
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| Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis.
|
| Stratmann A, et al.
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| Am J Pathol 153 : 1459-1466. 1998
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| 48 | ANGPT1, ANGPT2
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| Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.
|
| Suri C, et al.
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| Cell 87(7):1171-80. 1996
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| 49 | ANGPT1
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| Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.
|
| Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, Ryan TE, Bruno J, Radziejewski C, Maisonpierre PC, Yancopoulos GD.
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| Cell 87(7):1161-9. 1996
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| 50 | FGL2, ANGPT1
|
| Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein.
|
| Ruegg C, Pytela R.
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| Gene 160(2):257-62. 1995
|