Citations for
1ACE, APELA, APLNR
ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.
Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K.
Cardiovasc Res 113(7):760-769. doi: 10.1093/cvr/cvx061. 2017
2ACE
Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE).
Yates CJ, Masuyer G, Schwager SL, Akif M, Sturrock ED, Acharya KR.
J Biol Chem 289(3):1798-814. doi: 10.1074/jbc.M113.512335. Epub 2013 Dec 2. 2014
3ACE
Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer's-like cognitive decline.
Bernstein KE, Koronyo Y, Salumbides BC, Sheyn J, Pelissier L, Lopes DH, Shah KH, Bernstein EA, Fuchs DT, Yu JJ, Pham M, Black KL, Shen XZ, Fuchs S, Koronyo-Hamaoui M.
J Clin Invest 124(3):1000-12. 2014
4ACE, DCP1
The influence of Angiotensin converting enzyme and angiotensinogen gene polymorphisms on hypertrophic cardiomyopathy.
Luo R, Li X, Wang Y, Li Y, Deng Y, Wan Y, Jiang Z, Hua W, Wu X.
PLoS One 8(10):e77030. doi: 10.1371/journal.pone.0077030. eCollection 2013. Review. 2013
5ACE
The absence of intrarenal ACE protects against hypertension.
Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough AA.
J Clin Invest 123(5):2011-23. doi: 10.1172/JCI65460. Epub 2013 Apr 24. 2013
6ACE
Functional regulation of Alu element of human angiotensin-converting enzyme gene in neuron cells.
Wu SJ, Hsieh TJ, Kuo MC, Tsai ML, Tsai KL, Chen CH, Yang YH.
Neurobiol Aging 34(7):1921.e1-7. doi: 10.1016/j.neurobiolaging.2013.01.003. Epub 2013 Feb 5. 2013
7ACE, AGT
The influence of Angiotensin converting enzyme and angiotensinogen gene polymorphisms on hypertrophic cardiomyopathy.
Luo R, Li X, Wang Y, Li Y, Deng Y, Wan Y, Jiang Z, Hua W, Wu X.
PLoS One 8(10):e77030. doi: 10.1371/journal.pone.0077030. eCollection 2013. Review. 2013
8ACE, TEX101
Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa.
Fujihara Y, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M, Okabe M.
Proc Natl Acad Sci U S A 110(20):8111-6. doi: 10.1073/pnas.1222166110. Epub 2013 Apr 30. 2013
9ACE, AGT, AGTR1, REN, RTD1, RTD2, RTD3, RTD4
Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis.
Gribouval O, Morinière V, Pawtowski A, Arrondel C, Sallinen SL, Saloranta C, Clericuzio C, Viot G, Tantau J, Blesson S, Cloarec S, Machet MC, Chitayat D, Thauvin C, Laurent N, Sampson JR, Bernstein JA, Clemenson A, Prieur F, Daniel L, Levy-Mozziconacci A, Lachlan K, Alessandri JL, Cartault F, Rivière JP, Picard N, Baumann C, Delezoide AL, Belar Ortega M, Chassaing N, Labrune P, Yu S, Firth H, Wellesley D, Bitzan M, Alfares A, Braverman N, Krogh L, Tolmie J, Gaspar H, Doray B, Majore S, Bonneau D, Triau S, Loirat C, David A, Bartholdi D, Peleg A, Brackman D, Stone R, DeBerardinis R, Corvol P, Michaud A, Antignac C, Gubler MC.
Hum Mutat 33(2):316-26. doi: 10.1002/humu.21661. Epub 2011 Dec 22. Review. 2012
10ACE, ADAM9
LPS activates ADAM9 dependent shedding of ACE from endothelial cells.
English WR, Corvol P, Murphy G.
Biochem Biophys Res Commun 421(1):70-5. doi: 10.1016/j.bbrc.2012.03.113. Epub 2012 Mar 29. 2012
11ACE
Molecular recognition and regulation of human angiotensin-I converting enzyme (ACE) activity by natural inhibitory peptides.
Masuyer G, Schwager SL, Sturrock ED, Isaac RE, Acharya KR.
Sci Rep 2:717. doi: 10.1038/srep00717. Epub 2012 Oct 9. 2012
12ACE
Angiotensin-converting enzyme (ACE) gene II genotype protects against the development of diabetic peripheral neuropathy in type 2 diabetes mellitus.
