| 1 | EGLN3, TFAM, VHL
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| Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome
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| Li S, Li W, Yuan J, Bullova P, Wu J, Zhang X, Liu Y, Plescher M, Rodriguez J, Bedoya-Reina OC, Jannig PR, Valente-Silva P, Yu M, Henriksson MA, Zubarev RA, Smed-Sörensen A, Suzuki CK, Ruas JL, Holmberg J, Larsson C, Christofer Juhlin C, von Kriegsheim A, Cao Y, Schlisio S.
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| Nat Metab. Jun;4(6):739-758. doi: 10.1038/s42255-022-00593-x. Epub 2022 Jun 27. Erratum in: Nat Metab. 2022 Oct;4(10):1421. 2022
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| 2 | DAAM2, HIF1A, VHL
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| Dishevelled Associated Activator Of Morphogenesis (DAAM) Facilitates Invasion of Hepatocellular Carcinoma by Upregulating Hypoxia-Inducible Factor 1α (HIF-1α) Expression.
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| Fang X, Zhang D, Zhao W, Gao L, Wang L.
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| Med Sci Monit. Aug 9;26:e924670. doi: 10.12659/MSM.924670 2020
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| 3 | VHL, ZHX2
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| VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma.
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| Zhang J, Wu T, Simon J, Takada M, Saito R, Fan C, Liu XD, Jonasch E, Xie L, Chen X, Yao X, Teh BT, Tan P, Zheng X, Li M, Lawrence C, Fan J, Geng J, Liu X, Hu L, Wang J, Liao C, Hong K, Zurlo G, Parker JS, Auman JT, Perou CM, Rathmell WK, Kim WY, Kirschner MW, Kaelin WG Jr, Baldwin AS, Zhang Q.
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| Science Jul 20;361(6399):290-295. doi: 10.1126/science.aap8411 2018
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| 4 | MAPK7, VHL
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| Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis.
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| Serrano-Oviedo L, Giménez-Bachs JM, Nam-Cha SY, Cimas FJ, García-Cano J, Sánchez-Prieto R, Salinas-Sánchez AS.
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| Urol Oncol 35(3):114.e15-114.e22. doi: 10.1016/j.urolonc.2016.10.010. Epub 2016 Nov 8.
2017
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| 5 | DAAM2, VHL
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| Daam2 driven degradation of VHL promotes gliomagenesis.
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| Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B.
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| Elife Oct 20;6:e31926. doi: 10.7554/eLife.3192 2017
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| 6 | CERKL, VHL
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| pVHL interacts with Ceramide kinase like (CERKL) protein and ubiquitinates it for oxygen dependent proteasomal degradation.
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| Chen J, Liu F, Li H, Archacki S, Gao M, Liu Y, Liao S, Huang M, Wang J, Yu S, Li C, Tang Z, Liu M.
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| Cell Signal 27(11):2314-23. doi: 10.1016/j.cellsig.2015.08.011. Epub 2015 Aug 18.
2015
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| 7 | CDKN2A, VHL
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| Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein.
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| Minervini G, Mazzotta GM, Masiero A, Sartori E, Corrà S, Potenza E, Costa R, Tosatto SC.
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| Sci Rep 5:12605. doi: 10.1038/srep12605.
2015
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| 8 | RCC1, VHL
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| Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism.
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| Leisz S, Schulz K, Erb S, Oefner P, Dettmer K, Mougiakakos D, Wang E, Marincola FM, Stehle F, Seliger B.
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| Oncotarget 6(13):11395-406.
2015
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| 9 | RAN, VHL
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| Role of Ran-regulated nuclear-cytoplasmic trafficking of pVHL in the regulation of microtubular stability-mediated HIF-1α in hypoxic cardiomyocytes.
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| Jiang X, Zhang D, Zhang H, Huang Y, Teng M.
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| Sci Rep 5:9193. doi: 10.1038/srep09193. Erratum in: Sci Rep. 2015;5:11307.
2015
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| 10 | VHL, ZNF350
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| ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer.
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| Chen K, Yu G, Gumireddy K, Li A, Yao W, Gao L, Chen S, Hao J, Wang J, Huang Q, Xu H, Ye Z.
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| Oncotarget 6(9):6959-76.
2015
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| 11 | RWDD3, VHL
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| RSUME inhibits VHL and regulates its tumor suppressor function.
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| Gerez J, Tedesco L, Bonfiglio JJ, Fuertes M, Barontini M, Silberstein S, Wu Y, Renner U, Páez-Pereda M, Holsboer F, Stalla GK, Arzt E.
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| Oncogene 34(37):4855-66. doi: 10.1038/onc.2014.407. Epub 2014 Dec 15.
2015
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| 12 | AURKA, CTNNB1, VHL
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| β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma.
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| Dere R, Perkins AL, Bawa-Khalfe T, Jonasch D, Walker CL.
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| J Am Soc Nephrol 26(3):553-64. doi: 10.1681/ASN.2013090984. Epub 2014 Oct 13.
2015
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| 13 | NEK8, VHL
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| The tumor suppressor pVHL down-regulates never-in-mitosis A-related kinase 8 via hypoxia-inducible factors to maintain cilia in human renal cancer cells.
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| Ding XF, Zhou J, Hu QY, Liu SC, Chen G.
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| J Biol Chem 290(3):1389-94. doi: 10.1074/jbc.M114.589226. Epub 2014 Dec 1.
2015
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| 14 | CUL2, ELOB, ELOC, VHL
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| Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex.
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| Nguyen HC, Yang H, Fribourgh JL, Wolfe LS, Xiong Y.
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| Structure Mar 3;23(3):441-449. doi: 10.1016/j.str.2014.12.014. Epub 2015 Feb 5 2015
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| 15 | VHL
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| Sporadic hemangioblastomas are characterized by cryptic VHL inactivation.
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| Shankar GM, Taylor-Weiner A, Lelic N, Jones RT, Kim JC, Francis JM, Abedalthagafi M, Borges LF, Coumans JV, Curry WT, Nahed BV, Shin JH, Paek SH, Park SH, Stewart C, Lawrence MS, Cibulskis K, Thorner AR, Van Hummelen P, Stemmer-Rachamimov AO, Batchelor TT, Carter SL, Hoang MP, Santagata S, Louis DN, Barker FG, Meyerson M, Getz G, Brastianos PK, Cahill DP.
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| Acta Neuropathol Commun 2:167. doi: 10.1186/s40478-014-0167-x.
2014
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| 16 | VHL
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| Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.
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| Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E.
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| Dev Biol 393(1):124-36. doi: 10.1016/j.ydbio.2014.06.013. Epub 2014 Jun 24.
2014
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| 17 | VHL
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| The multifaceted von Hippel-Lindau tumour suppressor protein.
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| Robinson CM, Ohh M.
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| FEBS Lett 588(16):2704-11. doi: 10.1016/j.febslet.2014.02.026. Epub 2014 Feb 25. Review.
2014
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| 18 | VHL
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| Von Hippel-Lindau gene expression in human endometrium during menstrual cycle.
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| Lu YY, Zhu WJ, Xie BG.
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| Mol Med Rep 9(4):1355-8. doi: 10.3892/mmr.2014.1962. Epub 2014 Feb 18.
2014
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| 19 | VHL
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| The von hippel-lindau protein suppresses androgen receptor activity.
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| Wang J, Zhang W, Ji W, Liu X, Ouyang G, Xiao W.
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| Mol Endocrinol 28(2):239-48. doi: 10.1210/me.2013-1258. Epub 2014 Jan 1.
