Citations for
1AKR1C1, AKR1C2, AKR1C4
Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily.
Hara A, Endo S, Matsunaga T, Soda M, Yashiro K, El-Kabbani O.
J Biochem 162(5):371-379. doi: 10.1093/jb/mvx041. 2017
2AKR1C1, AKR1C4, AKR1D1
Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.
Rižner TL, Penning TM.
Steroids 79:49-63. doi: 10.1016/j.steroids.2013.10.012. Epub 2013 Nov 1. Review. 2014
3AKR1C4
Polymorphisms in AKR1C4 and HSD3B2 and differences in serum DHEAS and progesterone are associated with paranoid ideation during mania or hypomania in bipolar disorder.
Johansson AG, Nikamo P, Schalling M, Landén M.
Eur Neuropsychopharmacol 22(9):632-40. doi: 10.1016/j.euroneuro.2012.01.007. Epub 2012 Feb 21. 2012
4AKR1C1, AKR1C4
Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.
Jin Y, Mesaros AC, Blair IA, Penning TM.
Biochem J 437(1):53-61. doi: 10.1042/BJ20101804. 2011
5AKR1C4, AKR1D1
Structure-activity relationships of human AKR-type oxidoreductases involved in bile acid synthesis: AKR1D1 and AKR1C4.
Lee WH, Lukacik P, Guo K, Ugochukwu E, Kavanagh KL, Marsden B, Oppermann U.
Mol Cell Endocrinol 301(1-2):199-204. doi: 10.1016/j.mce.2008.09.042. Epub 2008 Oct 22. 2009
6AKR1C1, AKR1C2, AKR1C3, AKR1C4, AKR1C@, AKRC@
Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.
Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K.
Biochem J 351(Pt 1):67-77. 2000
7AKR1A1, AKR1B1, AKR1C1, AKR1C4, AKR1C@, AKR7A2
Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members.
O'connor T, Ireland LS, Harrison DJ, Hayes JD.
Biochem J 343 Pt 2:487-504 1999
8AKR1C1, AKR1C2, AKR1C3, AKR1C4, AKR1C@
Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2)and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chainreaction and fluorescence in situ hybridization.
Khanna M, et al.
Genomics 25 : 588-590. 1995
9AKR1C3, AKR1C4
Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.
Khanna M, et al.
J Biol Chem 270(34):20162-8. 1995
10AKR1C1, AKR1C2, AKR1C3, AKR1C4
Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.
Qin KN, et al.
J Steroid Biochem Mol Biol 46(6):673-9. 1993