Mansoor Q, Javaid A, Bilal N, Ismail M.
J Diabetes 4(3):257-61. doi: 10.1111/j.1753-0407.2012.00205.x. 2012
13ACE
Angiotensin-converting enzyme (CD143) specifies emerging lympho-hematopoietic progenitors in the human embryo.
Sinka L, Biasch K, Khazaal I, Péault B, Tavian M.
Blood 119(16):3712-23. doi: 10.1182/blood-2010-11-314781. Epub 2012 Jan 26. 2012
14ACE, EDC4, XRN1
A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation.
Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E.
Nat Struct Mol Biol 19(12):1324-31. doi: 10.1038/nsmb.2413. Epub 2012 Nov 11. 2012
15ACE
ACE as a mechanosensor to shear stress influences the control of its own regulation via phosphorylation of cytoplasmic Ser(1270).
Barauna VG, Campos LC, Miyakawa AA, Krieger JE.
PLoS One 6(8):e22803. doi: 10.1371/journal.pone.0022803. Epub 2011 Aug 25. 2011
16ACE, ACE2
Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis.
Wang G, Lai FM, Kwan BC, Lai KB, Chow KM, Li PK, Szeto CC.
Kidney Blood Press Res 34(3):141-9. doi: 10.1159/000324521. Epub 2011 Feb 24. 2011
17ACE
Angiotensin-converting enzyme is required for normal myelopoiesis.
Lin C, Datta V, Okwan-Duodu D, Chen X, Fuchs S, Alsabeh R, Billet S, Bernstein KE, Shen XZ.
FASEB J 25(4):1145-55. doi: 10.1096/fj.10-169433. Epub 2010 Dec 9. 2011
18ACE, LEP
Leptin regulates ACE activity in mice.
Hilzendeger AM, Morais RL, Todiras M, Plehm R, da Costa Goncalves A, Qadri F, Araujo RC, Gross V, Nakaie CR, Casarini DE, Carmona AK, Bader M, Pesquero JB.
J Mol Med (Berl) 88(9):899-907. doi: 10.1007/s00109-010-0649-7. Epub 2010 Jul 8. 2010
19ACE
Meta-analysis of the ACE gene polymorphism in cerebral infarction.
Tao HM, Shao B, Chen GZ.
Can J Neurol Sci 36(1):20-5. 2009
20ACE, CPM
Interaction of angiotensin-converting enzyme (ACE) with membrane-bound carboxypeptidase M (CPM) - a new function of ACE.
Sun X, Wiesner B, Lorenz D, Papsdorf G, Pankow K, Wang P, Dietrich N, Siems WE, Maul B.
Biol Chem 389(12):1477-85. doi: 10.1515/BC.2008.168. 2008
21RTD1, AGT, AGTR1, ACE, RTD2, REN, RTD4, RTD3
Inherited renal tubular dysgenesis: the first patients surviving the neonatal period.
Zingg-Schenk A, Bacchetta J, Corvol P, Michaud A, Stallmach T, Cochat P, Gribouval O, Gubler MC, Neuhaus TJ.
Eur J Pediatr [Epub ahead of print] 2007
22ACE, ARMD1, ARMD2, ARMD3, ARMD7, ARMD8, ARMDA, ARMDC, ARMS2, CFH, CX3CR1, FBLN5, HTRA1, MMP9, SOD2, VEGFA
Progress in defining the molecular biology of age related macular degeneration.
Lotery A, Trump D.
Hum Genet 122(3-4):219-36. Epub 2007 Jul 21. No abstract available. 2007
23AGTR1, CYP11B2, AGT, CMA1, ACE
RAAS gene polymorphisms influence progression of pediatric hypertrophic cardiomyopathy.
Kaufman BD, Auerbach S, Reddy S, Manlhiot C, Deng L, Prakash A, Printz BF, Gruber D, Papavassiliou DP, Hsu DT, Sehnert AJ, Chung WK, Mital S.
Hum Genet 122(5):515-23. Epub 2007 Sep 13. 2007
24ACE, APOE, CHRNB2, CST3, ESR1, GAPDHS, IDE, MTHFR, NCSTN, PRNP, PSEN1, TF, TFAM, TNF
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE.
Nat Genet 39(1):17-23. 2007
25ACE
Association between angiotensin-converting enzyme gene polymorphisms and diabetic nephropathy: case-control, haplotype, and family-based study in three European populations.
