| 1 | AGT, AGTR1, ARHGDIA
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| RhoGDI stability is regulated by SUMOylation and ubiquitination via the AT1 receptor and participates in Ang II-induced smooth muscle proliferation and vascular remodeling
|
| Dai F, Qi Y, Guan W, Meng G, Liu Z, Zhang T, Yao W.
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| Atherosclerosis. Sep;288:124-136. doi: 10.1016/j.atherosclerosis.2019.07.010. Epub 2019 Jul 23 2019
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| 2 | AGT, ERAP1, ERP44
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| ERp44 Exerts Redox-Dependent Control of Blood Pressure at the ER.
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| Hisatsune C, Ebisui E, Usui M, Ogawa N, Suzuki A, Mataga N, Takahashi-Iwanaga H, Mikoshiba K.
|
| Mol Cell 58(6):1015-27. doi: 10.1016/j.molcel.2015.04.008. Epub 2015 May 7.
2015
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| 3 | AGT, CEBPA
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| Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene.
|
| Wang F, Demura M, Cheng Y, Zhu A, Karashima S, Yoneda T, Demura Y, Maeda Y, Namiki M, Ono K, Nakamura Y, Sasano H, Akagi T, Yamagishi M, Saijoh K, Takeda Y.
|
| Hypertension 63(2):281-8. doi: 10.1161/HYPERTENSIONAHA.113.02303. Epub 2013 Nov 4.
2014
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| 4 | AGT, MSR1
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| Class A scavenger receptor deficiency augments angiotensin II-induced vascular remodeling.
|
| Qian L, Li X, Fang R, Wang Z, Xu Y, Zhang H, Bai H, Yang Q, Zhu X, Ben J, Xu Y, Chen Q.
|
| Biochem Pharmacol 90(3):254-64. doi: 10.1016/j.bcp.2014.05.015. Epub 2014 May 27.
2014
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| 5 | AGT, CAV1
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| Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase.
|
| Takayanagi T, Crawford KJ, Kobayashi T, Obama T, Tsuji T, Elliott KJ, Hashimoto T, Rizzo V, Eguchi S.
|
| Clin Sci (Lond) 126(11):785-94. doi: 10.1042/CS20130660.
2014
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| 6 | AGT, RGN
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| Senescence marker protein 30 inhibits angiotensin II-induced cardiac hypertrophy and diastolic dysfunction.
|
| Misaka T, Suzuki S, Miyata M, Kobayashi A, Ishigami A, Shishido T, Saitoh S, Kubota I, Takeishi Y.
|
| Biochem Biophys Res Commun 439(1):142-7. doi: 10.1016/j.bbrc.2013.08.002. Epub 2013 Aug 9.
2013
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| 7 | ACE, AGT
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| The influence of Angiotensin converting enzyme and angiotensinogen gene polymorphisms on hypertrophic cardiomyopathy.
|
| Luo R, Li X, Wang Y, Li Y, Deng Y, Wan Y, Jiang Z, Hua W, Wu X.
|
| PLoS One 8(10):e77030. doi: 10.1371/journal.pone.0077030. eCollection 2013. Review.
2013
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| 8 | AGT
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| Association of angiotensinogen gene polymorphisms and angiogenic factors with preeclampsia in Chinese women.
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| Song C, Xie S, Wang J, Lian J, Diao B, Tang Y.
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| Gynecol Obstet Invest 76(1):64-8. doi: 10.1159/000352070. Epub 2013 Jul 13.
2013
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| 9 | AGT
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| Melatonin ameliorates angiotensin II-induced vascular endothelial damage via its antioxidative properties.
|
| Nakao T, Morita H, Maemura K, Amiya E, Inajima T, Saito Y, Watanabe M, Manabe I, Kurabayashi M, Nagai R, Komuro I.
|
| J Pineal Res 55(3):287-93. doi: 10.1111/jpi.12071. Epub 2013 Jul 1.
2013
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| 10 | AGT
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| Angiotensin II contributes to diabetic renal dysfunction in rodents and humans via Notch1/Snail pathway.
|
| Gagliardini E, Perico N, Rizzo P, Buelli S, Longaretti L, Perico L, Tomasoni S, Zoja C, Macconi D, Morigi M, Remuzzi G, Benigni A.
|
| Am J Pathol 183(1):119-30. doi: 10.1016/j.ajpath.2013.03.025. Epub 2013 May 23.