2014
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| 20 | VHL
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| Tumor suppressor VHL functions in the control of mitotic fidelity.
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| Hell MP, Duda M, Weber TC, Moch H, Krek W.
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| Cancer Res 74(9):2422-31. doi: 10.1158/0008-5472.CAN-13-2040. Epub 2013 Dec 20.
2014
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| 21 | E2F1, VHL
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| pVHL acts as a downstream target of E2F1 to suppress E2F1 activity.
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| Ji W, Wang J, Zhang W, Liu X, Ouyang G, Xiao W.
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| Biochem J 457(1):185-95. doi: 10.1042/BJ20130793.
2014
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| 22 | GLI1, VHL
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| Tumor suppressor protein VHL inhibits Hedgehog-Gli activation through suppression of Gli1 nuclear localization.
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| Cho HK, Kim SY, Kim KH, Kim HH, Cheong J.
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| FEBS Lett 587(7):826-32. doi: 10.1016/j.febslet.2013.01.050. Epub 2013 Feb 8.
2013
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| 23 | NEK1, VHL
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| Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.
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| Patil M, Pabla N, Huang S, Dong Z.
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| Cell Cycle 12(1):166-71. doi: 10.4161/cc.23053. Epub 2012 Dec 19.
2013
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| 24 | VHL
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| Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice.
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| Puri S, García-Núñez A, Hebrok M, Cano DA.
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| PLoS One 8(8):e72213. doi: 10.1371/journal.pone.0072213. eCollection 2013.
2013
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| 25 | VHL
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| The von Hippel-Lindau protein pVHL inhibits ribosome biogenesis and protein synthesis.
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| Zhao WT, Zhou CF, Li XB, Zhang YF, Fan L, Pelletier J, Fang J.
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| J Biol Chem 288(23):16588-97. doi: 10.1074/jbc.M113.455121. Epub 2013 Apr 23.
2013
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| 26 | KDM5C, VHL
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| The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.
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| Niu X, Zhang T, Liao L, Zhou L, Lindner DJ, Zhou M, Rini B, Yan Q, Yang H.
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| Oncogene 31(6):776-86. doi: 10.1038/onc.2011.266. Epub 2011 Jul 4.
2012
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| 27 | EGLN1, VHL
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| Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition.
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| Chintala S, Najrana T, Toth K, Cao S, Durrani FA, Pili R, Rustum YM.
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| BMC Cancer 12:293. doi: 10.1186/1471-2407-12-293.
2012
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| 28 | HIF1A, VHL
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| Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development.
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| Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW.
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| Development 139(13):2340-50. doi: 10.1242/dev.070813. Epub 2012 May 23.
2012
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| 29 | VHL
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| Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma.
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| Perier A, Fregni G, Wittnebel S, Gad S, Allard M, Gervois N, Escudier B, Azzarone B, Caignard A.
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| Oncogene 30(23):2622-32. doi: 10.1038/onc.2010.638. Epub 2011 Jan 24.
2011
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| 30 | VHL
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| Von Hippel-Lindau gene product directs cytokinesis: a new tumor suppressor function.
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| Sinha S, Mondal G, Hwang EJ, Han da W, Dutta SK, Iyer S, Karumanchi SA, Kim KI, Couch FJ, Mukhopadhyay D.
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| J Cell Sci. 124(Pt 13):2132-42. 2011
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| 31 | VHL
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| Proteomic dissection of the von Hippel-Lindau (VHL) interactome.
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| Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y.
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| J Proteome Res. 10(11):5175-82. 2011
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| 32 | VHL
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| Quantitative proteomics identifies the Myb-binding protein p160 as a novel target of the von Hippel-Lindau tumor suppressor.
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| Lai Y, Qiao M, Song M, Weintraub ST, Shiio Y.
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| PLoS One. 6(2):e16975. 2011
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| 33 | SKP2, VHL
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| von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage.
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| Roe JS, Kim HR, Hwang IY, Cho EJ, Youn HD.
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| Oncogene. 30(28):3127-38. 2011
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| 34 | VHL
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| Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins.
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| Anderson K, Nordquist KA, Gao X, Hicks KC, Zhai B, Gygi SP, Patel TB.
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| J Biol Chem. 286(49):42027-36. 2011
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| 35 | ECYT2, JAK2, VHL
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| Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.
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| Russell RC, Sufan RI, Zhou B, Heir P, Bunda S, Sybingco SS, Greer SN, Roche O, Heathcote SA, Chow VW, Boba LM, Richmond TD, Hickey MM, Barber DL, Cheresh DA, Simon MC, Irwin MS, Kim WY, Ohh M.
|
| Nat Med 17(7):845-53. doi: 10.1038/nm.2370.
2011
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| 36 | SKP2, VHL
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| von Hippel-Lindau protein promotes Skp2 destabilization on DNA damage.
|
| Roe JS, Kim HR, Hwang IY, Cho EJ, Youn HD.
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| Oncogene 30(28):3127-38. doi: 10.1038/onc.2011.40. Epub 2011 Feb 28.
2011
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| 37 | CBL, VHL
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| The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR.
|
| Zhou L, Yang H.
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| PLoS One 6(9):e23936. doi: 10.1371/journal.pone.0023936. Epub 2011 Sep 16.
2011
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| 38 | MYBBP1A, VHL
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| Quantitative proteomics identifies the Myb-binding protein p160 as a novel target of the von Hippel-Lindau tumor suppressor.
|
| Lai Y, Qiao M, Song M, Weintraub ST, Shiio Y.
|
| PLoS One 6(2):e16975. doi: 10.1371/journal.pone.0016975.
2011
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| 39 | EPAS1, RNF4, VHL
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| RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha.
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| van Hagen M, Overmeer RM, Abolvardi SS, Vertegaal AC.
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| Nucleic Acids Res 38(6):1922-31. Epub 2009 Dec 21.
2010
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| 40 | VHL
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| Ubiquitin/SUMO modification regulates VHL protein stability and nucleocytoplasmic localization.
|
| Cai Q, Robertson ES.
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| PLoS One. 5(9). pii: e12636. 2010
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| 41 | ECYT1, ECYT2, ECYT3, ECYT4, EGLN1, EPAS1, EPOR, VHL
|
| Genetic origins and clinical phenotype of familial and acquired erythrocytosis and thrombocytosis.
|
| Percy MJ, Rumi E.
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| Am J Hematol 84(1):46-54. Review. 2009
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| 42 | CDH1, CLDN1, VHL
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| Regulation of renal epithelial tight junctions by the von Hippel-Lindau tumor suppressor gene involves occludin and claudin 1 and is independent of E-cadherin.
|
| Harten SK, Shukla D, Barod R, Hergovich A, Balda MS, Matter K, Esteban MA, Maxwell PH.
|
| Mol Biol Cell 20(3):1089-101. Epub 2008 Dec 10.PMID: 19073886 2009
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| 43 | VHL
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| Novel insights into the role of the tumor suppressor von Hippel Lindau in cellular differentiation, ciliary biology, and cyst repression.
|
| Wiesener MS, Maxwell PH, Eckardt KU.
|
| J Mol Med 87(9):871-7. Epub 2009 Jul 24.PMID: 19629420 2009
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| 44 | VHL
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| Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.
|
| Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS.
|
| Sci Signal. 2(78):ra33. 2009
|
| 45 | VHL
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| VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo.
|
| Lee CM, Hickey MM, Sanford CA, McGuire CG, Cowey CL, Simon MC, Rathmell WK.
|
| Oncogene. 28(14):1694-705. 2009
|
| 46 | BRK1, VHL
|
| Genotype-phenotype correlations in VHL exon deletions.
|
| McNeill A, Rattenberry E, Barber R, Killick P, MacDonald F, Maher ER.
|
| Am J Med Genet A 149A(10):2147-51. doi: 10.1002/ajmg.a.33023.
