Citations for
1AGTR1, APLNR
Stretch-Induced Biased Signaling in Angiotensin II Type 1 and Apelin Receptors for the Mediation of Cardiac Contractility and Hypertrophy.
Seo K, Parikh VN, Ashley EA.
Front Physiol 11:181. doi: 10.3389/fphys.2020.00181. eCollection 2020. Review. 2020
2AGTR1, AGTR2
Structural basis for selectivity and diversity in angiotensin II receptors.
Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Babaoglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V.
Nature 544(7650):327-332. doi: 10.1038/nature22035. Epub 2017 Apr 5. 2017
3AGTR1, ATP1A1
Low dose ouabain stimulates NaK ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells.
Ketchem CJ, Conner CD, Murray RD, DuPlessis M, Lederer ED, Wilkey D, Merchant M, Khundmiri SJ.
Biochim Biophys Acta 1863(11):2624-2636. doi: 10.1016/j.bbamcr.2016.07.008. Epub 2016 Aug 3. Erratum in: Biochim Biophys Acta. 2017 Oct;1864(10 ):192 2016
4AGTR1, AGTR2, IRF1
Interferon regulatory factor 1 attenuates vascular remodeling; roles of angiotensin II type 2 receptor.
Nakaoka H, Mogi M, Suzuki J, Kan-No H, Min LJ, Iwanami J, Horiuchi M.
J Am Soc Hypertens 10(10):811-818. doi: 10.1016/j.jash.2016.07.005. Epub 2016 Aug 4. 2016
5AGTR1, AGTR2
Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration.
Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, Perez-Costas E, Villar-Cheda B, Garrido-Gil P, Melendez-Ferro M, Soto-Otero R, Lanciego JL, Henrion D, Franco R, Labandeira-Garcia JL.
Cell Death Dis 7(10):e2427. doi: 10.1038/cddis.2016.327. 2016
6AGTR1, AGTR2
Attenuation of ligand-induced activation of angiotensin II type 1 receptor signaling by the type 2 receptor via protein kinase C.
Inuzuka T, Fujioka Y, Tsuda M, Fujioka M, Satoh AO, Horiuchi K, Nishide S, Nanbo A, Tanaka S, Ohba Y.
Sci Rep 6:21613. doi: 10.1038/srep21613. 2016
7AGTR1, DRD4
Activation of the D4 dopamine receptor attenuates proliferation and migration of vascular smooth muscle cells through downregulation of AT1a receptor expression.
Yu C, Chen J, Guan W, Han Y, Wang WE, Wang X, Wang H, Jose PA, Zeng C.
Hypertens Res 38(9):588-96. doi: 10.1038/hr.2015.48. Epub 2015 Apr 2. 2015
8AGTR1, SND1
Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFβ signaling.
Santhekadur PK, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson CL, Mukhopadhyay ND, Fisher PB, Sarkar D.
FEBS Open Bio 4:353-61. doi: 10.1016/j.fob.2014.03.012. eCollection 2014. 2014
9AGTR1, GRK4
Role of GRK4 in the regulation of arterial AT1 receptor in hypertension.
Chen K, Fu C, Chen C, Liu L, Ren H, Han Y, Yang J, He D, Zhou L, Yang Z, Zhang L, Jose PA, Zeng C.
Hypertension 63(2):289-96. doi: 10.1161/HYPERTENSIONAHA.113.01766. Epub 2013 Nov 11. 2014
10AGTR1, AGTR2
Association of angiotensin II type I and type II receptor genes polymorphisms with the presence of premature coronary disease and metabolic syndrome.
Abd El-Aziz TA, Mohamed RH, Rezk NA.
Mol Biol Rep 41(2):1027-33. doi: 10.1007/s11033-013-2947-y. Epub 2014 Jan 3. 2014
11AGTR1, CREB1
NF-κB and CREB are required for angiotensin II type 1 receptor upregulation in neurons.
Haack KK, Mitra AK, Zucker IH.
PLoS One 8(11):e78695. doi: 10.1371/journal.pone.0078695. eCollection 2013. 2013
12AGTR1
Stimulation of angiotensin type 1A receptors on catecholaminergic cells contributes to angiotensin-dependent hypertension.
