| 1 | AFF1, TGM2
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| AFF1 inhibits adipogenic differentiation via targeting TGM2 transcription.
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| Chen Y, Wang Y, Lin W, Sheng R, Wu Y, Xu R, Zhou C, Yuan Q.
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| Cell Prolif. Jun;53(6):e12831. doi: 10.1111/cpr.12831. Epub 2020 May 22 2020
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| 2 | AFF1, AFF4
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| Structure of the super-elongation complex subunit AFF4 C-terminal homology domain reveals requirements for AFF homo- and heterodimerization.
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| Chen Y, Cramer P.
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| J Biol Chem. Jul 5;294(27):10663-10673. doi: 10.1074/jbc.RA119.008577. Epub 2019 May 30 2019
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| 3 | AFF1, AFF4, DKK1
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| AFF1 and AFF4 differentially regulate the osteogenic differentiation of human MSCs.
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| Zhou CC, Xiong QC, Zhu XX, Du W, Deng P, Li XB, Jiang YZ, Zou SJ, Wang CY, Yuan Q.
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| Bone Res. Sep 26;5:17044. doi: 10.1038/boneres.2017.44. eCollection 2017. 2017
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| 4 | AFF1, TAF1A, TAF1B, TAF1C, TBP
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| TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription.
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| Okuda H, Takahashi S, Takaori-Kondo A, Yokoyama A.
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| Cell Cycle. Oct 17;15(20):2712-22. doi: 10.1080/15384101.2016.1222337. Epub 2016 Aug 26 2016
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| 5 | AFF1, FLT3, KMT2A
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| FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs.
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| Bueno C, Ayllón V, Montes R, Navarro-Montero O, Ramos-Mejia V, Real PJ, Romero-Moya D, Araúzo-Bravo MJ, Menendez P.
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| Blood 121(19):3867-78, S1-3. doi: 10.1182/blood-2012-11-470146. Epub 2013 Mar 11.
2013
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| 6 | AFF1
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| A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.
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| Okada Y, Shimane K, Kochi Y, Tahira T, Suzuki A, Higasa K, Takahashi A, Horita T, Atsumi T, Ishii T, Okamoto A, Fujio K, Hirakata M, Amano H, Kondo Y, Ito S, Takada K, Mimori A, Saito K, Kamachi M, Kawaguchi Y, Ikari K, Mohammed OW, Matsuda K, Terao C, Ohmura K, Myouzen K, Hosono N, Tsunoda T, Nishimoto N, Mimori T, Matsuda F, Tanaka Y, Sumida T, Yamanaka H, Takasaki Y, Koike T, Horiuchi T, Hayashi K, Kubo M, Kamatani N, Yamada R, Nakamura Y, Yamamoto K.
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| PLoS Genet 8(1):e1002455. doi: 10.1371/journal.pgen.1002455. Epub 2012 Jan 26.
2012
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| 7 | AFF1, AFF2, AFF3, AFF4
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| Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disability.
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| Melko M, Douguet D, Bensaid M, Zongaro S, Verheggen C, Gecz J, Bardoni B.
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| Hum Mol Genet 20(10):1873-85. Epub 2011 Feb 17.
2011
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| 8 | AFF1
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| The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.
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| Benedikt A, Baltruschat S, Scholz B, Bursen A, Arrey TN, Meyer B, Varagnolo L, Müller AM, Karas M, Dingermann T, Marschalek R.
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| Leukemia 25(1):135-44. Epub 2010 Oct 29.
2011
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| 9 | AFF1, AFF4
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| A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.
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| Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML.
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| Cancer Cell 17(2):198-212. 2010
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| 10 | AFF1
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| Molecular characterization of a rare MLL-AF4 (MLL-AFF1) fusion rearrangement in infant leukemia.
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| Bizarro S, Cerveira N, Correia C, Lisboa S, Peixoto A, Norton L, Teixeira MR.
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| Cancer Genet Cytogenet 178(1):61-4.
2007
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| 11 | AFF1, KMT2A
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| The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
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| Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ.
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| Proc Natl Acad Sci U S A 102(39):14028-33. Epub 2005 Sep 16. 2005
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| 12 | SIAH1, SIAH2, AFF2, AFF1
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| Mediation of Af4 protein function in the cerebellum by Siah proteins.