2009
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| 47 | ECYT1, ECYT2, ECYT3, ECYT4, EGLN1, EPAS1, EPOR, VHL
|
| A study of 36 unrelated cases with pure erythrocytosis revealed three new mutations in the erythropoietin receptor gene.
|
| Al-Sheikh M, Mazurier E, Gardie B, Casadevall N, Galactéros F, Goossens M, Wajcman H, Préhu C, Ugo V.
|
| Haematologica 93(7):1072-5. Epub 2008 May 19. 2008
|
| 48 | VHL
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| Allele-specific regulation of primary cilia function by the von Hippel-Lindau tumor suppressor.
|
| Lolkema MP, Mans DA, Ulfman LH, Volpi S, Voest EE, Giles RH.
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| Eur J Hum Genet 16(1):73-8. Epub 2007 Oct 3. 2008
|
| 49 | VHL, TGFBI, KLF10
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| Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors.
|
| Ivanov SV, Ivanova AV, Salnikow K, Timofeeva O, Subramaniam M, Lerman MI.
|
| Biochem Biophys Res Commun 370(4):536-40. Epub 2008 Mar 24. 2008
|
| 50 | TMEM115, VHL
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| Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours.
|
| Ivanova AV, Vortmeyer A, Ivanov SV, Nickerson ML, Maher ER, Lerman MI.
|
| J Pathol 214(1):46-57.PMID: 17973242 2008
|
| 51 | EGR1, UBE2S, VHL
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| Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway.
|
| Lim JH, Jung CR, Lee CH, Im DS.
|
| J Cell Biochem 105(4):1117-27.PMID: 18780286 2008
|
| 52 | KIF5C, VHL
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| Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2.
|
| Mans DA, Lolkema MP, van Beest M, Daenen LG, Voest EE, Giles RH.
|
| Exp Cell Res 314(6):1229-36. Epub 2008 Jan 5.PMID: 18261724 2008
|
| 53 | VHL
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| A novel von Hippel-Lindau point mutation presents as apparently sporadic pheochromocytoma.
|
| Rich TA, Jonasch E, Matin S, Waguespack SG, Gombos DS, Santarpia L, Stolle C, Jimenez C.
|
| Cancer Invest 26(6):642-6.PMID: 18584357 2008
|
| 54 | VHL
|
| Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.
|
| Zhou G, Dada LA, Chandel NS, Iwai K, Lecuona E, Ciechanover A, Sznajder JI.
|
| FASEB J 22(5):1335-42. Epub 2007 Dec 11.PMID: 18073334 2008
|
| 55 | VHL
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| Role of the VHL (von Hippel-Lindau) gene in renal cancer: a multifunctional tumour suppressor.
|
| Nyhan MJ, O'Sullivan GC, McKenna SL.
|
| Biochem Soc Trans 36(Pt 3):472-8. Review.PMID: 18481984 2008
|
| 56 | VHL
|
| PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
|
| Zehetner J, Danzer C, Collins S, Eckhardt K, Gerber PA, Ballschmieter P, Galvanovskis J, Shimomura K, Ashcroft FM, Thorens B, Rorsman P, Krek W.
|
| Genes Dev. 22(22):3135-46. 2008
|
| 57 | VHL
|
| VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail.
|
| Evans AJ, Russell RC, Roche O, Burry TN, Fish JE, Chow VW, Kim WY, Saravanan A, Maynard MA, Gervais ML, Sufan RI, Roberts AM, Wilson LA, Betten M, Vandewalle C, Berx G, Marsden PA, Irwin MS, Teh BT, Jewett MA, Ohh M.
|
| Mol Cell Biol 27(1):157-69. Epub 2006 Oct 23. 2007
|
| 58 | EGLN3, VHL
|
| EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability.
|
| Fu J, Menzies K, Freeman RS, Taubman MB.
|
| J Biol Chem 282(17):12410-8. Epub 2007 Mar 6. 2007
|
| 59 | VHL, KIF3A
|
| The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.
|
| Lolkema MP, Mans DA, Snijckers CM, van Noort M, van Beest M, Voest EE, Giles RH.
|
| FEBS Lett 581(24):4571-6. Epub 2007 Aug 31. 2007
|
| 60 | VHL
|
| Genotype-phenotype correlation in von Hippel-Lindau disease with retinal angiomatosis.
|
| Wong WT, Agrón E, Coleman HR, Reed GF, Csaky K, Peterson J, Glenn G, Linehan WM, Albert P, Chew EY.
|
| Arch Ophthalmol 125(2):239-45.
2007
|
| 61 | VHL
|
| VHL mutation analysis in patients with isolated central nervous system haemangioblastoma.
|
| Woodward ER, Wall K, Forsyth J, Macdonald F, Maher ER.
|
| Brain 130(Pt 3):836-42. Epub 2007 Jan 29.
2007
|
| 62 | VHL
|
| The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells.
|
| Zia MK, Rmali KA, Watkins G, Mansel RE, Jiang WG.
|
| Int J Mol Med 20(4):605-11.PMID: 17786294 2007
|
| 63 | VHL
|
| Mosaicism in von Hippel-Lindau disease: an event important to recognize.
|
| Santarpia L, Sarlis NJ, Santarpia M, Sherman SI, Trimarchi F, Benvenga S.
|
| J Cell Mol Med 11(6):1408-15.PMID: 18205710 2007
|
| 64 | VHL
|
| NAD(P)H oxidases regulate HIF-2alpha protein expression.
|
| Block K, Gorin Y, Hoover P, Williams P, Chelmicki T, Clark RA, Yoneda T, Abboud HE.
|
| J Biol Chem. 282(11):8019-26. 2007
|
| 65 | VHL
|
| PKCzetaII is a target for degradation through the tumour suppressor protein pVHL.
|
| Iturrioz X, Parker PJ.
|
| FEBS Lett. 581(7):1397-402. 2007
|
| 66 | VHL, CTNNB1
|
| The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells.
|
| Peruzzi B, Athauda G, Bottaro DP.
|
| Proc Natl Acad Sci U S A 103(39):14531-6. Epub 2006 Sep 18. 2006
|
| 67 | VHL
|
| The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth.
|
| Schermer B, Ghenoiu C, Bartram M, Muller RU, Kotsis F, Hohne M, Kuhn W, Rapka M, Nitschke R, Zentgraf H, Fliegauf M, Omran H, Walz G, Benzing T.
|
| J Cell Biol 175(4):547-54. Epub 2006 Nov 13. 2006
|
| 68 | VHL, PRKCD
|
| The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase Cdelta.
|
| Iturrioz X, Durgan J, Calleja V, Larijani B, Okuda H, Whelan R, Parker PJ.
|
| Biochem J 397(1):109-20. 2006
|
| 69 | VHL
|
| Molecular analysis of two uncharacterized sequence variants of the VHL gene.
|
| Martella M, Salviati L, Casarin A, Trevisson E, Opocher G, Polli R, Gross D, Murgia A.
|
| J Hum Genet 51(11):964-8. Epub 2006 Sep 28.
