| 1 | AGAP2
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| PIKE is essential for oligodendroglia development and CNS myelination.
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| Chan CB, Liu X, Zhao L, Liu G, Lee CW, Feng Y, Ye K.
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| Proc Natl Acad Sci U S A 111(5):1993-8. doi: 10.1073/pnas.1318185111. Epub 2014 Jan 21.
2014
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| 2 | AGAP2, PTK2, RACK1
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| RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.
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| Dwane S, Durack E, O'Connor R, Kiely PA.
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| Cell Signal 26(1):9-18. doi: 10.1016/j.cellsig.2013.08.036. Epub 2013 Sep 19. 2014
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| 3 | AGAP2
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| Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion and colony formation.
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| Qi Q, He K, Liu X, Pham C, Meyerkord C, Fu H, Ye K.
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| Oncogene 32(8):1030-40. doi: 10.1038/onc.2012.109. Epub 2012 Mar 26.
2013
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| 4 | AGAP2, ARRB1, ARRB2
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| The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β2-adrenergic receptor recycling and ERK activation.
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| Wu Y, Zhao Y, Ma X, Zhu Y, Patel J, Nie Z.
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| Biochem J 452(3):411-21. doi: 10.1042/BJ20121004.
2013
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| 5 | AGAP2, FYN, STAT5A
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| Fyn regulates adipogenesis by promoting PIKE-A/STAT5a interaction.
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| Tse MC, Liu X, Yang S, Ye K, Chan CB.
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| Mol Cell Biol 33(9):1797-808. doi: 10.1128/MCB.01410-12. Epub 2013 Feb 25.
2013
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| 6 | AGAP2
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| Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?
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| Chan CB, Ye K.
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| Rev Neurosci 23(2):153-61. doi: 10.1515/revneuro-2011-0066. Review.
2012
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| 7 | AGAP1, AGAP2, RHOA
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| GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
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| Luo R, Akpan IO, Hayashi R, Sramko M, Barr V, Shiba Y, Randazzo PA.
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| J Biol Chem 287(21):17176-85. doi: 10.1074/jbc.M111.334458. Epub 2012 Mar 27.
2012
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| 8 | AGAP2
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| PIKE mediates EGFR proliferative signaling in squamous cell carcinoma cells.
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| Xie Z, Jiang Y, Liao EY, Chen Y, Pennypacker SD, Peng J, Chang SM.
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| Oncogene 31(49):5090-8. doi: 10.1038/onc.2012.10. Epub 2012 Feb 20.
2012
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| 9 | AGAP1, AGAP2
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| GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.
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| Luo R, Akpan IO, Hayashi R, Sramko M, Barr V, Shiba Y, Randazzo PA.
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| J Biol Chem 287(21):17176-85. doi: 10.1074/jbc.M111.334458. Epub 2012 Mar 27.
2012
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| 10 | AGAP2, ARF1
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| AGAP2 regulates retrograde transport between early endosomes and the TGN.
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| Shiba Y, Römer W, Mardones GA, Burgos PV, Lamaze C, Johannes L.
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| J Cell Sci 123(Pt 14):2381-90. doi: 10.1242/jcs.057778. Epub 2010 Jun 15.
2010
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| 11 | AGAP2
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| PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development.
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| Chan CB, Liu X, Ensslin MA, Dillehay DL, Ormandy CJ, Sohn P, Serra R, Ye K.
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| EMBO J 29(5):956-68. doi: 10.1038/emboj.2009.406. Epub 2010 Jan 14.
2010
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| 12 | AGAP2, PTK2
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| Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling.
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| Zhu Y, Wu Y, Kim JI, Wang Z, Daaka Y, Nie Z.
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| J Biol Chem 284(20):13489-96. doi: 10.1074/jbc.M900469200. Epub 2009 Mar 24.
2009
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| 13 | AGAP2
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| Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion.
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| Liu R, Tian B, Gearing M, Hunter S, Ye K, Mao Z.
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| Proc Natl Acad Sci U S A 105(21):7570-5. Epub 2008 May 16. 2008
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| 14 | AGAP2
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| The centaurin gamma-1 GTPase-like domain functions as an NTPase.
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| Soundararajan M, Yang X, Elkins JM, Sobott F, Doyle DA.
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| Biochem J 401(3):679-88. 2007
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| 15 | AGAP2, PIK3CA
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| Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas.
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| Knobbe CB, Trampe-Kieslich A, Reifenberger G.
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| Neuropathol Appl Neurobiol 31(5):486-90. Erratum in: Neuropathol Appl Neurobiol. 2005 Dec;31(6):662. 2005
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| 16 | AGAP1, AGAP2
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| The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3.
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| Nie Z, Fei J, Premont RT, Randazzo PA.
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| J Cell Sci 118(Pt 15):3555-66.
2005
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| 17 | AGAP2
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| PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt.
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| Ahn JY, Hu Y, Kroll TG, Allard P, Ye K.
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| Proc Natl Acad Sci U S A 101(18):6993-8. Epub 2004 Apr 26. 2004
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| 18 | AGAP2, NF2
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| Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L.
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| Rong R, Tang X, Gutmann DH, Ye K.
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| Proc Natl Acad Sci U S A 101(52):18200-5. Epub 2004 Dec 14. 2004
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| 19 | AGAP2
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| Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N.
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| Ye K, Hurt KJ, Wu FY, Fang M, Luo HR, Hong JJ, Blackshaw S, Ferris CD, Snyder SH.
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| Cell 103(6):919-30. 2000
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| 20 | AGAP2, MDM2
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| Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers.
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| Elkahloun AG, Krizman DB, Wang Z, Hofmann TA, Roe B, Meltzer PS.
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| Genomics 42(2):295-301. 1997
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