1 | ADAMTS1, ADAMTS12, ADAMTS13, ADAMTS4
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| ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.
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| Namlı Kalem M, Kalem Z, Yüce T, Soylemez F.
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| Hypertens Pregnancy 37(1):9-17. doi: 10.1080/10641955.2017.1397690. Epub 2017 Nov 14.
2018
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2 | ADAMTS13
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| Update on ADAMTS13 and VWF in cardiovascular and hematological disorders.
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| Akyol O, Akyol S, Chen CH.
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| Clin Chim Acta 463:109-118. doi: 10.1016/j.cca.2016.10.017. Review.
2016
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3 | ADAMTS13, VWF
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| Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.
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| Tersteeg C, Fijnheer R, Pasterkamp G, de Groot PG, Vanhoorelbeke K, de Maat S, Maas C.
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| Semin Thromb Hemost 42(1):9-17. doi: 10.1055/s-0035-1564838. Review.
2016
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4 | ADAMTS13, VWF
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| The expression of ADAMTS13 in human microvascular endothelial cells.
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| Wang A, Duan Q, Wu J, Liu X, Sun Z.
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| Blood Coagul Fibrinolysis 27(4):464-6. doi: 10.1097/MBC.0000000000000405.
2016
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5 | ADAMTS13, TTPF
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| Congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) caused by novel ADAMTS13 mutations.
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| Kim HY, Lee KO, Yoo KH, Kim SH, Oh D, Kim HJ.
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| Br J Haematol 173(1):156-9. doi: 10.1111/bjh.13564. No abstract available.
2016
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6 | ADAMTS13, TTPF
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| Adult-onset congenital thrombotic thrombocytopenic purpura caused by a novel compound heterozygous mutation of the ADAMTS13 gene.
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| Krabbe JG, Kemna EW, Strunk AL, Jobse PA, Kramer PA, Dikkeschei LD, van den Heuvel LP, Fijnheer R, Verdonck LF.
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| Int J Hematol 102(4):477-81. doi: 10.1007/s12185-015-1849-2.
2015
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7 | ADAMTS13, VWF
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| Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13.
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| Kretz CA, Dai M, Soylemez O, Yee A, Desch KC, Siemieniak D, Tomberg K, Kondrashov FA, Meng F, Ginsburg D.
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| Proc Natl Acad Sci U S A 112(30):9328-33. doi: 10.1073/pnas.1511328112.
2015
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8 | ADAMTS13, VWF
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| Probing ADAMTS13 substrate specificity using phage display.
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| Desch KC, Kretz C, Yee A, Gildersleeve R, Metzger K, Agrawal N, Cheng J, Ginsburg D.
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| PLoS One 10(4):e0122931. doi: 10.1371/journal.pone.0122931.
2015
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9 | ADAMTS13
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| ADAMTS13 deficiency in mice does not affect adipose tissue development.
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| Geys L, Scroyen I, Roose E, Vanhoorelbeke K, Lijnen HR.
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| Biochim Biophys Acta 1850(7):1368-74. doi: 10.1016/j.bbagen.2015.03.008.
2015
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10 | ADAMTS13, VWF
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| The role of the ADAMTS13 cysteine-rich domain in VWF binding and proteolysis.
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| de Groot R, Lane DA, Crawley JT.
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| Blood 125(12):1968-75. doi: 10.1182/blood-2014-08-594556.
2015
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11 | ADAMTS13
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| ADAMTS13 and its variants promote angiogenesis via upregulation of VEGF and VEGFR2.
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| Lee M, Keener J, Xiao J, Long Zheng X, Rodgers GM.
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| Cell Mol Life Sci 72(2):349-56. doi: 10.1007/s00018-014-1667-3.
2015
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12 | ADAMTS13, VWF
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| Allosteric activation of ADAMTS13 by von Willebrand factor.
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| Muia J, Zhu J, Gupta G, Haberichter SL, Friedman KD, Feys HB, Deforche L, Vanhoorelbeke K, Westfield LA, Roth R, Tolia NH, Heuser JE, Sadler JE.