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| Oliver PL, Bitoun E, Clark J, Jones EL, Davies KE.
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| Proc Natl Acad Sci U S A 101(41):14901-6. Epub 2004 Sep 30. 2004
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| 13 | AFF4, EAF1, AFF2, AFF1
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| FMR2 function: insight from a mouse knockout model.
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| Gu Y, Nelson DL.
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| Cytogenet Genome Res 100(1-4):129-39. 2003
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| 14 | AFF1
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| Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia.
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| Sun L, et al.
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| Proc Natl Acad Sci U S A 96 : 680-685. 1999
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| 15 | AFF1, KMT2A
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| Clinical significance of MLL-AF4 fusion transcript expression in the absence of a cytogenetically detectable t(4;11)(q21;q23) chromosomal translocation.
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| Uckun FM, Herman-Hatten K, Crotty ML, Sensel MG, Sather HN, Tuel-Ahlgren L, Sarquis MB, Bostrom B, Nachman JB, Steinherz PG, Gaynon PS, Heerema N.
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| Blood 92 : 810-821. 1998
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| 16 | AFF1
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| AF4 encodes a ubiquitous protein that in both native and MLL-AF4 fusion types localizes to subnuclear compartments.
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| Li Q, Frestedt JL, Kersey JH.
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| Blood 92 : 3841-3847. 1998
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| 17 | AFF1
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| Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemia.
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| Nilson I, Reichel M, Ennas MG, Greim R, Knorr C, Siegler G, Greil J, Fey GH, Marschalek R.
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| Br J Haematol 98(1):157-69. 1997
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| 18 | AFF1, AFF4
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| AF4/FEL, a gene involved in infant leukemia : sequence variations, gene structure, and possible homology with a genomic sequence on 5q31.
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| Frestedt JL, et al.
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| DNA Cell Biol 15 : 669-678. 1996
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| 19 | AFF1, KMT2A, MLLT1, MLLT3
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| Identification of MLL and chimeric MLL gene products involved in 11q23 translocation and possible mechanisms of leukemogenesis by MLL truncation.
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| Joh T, et al.
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| Oncogene 13 : 1945-1953. 1996
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| 20 | AFF1, KMT2A
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| Molecular analysis of infant acute lymphoblastic leukemia : MLL gene rearrangement and reverse transcriptase-polymerase chain reaction for t(4;11)(q21;q23).
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| Hilden JM, et al.
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| Blood 86 : 3876-3882. 1995
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| 21 | AFF1
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| A mapping study of 13 genes on human chromosome bands 4q11-q25.
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| Chen CS, et al.
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| Cytogenet Cell Genet 69 : 260-265. 1995
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| 22 | AFF1, KMT2A
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| Detection of ALL-1/AF4 fusion transcript by reverse transcription-polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation.
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| Biondi A, et al.
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| Blood 82 : 2943-2947. 1993
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| 23 | AFF1, KMT2A, MLLT1, MLLT3
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| Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.
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| Nakamura T, et al.
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| Proc Natl Acad Sci U S A 90 : 4631-4635. 1993
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| 24 | AFF1
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| A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.
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| Morrissey J, et al.
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| Blood 81 : 1124-1131. 1993
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| 25 | AFF1, KMT2A
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| Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.
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| Domer PH, et al.
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| Proc Natl Acad Sci U S A 90 : 7884-7888. 1993
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| 26 | AFF1
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| The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.
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| Chen CS, et al.
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| Blood 82 : 1080-1085. 1993
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| 27 | AFF1, KMT2A
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| Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia.
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| Hilden JM, et al.
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| Cancer Res 53 : 3853-3856. 1993
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| 28 | AFF1, KMT2A
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| The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.
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| Gu Y, et al.
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| Cell 71 : 701-708. 1992
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| 29 | AFF1, BALMCR, KMT2A
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| The (4;11)(q21;q23) chromosome translocations in acute leukemias involve the VDJ recombinase.
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| Gu Y, et al.
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| Proc Natl Acad Sci U S A 89 : 10464-10468. 1992
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