Citations for
Afadin Facilitates Vascular Endothelial Growth Factor-Induced Network Formation and Migration of Vascular Endothelial Cells by Inactivating Rho-Associated Kinase Through ArhGAP29.
Tagashira T, Fukuda T, Miyata M, Nakamura K, Fujita H, Takai Y, Hirata KI, Rikitake Y.
Arterioscler Thromb Vasc Biol 38(5):1159-1169. doi: 10.1161/ATVBAHA.118.310991. Epub 2018 Mar 29. 2018
Afadin orients cell division to position the tubule lumen in developing renal tubules.
Gao L, Yang Z, Hiremath C, Zimmerman SE, Long B, Brakeman PR, Mostov KE, Bryant DM, Luby-Phelps K, Marciano DK.
Development 144(19):3511-3520. doi: 10.1242/dev.148908. Epub 2017 Aug 31. 2017
Roles of afadin in functional differentiations of hippocampal mossy fiber synapse.
Geng X, Maruo T, Mandai K, Supriyanto I, Miyata M, Sakakibara S, Mizoguchi A, Takai Y, Mori M.
Genes Cells 22(8):715-722. doi: 10.1111/gtc.12508. Epub 2017 Jun 20. 2017
Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression.
Xu Y, Chang R, Peng Z, Wang Y, Ji W, Guo J, Song L, Dai C, Wei W, Wu Y, Wan X, Shao C, Zhan L.
Nat Commun 6:7184. doi: 10.1038/ncomms8184. 2015
A short splicing isoform of afadin suppresses the cortical axon branching in a dominant-negative manner.
Umeda K, Iwasawa N, Negishi M, Oinuma I.
Mol Biol Cell 26(10):1957-70. doi: 10.1091/mbc.E15-01-0039. Epub 2015 Mar 25. 2015
Crystal structure of afadin PDZ domain-nectin-3 complex shows the structural plasticity of the ligand-binding site.
Fujiwara Y, Goda N, Tamashiro T, Narita H, Satomura K, Tenno T, Nakagawa A, Oda M, Suzuki M, Sakisaka T, Takai Y, Hiroaki H.
Protein Sci 24(3):376-85. doi: 10.1002/pro.2628. Epub 2015 Jan 13. 2015
Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.
Yoshida T, Iwata T, Takai Y, Birchmeier W, Yamato M, Okano T.
Genes Cells 19(11):842-52. doi: 10.1111/gtc.12184. Epub 2014 Oct 9. 2014
s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin.
Kobayashi R, Kurita S, Miyata M, Maruo T, Mandai K, Rikitake Y, Takai Y.
Genes Cells 19(12):853-63. doi: 10.1111/gtc.12185. Epub 2014 Sep 29. 2014
Afadin regulates puncta adherentia junction formation and presynaptic differentiation in hippocampal neurons.
Toyoshima D, Mandai K, Maruo T, Supriyanto I, Togashi H, Inoue T, Mori M, Takai Y.
PLoS One 9(2):e89763. doi: 10.1371/journal.pone.0089763. eCollection 2014. 2014
Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain.
Yamamoto H, Maruo T, Majima T, Ishizaki H, Tanaka-Okamoto M, Miyoshi J, Mandai K, Takai Y.
PLoS One 8(11):e80356. doi: 10.1371/journal.pone.0080356. eCollection 2013. 2013
Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells.
Kurita S, Yamada T, Rikitsu E, Ikeda W, Takai Y.
J Biol Chem 288(41):29356-68. doi: 10.1074/jbc.M113.453464. Epub 2013 Aug 29. 2013
Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus.
Beaudoin GM 3rd, Schofield CM, Nuwal T, Zang K, Ullian EM, Huang B, Reichardt LF.
J Neurosci 32(1):99-110. 2012
The effector and scaffolding proteins AF6 and MUPP1 interact with connexin36 and localize at gap junctions that form electrical synapses in rodent brain.
Li X, Lynn BD, Nagy JI.
Eur J Neurosci 35(2):166-81. doi: 10.1111/j.1460-9568.2011.07947.x. Epub 2011 Dec 29. 2012
R-Ras controls axon branching through afadin in cortical neurons.
Iwasawa N, Negishi M, Oinuma I.
Mol Biol Cell 23(14):2793-804. doi: 10.1091/mbc.E12-02-0103. Epub 2012 May 16. 2012
Afadin is required for maintenance of dendritic structure and excitatory tone.
Srivastava DP, Copits BA, Xie Z, Huda R, Jones KA, Mukherji S, Cahill ME, VanLeeuwen JE, Woolfrey KM, Rafalovich I, Swanson GT, Penzes P.
J Biol Chem 287(43):35964-74. doi: 10.1074/jbc.M112.363358. Epub 2012 Sep 4. 2012
Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.