Hadjadj S, Tarnow L, Forsblom C, Kazeem G, Marre M, Groop PH, Parving HH, Cambien F, Tregouet DA, Gut IG, Théva A, Gauguier D, Farrall M, Cox R, Matsuda F, Lathrop M, Hager-Vionnet N; EURAGEDIC (European Rational Approach for Genetics of Diabetic Complications) Study Group.
J Am Soc Nephrol 18(4):1284-91. Epub 2007 Mar 21. 2007
26ACE
The structure of testis angiotensin-converting enzyme in complex with the C domain-specific inhibitor RXPA380.
Corradi HR, Chitapi I, Sewell BT, Georgiadis D, Dive V, Sturrock ED, Acharya KR.
Biochemistry 46(18):5473-8. Epub 2007 Apr 18. 2007
27ACE, DCP1
The angiotensin-I converting enzyme I/D polymorphism is not associated with type 2 diabetes in individuals undergoing coronary angiography. (The Ludwigshafen Risk and Cardiovascular Health Study).
Grammer TB, Renner W, von Karger S, Boehm BO, Winkelmann BR, Maerz W.
Mol Genet Metab 88(4):378-83. Epub 2006 Jun 12. 2006
28ACE, DCP1
Angiotensin-converting enzyme gene polymorphism in chronic allograft nephropathy.
Biselli PM, Abbud-Filho M, Ferreira-Baptista MA, de Alvarenga MP, Goloni-Bertollo EM, Pavarino-Bertelli EC.
Transplant Proc 38(5):1327-8. 2006
29ACE
Angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms in children with subacute sclerosing panencephalitis.
Tasdemir N, Ece A, Tekes S, Dikici S, Gunes A, Balik H.
Am J Med Genet B Neuropsychiatr Genet 141B(5):445-448. 2006
30ACE, ACE2, AGTR2, AGTR1
Angiotensin-converting enzyme 2 protects from severe acute lung failure.
Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower MA, Fukamizu A, Hui CC, Hein L, Uhlig S, Slutsky AS, Jiang C, Penninger JM.
Nature 436(7047):112-6. 2005
31ACE
Angiotensin-converting enzyme (ACE) haplotypes and cyclosporine A (CsA) response: a model of the complex relationship between ACE quantitative trait locus and pathological phenotypes.
Catarsi P, Ravazzolo R, Emma F, Fruci D, Finos L, Frau A, Morreale G, Carrea A, Ghiggeri GM.
Hum Mol Genet 14(16):2357-67. Epub 2005 Jul 7. 2005
32RTD1, AGT, AGTR1, ACE, RTD2, REN, RTD4, RTD3
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis.
Gribouval O, Gonzales M, Neuhaus T, Aziza J, Bieth E, Laurent N, Bouton JM, Feuillet F, Makni S, Ben Amar H, Laube G, Delezoide AL, Bouvier R, Dijoud F, Ollagnon-Roman E, Roume J, Joubert M, Antignac C, Gubler MC.
Nat Genet 37(9):964-8. Epub 2005 Aug 14. 2005
33ACE, ACE2
Membrane-associated zinc peptidase families: comparing ACE and ACE2.
Guy JL, Lambert DW, Warner FJ, Hooper NM, Turner AJ.
Biochim Biophys Acta 1751(1):2-8. Epub 2004 Nov 6. Review. 2005
34ACE
A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity.
Katzov H, Bennet AM, Kehoe P, Wiman B, Gatz M, Blennow K, Lenhard B, Pedersen NL, de Faire U, Prince JA.
Hum Mol Genet 13(21):2647-57. Epub 2004 Sep 14. 2004
35ACE, ADD1
Interaction between ACE and ADD1 gene polymorphisms in the progression of IgA nephropathy in Japanese patients.
Narita I, Goto S, Saito N, Song J, Ajiro J, Sato F, Saga D, Kondo D, Akazawa K, Sakatsume M, Gejyo F.
Hypertension 42(3):304-9. Epub 2003 Jul 28. 2003
36ACE
Association between markers in chromosomal region 17q23 and young onset hypertension: a TDT study.
Wu SY, Fann CS, Jou YS, Chen JW, Pan WH.
J Med Genet 39(1):42-4. No abstract available. 2002
37ACE
Increased frequency of the homozygous II ACE genotype in Italian Olympic endurance athletes.