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| Proc Natl Acad Sci U S A 111(52):18584-9. doi: 10.1073/pnas.1413282112.
2014
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13 | ADAMTS13
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| Conformational activation of ADAMTS13.
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| South K, Luken BM, Crawley JT, Phillips R, Thomas M, Collins RF, Deforche L, Vanhoorelbeke K, Lane DA.
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| Proc Natl Acad Sci U S A 111(52):18578-83. doi: 10.1073/pnas.1411979112.
2014
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14 | ADAMTS13, TTPF
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| Inherited ADAMTS13 deficiency (Upshaw-Schulman syndrome): a short review.
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| Pérez-Rodríguez A, Lourés E, Rodríguez-Trillo Á, Costa-Pinto J, García-Rivero A, Batlle-López A, Batlle J, López-Fernández MF.
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| Thromb Res 134(6):1171-5. doi: 10.1016/j.thromres.2014.09.004. Review.
2014
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15 | ADAMTS13, VWF
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| The potential therapeutic benefit of targeting ADAMTS13 activity.
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| Eerenberg ES, Levi M.
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| Semin Thromb Hemost 40(1):28-33. doi: 10.1055/s-0033-1363156. Review.
2014
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16 | ADAMTS13, VWF
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| The WXXW motif in the TSR1 of ADAMTS13 is important for its secretion and proteolytic activity.
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| Ling J, Su J, Ma Z, Ruan C.
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| Thromb Res 131(6):529-34. doi: 10.1016/j.thromres.2013.04.024.
2013
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17 | ADAMTS13, VWF
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| Increased VWF antigen levels and decreased ADAMTS13 activity in preeclampsia.
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| Aref S, Goda H.
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| Hematology 18(4):237-41. doi: 10.1179/1607845412Y.0000000070.
2013
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18 | ADAMTS13, F8, VWF
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| Light chain of factor VIII is sufficient for accelerating cleavage of von Willebrand factor by ADAMTS13 metalloprotease.
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| Cao W, Sabatino DE, Altynova E, Lange AM, Casina VC, Camire RM, Zheng XL.
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| J Biol Chem 287(39):32459-66. 2012
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19 | ADAMTS13
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| ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.
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| Gandhi C, Motto DG, Jensen M, Lentz SR, Chauhan AK.
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| Blood 120(26):5224-30. doi: 10.1182/blood-2012-06-440255.
2012
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20 | ADAMTS13, TTPF
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| Residual plasmatic activity of ADAMTS13 is correlated with phenotype severity in congenital thrombotic thrombocytopenic purpura.
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| Lotta LA, Wu HM, Mackie IJ, Noris M, Veyradier A, Scully MA, Remuzzi G, Coppo P, Liesner R, Donadelli R, Loirat C, Gibbs RA, Horne A, Yang S, Garagiola I, Musallam KM, Peyvandi F.
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| Blood 120(2):440-8. doi: 10.1182/blood-2012-01-403113.
2012
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21 | ADAMTS13, PLG
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| Binding of von Willebrand factor cleaving protease ADAMTS13 to Lys-plasmin(ogen).
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| Shin Y, Akiyama M, Kokame K, Soejima K, Miyata T.
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| J Biochem 152(3):251-8. doi: 10.1093/jb/mvs066.
2012
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22 | ADAMTS13, PPIB
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| Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat).
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| Hershko K, Simhadri VL, Blaisdell A, Hunt RC, Newell J, Tseng SC, Hershko AY, Choi JW, Sauna ZE, Wu A, Bram RJ, Komar AA, Kimchi-Sarfaty C.
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| J Biol Chem 287(53):44361-71. doi: 10.1074/jbc.M112.383968. Epub 2012 Nov 9.
2012
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23 | ADAMTS13, VWF
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| A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13.
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| Zhou M, Dong X, Baldauf C, Chen H, Zhou Y, Springer TA, Luo X, Zhong C, Gräter F, Ding J.
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| Blood 117(17):4623-31. Epub 2011 Mar 8. 2011
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24 | ADAMTS13
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| Von Willebrand factor and ADAMTS13: a candidate couple for preeclampsia pathophysiology.