Jancovski N, Bassi JK, Carter DA, Choong YT, Connelly A, Nguyen TP, Chen D, Lukoshkova EV, Menuet C, Head GA, Allen AM.
Hypertension 62(5):866-71. doi: 10.1161/HYPERTENSIONAHA.113.01474. Epub 2013 Sep 3. 2013
13AGTR1
Essential role of angiotensin receptors in the modulation of intestinal epithelial cell apoptosis.
Wang W, Sun L, Xiao W, Yang H.
J Pediatr Gastroenterol Nutr 57(5):562-9. doi: 10.1097/MPG.0b013e31829f1336. 2013
14AGTR1
Two distinct calmodulin binding sites in the third intracellular loop and carboxyl tail of angiotensin II (AT(1A)) receptor.
Zhang R, Liu Z, Qu Y, Xu Y, Yang Q.
PLoS One 8(6):e65266. doi: 10.1371/journal.pone.0065266. Print 2013. 2013
15AGTR1
Angiotensin II activates NF-κB through AT1A receptor recruitment of β-arrestin in cultured rat vascular smooth muscle cells.
Morinelli TA, Lee MH, Kendall RT, Luttrell LM, Walker LP, Ullian ME.
Am J Physiol Cell Physiol 304(12):C1176-86. doi: 10.1152/ajpcell.00235.2012. Epub 2013 Apr 10. 2013
16AGTR1
The angiotensin II type 1 receptor C-terminal Lys residues interact with tubulin and modulate receptor export trafficking.
Zhang X, Wang H, Duvernay MT, Zhu S, Wu G.
PLoS One 8(2):e57805. doi: 10.1371/journal.pone.0057805. Epub 2013 Feb 25. 2013
17AGTR1, AGTR2
Angiotensin II modulates VEGF-driven angiogenesis by opposing effects of type 1 and type 2 receptor stimulation in the microvascular endothelium.
Carbajo-Lozoya J, Lutz S, Feng Y, Kroll J, Hammes HP, Wieland T.
Cell Signal 24(6):1261-9. Epub 2012 Feb 20. 2012
18ACE, AGT, AGTR1, REN, RTD1, RTD2, RTD3, RTD4
Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis.
Gribouval O, Morinière V, Pawtowski A, Arrondel C, Sallinen SL, Saloranta C, Clericuzio C, Viot G, Tantau J, Blesson S, Cloarec S, Machet MC, Chitayat D, Thauvin C, Laurent N, Sampson JR, Bernstein JA, Clemenson A, Prieur F, Daniel L, Levy-Mozziconacci A, Lachlan K, Alessandri JL, Cartault F, Rivière JP, Picard N, Baumann C, Delezoide AL, Belar Ortega M, Chassaing N, Labrune P, Yu S, Firth H, Wellesley D, Bitzan M, Alfares A, Braverman N, Krogh L, Tolmie J, Gaspar H, Doray B, Majore S, Bonneau D, Triau S, Loirat C, David A, Bartholdi D, Peleg A, Brackman D, Stone R, DeBerardinis R, Corvol P, Michaud A, Antignac C, Gubler MC.
Hum Mutat 33(2):316-26. doi: 10.1002/humu.21661. Epub 2011 Dec 22. Review. 2012
19AGTR1, ARAP1
Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II.
Doblinger E, Höcherl K, Mederle K, Kattler V, Walter S, Hansen PB, Jensen B, Castrop H.
Am J Physiol Renal Physiol 302(10):F1313-24. doi: 10.1152/ajprenal.00620.2011. Epub 2012 Feb 22. 2012
20AGTR1
Parallel changes in neuronal AT1R and GRK5 expression following exercise training in heart failure.
Haack KK, Engler CW, Papoutsi E, Pipinos II, Patel KP, Zucker IH.
Hypertension 60(2):354-61. doi: 10.1161/HYPERTENSIONAHA.112.195693. Epub 2012 Jul 2. 2012
21AGTR1
A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension.
Zhang JD, Patel MB, Song YS, Griffiths R, Burchette J, Ruiz P, Sparks MA, Yan M, Howell DN, Gomez JA, Spurney RF, Coffman TM, Crowley SD.
