1 | ACKR3, ARX, LHX6
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| Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position.
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| Vogt D, Hunt RF, Mandal S, Sandberg M, Silberberg SN, Nagasawa T, Yang Z, Baraban SC, Rubenstein JL.
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| Neuron 82(2):350-64. doi: 10.1016/j.neuron.2014.02.030. 2014
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2 | ACKR3, CXCL12, CXCR4
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| CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons.
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| Abe P, Mueller W, Schütz D, MacKay F, Thelen M, Zhang P, Stumm R.
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| Development 141(9):1857-63. doi: 10.1242/dev.104224. Epub 2014 Apr 9. 2014
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3 | ACKR3, CXCR4
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| Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular α₁-adrenergic receptor function.
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| Bach HH 4th, Wong YM, Tripathi A, Nevins AM, Gamelli RL, Volkman BF, Byron KL, Majetschak M.
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| Mol Med 20:435-47. doi: 10.2119/molmed.2014.00101.
2014
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4 | ACKR3
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| Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system.
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| Williams JL, Patel JR, Daniels BP, Klein RS.
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| J Exp Med 211(5):791-9. doi: 10.1084/jem.20131224. Epub 2014 Apr 14.
2014
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5 | ACKR3, CXCR4
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| CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12.
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| Melo Rde C, Longhini AL, Bigarella CL, Baratti MO, Traina F, Favaro P, de Melo Campos P, Saad ST.
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| PLoS One 9(1):e85926. doi: 10.1371/journal.pone.0085926. eCollection 2014.
2014
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6 | ACKR3
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| CXCR7 influences the migration of B cells during maturation.
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| Humpert ML, Pinto D, Jarrossay D, Thelen M.
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| Eur J Immunol 44(3):694-705. doi: 10.1002/eji.201343907. Epub 2014 Feb 19.
2014
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7 | ACKR3, CXCL2
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| Estrogen represses CXCR7 gene expression by inhibiting the recruitment of NFκB transcription factor at the CXCR7 promoter in breast cancer cells.
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| Kerdivel G, Boudot A, Pakdel F.
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| Biochem Biophys Res Commun 431(4):729-33. doi: 10.1016/j.bbrc.2013.01.050. Epub 2013 Jan 23.
2013
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8 | ACKR3, CXCL12
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| CXCR7 silencing attenuates cell adaptive response to stromal cell derived factor 1α after hypoxia.
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| Liu S, Jia X, Li C, Han X, Yan W, Xing Y.
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| PLoS One 8(1):e55290. doi: 10.1371/journal.pone.0055290. Epub 2013 Jan 31.
2013
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9 | ACKR3, CXCL12
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| CXCR7 mediates SDF1-induced melanocyte migration.
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| Lee E, Han J, Kim K, Choi H, Cho EG, Lee TR.
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| Pigment Cell Melanoma Res 26(1):58-66. doi: 10.1111/pcmr.12024. Epub 2012 Oct 26.
2013
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10 | ACKR3, ADRBK1
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| Grk2 is an essential regulator of CXCR7 signalling in astrocytes.
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| Lipfert J, Ödemis V, Engele J.
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| Cell Mol Neurobiol 33(1):111-8. doi: 10.1007/s10571-012-9876-5. Epub 2012 Sep 2.
2013
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11 | ACKR3, CXCL12
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| Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues.
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| Hoffmann F, Müller W, Schütz D, Penfold ME, Wong YH, Schulz S, Stumm R.
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| J Biol Chem 287(34):28362-77. doi: 10.1074/jbc.M111.335679. Epub 2012 Jun 26.
2012
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12 | ACKR3
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| Ubiquitination of CXCR7 controls receptor trafficking.
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| Canals M, Scholten DJ, de Munnik S, Han MK, Smit MJ, Leurs R.
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| PLoS One 7(3):e34192. doi: 10.1371/journal.pone.0034192. Epub 2012 Mar 23.
2012
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13 | ACKR3
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| Carboxy-terminus of CXCR7 regulates receptor localization and function.
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| Ray P, Mihalko LA, Coggins NL, Moudgil P, Ehrlich A, Luker KE, Luker GD.
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| Int J Biochem Cell Biol 44(4):669-78. doi: 10.1016/j.biocel.2012.01.007. Epub 2012 Jan 25.
2012
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14 | ACKR3, CXCL12
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| Chemokine receptor CXCR7 mediates human endothelial progenitor cells survival, angiogenesis, but not proliferation.
