Citations for
1AMFR, GPI
Neuroleukin/Autocrine Motility Factor Receptor Pathway Promotes Proliferation of Articular Chondrocytes through Activation of AKT and Smad2/3.
Tian K, Zhong W, Zheng X, Zhang J, Liu P, Zhang W, Liu H.
Sci Rep 5:15101. doi: 10.1038/srep15101. 2015
2AMFR
Autocrine motility factor receptor promotes the proliferation of human acute monocytic leukemia THP-1 cells.
Wang Y, Ma L, Wang C, Sheng G, Feng L, Yin C.
Int J Mol Med 36(3):627-32. doi: 10.3892/ijmm.2015.2267. Epub 2015 Jun 30. 2015
3AMFR, GPI, MFN1, MFN2
Distinct mechanisms controlling rough and smooth endoplasmic reticulum contacts with mitochondria.
Wang PT, Garcin PO, Fu M, Masoudi M, St-Pierre P, PantÚ N, Nabi IR.
J Cell Sci 128(15):2759-65. doi: 10.1242/jcs.171132. Epub 2015 Jun 11. 2015
4AMFR
Affinity proteomics discovers decreased levels of AMFR in plasma from Osteoporosis patients.
Qundos U, Drobin K, Mattsson C, Hong MG, Sj÷berg R, Forsstr÷m B, Solomon D, UhlÚn M, Nilsson P, MichaŰlsson K, Schwenk JM.
Proteomics Clin Appl roteomics Clin Appl. 2015 Feb 16. doi: 10.1002/prca.201400167. [Epub ahead of print] 2015
5AMFR, INSIG1, STING1
The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.
Wang Q, Liu X, Cui Y, Tang Y, Chen W, Li S, Yu H, Pan Y, Wang C.
Immunity 41(6):919-33. doi: 10.1016/j.immuni.2014.11.011. Epub 2014 Nov 28. 2014
6AMFR
gp78 elongates of polyubiquitin chains from the distal end through the cooperation of its G2BR and CUE domains.
Liu W, Shang Y, Li W.
Sci Rep 4:7138. doi: 10.1038/srep07138. 2014
7AMFR, DGAT2
Regulation of diacylglycerol acyltransferase 2 protein stability by gp78-associated endoplasmic-reticulum-associated degradation.
Choi K, Kim H, Kang H, Lee SY, Lee SJ, Back SH, Lee SH, Kim MS, Lee JE, Park JY, Kim J, Kim S, Song JH, Choi Y, Lee S, Lee HJ, Kim JH, Cho S.
FEBS J 281(13):3048-60. doi: 10.1111/febs.12841. Epub 2014 Jun 6. 2014
8AMFR, GPI, TRIM25
Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases.
Wang Y, Ha SW, Zhang T, Kho DH, Raz A, Xie Y.
Oncotarget 5(8):2044-51. 2014
9AMFR, PRNP
Ubiquitin ligase gp78 targets unglycosylated prion protein PrP for ubiquitylation and degradation.
Shao J, Choe V, Cheng H, Tsai YC, Weissman AM, Luo S, Rao H.
PLoS One 9(4):e92290. doi: 10.1371/journal.pone.0092290. eCollection 2014. 2014
10AMFR, BAG6, UBL4A, USP13
USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.
Liu Y, Soetandyo N, Lee JG, Liu L, Xu Y, Clemons WM Jr, Ye Y.
Elife 3:e01369. doi: 10.7554/eLife.01369. Epub 2014 Jan 14. 2014
11AMFR, AUP1, RNF139
Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.
Jo Y, Hartman IZ, DeBose-Boyd RA.
Mol Biol Cell 24(3):169-83. doi: 10.1091/mbc.E12-07-0564. Epub 2012 Dec 5. 2013
12AMFR
gp78 is specifically expressed in human prostate cancer rather than normal prostate tissue.
Shang Y, Zhu Z.
J Mol Histol 44(6):653-9. doi: 10.1007/s10735-013-9512-9. Epub 2013 May 12. 2013
13AMFR, MFN1
Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.
Fu M, St-Pierre P, Shankar J, Wang PT, Joshi B, Nabi IR.
Mol Biol Cell 24(8):1153-62. doi: 10.1091/mbc.E12-08-0607. Epub 2013 Feb 20. 2013
14AMFR
Promiscuous interactions of gp78 E3 ligase CUE domain with polyubiquitin chains.