Circ Res 110(12):1604-17. doi: 10.1161/CIRCRESAHA.111.261768. Epub 2012 Apr 24. 2012
22AGTR1, AGTR2
Identification and characterization of a functional mitochondrial angiotensin system.
Abadir PM, Foster DB, Crow M, Cooke CA, Rucker JJ, Jain A, Smith BJ, Burks TN, Cohn RD, Fedarko NS, Carey RM, O'Rourke B, Walston JD.
Proc Natl Acad Sci U S A 108(36):14849-54. Epub 2011 Aug 18. 2011
23AGTR1, AGTR2
Angiotensin II receptors modulate muscle microvascular and metabolic responses to insulin in vivo.
Chai W, Wang W, Dong Z, Cao W, Liu Z.
Diabetes 60(11):2939-46. Epub 2011 Sep 6. 2011
24AGTR1
Angiotensin II-induced upregulation of AT(1) receptor expression: sequential activation of NF-kappaB and Elk-1 in neurons.
Mitra AK, Gao L, Zucker IH.
Am J Physiol Cell Physiol 299(3):C561-9. Epub 2010 Jun 16.PMID: 20554912 2010
25AGT, AGTR1
Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway.
Zhao Y, Chen X, Cai L, Yang Y, Sui G, Fu S.
J Cell Physiol 225(1):168-73.PMID: 20458733 2010
26AGTR1, AGTR2
Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human.
Williams PJ, Mistry HD, Innes BA, Bulmer JN, Pipkin FB.
Placenta 31(5):448-55. Epub 2010 Mar 20.PMID: 20304486 2010
27AGTR1
The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase.
Godin CM, Ferguson SS.
Mol Pharmacol 77(6):903-11. Epub 2010 Feb 24.PMID: 20181817 2010
28AGTR1, AGTR2
Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum.
Mertens B, Vanderheyden P, Michotte Y, Sarre S.
Neuropharmacology 58(7):1038-44. Epub 2010 Jan 26.PMID: 20097214 2010
29AGTR1
Analysis of transmembrane domains 1 and 4 of the human angiotensin II AT1 receptor by cysteine-scanning mutagenesis.
Yan L, Holleran BJ, Lavigne P, Escher E, Guillemette G, Leduc R.
J Biol Chem 285(4):2284-93. Epub 2009 Nov 23.PMID: 19940150 2010
30AGTR1, CETP, EPAS1, GP1BA, IHH, TBX5
Genetic contributions to the development of retinopathy of prematurity.
Mohamed S, Schaa K, Cooper ME, Ahrens E, Alvarado A, Colaizy T, Marazita ML, Murray JC, Dagle JM.
Pediatr Res 65(2):193-7. 2009
31AGTR1, EDNRB
Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease.
Dimitrijevic I, Edvinsson ML, Chen Q, Malmsjö M, Kimblad PO, Edvinsson L.
BMC Cardiovasc Disord 9:40.PMID: 19706169 2009
32AGTR1
Role of angiotensin II type 1 receptor in cerebral aneurysm formation in rats.
Aoki T, Nishimura M, Kataoka H, Ishibashi R, Miyake T, Takagi Y, Morishita R, Hashimoto N.
Int J Mol Med 24(3):353-9.PMID: 19639227 2009
33AGT, AGTR1
Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging.
Modrick ML, Didion SP, Sigmund CD, Faraci FM.
Am J Physiol Heart Circ Physiol 296(6):H1914-9. Epub 2009 Apr 24.PMID: 19395552 2009
34AGT, AGTR1, AGTR2
Neuronal and glial cell expression of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in the rat retina.
Downie LE, Vessey K, Miller A, Ward MM, Pianta MJ, Vingrys AJ, Wilkinson-Berka JL, Fletcher EL.
Neuroscience 161(1):195-213. Epub 2009 Mar 17.PMID: 19298848 2009
35AGTR1, DRD5
Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells.
Li H, Armando I, Yu P, Escano C, Mueller SC, Asico L, Pascua A, Lu Q, Wang X, Villar VA, Jones JE, Wang Z, Periasamy A, Lau YS, Soares-da-Silva P, Creswell K, Guillemette G, Sibley DR, Eisner G, Gildea JJ, Felder RA, Jose PA.
