| 1 | AIFM1, CHCHD4
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| Haploinsufficiency in the mitochondrial protein CHCHD4 reduces brain injury in a mouse model of neonatal hypoxia-ischemia.
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| Sun Y, Li T, Xie C, Xu Y, Zhou K, Rodriguez J, Han W, Wang X, Kroemer G, Modjtahedi N, Blomgren K, Zhu C.
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| Cell Death Dis 8(5):e2781. doi: 10.1038/cddis.2017.196.
2017
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| 2 | AIFM1, PPIA
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| Structural and biochemical insights of CypA and AIF interaction.
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| Farina B, Di Sorbo G, Chambery A, Caporale A, Leoni G, Russo R, Mascanzoni F, Raimondo D, Fattorusso R, Ruvo M, Doti N.
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| Sci Rep 7(1):1138. doi: 10.1038/s41598-017-01337-8.
2017
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| 3 | AIFM1, BST2
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| CD317 Promotes the survival of cancer cells through apoptosis-inducing factor.
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| Li X, Zhang G, Chen Q, Lin Y, Li J, Ruan Q, Chen Y, Yu G, Wan X.
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| J Exp Clin Cancer Res 35(1):117. doi: 10.1186/s13046-016-0391-2.
2016
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| 4 | AIFM1, CHCHD4
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| CHCHD4 links AIF to the biogenesis of respiratory chain complex I.
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| Modjtahedi N, Kroemer G.
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| Mol Cell Oncol 3(2):e1074332. doi: 10.1080/23723556.2015.1074332. eCollection 2016 Mar.
2015
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| 5 | AIFM1, CHCHD4
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| Metabolic epistasis among apoptosis-inducing factor and the mitochondrial import factor CHCHD4.
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| Modjtahedi N, Hangen E, Gonin P, Kroemer G.
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| Cell Cycle 14(17):2743-7. doi: 10.1080/15384101.2015.1068477. Epub 2015 Jul 15.
2015
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| 6 | AIFM1, CHCHD4
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| Loss of apoptosis-inducing factor critically affects MIA40 function.
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| Meyer K, Buettner S, Ghezzi D, Zeviani M, Bano D, Nicotera P.
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| Cell Death Dis 6:e1814. doi: 10.1038/cddis.2015.170.
2015
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| 7 | AIFM1, CHCHD4
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| Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis.
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| Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam NV, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini JL, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N.
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| Mol Cell 58(6):1001-14. doi: 10.1016/j.molcel.2015.04.020. Epub 2015 May 21.
2015
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| 8 | AIFM1, RAD23A
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| Human RAD23 homolog A is required for the nuclear translocation of apoptosis-inducing factor during induction of cell death.
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| Sudhakar JN, Chow KC.
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| Biol Cell 106(10):359-76. doi: 10.1111/boc.201400013. Epub 2014 Sep 11.
2014
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| 9 | AIFM1, PPIA
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| Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress.
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| Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C.
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| Cell Death Dis 5:e993. doi: 10.1038/cddis.2013.518.
2014
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| 10 | AIFM1, AKIP1
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| AKIP1, a cardiac hypertrophy induced protein that stimulates cardiomyocyte growth via the Akt pathway.
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| Yu H, Tigchelaar W, Lu B, van Gilst WH, de Boer RA, Westenbrink BD, Silljé HH.
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| Int J Mol Sci 14(11):21378-93. doi: 10.3390/ijms141121378.
2013
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| 11 | AIFM1, NAMSD
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| Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.
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| Rinaldi C, Grunseich C, Sevrioukova IF, Schindler A, Horkayne-Szakaly I, Lamperti C, Landouré G, Kennerson ML, Burnett BG, Bönnemann C, Biesecker LG, Ghezzi D, Zeviani M, Fischbeck KH.
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| Am J Hum Genet 91(6):1095-102. doi: 10.1016/j.ajhg.2012.10.008.
2012
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| 12 | AIFM1
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| A role for apoptosis-inducing factor in T cell development.