Scanavini D, Bernardi F, Castoldi E, Conconi F, Mazzoni G.
Eur J Hum Genet 10(10):576-7. No abstract available. 2002
38ACE
Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration.
Hamdi HK, Reznik J, Castellon R, Atilano SR, Ong JM, Udar N, Tavis JH, Aoki AM, Nesburn AB, Boyer DS, Small KW, Brown DJ, Kenney MC.
Biochem Biophys Res Commun 295(3):668-72. 2002
39ACE
The ACE I allele is associated with increased risk for ruptured intracranial aneurysms.
Keramatipour M, McConnell RS, Kirkpatrick P, Tebbs S, Furlong RA, Rubinsztein DC.
J Med Genet 37(7):498-500. 2000
40ACE
The ACE gene and Alzheimer's disease susceptibility.
Narain Y, Yip A, Murphy T, Brayne C, Easton D, Evans JG, Xuereb J, Cairns N, Esiri MM, Furlong RA, Rubinsztein DC.
J Med Genet 37(9):695-7. 2000
41ACE
Association of ACE I/D polymorphism with cardiovascular risk factors
Uemura K, Nakura J, Kohara K, Miki T.
Hum Genet 107(3):239-42. 2000
42ACE, AGT
Angiotensin I-converting enzyme gene insertion/deletion and angiotensinogen M235T polymorphisms: risk of chronic renal failure. End-Stage Renal Disease Study Group.
Gumprecht J, Zychma MJ, Grzeszczak W, Zukowska-Szczechowska E.
Kidney Int 58(2):513-9. 2000
43ACE
Association of essential hypertension in elderly Japanese with I/D polymorphism of the angiotensin-converting enzyme (ACE) gene.
Yoshida K, Ishigami T, Nakazawa I, Ohno A, Tamura K, Fukuoka M, Mizushima S, Umemura S.
J Hum Genet 45(5):294-8. 2000
44ACE
The insertion/deletion polymorphism of the angiotensin-converting enzyme gene determines coronary vascular tone and nitric oxide activity.
Prasad A, Narayanan S, Waclawiw MA, Epstein N, Quyyumi AA.
J Am Coll Cardiol 36(5):1579-86. 2000
45ACE
Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease.
Kehoe PG, et al.
Nat Genet 21 : 71-72. 1999
46ACE
Angiotensin I-converting enzyme gene polymorphism in a low-risk European population for coronary artery disease.
Ferrieres J, et al.
Atherosclerosis 142(1):211-6. 1999
47ACE
Sequence variation in the human angiotensin converting enzyme.
Rieder MJ, et al.
Nat Genet 22(1):59-62. 1999
48ACE
The DD genotype of the ACE gene polymorphism is associated with progression of diabetic nephropathy to end stage renal failure in IDDM.
Vleming LJ, et al.
Clin Nephrol 51(3):133-40. 1999
49ACE
Insertion/deletion angiotensin converting enzyme gene polymorphism affects the microvascular structure of the kidney in patients with nondiabetic renal disease.
Teranishi M, et al.
J Hypertens 17(3):351-6. 1999
50ACE
Angiotensin-converting enzyme insertion-deletion polymorphism in normotensive and pre-eclamptic pregnancies.
Morgan L, et al.
J Hypertens 17(6):765-8 1999
51AGT, AGTR1, ACE
A multilocus genotyping assay for candidate markers of cardiovascular disease risk.
Cheng S, Grow MA, Pallaud C, Klitz W, Erlich HA, Visvikis S, Chen JJ, Pullinger CR, Malloy MJ, Siest G, Kane JP.
Genome Res 9(10):936-49 1999
52AGT, ACE
Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project.
Bengtsson K, Orho-Melander M, Lindblad U, Melander O, Bog-Hansen E, Ranstam J, Rastam L, Groop L.
J Hypertens 17(11):1569-75 1999
53CYP7A1, ACE, TGM4
The human prostate-specific transglutaminase gene (TGM4) : genomic organization, tissue-specific expression, and promoter characterization.
Dubbink HJ, et al.
Genomics 51 : 434-444. 1998
54AGTR1, ACE
Angiotensin-converting enzyme and angiotensin II receptor 1 polymorphisms : association with early coronary disease.
Alvarez R, et al.
Cardiovasc Res 40 : 375-379. 1998
55AGTR1, ACE
Mapping tissue angiotensin-converting enzyme and angiotensin AT1, AT2 and AT4 receptors.
