| 1 | CUL3, KLHL3, PHA2B, PHA2C, PHA2D, PHA2E, WNK2, WNK4
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| Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.
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| Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E.
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| Biochem Biophys Res Commun 467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3. 2015
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| 2 | PHA2B, WNK4
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| Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.
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| Na T, Wu G, Peng JB.
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| Biochem Biophys Res Commun 419(2):293-8. doi: 10.1016/j.bbrc.2012.02.013. Epub 2012 Feb 11.
2012
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| 3 | PHA2B, SLC12A3, WNK4
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| Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
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| San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G.
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| Proc Natl Acad Sci U S A 106(11):4384-9. Epub 2009 Feb 24.
2009
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| 4 | KCNJ1, PHA2B, WNK4
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| The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK.
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| Murthy M, Cope G, O'Shaughnessy KM.
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| Biochem Biophys Res Commun 375(4):651-4. Epub 2008 Aug 26.
2008
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| 5 | CYPHB1, CYPHB2, NR3C2, HSD11B2, SCNN1B, SCNN1G, PSALD, PHA2C, WNK1, PHA2B, WNK4, DIDAN, PPARG, MTHHH, MT-TI
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| The genetic dissection of essential hypertension.
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| Cowley AW Jr.
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| Nat Rev Genet 7(11):829-40. Epub 2006 Oct 10. Review. 2006
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| 6 | PHA2B, WNK4
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| A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene.
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| Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, O'Shaughnessy KM.
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| Hypertension 46(2):295-300. Epub 2005 Jul 5. 2005
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| 7 | WNK4, PHA2B
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| Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
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| Kahle KT, Macgregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP.
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| Proc Natl Acad Sci U S A 101(41):14877-82. Epub 2004 Oct 1. 2004
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| 8 | PHA2B, PHA2C, WNK1, WNK4
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| Human hypertension caused by mutations in WNK kinases.
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| Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP.
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| Science 293(5532):1107-12. 2001
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| 9 | PHA2A, PHA2B
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| Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21.
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| Mansfield TA, Simon DB, Farfel Z, Bia M, Tucci JR, Lebel M, Gutkin M, Vialettes B, Christofilis MA, Kauppinen-Makelin R, Mayan H, Risch N, Lifton RP.
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| Nat Genet 16(2):202-5. 1997
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