| 1 | CUL3, KLHL3, PHA2B, PHA2C, PHA2D, PHA2E, WNK2, WNK4
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| Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.
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| Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E.
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| Biochem Biophys Res Commun 467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3. 2015
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| 2 | PHA2C, WNK1
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| Chloride sensing by WNK1 involves inhibition of autophosphorylation.
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| Piala AT, Moon TM, Akella R, He H, Cobb MH, Goldsmith EJ.
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| Sci Signal 7(324):ra41. doi: 10.1126/scisignal.2005050.
2014
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| 3 | PHA2C, WNK1
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| WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.
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| Vidal-Petiot E, Elvira-Matelot E, Mutig K, Soukaseum C, Baudrie V, Wu S, Cheval L, Huc E, Cambillau M, Bachmann S, Doucet A, Jeunemaitre X, Hadchouel J.
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| Proc Natl Acad Sci U S A 110(35):14366-71. doi: 10.1073/pnas.1304230110. Epub 2013 Aug 12.
2013
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| 4 | PHA2C, WNK1
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| Novel missense mutations of WNK1 in patients with hypokalemic salt-losing tubulopathies.
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| Zhang C, Zhu Y, Huang F, Jiang G, Chang J, Li R.
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| Clin Genet 83(6):545-52. doi: 10.1111/cge.12008. Epub 2012 Sep 27.
2013
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| 5 | CYPHB1, CYPHB2, NR3C2, HSD11B2, SCNN1B, SCNN1G, PSALD, PHA2C, WNK1, PHA2B, WNK4, DIDAN, PPARG, MTHHH, MT-TI
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| The genetic dissection of essential hypertension.
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| Cowley AW Jr.
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| Nat Rev Genet 7(11):829-40. Epub 2006 Oct 10. Review. 2006
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| 6 | WNK1, PHA2C
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| Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study.
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| Newhouse SJ, Wallace C, Dobson R, Mein C, Pembroke J, Farrall M, Clayton D, Brown M, Samani N, Dominiczak A, Connell JM, Webster J, Lathrop GM, Caulfield M, Munroe PB.
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| Hum Mol Genet 14(13):1805-14. Epub 2005 May 11. 2005
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| 7 | WNK1, PHA2C
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| WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain.
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| O'Reilly M, Marshall E, Speirs HJ, Brown RW.
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| J Am Soc Nephrol 14(10):2447-56. 2003
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| 8 | PHA2B, PHA2C, WNK1, WNK4
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| Human hypertension caused by mutations in WNK kinases.
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| Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, Feely MP, Dussol B, Berland Y, Unwin RJ, Mayan H, Simon DB, Farfel Z, Jeunemaitre X, Lifton RP.
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| Science 293(5532):1107-12. 2001
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| 9 | PHA2C, PHA2A
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| A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension.
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| Disse-Nicodeme S, Achard JM, Desitter I, Houot AM, Fournier A, Corvol P, Jeunemaitre X.
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| Am J Hum Genet 67(2):302-10. 2000
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