Citations for
1ACLY, BRCA1
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
Sivanand S, Rhoades S, Jiang Q, Lee JV, Benci J, Zhang J, Yuan S, Viney I, Zhao S, Carrer A, Bennett MJ, Minn AJ, Weljie AM, Greenberg RA, Wellen KE.
Mol Cell ol Cell. 2017 Jul 1. pii: S1097-2765(17)30435-5. doi: 10.1016/j.molcel.2017.06.008. [Epub ahead of print] 2017
2ACLY
ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia.
Burke AC, Huff MW.
Curr Opin Lipidol 28(2):193-200. doi: 10.1097/MOL.0000000000000390. 2017
3ACLY
ATP citrate lyase is increased in human breast cancer, depletion of which promotes apoptosis.
Wang D, Yin L, Wei J, Yang Z, Jiang G.
Tumour Biol 39(4):1010428317698338. doi: 10.1177/1010428317698338. 2017
4ACLY
ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch.
Zhao S, Torres A, Henry RA, Trefely S, Wallace M, Lee JV, Carrer A, Sengupta A, Campbell SL, Kuo YM, Frey AJ, Meurs N, Viola JM, Blair IA, Weljie AM, Metallo CM, Snyder NW, Andrews AJ, Wellen KE.
Cell Rep 17(4):1037-1052. doi: 10.1016/j.celrep.2016.09.069. 2016
5ACLY, CUL3, KLHL25
Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. 2016
Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W, Feng Z.
Genes Dev. Sep 1;30(17):1956-70. doi: 10.1101/gad.283283.116 2016
6ACACA, ACLY, ETV4
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.
Keenan MM, Liu B, Tang X, Wu J, Cyr D, Stevens RD, Ilkayeva O, Huang Z, Tollini LA, Murphy SK, Lucas J, Muoio DM, Kim SY, Chi JT.
PLoS Genet 11(10):e1005599. doi: 10.1371/journal.pgen.1005599. eCollection 2015 Oct. 2015
7ACLY
ATP citrate lyase improves mitochondrial function in skeletal muscle.
Das S, Morvan F, Jourde B, Meier V, Kahle P, Brebbia P, Toussaint G, Glass DJ, Fornaro M.
Cell Metab 21(6):868-76. doi: 10.1016/j.cmet.2015.05.006. 2015
8ACLY
ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway.
Lee JH, Jang H, Lee SM, Lee JE, Choi J, Kim TW, Cho EJ, Youn HD.
FEBS J 282(2):361-71. doi: 10.1111/febs.13139. Epub 2014 Nov 23. 2015
9ACLY, MORC2
Cytosolic functions of MORC2 in lipogenesis and adipogenesis.
Sánchez-Solana B, Li DQ, Kumar R.
Biochim Biophys Acta 1843(2):316-26. doi: 10.1016/j.bbamcr.2013.11.012. Epub 2013 Nov 25. 2014
10ACLY
ATP-citrate lyase is essential for macrophage inflammatory response.
Infantino V, Iacobazzi V, Palmieri F, Menga A.
Biochem Biophys Res Commun 440(1):105-11. doi: 10.1016/j.bbrc.2013.09.037. Epub 2013 Sep 17. 2013
11ACLY
High level of ATP citrate lyase expression in human and rat pancreatic islets.
MacDonald MJ, Longacre MJ, Warner TF, Thonpho A.
Horm Metab Res 45(5):391-3. doi: 10.1055/s-0032-1329987. Epub 2012 Dec 7. 2013
12ACLY
On the catalytic mechanism of human ATP citrate lyase.
Fan F, Williams HJ, Boyer JG, Graham TL, Zhao H, Lehr R, Qi H, Schwartz B, Raushel FM, Meek TD.
Biochemistry 51(25):5198-211. doi: 10.1021/bi300611s. Epub 2012 Jun 15. 2012
13ACLY
ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells.
Chu KY, Lin Y, Hendel A, Kulpa JE, Brownsey RW, Johnson JD.
J Biol Chem 285(42):32606-15. doi: 10.1074/jbc.M110.157172. Epub 2010 Aug 7. 2010
14ACLY
ATP-citrate lyase links cellular metabolism to histone acetylation.
Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB.
Science 324(5930):1076-80. doi: 10.1126/science.1164097. 2009
15ACLY
ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.
Migita T, Narita T, Nomura K, Miyagi E, Inazuka F, Matsuura M, Ushijima M, Mashima T, Seimiya H, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y.
Cancer Res 68(20):8547-54. doi: 10.1158/0008-5472.CAN-08-1235. 2008
16ACLY
The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus.
Michno A, Skibowska A, Raszeja-Specht A, Cwikowska J, Szutowicz A.
Metabolism 53(1):66-72. 2004
17ACLY
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes.
Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM.
J Biol Chem 277(37):33895-900. Epub 2002 Jul 9. 2002
18ACLY
Cloning and characterization of the 5' flanking region of human ATP-citrate lyase gene.
Park S, Moon Y, Kim K, Ahn Y, Kim Y.
Biochim Biophys Acta 1353(3):236-40. 1997
19ACLY
Localization of the gene for ATP citrate lyase (ACLY) distal to gastrin (GAS) and proximal to D17S856 on chromosome 17q12-q21.
Couch FJ, et al.
Genomics 21 : 444-446. 1994
20ACLY, BRCA1, CNP, KAT2A, NBR1, PSME3, PYY, RAB5C
A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21.
Albertsen HM, et al.
Nat Genet 7 : 472-479. 1994