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| Banerjee H, Das A, Srivastava S, Mattoo HR, Thyagarajan K, Khalsa JK, Tanwar S, Das DS, Majumdar SS, George A, Bal V, Durdik JM, Rath S.
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| J Exp Med 209(9):1641-53. doi: 10.1084/jem.20110306. Epub 2012 Aug 6.
2012
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| 13 | AIFM1, BNIP3
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| Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
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| Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S.
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| J Cell Biol 198(1):103-14. doi: 10.1083/jcb.201111063. Epub 2012 Jul 2.
2012
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| 14 | AIFM1, NCOA1
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| Steroid receptor coactivator-interacting protein (SIP) inhibits caspase-independent apoptosis by preventing apoptosis-inducing factor (AIF) from being released from mitochondria.
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| Wang D, Liang J, Zhang Y, Gui B, Wang F, Yi X, Sun L, Yao Z, Shang Y.
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| J Biol Chem 287(16):12612-21. doi: 10.1074/jbc.M111.334151. Epub 2012 Feb 27.
2012
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| 15 | AIFM1
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| An alternative import pathway of AIF to the mitochondria.
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| Chiang SF, Huang CY, Lin TY, Chiou SH, Chow KC.
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| Int J Mol Med 29(3):365-72. doi: 10.3892/ijmm.2011.849. Epub 2011 Nov 29.
2012
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| 16 | AIFM1, BNIP3
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| Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis.
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| Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S.
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| J Cell Biol 198(1):103-14. doi: 10.1083/jcb.201111063. Epub 2012 Jul 2. Erratum in: J Cell Biol. 2013 Apr 1;201(1):165.
2012
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| 17 | AIFM1
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| Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion.
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| Choudhury S, Bae S, Ke Q, Lee JY, Kim J, Kang PM.
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| Basic Res Cardiol 106(3):397-407. doi: 10.1007/s00395-011-0164-1. Epub 2011 Mar 9.
2011
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| 18 | AIFM1, STUB1, USP2
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| Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme.
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| Oh KH, Yang SW, Park JM, Seol JH, Iemura S, Natsume T, Murata S, Tanaka K, Jeon YJ, Chung CH.
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| Cell Death Differ 18(8):1326-36. doi: 10.1038/cdd.2011.3. Epub 2011 Feb 4.
2011
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| 19 | AIFM1, COXPD6
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| Severe X-linked mitochondrial encephalomyopathy associated with a mutation in apoptosis-inducing factor.
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| Ghezzi D, Sevrioukova I, Invernizzi F, Lamperti C, Mora M, D'Adamo P, Novara F, Zuffardi O, Uziel G, Zeviani M.
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| Am J Hum Genet 86(4):639-49. Epub 2010 Apr 1.PMID: 20362274 2010
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| 20 | AIFM1
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| AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX.
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| Artus C, Boujrad H, Bouharrour A, Brunelle MN, Hoos S, Yuste VJ, Lenormand P, Rousselle JC, Namane A, England P, Lorenzo HK, Susin SA.
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| EMBO J 29(9):1585-99. doi: 10.1038/emboj.2010.43. Epub 2010 Apr 1.
2010
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| 21 | AIFM1, HDAC2, HTRA1, LGALS9, MX1, NR4A2, PRDX2, TFNA13, UNC5D
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| Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy.
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| Colak D, Kaya N, Al-Zahrani J, Al Bakheet A, Muiya P, Andres E, Quackenbush J, Dzimiri N.
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| Genomics 94(1):20-31. Epub 2009 Mar 28.
2009
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| 22 | AIFM1
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| Changes of mitochondria and relocation of the apoptosis-inducing factor during apoptosis.
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| Scovassi AI, Soldani C, Veneroni P, Bottone MG, Pellicciari C.
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| Ann N Y Acad Sci 1171:12-7.PMID: 19723032 2009
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| 23 | AIFM1
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| AIF: not just an apoptosis-inducing factor.