2006
|
| 70 | VHL
|
| p53 stabilization and transactivation by a von Hippel-Lindau protein.
|
| Roe JS, Kim H, Lee SM, Kim ST, Cho EJ, Youn HD.
|
| Mol Cell. 22(3):395-405. 2006
|
| 71 | VHL
|
| Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice.
|
| Ding M, Cui S, Li C, Jothy S, Haase V, Steer BM, Marsden PA, Pippin J, Shankland S, Rastaldi MP, Cohen CD, Kretzler M, Quaggin SE.
|
| Nat Med. 12(9):1081-7. 2006
|
| 72 | VHL
|
| Hereditary prostate cancer in Finland: fine-mapping validates 3p26 as a major predisposition locus.
|
| Rokman A, Baffoe-Bonnie AB, Gillanders E, Fredriksson H, Autio V, Ikonen T, Gibbs KD Jr, Jones M, Gildea D, Freas-Lutz D, Markey C, Matikainen MP, Koivisto PA, Tammela TL, Kallioniemi OP, Trent J, Bailey-Wilson JE, Schleutker J.
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| Hum Genet 116(1-2):43-50. Epub 2004 Nov 11. 2005
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| 73 | VHL
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| Folding and quality control of the VHL tumor suppressor proceed through distinct chaperone pathways.
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| McClellan AJ, Scott MD, Frydman J.
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| Cell 121(5):739-48. 2005
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| 74 | JADE1, VHL
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| Jade-1, a candidate renal tumor suppressor that promotes apoptosis.
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| Zhou MI, Foy RL, Chitalia VC, Zhao J, Panchenko MV, Wang H, Cohen HT.
|
| Proc Natl Acad Sci U S A 102(31):11035-40. Epub 2005 Jul 26. 2005
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| 75 | RCC3, RCC1, VHL, RNF139, CRCC
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| About the origin and development of hereditary conventional renal cell carcinoma in a four-generation t(3;8)(p14.1;q24.23) family.
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| Valle L, Cascon A, Melchor L, Otero I, Rodriguez-Perales S, Sanchez L, Cruz Cigudosa J, Robledo M, Weber B, Urioste M, Benitez J.
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| Eur J Hum Genet 13(5):570-8. 2005
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| 76 | ECYT2, VHL
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| Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis.
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| Cario H, Schwarz K, Jorch N, Kyank U, Petrides PE, Schneider DT, Uhle R, Debatin KM, Kohne E.
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| Haematologica 90(1):19-24. 2005
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| 77 | VHL
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| Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain.
|
| Lolkema MP, Gervais ML, Snijckers CM, Hill RP, Giles RH, Voest EE, Ohh M.
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| J Biol Chem 280(23):22205-11. Epub 2005 Apr 11. 2005
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| 78 | HIF1A, VHL
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| Induction of the von Hippel-Lindau tumor suppressor gene by late hypoxia limits HIF-1 expression.
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| Karhausen J, Kong T, Narravula S, Colgan SP.
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| J Cell Biochem 95(6):1264-75. 2005
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| 79 | VHL
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| Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.
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| Alberghini A, Recalcati S, Tacchini L, Santambrogio P, Campanella A, Cairo G.
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| J Biol Chem 280(34):30120-8. Epub 2005 Jun 28. 2005
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| 80 | VHL
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| The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL.
|
| Wang J, Pantopoulos K.
|
| Biochim Biophys Acta. 1743(1-2):79-85. 2005
|
| 81 | VHL
|
| Tid-1 interacts with the von Hippel-Lindau protein and modulates angiogenesis by destabilization of HIF-1alpha.
|
| Bae MK, Jeong JW, Kim SH, Kim SY, Kang HJ, Kim DM, Bae SK, Yun I, Trentin GA, Rozakis-Adcock M, Kim KW.
|
| Cancer Res. 65(7):2520-5. 2005
|
| 82 | JADE1, VHL
|
| Tumor suppressor von Hippel-Lindau (VHL) stabilization of Jade-1 protein occurs through plant homeodomains and is VHL mutation dependent.
|
| Zhou MI, Wang H, Foy RL, Ross JJ, Cohen HT.
|
| Cancer Res 64(4):1278-86. 2004
|
| 83 | VHL
|
| Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.
|
| Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E.
|
| Development 131(10):2497-508. 2004
|
| 84 | MYC, VHL
|
| The allelic loss of chromosome 3p25 with c-myc gain is related to the development of clear-cell renal cell carcinoma.
|
| Yamaguchi S, Yoshihiro S, Matsuyama H, Nagao K, Fukunaga K, Matsumoto H, Matsuda K, Oba K, Naito K.
|
| Clin Genet 63(3):184-91. 2003
|
| 85 | CXCR4, VHL
|
| Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.
|
| Staller P, Sulitkova J, Lisztwan J, Moch H, Oakeley EJ, Krek W.
|
| Nature 425(6955):307-11. 2003
|
| 86 | PSMC3, VHL
|
| Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein.
|
| Corn PG, McDonald ER 3rd, Herman JG, El-Deiry WS.
|
| Nat Genet 35(3):229-37. Epub 2003 Oct 12. 2003
|
| 87 | HIF3A, VHL
|
| Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.
|
| Maynard MA, Qi H, Chung J, Lee EH, Kondo Y, Hara S, Conaway RC, Conaway JW, Ohh M.
|
| J Biol Chem 278(13):11032-40. Epub 2003 Jan 21. 2003
|
| 88 | NDRG1, VHL
|
| Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells.
|
| Masuda K, Ono M, Okamoto M, Morikawa W, Otsubo M, Migita T, Tsuneyoshi M, Okuda H, Shuin T, Naito S, Kuwano M.
|
| Int J Cancer 105(6):803-10. 2003
|
| 89 | RASSF1, FHIT, VHL, FHIT, RARB
|
| Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.
|
| Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Mori M, Croce CM.
|
| Cancer Res 63(13):3724-8. 2003
|
| 90 | POLR2G, VHL
|
| Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein.
|
| Na X, Duan HO, Messing EM, Schoen SR, Ryan CK, di Sant'Agnese PA, Golemis EA, Wu G.
|
| EMBO J 22(16):4249-59. 2003
|
| 91 | MSH4, VHL
|
| Human MutS homologue MSH4 physically interacts with von Hippel-Lindau tumor suppressor-binding protein 1.
|
| Her C, Wu X, Griswold MD, Zhou F.
|
| Cancer Res 63(4):865-72. 2003
|
| 92 | ECYT2, VHL
|
| Chuvash-type congenital polycythemia in 4 families of Asian and Western European ancestry.
|
| Percy MJ, McMullin MF, Jowitt SN, Potter M, Treacy M, Watson WH, Lappin TR.
|
| Blood 102(3):1097-9. Epub 2003 Apr 17. 2003
|
| 93 | VHL
|
| von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.
|
| Kuznetsova AV, Meller J, Schnell PO, Nash JA, Ignacak ML, Sanchez Y, Conaway JW, Conaway RC, Czyzyk-Krzeska MF.
|
| Proc Natl Acad Sci U S A. 100(5):2706-11. 2003
|
| 94 | VHL
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| VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.
|
| Bindra RS, Vasselli JR, Stearman R, Linehan WM, Klausner RD.
|
| Cancer Res 62(11):3014-9. 2002
|
| 95 | USP20, USP33, VHL
|
| Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.
|
| Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G.
|
| Biochem Biophys Res Commun 294(3):700-9. 2002
|
| 96 | VHL
|
| Somatic von Hippel-Lindau disease gene mutation in clear-cell renal carcinomas associated with end-stage renal disease/acquired cystic disease of the kidney.