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| Stepanian A, Cohen-Moatti M, Sanglier T, Legendre P, Ameziane N, Tsatsaris V, Mandelbrot L, de Prost D, Veyradier A; ECLAXIR Study Group.
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| Arterioscler Thromb Vasc Biol 31(7):1703-9. Epub 2011 Apr 21.
2011
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25 | ADAMTS13, VWF
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| Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor.
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| Crawley JT, de Groot R, Xiang Y, Luken BM, Lane DA.
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| Blood 118(12):3212-21. Epub 2011 Jun 29. Review.
2011
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26 | ADAMTS13, TTPF
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| ADAMTS13 mutations and polymorphisms in congenital thrombotic thrombocytopenic purpura.
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| Lotta LA, Garagiola I, Palla R, Cairo A, Peyvandi F.
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| Hum Mutat 31(1):11-9. Review.PMID: 19847791 2010
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27 | ADAMTS13, THBS1, VWF
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| Thrombospondin-1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro.
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| Wang A, Liu F, Dong N, Ma Z, Zhang J, Su J, Zhao Y, Ruan C.
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| Thromb Res 126(4):e260-5. Epub 2010 Aug 11.
2010
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28 | ADAMTS13
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| A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF.
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| Zanardelli S, Chion AC, Groot E, Lenting PJ, McKinnon TA, Laffan MA, Tseng M, Lane DA.
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| Blood 114(13):2819-28. Epub 2009 Jul 8.
2009
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29 | ADAMTS13
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| ADAMTS13 in health and disease.
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| Feys HB, Deckmyn H, Vanhoorelbeke K.
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| Acta Haematol 121(2-3):183-5. Epub 2009 Jun 8. Review.
2009
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30 | ADAMTS13
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| Essential role of the disintegrin-like domain in ADAMTS13 function.
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| de Groot R, Bardhan A, Ramroop N, Lane DA, Crawley JT.
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| Blood 113(22):5609-16. Epub 2009 Feb 20.
2009
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31 | ADAMTS13
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| ADAMTS13 bound to endothelial cells exhibits enhanced cleavage of von Willebrand factor.
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| Vomund AN, Majerus EM.
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| J Biol Chem 284(45):30925-32. Epub 2009 Sep 3.
2009
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32 | ADAMTS13
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| ADAMTS13 activity and inhibitor.
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| Doldan-Silvero A, Acevedo-Gadea C, Habib C, Freeman J, Johari V.
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| Am J Hematol 83(10):811-4.
2008
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33 | ADAMTS13, TTPF
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| A first case of congenital TTP on the African continent due to a new homozygous mutation in the catalytic domain of ADAMTS13.
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| Meyer SC, Jeddi R, Meddeb B, Gouider E, Lämmle B, Kremer Hovinga JA.
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| Ann Hematol 87(8):663-6. Epub 2008 Apr 29.PMID: 18443791 2008
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34 | ADAMTS13, VWA2
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| Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity.
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| Gao W, Anderson PJ, Sadler JE.
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| Blood 112(5):1713-9. doi: 10.1182/blood-2008-04-148759. Epub 2008 May 20.
2008
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35 | ADAMTS13, TTPF
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| ADAMTS13 phenotype in plasma from normal individuals and patients with thrombotic thrombocytopenic purpura.
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| Manea M, Kristoffersson A, Tsai HM, Zhou W, Winqvist I, Oldaeus G, Billström R, Björk P, Holmberg L, Karpman D.
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| Eur J Pediatr 166(3):249-57. Epub 2006 Dec 24.
2007
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36 | ADAMTS13, TTPF
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| Molecular characterization of four ADAMTS13 mutations responsible for congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome).
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| Hommais A, Rayes J, Houllier A, Obert B, Legendre P, Veyradier A, Girma JP, Ribba AS.
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| Thromb Haemost 98(3):593-9.
2007
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37 | ADAMTS13, THBS1
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| The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow.
