Citations for
RAGE signaling deficiency in rhabdomyosarcoma cells causes upregulation of PAX7 and uncontrolled proliferation.
Riuzzi F, Sorci G, Sagheddu R, Sidoni A, Alaggio R, Ninfo V, Donato R.
J Cell Sci Cell Sci. 2014 Feb 19. [Epub ahead of print] 2014
Receptor for advanced glycation end products (RAGE) in vascular and inflammatory diseases.
Mahajan N, Dhawan V.
Int J Cardiol nt J Cardiol. 2013 May 27. doi:pii: S0167-5273(13)00922-4. 10.1016/j.ijcard.2013.05.013. [Epub ahead of print] 2013
Stable RAGE-Heparan Sulfate Complexes Are Essential for Signal Transduction.
Xu D, Young JH, Krahn JM, Song D, Corbett KD, Chazin WJ, Pedersen LC, Esko JD.
ACS Chem Biol CS Chem Biol. 2013 May 28. [Epub ahead of print] 2013
Keratinocyte-Specific Deletion of the Receptor RAGE Modulates the Kinetics of Skin Inflammation In Vivo.
Leibold JS, Riehl A, Hettinger J, Durben M, Hess J, Angel P.
J Invest Dermatol Invest Dermatol. 2013 Apr 17. doi: 10.1038/jid.2013.185. [Epub ahead of print] 2013
RAGE regulation and signaling in inflammation and beyond.
Kierdorf K, Fritz G.
J Leukoc Biol Leukoc Biol. 2013 Mar 29. [Epub ahead of print] 2013
DOCK7 is a critical regulator of the RAGE-Cdc42 signaling axis that induces formation of dendritic pseudopodia in human cancer cells.
Yamamoto K, Murata H, Putranto EW, Kataoka K, Motoyama A, Hibino T, Inoue Y, Sakaguchi M, Huh NH.
Oncol Rep 29(3):1073-9. doi: 10.3892/or.2012.2191. Epub 2012 Dec 17. 2013
Disulfide bonds within the C2 domain of RAGE play key roles in its dimerization and biogenesis.
Wei W, Lampe L, Park S, Vangara BS, Waldo GS, Cabantous S, Subaran SS, Yang D, Lakatta EG, Lin L.
PLoS One 7(12):e50736. doi: 10.1371/journal.pone.0050736. Epub 2012 Dec 17. 2012
Lysophosphatidic acid targets vascular and oncogenic pathways via RAGE signaling.
Rai V, Tourť F, Chitayat S, Pei R, Song F, Li Q, Zhang J, Rosario R, Ramasamy R, Chazin WJ, Schmidt AM.
J Exp Med 209(13):2339-50. doi: 10.1084/jem.20120873. Epub 2012 Dec 3. 2012
NMR characterization of the C-terminal tail of full-length RAGE in a membrane mimicking environment.
Borsi V, Cerofolini L, Fragai M, Luchinat C.
J Biomol NMR 54(3):285-90. doi: 10.1007/s10858-012-9671-0. Epub 2012 Sep 22. 2012
Induction of RAGE shedding by activation of G protein-coupled receptors.
Metz VV, Kojro E, Rat D, Postina R.
PLoS One 7(7):e41823. doi: 10.1371/journal.pone.0041823. Epub 2012 Jul 30. 2012
RAGE expression in human T cells: a link between environmental factors and adaptive immune responses.
Akirav EM, Preston-Hurlburt P, Garyu J, Henegariu O, Clynes R, Schmidt AM, Herold KC.
PLoS One 7(4):e34698. doi: 10.1371/journal.pone.0034698. Epub 2012 Apr 11. 2012
Receptor for advanced glycation end products (RAGE) and implications for the pathophysiology of heart failure.
Ramasamy R, Schmidt AM.
Curr Heart Fail Rep 9(2):107-16. doi: 10.1007/s11897-012-0089-5. Review. 2012
RAGE binds C1q and enhances C1q-mediated phagocytosis.
Ma W, Rai V, Hudson BI, Song F, Schmidt AM, Barile GR.
Cell Immunol 274(1-2):72-82. doi: 10.1016/j.cellimm.2012.02.001. Epub 2012 Feb 13. 2012
Targeting receptor for advanced glycation end products (RAGE) expression induces apoptosis and inhibits prostate tumor growth.
Elangovan I, Thirugnanam S, Chen A, Zheng G, Bosland MC, Kajdacsy-Balla A, Gnanasekar M.
Biochem Biophys Res Commun 417(4):1133-8. doi: 10.1016/j.bbrc.2011.12.060. Epub 2011 Dec 20. 2012
15AGER, S100B
S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-κB signaling.
Villarreal A, Aviles Reyes RX, Angelo MF, Reines AG, Ramos AJ.
J Neurochem 117(2):321-32. doi: 10.1111/j.1471-4159.2011.07207.x. Epub 2011 Feb 25. 2011
16AGER, S100B
S100B protein regulates myoblast proliferation and differentiation by activating FGFR1 in a bFGF-dependent manner.
Riuzzi F, Sorci G, Donato R.
J Cell Sci 124(Pt 14):2389-400. Epub 2011 Jun 21. 2011
RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner.
Frommhold D, Kamphues A, Dannenberg S, Buschmann K, Zablotskaya V, Tschada R, Lange-Sperandio B, Nawroth PP, Poeschl J, Bierhaus A, Sperandio M.
BMC Immunol 12:56. doi: 10.1186/1471-2172-12-56. 2011
TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.