2013
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| 11 | AGT, MMP9
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| Important role of the angiotensin II pathway in producing matrix metalloproteinase-9 in human thoracic aortic aneurysms.
|
| Nagasawa A, Yoshimura K, Suzuki R, Mikamo A, Yamashita O, Ikeda Y, Tsuchida M, Hamano K.
|
| J Surg Res 183(1):472-7. doi: 10.1016/j.jss.2012.12.012. Epub 2013 Jan 1.
2013
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| 12 | AGT
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| Association of angiotensinogen M235T gene polymorphism with end-stage renal disease risk: a meta-analysis.
|
| Zhou TB, Yin SS, Qin YH.
|
| Mol Biol Rep 40(2):765-72. doi: 10.1007/s11033-012-2114-x. Epub 2012 Oct 13.
2013
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| 13 | AGT, RPL27
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| Aldosterone and angiotensin II induce protein aggregation in renal proximal tubules.
|
| Cheema MU, Poulsen ET, Enghild JJ, Hoorn EJ, Fenton RA, Praetorius J.
|
| Physiol Rep. Sep;1(4):e00064. doi: 10.1002/phy2.64. Epub 2013 Sep 10. Erratum in: Physiol Rep. 2014 Feb 1;2(2):e00251. Hoorn, Ewout [correcte 2013
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| 14 | ACE, AGT, AGTR1, REN, RTD1, RTD2, RTD3, RTD4
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| Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis.
|
| Gribouval O, Morinière V, Pawtowski A, Arrondel C, Sallinen SL, Saloranta C, Clericuzio C, Viot G, Tantau J, Blesson S, Cloarec S, Machet MC, Chitayat D, Thauvin C, Laurent N, Sampson JR, Bernstein JA, Clemenson A, Prieur F, Daniel L, Levy-Mozziconacci A, Lachlan K, Alessandri JL, Cartault F, Rivière JP, Picard N, Baumann C, Delezoide AL, Belar Ortega M, Chassaing N, Labrune P, Yu S, Firth H, Wellesley D, Bitzan M, Alfares A, Braverman N, Krogh L, Tolmie J, Gaspar H, Doray B, Majore S, Bonneau D, Triau S, Loirat C, David A, Bartholdi D, Peleg A, Brackman D, Stone R, DeBerardinis R, Corvol P, Michaud A, Antignac C, Gubler MC.
|
| Hum Mutat 33(2):316-26. doi: 10.1002/humu.21661. Epub 2011 Dec 22. Review.
2012
|
| 15 | AGT, BGLAP
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| From skeleton to cytoskeleton: osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4.
|
| Yuen CY, Wong SL, Lau CW, Tsang SY, Xu A, Zhu Z, Ng CF, Yao X, Kong SK, Lee HK, Huang Y.
|
| Circ Res 111(3):e55-66. doi: 10.1161/CIRCRESAHA.112.271361. Epub 2012 Jun 7.
2012
|
| 16 | AGT, STAR
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| Angiotensin II-dependent transcriptional activation of human steroidogenic acute regulatory protein gene by a 25-kDa cAMP-responsive element modulator protein isoform and Yin Yang 1.
|
| Meier RK, Clark BJ.
|
| Endocrinology 153(3):1256-68. doi: 10.1210/en.2011-1744. Epub 2012 Jan 17.
2012
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| 17 | AGT
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| Angiotensin II increases the permeability and PV-1 expression of endothelial cells.
|
| Bodor C, Nagy JP, Végh B, Németh A, Jenei A, MirzaHosseini S, Sebe A, Rosivall L.
|
| Am J Physiol Cell Physiol 302(1):C267-76. doi: 10.1152/ajpcell.00138.2011. Epub 2011 Oct 19.
2012
|
| 18 | AGT, GATA6
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| Angiotensin II induces apoptosis in intestinal epithelial cells through the AT2 receptor, GATA-6 and the Bax pathway.
|
| Sun L, Wang W, Xiao W, Liang H, Yang Y, Yang H.
|
| Biochem Biophys Res Commun 424(4):663-8. doi: 10.1016/j.bbrc.2012.07.003. Epub 2012 Jul 7.
2012
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| 19 | AGT, FLT1, SYK
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| Angiotensin II-induced process of angiogenesis is mediated by spleen tyrosine kinase via VEGF receptor-1 phosphorylation.
|
| Buharalioglu CK, Song CY, Yaghini FA, Ghafoor HU, Motiwala M, Adris T, Estes AM, Malik KU.
|
| Am J Physiol Heart Circ Physiol 301(3):H1043-55. doi: 10.1152/ajpheart.01018.2010. Epub 2011 Jun 3.