|
| Yoshida M, Yao M, Ishikawa I, Kishida T, Nagashima Y, Kondo K, Nakaigawa N, Hosaka M.
|
| Genes Chromosomes Cancer 35(4):359-64. 2002
|
| 97 | ECYT2, VHL
|
| Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia.
|
| Ang SO, Chen H, Hirota K, Gordeuk VR, Jelinek J, Guan Y, Liu E, Sergueeva AI, Miasnikova GY, Mole D, Maxwell PH, Stockton DW, Semenza GL, Prchal JT.
|
| Nat Genet 32(4):614-21. 2002
|
| 98 | JADE1, VHL
|
| The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1.
|
| Zhou MI, Wang H, Ross JJ, Kuzmin I, Xu C, Cohen HT.
|
| J Biol Chem 277(42):39887-98. Epub 2002 Aug 06. 2002
|
| 99 | USP33, VHL
|
| Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein.
|
| Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G.
|
| J Biol Chem 277(7):4656-62. Epub 2001 Dec 05. 2002
|
| 100 | VHL
|
| The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.
|
| Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, Zeng C, Erickson PF, Hooper JE, Drabkin HA.
|
| Oncogene. 21(22):3507-16. 2002
|
| 101 | VHL
|
| von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.
|
| Hoffman MA, Ohh M, Yang H, Klco JM, Ivan M, Kaelin WG Jr.
|
| Hum Mol Genet 10(10):1019-27. 2001
|
| 102 | VHL
|
| Localization of a novel susceptibility gene for familial ovarian cancer to chromosome 3p22-p25.
|
| Sekine M, Nagata H, Tsuji S, Hirai Y, Fujimoto S, Hatae M, Kobayashi I, Fujii T, Nagata I, Ushijima K, Obata K, Suzuki M, Yoshinaga M, Umesaki N, Satoh S, Enomoto T, Motoyama S, Tanaka K.
|
| Hum Mol Genet 10(13):1421-9. 2001
|
| 103 | VHL, TSG3E, TSG3G
|
| Multiple regions with allelic loss at chromosome 3 in superficial multifocal bladder tumors.
|
| Louhelainen J, Wijkstrom H, Hemminki K.
|
| Int J Oncol 18(1):203-10. 2001
|
| 104 | FHIT, RASSF1, ROBO1, VHL
|
| Tumor suppressors on 3p: a neoclassic quartet.
|
| Huebner K.
|
| Proc Natl Acad Sci U S A 98(26):14763-5. No abstract available. 2001
|
| 105 | VHL
|
| Endoplasmic reticulum/cytosolic localization of von Hippel-Lindau gene products is mediated by a 64-amino acid region.
|
| Schoenfeld AR, Davidowitz EJ, Burk RD.
|
| Int J Cancer 91(4):457-67. 2001
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| 106 | BCS1L, C10orf2, COX10, COX10D, COX17, DSPP, FRDA, MNGIE, NARP, NDUFS1, NDUFS2, NDUFS4, NDUFS7, NDUFS8, NDUFV1, NDUFV1D, NF1, OPA1, PGL1, PGL2, PGL3, POLG, SCO1, SCO2, SDHA, SDHB, SDHC, SDHD, SLC25A4, SPG7, SURF1, VHL
|
| Nuclear genetic defects of oxidative phosphorylation.
|
| Shoubridge EA.
|
| Hum Mol Genet 10(20):2277-84. Review. 2001
|
| 107 | VHL
|
| Frequent loss of heterozygosity at 3p25-p26 is associated with invasive oral squamous cell carcinoma.
|
| Kayahara H, Yamagata H, Tanioka H, Miki T, Hamakawa H.
|
| J Hum Genet 46(6):335-41. 2001
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| 108 | TSG13D, TSG17A, VHL, TSG9H
|
| Loss of heterozygosity on chromosomes 3, 9, 13, and 17, including the retinoblastoma locus, in uveal melanoma.
|
| Scholes AG, Liloglou T, Maloney P, Hagan S, Nunn J, Hiscott P, Damato BE, Grierson I, Field JK.
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| Invest Ophthalmol Vis Sci 42(11):2472-7. 2001
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| 109 | VHL
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| FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity.
|
| Mahon PC, Hirota K, Semenza GL.
|
| Genes Dev. 15(20):2675-86. 2001
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| 110 | VHL
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| The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression.
|
| Pioli PA, Rigby WF.
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| J Biol Chem. 276(43):40346-52. 2001
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| 111 | VHL
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| Genotype-phenotype correlations in families with deletions in the von Hippel-Lindau (VHL) gene.
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| Hes F, Zewald R, Peeters T, Sijmons R, Links T, Verheij J, Matthijs G, Leguis E, Mortier G, van der Torren K, Rosman M, Lips C, Pearson P, van der Luijt R.
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| Hum Genet 106(4):425-31. 2000
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| 112 | VHL
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| Comparative sequence analysis of the VHL tumor suppressor gene.
|
| Woodward ER, Buchberger A, Clifford SC, Hurst LD, Affara NA, Maher ER.
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| Genomics 65(3):253-65. 2000
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| 113 | VHL, DLEC1
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| Combined LOH/CGH analysis proves the existence of interstitial 3p deletions in renal cell carcinoma.
|
| Alimov A, Kost-Alimova M, Liu J, Li C, Bergerheim U, Imreh S, Klein G, Zabarovsky ER.
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| Oncogene 19(11):1392-9. 2000
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| 114 | VHL
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| Cryptic von hippel-lindau disease: germline mutations in patients with haemangioblastoma only
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| Hes FJ, McKee S, Taphoorn MJ, Rehal P, van Der Luijt RB , McMahon R, van Der Smagt JJ , Dow D, Zewald RA, Whittaker J, Lips CJ, MacDonald F, Pearson PL, Maher ER.
|
| J Med Genet 37(12):939-43. 2000
|
| 115 | VHL, TSG3G
|
| Loss of heterozygosity on the short arm of chromosome 3 in renal cancer.
|
| Maestro ML, del Barco V, Sanz-Casla MT, Moreno J, Adrover E, Izquierdo L, Zanna I, Fernandez C, Redondo E, Blanco J, Resel L.
|
| Oncology 59(2):126-30. 2000
|
| 116 | VHL
|
| Differential genetic alterations in von Hippel-Lindau syndrome-associated and sporadic pheochromocytomas.
|
| Bender BU, Gutsche M, Glasker S, Muller B, Kirste G, Eng C, Neumann HP.
|
| J Clin Endocrinol Metab 85(12):4568-74. 2000
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| 117 | CUL2, ELOC, HIF1A, VHL
|
| Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.
|
| Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW.
|
| Proc Natl Acad Sci U S A 97(19):10430-5. 2000
|
| 118 | EPAS1, VHL
|
| Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
|
| Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH.
|
| J Biol Chem 275(33):25733-41.
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| 119 | ELOB, ELOC, VHL
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| Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products.
|
| Schoenfeld AR, Davidowitz EJ, Burk RD.
|
| Proc Natl Acad Sci U S A Jul 18;97(15):8507-12. doi: 10.1073/pnas.97.15.8507 2000
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| 120 | RCC1, VHL
|
| Mutations of the VHL gene in sporadic renal cell carcinoma: definition of a risk factor for VHL patients to develop an RCC.
|
| Gallou C, Joly D, Mejean A, Staroz F, Martin N, Tarlet G, Orfanelli MT, Bouvier R, Droz D, Chretien Y, Marechal JM, Richard S, Junien C, Beroud C.
|
| Hum Mutat 13(6):464-75 1999
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| 121 | VHL
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| Identification of the von hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex.
|
| Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A.
|
| Proc Natl Acad Sci U S A 96(22):12436-41 1999
|
| 122 | VHL
|
| VHL: A very hip ligase.