J Clin Invest 118(6):2180-9. Erratum in: J Clin Invest. 2008 Aug;118(8):2986. Gildea, John J [added]. PMID: 18464932 2008
36AGTR1, SIRT1
SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells.
Miyazaki R, Ichiki T, Hashimoto T, Inanaga K, Imayama I, Sadoshima J, Sunagawa K.
Arterioscler Thromb Vasc Biol 28(7):1263-9. Epub 2008 Apr 17.PMID: 18420994 2008
37RTD1, AGT, AGTR1, ACE, RTD2, REN, RTD4, RTD3
Inherited renal tubular dysgenesis: the first patients surviving the neonatal period.
Zingg-Schenk A, Bacchetta J, Corvol P, Michaud A, Stallmach T, Cochat P, Gribouval O, Gubler MC, Neuhaus TJ.
Eur J Pediatr [Epub ahead of print] 2007
38AGTR1, CYP11B2, AGT, CMA1, ACE
RAAS gene polymorphisms influence progression of pediatric hypertrophic cardiomyopathy.
Kaufman BD, Auerbach S, Reddy S, Manlhiot C, Deng L, Prakash A, Printz BF, Gruber D, Papavassiliou DP, Hsu DT, Sehnert AJ, Chung WK, Mital S.
Hum Genet 122(5):515-23. Epub 2007 Sep 13. 2007
39AGTR1, TRI21
Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes.
Sethupathy P, Borel C, Gagnebin M, Grant GR, Deutsch S, Elton TS, Hatzigeorgiou AG, Antonarakis SE.
Am J Hum Genet 81(2):405-13. Epub 2007 Jul 12. 2007
40AGTR1
Altered transmission of maternal angiotensin II receptor haplotypes in fetal growth restriction.
Tower C, Chappell S, Acharya M, Crane R, Szolin S, Symonds L, Chevins H, Kalsheker N, Baker P, Morgan L.
Hum Mutat 27(2):138-44. 2006
41AGTR1, RTD3, AGTR2
Angiotensin II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic scars.
Liu HW, Cheng B, Yu WL, Sun RX, Zeng D, Wang J, Liao YX, Fu XB.
Life Sci 79(5):475-83. Epub 2006 Mar 7. 2006
42ACE, ACE2, AGTR2, AGTR1
Angiotensin-converting enzyme 2 protects from severe acute lung failure.
Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower MA, Fukamizu A, Hui CC, Hein L, Uhlig S, Slutsky AS, Jiang C, Penninger JM.
Nature 436(7047):112-6. 2005
43RTD1, AGT, AGTR1, ACE, RTD2, REN, RTD4, RTD3
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.
Gribouval O, Gonzales M, Neuhaus T, Aziza J, Bieth E, Laurent N, Bouton JM, Feuillet F, Makni S, Ben Amar H, Laube G, Delezoide AL, Bouvier R, Dijoud F, Ollagnon-Roman E, Roume J, Joubert M, Antignac C, Gubler MC.
Nat Genet 37(9):964-8. Epub 2005 Aug 14. 2005
44AGTR1, RTD3
Renin-angiotensin system and haemostasis gene polymorphisms and outcome after coronary artery bypass graft surgery.
Volzke H, Kleine V, Robinson DM, Grimm R, Hertwig S, Schwahn C, Eckel L, Rettig R.
Int J Cardiol 98(1):133-9. 2005
45AGTR1, AGTR2
Haplotypes of the angiotensin II receptor genes AGTR1 and AGTR2 in women with normotensive pregnancy and women with preeclampsia.
Plummer S, Tower C, Alonso P, Morgan L, Baker P, Broughton-Pipkin F, Kalsheker N.
Hum Mutat 24(1):14-20. 2004
46AGTR1
Identification, distribution, and expression of angiotensin II receptors in the normal human prostate and benign prostatic hyperplasia.
Dinh DT, Frauman AG, Sourial M, Casley DJ, Johnston CI, Fabiani ME.
Endocrinology 142(3):1349-56. 2001
47AGTR1
Identification and characterization of functional angiotensin II type 1 receptors on immortalized human fetal aortic vascular smooth muscle cells
Martin MM, Victor X, Zhao X, McDougall JK, Elton TS.
Mol Cell Endocrinol 183(1-2):81-91. 2001
48AGTR1
Angiotensin II type 1 receptor gene polymorphism and the response to hyperglycemia in early type 1 diabetes.