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| Yan X, Cai S, Xiong X, Sun W, Dai X, Chen S, Ye Q, Song Z, Jiang Q, Xu Z.
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| J Cell Biochem 113(4):1437-46. doi: 10.1002/jcb.24015.
2012
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15 | ACKR3, CXCL12, CXCR4
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| The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells.
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| Dai X, Tan Y, Cai S, Xiong X, Wang L, Ye Q, Yan X, Ma K, Cai L.
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| J Cell Mol Med 15(6):1299-309. doi: 10.1111/j.1582-4934.2011.01301.x.
2011
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16 | ACKR3
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| The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.
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| Yu S, Crawford D, Tsuchihashi T, Behrens TW, Srivastava D.
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| Dev Dyn 240(2):384-93. doi: 10.1002/dvdy.22549.
2011
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17 | ACKR3
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| CXCR7 protein is not expressed on human or mouse leukocytes.
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| Berahovich RD, Zabel BA, Penfold ME, Lewén S, Wang Y, Miao Z, Gan L, Pereda J, Dias J, Slukvin II, McGrath KE, Jaen JC, Schall TJ.
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| J Immunol 185(9):5130-9. doi: 10.4049/jimmunol.1001660. Epub 2010 Oct 1.
2010
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18 | ACKR3, CXCL11, CXCL12
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| CXCR7 functions as a scavenger for CXCL12 and CXCL11.
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| Naumann U, Cameroni E, Pruenster M, Mahabaleshwar H, Raz E, Zerwes HG, Rot A, Thelen M.
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| PLoS One 5(2):e9175. doi: 10.1371/journal.pone.0009175.
2010
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19 | ACKR3, HIC1
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| Scavenger Chemokine (CXC Motif) Receptor 7 (CXCR7) Is a Direct Target Gene of HIC1 (Hypermethylated in Cancer 1).
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| Van Rechem C, Rood BR, Touka M, Pinte S, Jenal M, Guérardel C, Ramsey K, Monté D, Bégue A, Tschan MP, Stephan DA, Leprince D.
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| J Biol Chem 284(31):20927-35. Epub 2009 Jun 12. 2009
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20 | ACKR3
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| Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer.
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| Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, Wada H, Date H, Miyahara R.
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| Cancer 115(11):2580-93. 2009
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21 | ACKR3
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| Differential expression of RDC1/CXCR7 in the human placenta.
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| Tripathi V, Verma R, Dinda A, Malhotra N, Kaur J, Luthra K.
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| J Clin Immunol 29(3):379-86. Epub 2008 Oct 28. 2009
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22 | ACKR3
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| A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells.
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| Hartmann TN, Grabovsky V, Pasvolsky R, Shulman Z, Buss EC, Spiegel A, Nagler A, Lapidot T, Thelen M, Alon R.
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| J Leukoc Biol 84(4):1130-40. Epub 2008 Jul 24. 2008
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23 | ACKR3
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| The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer.
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| Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Loberg R, Taichman RS.
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| J Biol Chem 283(7):4283-94. Epub 2007 Dec 5. 2008
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24 | ACKR3
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| CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.
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| Miao Z, Luker KE, Summers BC, Berahovich R, Bhojani MS, Rehemtulla A, Kleer CG, Essner JJ, Nasevicius A, Luker GD, Howard MC, Schall TJ.
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| Proc Natl Acad Sci U S A 104(40):15735-40. Epub 2007 Sep 26. 2007
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25 | ACKR3
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| A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.
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| Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, Wei K, McMaster BE, Wright K, Howard MC, Schall TJ.
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| J Exp Med 203(9):2201-13. Epub 2006 Aug 28. 2006
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26 | ACKR3
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| A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.
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| Burns JM, Summers BC, Wang Y, Melikian A, Berahovich R, Miao Z, Penfold ME, Sunshine MJ, Littman DR, Kuo CJ, Wei K, McMaster BE, Wright K, Howard MC, Schall TJ.
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| J Exp Med 203(9):2201-13. Epub 2006 Aug 28. 2006
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27 | ACKR3, CXCL12
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| The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes.
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| Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F.
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| J Biol Chem 280(42):35760-6. Epub 2005 Aug 17. 2005
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28 | ACKR3, HMGA2
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| Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15.
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| Broberg K, Zhang M, Strombeck B, Isaksson M, Nilsson M, Mertens F, Mandahl N, Panagopoulos I.
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| Int J Oncol 21(2):321-6. 2002
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