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| Tyers M, Rottapel R.
|
| Proc Natl Acad Sci U S A 96(22):12230-2. No abstract available 1999
|
| 123 | VHL
|
| The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity.
|
| Lisztwan J, et al.
|
| Genes Dev 13(14):1822-33 1999
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| 124 | VHL
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| The von Hippel-Lindau tumour suppressor protein: new perspectives.
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| Ohh M, et al.
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| Mol Med Today 5(6):257-63. Review 1999
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| 125 | VHL
|
| Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.
|
| Stebbins CE, et al.
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| Science 284(5413):455-61 1999
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| 126 | VHL
|
| Two distinct phenotypes caused by two different missense mutations in the same codon of the VHL gene.
|
| Bradley JF, et al.
|
| Am J Med Genet 87(2):163-7 1999
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| 127 | VHL, ST11, TSG3G
|
| Detailed genetic and physical mapping of tumor suppressor loci on chromosome 3p in ovarian cancer.
|
| Fullwood P, Marchini S, Rader JS, Martinez A, Macartney D, Broggini M, Morelli C, Barbanti-Brodano G, Maher ER, Latif F.
|
| Cancer Res 59(18):4662-7 1999
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| 128 | CUL2, NEDD8, VHL
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| The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2.
|
| Wada H, Yeh ET, Kamitani T.
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| J Biol Chem 274(50):36025-9. 1999
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| 129 | VHL
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| An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association.
|
| Cohen HT, Zhou M, Welsh AM, Zarghamee S, Scholz H, Mukhopadhyay D, Kishida T, Zbar B, Knebelmann B, Sukhatme VP.
|
| Biochem Biophys Res Commun 266(1):43-50. 1999
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| 130 | VHL
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| The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
|
| Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ.
|
| Nature 399(6733):271-5. 1999
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| 131 | VHL
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| Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC.
|
| Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J.
|
| Mol Cell. 4(6):1051-61. 1999
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| 132 | VHL, TSG3B, TSG3G
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| Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma : evidence for a VHL-independent pathway in clear cell renal tumourigenesis.
|
| Clifford SC, et al.
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| Genes Chromosomes Cancer 22 : 200-209. 1998
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| 133 | TSG8D, TSG17A, VHL
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| Intratumoral heterogeneity of von Hippel-Lindau gene deletions in renal cell carcinoma detected by fluorescence in situ hybridization.
|
| Moch H, Schraml P, Bubendorf L, Richter J, Gasser TC, Mihatsch MJ, Sauter G.
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| Cancer Res 58 : 2304-2309. 1998
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| 134 | VHL
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| A common region of allelic loss on chromosome region 3p25.3-26.3 in nasopharyngeal carcinoma.
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| Deng L, Jing N, Tan G, Zhou M, Zhan F, Xie Y, Cao L, Li G.
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| Genes Chromosomes Cancer 23 : 21-25. 1998
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| 135 | VHL
|
| Functions of the von Hippel-Lindau tumour suppressor protein.
|
| Kaelin WG, Iliopoulos O, Lonergan KM, Ohh M.
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| J Intern Med 243 : 535-539. 1998
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| 136 | VHL
|
| Germline mutation profile of the VHL gene in von Hippel-Lindau disease and in sporadic hemangioblastoma.
|
| Olschwang S, Richard S, Boisson C, Giraud S, Laurent-Puig P, Resche F, Thomas G.
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| Hum Mutat 12 : 424-430. 1998
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| 137 | VHL
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| Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene.
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| Stolle C, Glenn G, Zbar B, Humphrey JS, Choyke P, Walther M, Pack S, Hurley K, Andrey C, Klausner R, Linehan WM.
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| Hum Mutat 12 : 417-423. 1998
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| 138 | VHL
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| An analysis of phenotypic variation in the familial cancer syndrome von Hippel-Lindau disease : evidence for modifier effects.
|
| Webster AR, et al.
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| Am J Hum Genet 63 : 1025-1035. 1998
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| 139 | VHL
|
| Loss of heterozygosity of the von Hippel Lindau gene locus in polypoid dysplasia but not flat dysplasia in ulcerative colitis or sporadic adenomas.
|
| Fogt F, Vortmeyer AO, Stolte M, Mueller E, Mueller J, Noffsinger A, Poremba C, Zhuang Z.
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| Hum Pathol 29 : 961-964. 1998
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| 140 | APC, BRCA1, DPP4, MLH1, MSH2, MSH6, NF1, PMS2, RB1, TP53, VHL, WT1, FAP
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| Tumour suppressor gene mutations in humans and mice : parallels and contrasts.
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| Hooper ML.
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| EMBO J 17(23):6783-9. 1998
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| 141 | VHL
|
| Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function.
|
| Krieg M, Marti HH, Plate KH.
|
| Blood 92 : 3388-3393. 1998
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| 142 | VHL
|
| Mapping of chromosome 3p deletions in human epithelial ovarian tumors.
|
| Lounis H, Mes-Masson AM, Dion F, Bradley WE, Seymour RJ, Provencher D, Tonin PN.
|
| Oncogene 17 : 2359-2365. 1998
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| 143 | PPARA, CDKN1B, VHL
|
| Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis.
|
| Costet P, et al.
|
| J Biol Chem 273(45):29577-85. 1998
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| 144 | VHL
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| The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal.
|
| Pause A, et al.
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| Proc Natl Acad Sci U S A 95(3):993-8 1998
|
| 145 | VHL
|
| The VHL tumour-suppressor gene paradigm.
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| Kaelin WG Jr, et al.
|
| Trends Genet 14(10):423-6. Review 1998
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| 146 | CUL2, ELOB, ELOC, VHL
|
| Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2.
|
| Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG Jr.
|
| Mol Cell Biol 18(2):732-41. 1998
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| 147 | VHL
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| The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix.
|
| Ohh M, Yauch RL, Lonergan KM, Whaley JM, Stemmer-Rachamimov AO, Louis DN, Gavin BJ, Kley N, Kaelin WG Jr, Iliopoulos O.
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| Mol Cell. 1(7):959-68. 1998
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| 148 | CUL2, VHL
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| The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.
|
| Pause A, et al.
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| Proc Natl Acad Sci U S A 94 : 2156-2161. 1997
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| 149 | VHL
|
| Somatic mutations of the von Hippel-Lindau tumor suppressor gene and loss of heterozygosity on chromosome 3p in human glial tumors.
|
| Kanno H, Shuin T, Kondo K, Yamamoto I, Ito S, Shinonaga M, Yoshida M, Yao M.