Zhuo J, et al.
J Hypertens 16(12 Pt 2):2027-37. 1998
56AGT, AGTR1, ACE
Genetic polymorphisms of the renin-angiotensin system and angiographic extent and severity of coronary artery disease : the CORGENE study.
Jeunemaitre X, et al.
Hum Genet 99 : 66-73. 1997
57AGT, ACE
Association of angiotensinogen gene T235 variant with progression of immunoglobin A nephropathy in Caucasian patients.
Pei Y, Scholey J, Thai K, Suzuki M, Cattran D.
J Clin Invest 100(4):814-20. 1997
58ACE
Angiotensin-converting enzyme deletion polymorphism is associated with hypertension in a Sikh population.
Mastana S, Nunn J.
Hum Hered 47(5):250-3. 1997
59ACE
Association between angiotensin-converting-enzyme gene polymorphism and failure of renoprotective therapy.
van Essen GG, et al.
Lancet 347 : 94-95. 1996
60ACE
Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE levels by two-QTL segregation-linkage analysis.
Villard E, et al.
Am J Hum Genet 58 : 1268-1278. 1996
61ACE
A deletion in the angiotensin converting enzyme (ACE) gene is common among African Americans with essential hypertension.
Asamoah A, et al.
Clin Chim Acta 254 : 41-46. 1996
62ACE
Proteolytic release of membrane-bound angiotensin-converting enzyme: role of the juxtamembrane stalk sequence.
Ehlers MR, Schwager SL, Scholle RR, Manji GA, Brandt WF, Riordan JF.
Biochemistry 35(29):9549-59. 1996
63ACE
Role of the deletion polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy.
Yoshida H, et al.
J Clin Invest 96 : 2162-2169. 1995
64ACE
Angiotensin-converting enzyme gene polymorphism is associated with myocardial infarction but not with development of coronary stenosis.
Ludwig E, et al.
Circulation 91 : 2120-2124. 1995
65ACE
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.
Ruiz J, et al.
Proc Natl Acad Sci U S A 91 : 3662-3665. 1994
66ACE
Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy.
Schunkert H, et al.
N Engl J Med 330 : 1634-1638. 1994
67ACE
Molecular characterization of a DDEI melting polymorphism at the angiotensin I-Converting Enzyme (ACE) locus.
Doria A, et al.
Hum Mutat 4 : 155-157. 1994
68ACE
Relationship between angiotensin 1 converting enzyme gene polymorphism, plasma levels and diabetic retinal, and renal complications.
Marre M, et al.
Diabetes 43 : 384-388. 1994
69ACE
A potent genetic risk factor for restenosis.
Ohishi M, et al.
Nat Genet 5 : 324-325. 1993
70ACE
Angiotensin I-converting enzyme in human circulating mononuclear cells : genetic polymorphism of expression in T-lymphocytes.
Costerousse O, et al.
Biochem J 290 : 33-40. 1993
71ACE
The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy.
Lewis EJ, et al.
N Engl J Med 329 : 1456-1462. 1993
72ACE
Angiotensin-converting enzyme polymorphism in hypertrophic cardiomyopathy and sudden cardiac death.
Marian AJ, et al.
Lancet 342 : 1085-1086. 1993
73ACE
Angiotensin-converting enzyme DD genotype in patients with ischaemic or idiopathic dilated cardiomyopathy.
Raynolds MV, et al.
Lancet 342 : 1073-1075. 1993
74ACE
Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension.
Jeunemaitre X, et al.
Nat Genet 1 : 72-75. 1992
75ACE
PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1).
Rigat B, et al.
Nucleic Acids Res 20 : 1433. 1992
76ACE
Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction.
Cambien F, et al.
Nature 359 : 641-644. 1992
77ACE
Association of a polymorphism of the angiotensin I-converting enzyme gene with essential hypertension.
Zee RYL, et al.
Biochem Biophys Res Commun 184 : 9-15. 1992
78ACE
The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors.
Wei L, Clauser E, Alhenc-Gelas F, Corvol P.
J Biol Chem 267(19):13398-405. 1992
79ACE
Angiotensin-I converting enzyme gene is on chromosome 17.
Mattei MG, et al.
(HGM10) Cytogenet Cell Genet 51 : 1041. 1989
80ACE
Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P.
Proc Natl Acad Sci U S A 85(24):9386-90. 1988