2011
|
| 20 | AGT, ARHGEF1
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| The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.
|
| Guilluy C, Brégeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E, Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G.
|
| Nat Med 16(2):183-90. Epub 2010 Jan 24.PMID: 20098430 2010
|
| 21 | AGT, AGTR1
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| Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway.
|
| Zhao Y, Chen X, Cai L, Yang Y, Sui G, Fu S.
|
| J Cell Physiol 225(1):168-73.PMID: 20458733 2010
|
| 22 | AGT, HNF4A
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| A nuclear receptor, hepatocyte nuclear factor 4, differently contributes to the human and mouse angiotensinogen promoter activities.
|
| Oishi T, Date S, Shimamoto Y, Saito T, Hirota K, Sugaya T, Kon Y, Fukamizu A, Tanimoto K.
|
| J Recept Signal Transduct Res 30(6):484-92. Epub 2010 Aug 4.
2010
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| 23 | AGT, ELF3
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| The counter-regulatory effects of ESE-1 during angiotensin II-mediated vascular inflammation and remodeling.
|
| Zhan Y, Yuan L, Kondo M, Oettgen P.
|
| Am J Hypertens 23(12):1312-7. doi: 10.1038/ajh.2010.164. Epub 2010 Aug 5.
2010
|
| 24 | AGT, AGTR1
|
| Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging.
|
| Modrick ML, Didion SP, Sigmund CD, Faraci FM.
|
| Am J Physiol Heart Circ Physiol 296(6):H1914-9. Epub 2009 Apr 24.PMID: 19395552 2009
|
| 25 | AGT, AGTR1, AGTR2
|
| Neuronal and glial cell expression of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in the rat retina.
|
| Downie LE, Vessey K, Miller A, Ward MM, Pianta MJ, Vingrys AJ, Wilkinson-Berka JL, Fletcher EL.
|
| Neuroscience 161(1):195-213. Epub 2009 Mar 17.PMID: 19298848 2009
|
| 26 | AGT, TTF1
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| Expression and role of TTF-1 in the rat suprachiasmatic nucleus.
|
| Son YJ, Yun CH, Kim JG, Park JW, Kim JH, Kang SG, Lee BJ.
|
| Biochem Biophys Res Commun 380(3):559-63. doi: 10.1016/j.bbrc.2009.01.119. Epub 2009 Jan 25.
2009
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| 27 | AGT, MGP
|
| Upregulation of cardiac matrix Gla protein expression in response to hypertrophic stimuli.
|
| Mustonen E, Pohjolainen V, Aro J, Pikkarainen S, Leskinen H, Ruskoaho H, Rysä J.
|
| Blood Press 18(5):286-93. doi: 10.3109/08037050903244643.
2009
|
| 28 | AGT, INS, MAPK7, MODY10
|
| Regulation of ERK5 by insulin and angiotensin-II in vascular smooth muscle cells.
|
| Sharma G, Goalstone ML.
|
| Biochem Biophys Res Commun 354(4):1078-83. Epub 2007 Jan 26. 2007
|
| 29 | RTD1, AGT, AGTR1, ACE, RTD2, REN, RTD4, RTD3
|
| Inherited renal tubular dysgenesis: the first patients surviving the neonatal period.
|
| Zingg-Schenk A, Bacchetta J, Corvol P, Michaud A, Stallmach T, Cochat P, Gribouval O, Gubler MC, Neuhaus TJ.
|
| Eur J Pediatr [Epub ahead of print] 2007
|
| 30 | AGTR1, CYP11B2, AGT, CMA1, ACE
|
| RAAS gene polymorphisms influence progression of pediatric hypertrophic cardiomyopathy.
|
| Kaufman BD, Auerbach S, Reddy S, Manlhiot C, Deng L, Prakash A, Printz BF, Gruber D, Papavassiliou DP, Hsu DT, Sehnert AJ, Chung WK, Mital S.
|
| Hum Genet 122(5):515-23. Epub 2007 Sep 13. 2007
|
| 31 | AGT, CTSF
|
| Angiotensin II increases expression and secretion of cathepsin F in cultured human monocyte-derived macrophages: an angiotensin II type 2 receptor-mediated effect.
|
| Kaakinen R, Lindstedt KA, Sneck M, Kovanen PT, Oörni K.
|
| Atherosclerosis 192(2):323-7. Epub 2006 Sep 11. 2007
|
| 32 | AGT
|
| Sequence variants of ACE, AGT, AT1R, and PAI-1 as genetic risk factors for vascular dementia.
|
| Kim Y, Kim JH, Nam YJ, Kim YJ, Yu KH, Lee BC, Lee C.