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| Joza N, Pospisilik JA, Hangen E, Hanada T, Modjtahedi N, Penninger JM, Kroemer G.
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| Ann N Y Acad Sci 1171:2-11. Review.PMID: 19723031 2009
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| 24 | AIFM1
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| Deletion of the mitochondrial flavoprotein apoptosis inducing factor (AIF) induces beta-cell apoptosis and impairs beta-cell mass.
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| Schulthess FT, Katz S, Ardestani A, Kawahira H, Georgia S, Bosco D, Bhushan A, Maedler K.
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| PLoS One 4(2):e4394. Epub 2009 Feb 6.PMID: 19197367 2009
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| 25 | AIFM1
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| An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death.
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| Norberg E, Gogvadze V, Ott M, Horn M, Uhlén P, Orrenius S, Zhivotovsky B.
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| Cell Death Differ 15(12):1857-64. Epub 2008 Sep 19.
2008
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| 26 | AIFM1, BAG6
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| Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis.
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| Desmots F, Russell HR, Michel D, McKinnon PJ.
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| J Biol Chem 283(6):3264-71. Epub 2007 Dec 3.PMID: 18056262 2008
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| 27 | AIFM1, XIAP
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| Apoptosis-inducing factor is a target for ubiquitination through interaction with XIAP.
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| Wilkinson JC, Wilkinson AS, Galbán S, Csomos RA, Duckett CS.
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| Mol Cell Biol 28(1):237-47. Epub 2007 Oct 29.PMID: 17967870 2008
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| 28 | AIFM1, SUPV3L1
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| Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway.
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| Szczesny RJ, Obriot H, Paczkowska A, Jedrzejczak R, Dmochowska A, Bartnik E, Formstecher P, Polakowska R, Stepien PP.
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| Biol Cell 99(6):323-32. 2007
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| 29 | AIFM1, ENDOG, BAX
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| The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways.
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| Whiteman M, Chu SH, Siau JL, Rose P, Sabapathy K, Schantz JT, Cheung NS, Spencer JP, Armstrong JS.
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| Cell Signal 19(4):705-14. Epub 2006 Nov 14. 2007
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| 30 | AIFM1, UBASH3A
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| T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.
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| Collingwood TS, Smirnova EV, Bogush M, Carpino N, Annan RS, Tsygankov AY.
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| J Biol Chem 282(42):30920-8. Epub 2007 Aug 20.PMID: 17709377 2007
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| 31 | AIFM1, EIF3G, CASP7
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| Apoptosis-inducing factor (AIF) inhibits protein synthesis by interacting with the eukaryotic translation initiation factor 3 subunit p44 (eIF3g).
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| Kim JT, Kim KD, Song EY, Lee HG, Kim JW, Kim JW, Chae SK, Kim E, Lee MS, Yang Y, Lim JS.
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| FEBS Lett 580(27):6375-83. Epub 2006 Nov 3. 2006
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| 32 | AIFM1
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| Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death.
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| Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zuniga-Pflucker JC, Kroemer G, Penninger JM.
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| Nature 410(6828):549-54. 2001
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| 33 | AIFM1
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| Apoptosis-inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis.
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| Daugas E, Nochy D, Ravagnan L, Loeffler M, Susin SA, Zamzami N, Kroemer G.
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| FEBS Lett 476(3):118-23. Review. 2000
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| 34 | APAF1, CAD, AIFM1
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| Apoptosis. A cellular poison cupboard.
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| Earnshaw WC.
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| Nature 397 : 387-389. 1999
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| 35 | AIFM1
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| Molecular characterization of mitochondrial apoptosis-inducing factor.
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| Susin SA, et al.
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| Nature 397(6718):441-6. 1999
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| 36 | AIFM1
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| Mitochondrial release of caspase-2 and -9 during the apoptotic process.
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| Susin SA, Lorenzo HK, Zamzami N, Marzo I, Brenner C, Larochette N, Prevost MC, Alzari PM, Kroemer G.
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| J Exp Med 189(2):381-94. 1999
|