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| Cancer Res 57 : 1035-1038. 1997
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| 150 | VHL
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| Somatic inactivation of the VHL gene in Von Hippel-Lindau disease tumors.
|
| Prowse AH, Webster AR, Richards FM, Richard S, Olschwang S, Resche F, Affara NA, Maher ER.
|
| Am J Hum Genet 60 : 765-771. 1997
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| 151 | VHL, TSG3B, DLEC1
|
| Involvement of multiple loci on chromosome 3 in renal cell cancer development.
|
| van den Berg A, Buys CH.
|
| Genes Chromosomes Cancer 19(2):59-76. 1997
|
| 152 | GDNF, MTC1, VHL
|
| Genetic predisposition to phaeochromocytoma: analysis of candidate genes GDNF, RET and VHL.
|
| Woodward ER, Eng C, McMahon R, Voutilainen R, Affara NA, Ponder BA, Maher ER.
|
| Hum Mol Genet 6(7):1051-6. 1997
|
| 153 | RCC3, VHL, TSG3B, TSG3G
|
| Analysis of multiple renal cell adenomas and carcinomas suggests allelic loss at 3p21 to be a prerequisite for malignant development.
|
| van den Berg A, Dijkhuizen T, Draaijers TG, Hulsbeek MM, Maher ER, van den Berg E, Storkel S, Buys CH.
|
| Genes Chromosomes Cancer 19(4):228-32. 1997
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| 154 | VHL
|
| Novel germline mutations in Swedish von Hippel-Lindau disease patients : correlation to clinical manifestations.
|
| Wiklund L, et al.
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| Int J Oncol 11 : 509-512. 1997
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| 155 | VHL
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| Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein.
|
| Takagi Y, Pause A, Conaway RC, Conaway JW.
|
| J Biol Chem 272(43):27444-9. 1997
|
| 156 | ECYT2, VHL
|
| Congenital polycythemia in Chuvashia.
|
| Sergeyeva A, Gordeuk VR, Tokarev YN, Sokol L, Prchal JF, Prchal JT.
|
| Blood 89(6):2148-54. 1997
|
| 157 | VHL
|
| The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity.
|
| Mukhopadhyay D, Knebelmann B, Cohen HT, Ananth S, Sukhatme VP.
|
| Mol Cell Biol. 17(9):5629-39. 1997
|
| 158 | VHL
|
| Familial pheochromocytoma associated with a novel mutation in the von Hippel-Lindau gene.
|
| Gross DJ, et al.
|
| J Clin Endocrinol Metab 81 : 147-149. 1996
|
| 159 | VHL
|
| Identification of two sporadically derived mutations in the Von Hippel-Lindau gene.
|
| Martin RL, et al.
|
| Hum Mutat 7 : 185. 1996
|
| 160 | VHL
|
| Detection of a germline mutation and somatic homozygous loss of the von Hippel-Lindau tumor-suppressor gene in a family with a De novo mutation. A combined genetic study, including cytogenetics, PCR/SSCP, FISh, and CGH.
|
| Decker HJ, Neuhaus C, Jauch A, Speicher M, Ried T, Bujard M, Brauch H, Storkel S, Stockle M, Seliger B, Huber C.
|
| Hum Genet 97 : 770-776. 1996
|
| 161 | VHL
|
| Mutations in the VHL tumor suppressor gene and associated lesions in families with von Hippel-Lindau disease from central Europe.
|
| Glavac D, Neumann HP, Wittke C, Jaenig H, Masek O, Streicher T, Pausch F, Engelhardt D, Plate KH, Hofler H, Chen F, Zbar B, Brauch H.
|
| Hum Genet 98 : 271-280. 1996
|
| 162 | VHL
|
| Genotype-phenotype correlation in von Hippel-Lindau disease : identification of a mutation associated with VHL type 2A.
|
| Chen F, et al.
|
| J Med Genet 33 : 716-717. 1996
|
| 163 | VHL
|
| Isolation and characterization of the full-length 3' untranslated region of the human von Hippel-Lindau tumor suppressor gene.
|
| Renbaum P, Duh FM, Latif F, Zbar B, Lerman MI, Kuzmin I.
|
| Hum Genet 98 : 666-671. 1996
|
| 164 | VHL
|
| Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan.
|
| Zbar B, et al.
|
| Hum Mutat 8 : 348-357. 1996
|
| 165 | VHL
|
| Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product.
|
| Tsuchiya H, Iseda T, Hino O.
|
| Cancer Res. 56(13):2881-5. 1996
|
| 166 | VHL
|
| Germline mutations in the Von Hippel-Lindau disease tumor suppressor gene : correlations with phenotype.
|
| Chen F, Kishida T, Yao M, Hustad T, Glavac D, Dean M, Gnarra JR, Orcutt ML, Duh FM, Glenn G, et al.
|
| Hum Mutat 5 : 66-75. 1995
|
| 167 | VHL
|
| Von Hippel-Lindau (VHL) disease with pheochromocytoma in the Black Forest region of Germany : evidence for a founder effect.
|
| Brauch H, et al.
|
| Hum Genet 95 : 551-556. 1995
|
| 168 | VHL
|
| Molecular analysis of De novo germline mutations in the von Hippel-Lindau disease gene.
|
| Richards FM, et al.
|
| Hum Mol Genet 4 : 2139-2143. 1995
|
| 169 | VHL
|
| Germline mutations in the von Hippel-Lindau disease (VHL) gene in Japanese VHL.
|
| Clinical Research Group for VHL in Japan.
|
| Hum Mol Genet 4 : 2233-2237. 1995
|
| 170 | MTC1, RET, VHL
|
| Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas.
|
| Eng C, et al.
|
| J Med Genet 32 : 934-937. 1995
|
| 171 | VHL
|
| Detection of germline mutations in the von Hippel-Lindau disease gene by the primer specified restriction map modification method.
|
| Kishida T, et al.
|
| J Med Genet 32 : 938-941. 1995
|
| 172 | VHL
|
| Terminal deletion of chromosome 3p sequences in nonpapillary renal cell carcinomas : a breakpoint cluster between loci D3S1285 and D3S1603.
|
| Wilhelm M, Bugert P, Kenck C, Staehler G, Kovacs G.
|
| Cancer Res 55 : 5383-5385. 1995
|
| 173 | VHL, RCC1
|
| Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene.
|
| Chen F, Kishida T, Duh FM, Renbaum P, Orcutt ML, Schmidt L, Zbar B.
|
| Cancer Res 55 : 4804-4807. 1995
|
| 174 | VHL, RCC1
|
| Somatic mutations of von Hippel-Lindau (VHL) tumor-suppressor gene in european kidney cancers.
|
| Bailly M, Bain C, Favrot MC, Ozturk M.
|
| Int J Cancer 63 : 660-664. 1995
|
| 175 | VHL
|
| Identification of the promoter of the human von Hippel-Lindau disease tumor suppressor gene.
|
| Kuzmin I, Duh FM, Latif F, Geil L, Zbar B, Lerman MI.
|
| Oncogene 10 : 2185-2194. 1995
|
| 176 | VHL
|
| Loss of heterozygosity on the short arm of chromosome 3 in sporadic, von Hippel-Lindau disease-associated, and familial pheochromocytoma.
|
| Zeiger MA, Zbar B, Keiser H, Linehan WM, Gnarra JR.
|
| Genes Chromosomes Cancer 13 : 151-156. 1995
|
| 177 | VHL
|
| Characterization of the VHL tumor suppressor gene product : localization, complex formation, and the effect of natural inactivating mutations.
|
| Duan DR, et al.
|
| Proc Natl Acad Sci U S A 92 : 6459-6463. 1995
|
| 178 | VHL
|
| Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C.
|
| Kibel A, Iliopoulos O, DeCaprio JA, Kaelin WG Jr.
|
| Science. 269(5229):1444-6. 1995
|
| 179 | VHL
|
| Tumour suppression by the human von Hippel-Lindau gene product.
|
| Iliopoulos O, Kibel A, Gray S, Kaelin WG Jr.