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| Zhang P, Pan W, Rux AH, Sachais BS, Zheng XL.
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| Blood 110(6):1887-94. Epub 2007 May 31.
2007
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38 | ADAMTS13
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| Mechanisms of the interaction between two ADAMTS13 gene mutations leading to severe deficiency of enzymatic activity.
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| Peyvandi F, Lavoretano S, Palla R, Valsecchi C, Merati G, De Cristofaro R, Rossi E, Mannuccio Mannucci P.
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| Hum Mutat 27(4):330-6. 2006
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39 | ADAMTS13, ADAMTS15
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| Impact of mutations in the von Willebrand factor A2 domain on ADAMTS13-dependent proteolysis.
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| Hassenpflug WA, Budde U, Obser T, Angerhaus D, Drewke E, Schneppenheim S, Schneppenheim R.
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| Blood 107(6):2339-45. Epub 2005 Dec 1. 2006
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40 | VWF, ADAMTS13
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| Characterization of a core binding site for ADAMTS-13 in the A2 domain of von Willebrand factor.
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| Wu JJ, Fujikawa K, McMullen BA, Chung DW.
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| Proc Natl Acad Sci U S A 103(49):18470-4. Epub 2006 Nov 22. 2006
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41 | ADAMTS13
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| ADAMTS13-binding IgG are present in patients with thrombotic thrombocytopenic purpura.
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| Tsai HM, Raoufi M, Zhou W, Guinto E, Grafos N, Ranzurmal S, Greenfield RS, Rand JH.
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| Thromb Haemost 95(5):886-92. 2006
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42 | ADAMTS13
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| ADAMTS-13 regulates platelet adhesion under flow. A new method for differentiation between inherited and acquired thrombotic thrombocytopenic purpura.
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| Shenkman B, Budde U, Angerhaus D, Lubetsky A, Savion N, Seligsohn U, Varon D.
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| Thromb Haemost 96(2):160-6. 2006
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43 | VWF, ADAMTS13
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| Molecular mapping of the chloride-binding site in von Willebrand factor (VWF): energetics and conformational effects on the VWF/ADAMTS-13 interaction.
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| De Cristofaro R, Peyvandi F, Baronciani L, Palla R, Lavoretano S, Lombardi R, Di Stasio E, Federici AB, Mannucci PM.
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| J Biol Chem 281(41):30400-11. Epub 2006 Aug 9. 2006
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44 | ADAMTS13, TTPS
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| In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura.
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| Donadelli R, Banterla F, Galbusera M, Capoferri C, Bucchioni S, Gastoldi S, Nosari S, Monteferrante G, Ruggeri ZM, Bresin E, Scheiflinger F, Rossi E, Martinez C, Coppo R, Remuzzi G, Noris M; International Registry of Recurrent and Familial HUS/TTP.
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| Thromb Haemost 96(4):454-64.
2006
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45 | ADAMTS13
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| Binding of ADAMTS13 to von Willebrand factor.
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| Majerus EM, Anderson PJ, Sadler JE.
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| J Biol Chem 280(23):21773-8. Epub 2005 Apr 11. 2005
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46 | ADAMTS13, VWF
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| The proximal carboxyl-terminal domains of ADAMTS13 determine substrate specificity and are all required for cleavage of von Willebrand factor.
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| Ai J, Smith P, Wang S, Zhang P, Zheng XL.
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| J Biol Chem 280(33):29428-34. Epub 2005 Jun 23. 2005
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47 | TTPF, ADAMTS13
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| Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers.
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| Nolasco LH, Turner NA, Bernardo A, Tao Z, Cleary TG, Dong JF, Moake JL.
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| Blood 106(13):4199-209. Epub 2005 Aug 30. 2005
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48 | ADAMTS13, TTPF
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| Identification of novel mutations in ADAMTS13 in an adult patient with congenital thrombotic thrombocytopenic purpura.
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| Uchida T, Wada H, Mizutani M, Iwashita M, Ishihara H, Shibano T, Suzuki M, Matsubara Y, Soejima K, Matsumoto M, Fujimura Y, Ikeda Y, Murata M; Research Project on Genetics of Thrombosis.