Sakaguchi M, Murata H, Yamamoto K, Ono T, Sakaguchi Y, Motoyama A, Hibino T, Kataoka K, Huh NH.
PLoS One 6(8):e23132. doi: 10.1371/journal.pone.0023132. Epub 2011 Aug 1. 2011
RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo.
Frommhold D, Kamphues A, Hepper I, Pruenster M, Lukic IK, Socher I, Zablotskaya V, Buschmann K, Lange-Sperandio B, Schymeinsky J, Ryschich E, Poeschl J, Kupatt C, Nawroth PP, Moser M, Walzog B, Bierhaus A, Sperandio M.
Blood 116(5):841-9. Epub 2010 Apr 20.PMID: 20407037 2010
The role of HMGB1/RAGE in inflammatory cardiomyopathy.
Volz HC, Kaya Z, Katus HA, Andrassy M.
Semin Thromb Hemost 36(2):185-94. Epub 2010 Apr 22. Review.PMID: 20414834 2010
RAGE-TXNIP axis is required for S100B-promoted Schwann cell migration, fibronectin expression and cytokine secretion.
Sbai O, Devi TS, Melone MA, Feron F, Khrestchatisky M, Singh LP, Perrone L.
J Cell Sci 123(Pt 24):4332-9. Epub 2010 Nov 23. 2010
Expression of advanced glycation end-product receptors in the cochlea.
Hanusek C, Setz C, Radojevic V, Brand Y, Levano S, Bodmer D.
Laryngoscope 120(6):1227-32. 2010
PLC/CAMK IV-NF-kappaB involved in the receptor for advanced glycation end products mediated signaling pathway in human endothelial cells.
You J, Peng W, Lin X, Huang QL, Lin JY.
Mol Cell Endocrinol 320(1-2):111-7. doi: 10.1016/j.mce.2010.01.036. Epub 2010 Feb 18. 2010
Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms.
Sterenczak KA, Willenbrock S, Barann M, Klemke M, Soller JT, Eberle N, Nolte I, Bullerdiek J, Murua Escobar H.
Gene 434(1-2):35-42. Epub 2008 Nov 12. 2009
RAGE expression and NF-kappaB activation attenuated by extracellular domain of RAGE in human salivary gland cell line.
Chuong C, Katz J, Pauley KM, Bulosan M, Cha S.
J Cell Physiol 221(2):430-4. 2009
RAGE: a novel biological and genetic marker for vascular disease.
Kalea AZ, Schmidt AM, Hudson BI.
Clin Sci (Lond) 116(8):621-37. Review. 2009
Polymorphisms in advanced glycosylation end product-specific receptor (AGER) gene, insulin resistance, and type 2 diabetes mellitus.
Goulart AC, Germer S, Rexrode KM, Martin M, Zee RY.
Clin Chim Acta 398(1-2):95-8. Epub 2008 Sep 3. 2008
Endogenous soluble receptor for advanced glycation endproducts is increased in preeclampsia.
Fasshauer M, Seeger J, Waldeyer T, Schrey S, Ebert T, Lossner U, Bluher M, Stumvoll M, Faber R, Stepan H.
J Hypertens 26(9):1824-8. 2008
Structural basis for pattern recognition by the receptor for advanced glycation end products (RAGE).
Xie J, Reverdatto S, Frolov A, Hoffmann R, Burz DS, Shekhtman A.
J Biol Chem 283(40):27255-69. Epub 2008 Jul 30. 2008
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10).
Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME.
FASEB J 22(10):3716-27. Epub 2008 Jul 4. 2008
Expression of CD64, CD206, and RAGE in adherent cells of diabetic patients infected with Mycobacterium tuberculosis.
Arce-Mendoza A, Rodriguez-de Ita J, Salinas-Carmona MC, Rosas-Taraco AG.
Arch Med Res 39(3):306-11. 2008
Identification, classification, and expression of RAGE gene splice variants.
Hudson BI, Carter AM, Harja E, Kalea AZ, Arriero M, Yang H, Grant PJ, Schmidt AM.
FASEB J 22(5):1572-80. Epub 2007 Dec 18.PMID: 18089847 2008
Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma.
Stav D, Bar I, Sandbank J.
Int J Biol Markers 22(2):108-13. 2007
C-Reactive protein upregulates receptor for advanced glycation end products expression in human endothelial cells.
Zhong Y, Li SH, Liu SM, Szmitko PE, He XQ, Fedak PW, Verma S.
Hypertension 48(3):504-11. Epub 2006 Jul 17. 2006
Advanced glycation end product (AGE) receptor 1 suppresses cell oxidant stress and activation signaling via EGF receptor.
Cai W, He JC, Zhu L, Lu C, Vlassara H.
Proc Natl Acad Sci U S A 103(37):13801-6. Epub 2006 Sep 5. 2006
The -374 T/A polymorphism in the gene encoding RAGE is associated with diabetic nephropathy and retinopathy in type 1 diabetic patients.
Lindholm E, Bakhtadze E, Sjögren M, Cilio CM, Agardh E, Groop L, Agardh CD.
Diabetologia 49(11):2745-55. Epub 2006 Sep 13. 2006
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B.
Nat Med 9(7):907-13. 2003
RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease.
Yan SD, et al.
Nature 382 : 685-691. 1996
Three genes in the human MHC class III region near the junction with the class II : gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart of mouse mammary tumor gene int-3.
Sugaya K, et al.
Genomics 23 : 408-419. 1994
Localization of the human gene for advanced glycosylation end product-specific receptor (AGER) to chromosome 6p21.3.
Vissing H, et al.
Genomics 24 : 606-608. 1994