Liu S, Chen Y, Li J, Huang T, Tarasov S, King A, Weissman AM, Byrd RA, Das R.
Structure 20(12):2138-50. doi: 10.1016/j.str.2012.09.020. Epub 2012 Nov 1. 2012
15AMFR, HMGCR, INSIG1, RNF139
Differential regulation of HMG-CoA reductase and Insig-1 by enzymes of the ubiquitin-proteasome system.
Tsai YC, Leichner GS, Pearce MM, Wilson GL, Wojcikiewicz RJ, Roitelman J, Weissman AM.
Mol Biol Cell 23(23):4484-94. doi: 10.1091/mbc.E12-08-0631. Epub 2012 Oct 19. 2012
16AMFR
RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase.
Fairbank M, Huang K, El-Husseini A, Nabi IR.
FEBS Lett 586(16):2488-93. doi: 10.1016/j.febslet.2012.06.011. Epub 2012 Jun 21. 2012
17AMFR
Peripheral endoplasmic reticulum localization of the Gp78 ubiquitin ligase activity.
St-Pierre P, Dang T, Joshi B, Nabi IR.
J Cell Sci 125(Pt 7):1727-37. doi: 10.1242/jcs.096396. Epub 2012 Feb 10. 2012
18AMFR, INSIG1, INSIG2, RNF139
Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.
Jo Y, Lee PC, Sguigna PV, DeBose-Boyd RA.
Proc Natl Acad Sci U S A 108(51):20503-8. doi: 10.1073/pnas.1112831108. Epub 2011 Dec 5. 2011
19AMFR, ERLIN2, TMUB1
Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Jo Y, Sguigna PV, DeBose-Boyd RA.
J Biol Chem 286(17):15022-31. doi: 10.1074/jbc.M110.211326. Epub 2011 Feb 22. 2011
20AMFR, CD82
A role for KAI1 in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase.
Joshi B, Li L, Nabi IR.
J Biol Chem 285(12):8830-9. doi: 10.1074/jbc.M109.074344. Epub 2010 Jan 20. 2010
21AMFR
Allosteric activation of E2-RING finger-mediated ubiquitylation by a structurally defined specific E2-binding region of gp78.
Das R, Mariano J, Tsai YC, Kalathur RC, Kostova Z, Li J, Tarasov SG, McFeeters RL, Altieri AS, Ji X, Byrd RA, Weissman AM.
Mol Cell 34(6):674-85.PMID: 19560420 2009
22AMFR, ATXN3, SOD1
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation.
Ying Z, Wang H, Fan H, Zhu X, Zhou J, Fei E, Wang G.
Hum Mol Genet 18(22):4268-81. Epub 2009 Aug 6.PMID: 19661182 2009
23AMFR, CFTR, RNF5
Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.
Morito D, Hirao K, Oda Y, Hosokawa N, Tokunaga F, Cyr DM, Tanaka K, Iwai K, Nagata K.
Mol Biol Cell 19(4):1328-36. Epub 2008 Jan 23.PMID: 18216283 2008
24AMFR, NPLOC4, UFD1L
Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase.
Cao J, Wang J, Qi W, Miao HH, Wang J, Ge L, DeBose-Boyd RA, Tang JJ, Li BL, Song BL.
Cell Metab 6(2):115-28. 2007
25AMFR,INSIG1
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.
Song BL, Sever N, DeBose-Boyd RA.
Mol Cell 19(6):829-40. 2005
26AMFR
The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum.
Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM.
Proc Natl Acad Sci U S A 98(25):14422-7. Epub 2001 Nov 27.PMID: 11724934 2001
27AMFR
The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein.
Shimizu K, Tani M, Watanabe H, Nagamachi Y, Niinaka Y, Shiroishi T, Ohwada S, Raz A, Yokota J.
FEBS Lett 456(2):295-300. 1999
28AMFR
Expression of autocrine motility factor receptor correlates with disease progression in human gastric cancer.
Hirono Y, Fushida S, Yonemura Y, Yamamoto H, Watanabe H, Raz A.
Br J Cancer 74(12):2003-7. 1996
29AMFR
Autocrine motility factor receptor in human bladder carcinoma : gene expression, loss of cell-contact regulation and chromosomal mapping.
Silletti S, et al.
Int J Oncol 3 : 801-807. 1993
30AMFR
Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor.
Watanabe H, et al.
J Biol Chem 266 : 13442-13448. 1991