| 1 | ALDH1A2, DIH4
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| ALDH1A2-related disorder: A new genetic syndrome due to alteration of the retinoic acid pathway. 2023 PMID:
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| Leon E, Nde C, Ray RS, Preciado D, Zohn IE.
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| Am J Med Genet A. Jan;191(1):90-99. doi: 10.1002/ajmg.a.62991. Epub 2022 Oct 19. 2023
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| 2 | ALDH1A1, ALDH1A2
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| Global Deletion of ALDH1A1 and ALDH1A2 Genes Does Not Affect Viability but Blocks Spermatogenesis
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| Topping T, Griswold MD.
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| Front Endocrinol (Lausanne) Apr 28;13:871225. doi: 10.3389/fendo.2022.871225. 2022
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| 3 | ALDH1A2, DIH4
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| Biallelic hypomorphic variants in ALDH1A2 cause a novel lethal human multiple congenital anomaly syndrome encompassing diaphragmatic, pulmonary, and cardiovascular defects.
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| Beecroft SJ, Ayala M, McGillivray G, Nanda V, Agolini E, Novelli A, Digilio MC, Dotta A, Carrozzo R, Clayton J, Gaffney L, McLean CA, Ng J, Laing NG, Matteson P, Millonig J, Ravenscroft G.
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| Hum Mutat. May;42(5):506-519. doi: 10.1002/humu.24179. Epub 2021 Apr 1. 2021
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| 4 | ALDH1A2, STAT3
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| ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3.
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| Wang Y, Shao F, Chen L.
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| Onco Targets Ther. Jan 31;11:599-608. doi: 10.2147/OTT.S145864. 2018
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| 5 | ALDH1A2
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| Kinetic characterization and regulation of the human retinaldehyde dehydrogenase 2 enzyme during production of retinoic acid. 2016 PMID:
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| Shabtai Y, Jubran H, Nassar T, Hirschberg J, Fainsod A.
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| Biochem J. May 15;473(10):1423-31. doi: 10.1042/BCJ20160101. Epub 2016 Mar 21. 2016
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| 6 | ALDH1A1, ALDH1A2
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| Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations.
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| Arnold SL, Kent T, Hogarth CA, Schlatt S, Prasad B, Haenisch M, Walsh T, Muller CH, Griswold MD, Amory JK, Isoherranen N.
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| J Lipid Res. Feb;56(2):342-57. doi: 10.1194/jlr.M054718. Epub 2014 Dec 11. 2015
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| 7 | ALDH1A2
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| Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma
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| Hartomo TB, Van Huyen Pham T, Yamamoto N, Hirase S, Hasegawa D, Kosaka Y, Matsuo M, Hayakawa A, Takeshima Y, Iijima K, Nishio H, Nishimura N.
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| Int J Oncol. Mar;46(3):1089-98. doi: 10.3892/ijo.2014.2801. Epub 2014 Dec 17. 2015
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| 8 | ALDH1A2, HOXA13
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| HOXA13 regulates Aldh1a2 expression in the autopod to facilitate interdigital programmed cell death.
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| Shou S, Carlson HL, Perez WD, Stadler HS.
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| Dev Dyn 242(6):687-98. doi: 10.1002/dvdy.23966. Epub 2013 Apr 28.
2013
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| 9 | ALDH1A2, RDH10
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| Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males.
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| Tong MH, Yang QE, Davis JC, Griswold MD.
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| Proc Natl Acad Sci U S A 110(2):543-8. doi: 10.1073/pnas.1214883110. Epub 2012 Dec 24.
2013
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| 10 | ALDH1A2, WT1
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| Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2.
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| Guadix JA, Ruiz-Villalba A, Lettice L, Velecela V, Muñoz-Chápuli R, Hastie ND, Pérez-Pomares JM, Martínez-Estrada OM.
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| Development 138(6):1093-7. doi: 10.1242/dev.044594.
2011
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| 11 | ALDH1A2
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| A human ALDH1A2 gene variant is associated with increased newborn kidney size and serum retinoic acid.
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| El Kares R, Manolescu DC, Lakhal-Chaieb L, Montpetit A, Zhang Z, Bhat PV, Goodyer P.
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| Kidney Int 78(1):96-102. Epub 2010 Apr 14.
2010
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| 12 | ALDH1A2
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| Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer.
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| Castillo HA, Cravo RM, Azambuja AP, Simões-Costa MS, Sura-Trueba S, Gonzalez J, Slonimsky E, Almeida K, Abreu JG, de Almeida MA, Sobreira TP, de Oliveira SH, de Oliveira PS, Signore IA, Colombo A, Concha ML, Spengler TS, Bronner-Fraser M, Nobrega M, Rosenthal N, Xavier-Neto J.
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| Development 137(3):507-18.
2010
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| 13 | ALDH1A2
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| ALDH1A2 (RALDH2) genetic variation in human congenital heart disease.
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| Pavan M, Ruiz VF, Silva FA, Sobreira TJ, Cravo RM, Vasconcelos M, Marques LP, Mesquita SM, Krieger JE, Lopes AA, Oliveira PS, Pereira AC, Xavier-Neto J.
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| BMC Med Genet 10:113.
2009
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| 14 | ALDH1A2, ALDH1A3
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| Expression of retinaldehyde dehydrogenase (RALDH)2 and RALDH3 but not RALDH1 in the developing anterior pituitary glands of rats.
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| Fujiwara K, Maekawa F, Kikuchi M, Takigami S, Yada T, Yashiro T.
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| Cell Tissue Res 328(1):129-35. Epub 2006 Dec 19.
2007
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| 15 | ALDH1A2
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| Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation.
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| Mic FA, Sirbu IO, Duester G.
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| J Biol Chem 279(25):26698-706. Epub 2004 Apr 6.
2004
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| 16 | ALDH1A2, ALDH1A3, ALDH1A1
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| Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina.
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| Fan X, Molotkov A, Manabe S, Donmoyer CM, Deltour L, Foglio MH, Cuenca AE, Blaner WS, Lipton SA, Duester G.
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| Mol Cell Biol 23(13):4637-48. 2003
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| 17 | ALDH1A2
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| Embryonic retinoic acid synthesis is essential for early mouse post-implantation development.
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| Niederreither K, Subbarayan V, Dolle P, Chambon P.
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| Nat Genet 21(4):444-8. 1999
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| 18 | ALDH1A1,ALDH1A2,ALDH1A3,ALDH1B1,ALDH2,ALDH3A1,ALDH3A2,ALDH3B1,ALDH3B2,ALDH7A1,ALDH8A1,ALDH9A1
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| Human aldehyde dehydrogenase gene family.
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| Yoshida A, Rzhetsky A, Hsu LC, Chang C.
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| Eur J Biochem 251(3):549-57. 1998
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| 19 | LMO2, TAL1, ALDH1A2
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| TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.
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| Ono Y, Fukuhara N, Yoshie O.
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| Mol Cell Biol 18(12):6939-50. 1998
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| 20 | ALDH1A2
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| Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase.
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| Zhao D, McCaffery P, Ivins KJ, Neve RL, Hogan P, Chin WW, Drager UC.
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| Eur J Biochem 240(1):15-22. 1996
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| 21 | ALDH1A2
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| Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate.
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| Wang X, Penzes P, Napoli JL.
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| J Biol Chem 271(27):16288-93. 1996
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