Miller JA, Thai K, Scholey JW.
Diabetes 49(9):1585-9. 2000
49AGTR1, AGTR2
Molecular biology and signaling of angiotensin receptors: an overview.
Inagami T.
J Am Soc Nephrol 10 Suppl 11:S2-7. Review. 1999
50AGTR1, AGTR2
Localization of angiotensin AT1 and AT2 receptors.
Allen AM, et al.
J Am Soc Nephrol 10 Suppl 11:S23-9. Review. 1999
51ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
Sequence diversity in 36 candidate genes for cardiovascular disorders.
Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
Am J Hum Genet 65(1):183-91. 1999
52AGT, AGTR1, ACE
A multilocus genotyping assay for candidate markers of cardiovascular disease risk.
Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, Kane JP.
Genome Res 9(10):936-49 1999
53AGTR1
Characterization of polymorphisms in the promoter of the human angiotensin II subtype 1 (AT1) receptor gene.
Erdmann J, Riedel K, Rohde K, Folgmann I, Wienker T, Fleck E, Regitz-Zagrosek V.
Ann Hum Genet 63:369-374 1999
54AGTR1, IDDM9
Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q : results of novel discordant sib-pair analysis.
Moczulski DK, et al.
Diabetes 47 : 1164-1169. 1998
55AGTR1, AGTR2
Genetic deletion and overexpression of angiotensin II receptors.
Hein L.
J Mol Med 76 : 756-763. 1998
56AGTR1, ACE
Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphisms : association with early coronary disease.
Alvarez R, et al.
Cardiovasc Res 40 : 375-379. 1998
57AGTR1
AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy.
Osterop AP, et al.
Hypertension 32 : 825-830. 1998
58AGTR1, ACE
Mapping tissue angiotensin-converting enzyme and angiotensin AT1, AT2 and AT4 receptors.
Zhuo J, et al.
J Hypertens 16(12 Pt 2):2027-37. 1998
59AGT, AGTR1, ACE
Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease : the CORGENE study.
Jeunemaitre X, et al.
Hum Genet 99 : 66-73. 1997
60AGTR1
A DNA polymorphism at the angiotensin II type 1 receptor (AT1R) locus and myocardial infarction.
Berge KE, Bakken A, Bohn M, Erikssen J, Berg K.
Clin Genet 52(2):71-6. 1997
61AGTR1, AGTR2
Molecular biology of angiotensin receptors and their role in human cardiovascular disease.
Regitz-Zagrosek V, et al.
J Mol Med 74 : 233-251. 1996
62AGTR1
MnlI polymorphism for the AGTR1 gene.
Rolfs A, et al.
Hum Mol Genet 3 : 213. 1994
63AGTR1
Angiotensin II (type-1) receptor locus : CA repeat polymorphism and genetic mapping.
Davies E, et al.
Hum Mol Genet 3 : 838. 1994
64AGTR1
Ddel polymorphism in the AGTR1 gene.
Doria A, et al.
Hum Mol Genet 3 : 1444. 1994
65AGTR1
Angiotensin II type 1 receptor gene abnormality in a patient with Bartter's syndrome.
Yoshida H, et al.
Kidney Int 46 : 1505-1509. 1994
66AGTR1
Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension.
Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, Tiret L, Cambien F, Corvol P, Soubrier F.
Hypertension 24(1):63-9 1994
67AGTR1
Novel subtype of human angiotensin II type 1 receptor: cDNA cloning and expression.
Konishi H, Kuroda S, Inada Y, Fujisawa Y.
Biochem Biophys Res Commun 199(2):467-74. 1994
68AGTR1, ACSM3
Chromosomal assignment of human and rat hypertension candidate genes : type 1 angiotensin II receptor genes and the SA gene.
Szpirer C, et al.
J Hypertens 11 : 919-925. 1993
69AGTR1
Genetic analysis of the human type-1 angiotensin II receptor.
Curnow KM, et al.
Mol Endocrinol 6 : 1113-1118. 1992
70AGTR1
Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor.
Mauzy CA, Hwang O, Egloff AM, Wu LH, Chung FZ.
Biochem Biophys Res Commun 186(1):277-84. 1992