Fournier G, Cabaud O, Josselin E, Chaix A, Adélaïde J, Isnardon D, Restouin A, Castellano R, Dubreuil P, Chaffanet M, Birnbaum D, Lopez M.
Oncogene 30(36):3862-74. doi: 10.1038/onc.2011.106. Epub 2011 Apr 11. 2011
Involvement of afadin in barrier function and homeostasis of mouse intestinal epithelia.
Tanaka-Okamoto M, Hori K, Ishizaki H, Itoh Y, Onishi S, Yonemura S, Takai Y, Miyoshi J.
J Cell Sci 124(Pt 13):2231-40. Epub 2011 Jun 7. 2011
The interaction of Jagged-1 cytoplasmic tail with afadin PDZ domain is local, folding-independent, and tuned by phosphorylation.
Popovic M, Bella J, Zlatev V, Hodnik V, Anderluh G, Barlow PN, Pintar A, Pongor S.
J Mol Recognit 24(2):245-53. doi: 10.1002/jmr.1042. 2011
Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis.
Tawa H, Rikitake Y, Takahashi M, Amano H, Miyata M, Satomi-Kobayashi S, Kinugasa M, Nagamatsu Y, Majima T, Ogita H, Miyoshi J, Hirata K, Takai Y.
Circ Res 106(11):1731-42. Epub 2010 Apr 22. 2010
Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration.
Severson EA, Lee WY, Capaldo CT, Nusrat A, Parkos CA.
Mol Biol Cell 20(7):1916-25. Epub 2009 Jan 28. 2009
Involvement of afadin in the formation and remodeling of synapses in the hippocampus.
Majima T, Ogita H, Yamada T, Amano H, Togashi H, Sakisaka T, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Takai Y.
Biochem Biophys Res Commun 385(4):539-44. Epub 2009 May 27. 2009
Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons.
Lim ST, Lim KC, Giuliano RE, Federoff HJ.
J Comp Neurol 507(2):1228-44.PMID: 18181141 2008
Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer.
Letessier A, Garrido-Urbani S, Ginestier C, Fournier G, Esterni B, Monville F, Adelaide J, Geneix J, Xerri L, Dubreuil P, Viens P, Charafe-Jauffret E, Jacquemier J, Birnbaum D, Lopez M, Chaffanet M.
Oncogene 26(2):298-307. Epub 2006 Jul 3. 2007
RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6.
Trivier E, Ganesan TS.
J Biol Chem 277(25):23037-43. Epub 2002 Apr 15. 2002
Granulocytic sarcomas in body cavities in childhood acute myeloid leukemias with 11q23/MLL rearrangements.
Johansson B, Fioretos T, Kullendorff CM, Wiebe T, Bekassy AN, Garwicz S, Forestier E, Roos G, Akerman M, Mitelman F, Billstrom R.
Genes Chromosomes Cancer 27(2):136-42. Review 2000
The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin.
Boettner B, Govek EE, Cross J, Van Aelst L.
Proc Natl Acad Sci U S A 97(16):9064-9. 2000
27AFDN, C6orf123, C6orf124, C6orf54, HGC6.3, ST8
Complete DNA sequence and characterization of a 330-kb VNTR-rich region on chromosome 6q27 that is commonly deleted in ovarian cancer.
Minaguchi T, Matsushima M, Saito S, Kanamori Y, Shirahama S, Okamoto S,Minami M, Taketani Y, Nakamura Y.
DNA Res 6(2):131-6. 1999
Complete genomic structure, DNA polymorphisms, and alternative splicing of the human AF-6 gene.
Saito S, et al.
DNA Res 5 : 115-120. 1998
Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11) (q27;q23) leukemia localize in the nucleus.
Joh T, Yamamoto K, Kagami Y, Kakuda H, Sato T, Yamamoto T, Takahashi T, Ueda R, Kaibuchi K, Seto M.
Oncogene 15(14):1681-7. 1997
Afadin: A novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction.
Mandai K, Nakanishi H, Satoh A, Obaishi H, Wada M, Nishioka H, Itoh M, Mizoguchi A, Aoki T, Fujimoto T, Matsuda Y, Tsukita S, Takai Y.
J Cell Biol 139(2):517-28. 1997
Analysis of the t(6;11)(q27;q23) in leukemia shows a consistent breakpoint in AF6 in three patients and in the ML-2 cell line.
Tanabe S, et al.
Genes Chromosomes Cancer 15 : 206-216. 1996
Identification of AF-6 and canoe as putative targets for Ras.
Kuriyama M, et al.
J Biol Chem 271 : 607-610. 1996
AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer.
Saha V, et al.
Genes Chromosomes Cancer 14 : 220-222. 1995
Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.
Prasad R, et al.
Cancer Res 53 : 5624-5628. 1993