|
| Neurosci Lett 401(3):276-9. Epub 2006 Apr 17. 2006
|
| 33 | RTD1, AGT
|
| A case surviving for over a year of renal tubular dysgenesis with compound heterozygous angiotensinogen gene mutations.
|
| Uematsu M, Sakamoto O, Nishio T, Ohura T, Matsuda T, Inagaki T, Abe T, Okamura K, Kondo Y, Tsuchiya S.
|
| Am J Med Genet A 140(21):2355-60. 2006
|
| 34 | AGT
|
| Upregulation of human angiotensinogen (AGT) gene transcription by interferon-gamma: involvement of the STAT1-binding motif in the AGT promoter.
|
| Jain S, Shah M, Li Y, Vinukonda G, Sehgal PB, Kumar A.
|
| Biochim Biophys Acta 1759(7):340-7. Epub 2006 Jul 28. 2006
|
| 35 | AGT, ADAM17, EGFR
|
| Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach.
|
| Lautrette A, Li S, Alili R, Sunnarborg SW, Burtin M, Lee DC, Friedlander G, Terzi F.
|
| Nat Med 11(8):867-74. Epub 2005 Jul 24. 2005
|
| 36 | RTD1, AGT, AGTR1, ACE, RTD2, REN, RTD4, RTD3
|
| Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.
|
| Gribouval O, Gonzales M, Neuhaus T, Aziza J, Bieth E, Laurent N, Bouton JM, Feuillet F, Makni S, Ben Amar H, Laube G, Delezoide AL, Bouvier R, Dijoud F, Ollagnon-Roman E, Roume J, Joubert M, Antignac C, Gubler MC.
|
| Nat Genet 37(9):964-8. Epub 2005 Aug 14. 2005
|
| 37 | AGTRAP, CAMLG, NFATC2, AGT
|
| Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation.
|
| Guo S, Lopez-Ilasaca M, Dzau VJ.
|
| J Biol Chem 280(13):12536-41. Epub 2005 Jan 24. 2005
|
| 38 | RREB1, AGT
|
| Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene.
|
| Date S, Nibu Y, Yanai K, Hirata J, Yagami K, Fukamizu A.
|
| Int J Mol Med 13(5):637-42. 2004
|
| 39 | SPP1, AGT
|
| AP-1 is involved in UTP-induced osteopontin expression in arterial smooth muscle cells.
|
| Renault MA, Jalvy S, Belloc I, Pasquet S, Sena S, Olive M, Desgranges C, Gadeau AP.
|
| Circ Res 93(7):674-81. Epub 2003 Sep 11. 2003
|
| 40 | AGT, YBX1
|
| Molecular cloning and functional analysis of a factor that binds to the proximal promoter of human angiotensinogen.
|
| Nakajima T, Inoue I, Cheng T, Lalouel JM.
|
| J Hum Genet 47(1):7-13. 2002
|
| 41 | ACE, AGT
|
| Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T polymorphisms: risk of chronic renal failure. End-Stage Renal Disease Study Group.
|
| Gumprecht J, Zychma MJ, Grzeszczak W, Zukowska-Szczechowska E.
|
| Kidney Int 58(2):513-9. 2000
|
| 42 | AGT
|
| Role of C/A polymorphism at -20 on the expression of human angiotensinogen gene.
|
| Zhao YY, et al.
|
| Hypertension 33(1):108-15. 1999
|
| 43 | AGT
|
| Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease.
|
| Winkelmann BR, et al.
|
| Am Heart J 137(4 Pt 1):698-705. 1999
|
| 44 | AGT, AGTR1, ACE
|
| A multilocus genotyping assay for candidate markers of cardiovascular disease risk.
|
| Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, Kane JP.
|
| Genome Res 9(10):936-49 1999
|
| 45 | AGT
|
| Angiotensinogen T174M and M235T gene polymorphisms are associated with the extent of coronary atherosclerosis.
|
| Gardemann A, Stricker J, Humme J, Nguyen QD, Katz N, Philipp M, Tillmanns H, Hehrlein FW, Haberbosch W.
|
| Atherosclerosis 145(2):309-14 1999
|
| 46 | AGT
|
| Exclusion of angiotensinogen gene in molecular basis of human hypertension: sibpair linkage and association analyses in Australian anglo-caucasians.
|
| Wang WY, Glenn CL, Zhang W, Benjafield AV, Nyholt DR, Morris BJ.
|
| Am J Med Genet 87(1):53-60 1999
|
| 47 | AGT, ACE
|
| Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project.