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| Blood 104(7):2081-3. Epub 2004 May 4. 2004
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49 | ADAMTS13, GP1BA, VWF
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| Binding of platelet glycoprotein Ibalpha to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13.
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| Nishio K, Anderson PJ, Zheng XL, Sadler JE.
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| Proc Natl Acad Sci U S A 101(29):10578-83. Epub 2004 Jul 12. 2004
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50 | ADAMTS13
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| Detection of von Willebrand factor-cleaving protease (ADAMTS-13) in human platelets.
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| Suzuki M, Murata M, Matsubara Y, Uchida T, Ishihara H, Shibano T, Ashida S, Soejima K, Okada Y, Ikeda Y.
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| Biochem Biophys Res Commun 313(1):212-6. 2004
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51 | ADAMTS13, TTPF
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| Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome.
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| Matsumoto M, Kokame K, Soejima K, Miura M, Hayashi S, Fujii Y, Iwai A, Ito E, Tsuji Y, Takeda-Shitaka M, Iwadate M, Umeyama H, Yagi H, Ishizashi H, Banno F, Nakagaki T, Miyata T, Fujimura Y.
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| Blood 103(4):1305-10. Epub 2003 Oct 16. 2004
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52 | TTPF, ADAMTS13
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| Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS).
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| Licht C, Stapenhorst L, Simon T, Budde U, Schneppenheim R, Hoppe B.
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| Kidney Int 66(3):955-8. 2004
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53 | ADAMTS13, VWF
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| ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor.
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| Dong JF, Moake JL, Bernardo A, Fujikawa K, Ball C, Nolasco L, Lopez JA, Cruz MA.
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| J Biol Chem 278(32):29633-9. Epub 2003 May 29. 2003
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54 | ADAMTS13
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| Cleavage of the ADAMTS13 propeptide is not required for protease activity.
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| Majerus EM, Zheng X, Tuley EA, Sadler JE.
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| J Biol Chem 278(47):46643-8. Epub 2003 Sep 15. 2003
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55 | ADAMTS13
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| ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage.
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| Soejima K, Matsumoto M, Kokame K, Yagi H, Ishizashi H, Maeda H, Nozaki C, Miyata T, Fujimura Y, Nakagaki T.
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| Blood 102(9):3232-7. Epub 2003 Jul 17. 2003
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56 | ADAMTS13, TTPF
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| Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity.
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| Kokame K, Matsumoto M, Soejima K, Yagi H, Ishizashi H, Funato M, Tamai H, Konno M, Kamide K, Kawano Y, Miyata T, Fujimura Y.
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| Proc Natl Acad Sci U S A 99(18):11902-7. Epub 2002 Aug 14. 2002
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57 | ADAMTS13
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| Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13).
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| Plaimauer B, Zimmermann K, Volkel D, Antoine G, Kerschbaumer R, Jenab P, Furlan M, Gerritsen H, Lammle B, Schwarz HP, Scheiflinger F.
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| Blood 100(10):3626-32. Epub 2002 Jul 12. 2002
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58 | ADAMTS13, TTPF
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| Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura.
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| Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H, Bouhassira EE, Upshaw JD Jr, Ginsburg D, Tsai HM.
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| Nature 413(6855):488-94. 2001
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59 | ADAMTS13, TTPF
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| Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura.
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| Zheng X, Chung D, Takayama TK, Majerus EM, Sadler JE, Fujikawa K.
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| J Biol Chem 276(44):41059-41063. 2001
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60 | ADAMTS13
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| Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family.
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| Fujikawa K, Suzuki H, McMullen B, Chung D.
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| Blood 98(6):1662-6. 2001
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61 | ADAMTS13, HUS1, TTPF
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| von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
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| Furlan M, Robles R, Galbusera M, Remuzzi G, Kyrle PA, Brenner B, Krause M, Scharrer I, Aumann V, Mittler U, Solenthaler M, Lammle B.
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| N Engl J Med 339(22):1578-84. 1998
|