|
| Bengtsson K, Orho-Melander M, Lindblad U, Melander O, Bog-Hansen E, Ranstam J, Rastam L, Groop L.
|
| J Hypertens 17(11):1569-75 1999
|
| 48 | AGT
|
| Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression.
|
| Cui Y, et al.
|
| Gene 224(1-2):97-107. 1998
|
| 49 | AGT, AGTR1, ACE
|
| Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease : the CORGENE study.
|
| Jeunemaitre X, et al.
|
| Hum Genet 99 : 66-73. 1997
|
| 50 | AGT
|
| Haplotypes of angiotensinogen in essential hypertension.
|
| Jeunemaitre X, Inoue I, Williams C, Charru A, Tichet J, Powers M, Sharma AM, Gimenez-Roqueplo AP, Hata A, Corvol P, Lalouel JM.
|
| Am J Hum Genet 60(6):1448-60. 1997
|
| 51 | AGT, ACE
|
| Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients.
|
| Pei Y, Scholey J, Thai K, Suzuki M, Cattran D.
|
| J Clin Invest 100(4):814-20. 1997
|
| 52 | AGT
|
| DNA polymorphisms and linkage disequilibrium in the angiotensinogen gene.
|
| Morgan L, et al.
|
| Hum Genet 98 : 194-198. 1996
|
| 53 | AGT
|
| Short report on DNA marker at candidate locus. Nested PCR for detection of the Met235-Thr variant of the human angiotensinogen gene from small volumes of serum.
|
| Davis DR, et al.
|
| Clin Genet 50 : 435-436. 1996
|
| 54 | AGT
|
| Genetic control of blood pressure and the angiotensinogen locus.
|
| Kim HS, et al.
|
| Proc Natl Acad Sci U S A 92 : 2735-2739. 1995
|
| 55 | AGT
|
| Detection and characterization of new mutations in the human angiotensinogen gene (AGT).
|
| Hixson JE, et al.
|
| Hum Genet 96 : 110-112. 1995
|
| 56 | AGT
|
| Association of angiotensinogen gene T235 variant with increased risk of coronary heart disease.
|
| Katsuya T, et al.
|
| Lancet 345 : 1600-1603. 1995
|
| 57 | AGT
|
| Variation at the M235T locus of the angiotensinogen gene and essential hypertension : a population-based case-control study from Rochester, Minnesota.
|
| Fornage M, et al.
|
| Hum Genet 96 : 295-300. 1995
|
| 58 | AGT
|
| Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.
|
| Caulfield M, et al.
|
| J Clin Invest 96 : 687-692. 1995
|
| 59 | AGT
|
| A mutation of angiotensinogen in a patient with preeclampsia leads to altered kinetics of the renin-angiotensin system.
|
| Inoue I, et al.
|
| J Biol Chem 270 : 11430-11436. 1995
|
| 60 | AGT
|
| Linkage of the angiotensinogen gene to essential hypertension.
|
| Caulfield M, et al.
|
| N Engl J Med 330 : 1629-1633. 1994
|
| 61 | AGT
|
| Rapid detection of the hypertension-associated Met235-Thr allele of the human angiotensinogen gene.
|
| Russ AP, et al.
|
| Hum Mol Genet 2 : 609-610. 1993
|
| 62 | AGT
|
| Cross-sectional analysis of Met235-Thr variant of angiotensinogen gene in severe, familial hypertension.
|
| Bennett CL, et al.
|
| Biochem Biophys Res Commun 197 : 833-839. 1993
|
| 63 | AGT
|
| A molecular variant of angiotensinogen associated with preeclampsia.
|
| Ward K, et al.
|
| Nat Genet 4 : 59-61. 1993
|
| 64 | AGT
|
| Molecular basis of human hypertension : role of angiotensinogen.
|
| Jeunemaitre X, et al.
|
| Cell 71 : 169-180. 1992
|
| 65 | AGT
|
| Dinucleotide repeat polymorphism in the human angiotensinogen gene.
|
| Kotelevtsev YV, et al.
|
| Nucleic Acids Res 19 : 6978. 1991
|
| 66 | AGT
|
| Assignment of the human angiotensinogen gene to chromosome 1q42-43 by nonisotopic in situ hybridization.
|
| Isa MN, et al.
|
| Genomics 8 : 598-600. 1990
|
| 67 | AGT
|
| Assignment by in situ hybridization of the angiotensinogen gene to chromosome band 1q4, the same region as the human renin gene.
|
| Gaillard-Sanchez I, et al.
|
| Hum Genet 84 : 341-343. 1990
|