|
| Nat Med. 1(8):822-6. 1995
|
| 180 | VHL
|
| Molecular genetic investigations of the mechanism of tumourigenesis in von Hippel-Lindau disease : analysis of allele loss in VHL tumours.
|
| Crossey PA, Foster K, Richards FM, Phipps ME, Latif F, Tory K, Jones MH, Bentley E, Kumar R, Lerman MI, et al.
|
| Hum Genet 93 : 53-58. 1994
|
| 181 | VHL
|
| A PCR generated Accl RFLP in the 3' untranslated region of the von Hippel-Lindau disease (VHL) tumour suppressor gene.
|
| Payne SJ, et al.
|
| Hum Mol Genet 3 : 390. 1994
|
| 182 | VHL
|
| Detailed mapping of germline deletions of the von Hippel-Lindau disease tumour suppressor gene.
|
| Richards FM, Crossey PA, Phipps ME, Foster K, Latif F, Evans G, Sampson J, Lerman MI, Zbar B, Affara NA, et al.
|
| Hum mol Genet 3 : 595-598. 1994
|
| 183 | VHL, TSG3B, DLEC1
|
| Molecular genetic investigation of sporadic renal cell carcinoma : analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22.
|
| Foster K, Crossey PA, Cairns P, Hetherington JW, Richards FM, Jones MH, Bentley E, Affara NA, Ferguson-Smith MA, Maher ER.
|
| Br J Cancer 69 : 230-234. 1994
|
| 184 | VHL
|
| Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines.
|
| Sekido Y, Bader S, Latif F, Gnarra JR, Gazdar AF, Linehan WM, Zbar B, Lerman MI, Minna JD.
|
| Oncogene 9 : 1599-1604. 1994
|
| 185 | VHL, RCC1
|
| Mutations of the VHL tumour suppressor gene in renal carcinoma.
|
| Gnarra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, Liu S, Chen F, Duh FM, et al.
|
| Nat Genet 7 : 85-90. 1994
|
| 186 | VHL
|
| One-megabase yeast artificial chromosome and 400-kilobase cosmid-phage contigs containing the von Hippel-Lindau tumor suppressor and Ca2+ - transporting adenosine triphosphatase isoform 2 genes.
|
| Kuzmin I, et al.
|
| Cancer Res 54 : 2486-2491. 1994
|
| 187 | VHL
|
| A novel donor splice site mutation associated with two mRNAs in von Hippel-Lindau disease.
|
| Kishida T, et al.
|
| Hum Mol Genet 3 : 1191-1192. 1994
|
| 188 | VHL, RCC1
|
| Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas.
|
| Shuin T, Kondo K, Torigoe S, Kishida T, Kubota Y, Hosaka M, Nagashima Y, Kitamura H, Latif F, Zbar B, et al.
|
| Cancer Res 54 : 2852-2855. 1994
|
| 189 | VHL
|
| A novel mutation in the von Hippel-Lindau gene.
|
| Loeb DB, et al.
|
| Hum Mol Genet 3 : 1423-1424. 1994
|
| 190 | VHL
|
| Identification of intragenic mutations in the Von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype.
|
| Crossey PA, et al.
|
| Hum Mol Genet 3 : 1303-1308. 1994
|
| 191 | VHL, RCC1
|
| Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
|
| Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan DS, Gnarra JR, Linehan WM, et al.
|
| Proc Natl Acad Sci U S A 91 : 9700-9704. 1994
|
| 192 | VHL
|
| Somatic mutations of the Von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas.
|
| Kanno H, Kondo K, Ito S, Yamamoto I, Fujii S, Torigoe S, Sakai N, Hosaka M, Shuin T, Yao M.
|
| Cancer Res 54 : 4845-4847. 1994
|
| 193 | VHL, TSG3B, DLEC1
|
| Transfer of human chromosome 3 to an ovarian carcinoma cell line identifies three regions on 3p involved in ovarian cancer.
|
| Rimessi P, Gualandi F, Morelli C, Trabanelli C, Wu Q, Possati L, Montesi M, Barrett JC, Barbanti-Brodano G.
|
| Oncogene 9 : 3467-3474. 1994
|
| 194 | VHL, RCC1
|
| Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma.
|
| Foster K, Prowse A, van den Berg A, Fleming S, Hulsbeek MM, Crossey PA, Richards FM, Cairns P, Affara NA, Ferguson-Smith MA, et al.
|
| Hum Mol Genet 3 : 2169-2173. 1994
|
| 195 | VHL, RCC1
|
| Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma.
|
| Whaley JM, Naglich J, Gelbert L, Hsia YE, Lamiell JM, Green JS, Collins D, Neumann HP, Laidlaw J, Li FP, et al.
|
| Am J Hum Genet 55 : 1092-1102. 1994
|
| 196 | VHL, RCC1
|
| Cytogenetic and fluorescence in situ hybridization studies on sporadic and hereditary tumors associated with von Hippel-Lindau syndrome (VHL).
|
| Decker HJ, Klauck SM, Lawrence JB, McNeil J, Smith D, Gemmill RM, Sandberg AA, Neumann HH, Simon B, Green J, et al.
|
| Cancer Genet Cytogenet 77 : 1-13. 1994
|
| 197 | VHL, D3S1038, D3S1110, D3S651
|
| Genetic linkage between Von Hippel-Lindau disease and three microsatellite polymorphisms refines the localisation of the VHL locus.
|
| Crossey PA, et al.
|
| Hum Mol Genet 2 : 279-282. 1993
|
| 198 | VHL, ATP2B2
|
| Von Hippel-Lindau syndrome : cloning and identification of the plasma membrane Ca++-transporting ATPase isoform 2 gene that resides in the Von Hippel-Lindau gene region.
|
| Latif F, et al.
|
| Cancer Res 53 : 861-867. 1993
|
| 199 | VHL
|
| Von Hippel-Lindau disease : identification of deletion mutations by pulsed-field gel electrophoresis.
|
| Yao M, et al.
|
| Hum Genet 92 : 605-614. 1993
|
| 200 | VHL
|
| Identification of the von Hippel-Lindau disease tumor suppressor gene.
|
| Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, et al.
|
| Science 260 : 1317-1320. 1993
|
| 201 | VHL
|
| Mapping the von Hippel-Lindau disease tumour suppressor gene : identification of germline deletions by pulsed field gel electrophoresis.
|
| Richards FM, Phipps ME, Latif F, Yao M, Crossey PA, Foster K, Linehan WM, Affara NA, Lerman MI, Zbar B, et al.
|
| Hum Mol Genet 2 : 879-882. 1993
|
| 202 | VHL
|
| Detailed genetic mapping of the von Hippel-Lindau disease tumour suppressor gene.
|
| Richards FM, et al.
|
| J Med Genet 30 : 104-107. 1993
|
| 203 | VHL, RAF1
|
| Physical mapping of chromosome 3p25-p26 by fluorescence in situ hybridisation (FISH).
|
| Phipps ME, et al.
|
| Hum Genet 92 : 18-22. 1993
|
| 204 | VHL
|
| The isolation of a yeast artificial chromosome (YAC) contig extending for 2 megabases in the vicinity of the Von Hippel Lindau disease gene.
|
| Liu W, et al.
|
| Hum Mol Genet 2 : 1177-1182. 1993
|
| 205 | RAF1, VHL, D3S1255
|
| Genetic mapping of dinucleotide repeat polymorphisms and von Hippel-Lindau disease on chromosome 3p25-26.
|
| Pericak-Vance MA, et al.
|
| J Med Genet 30 : 487-491. 1993
|
| 206 | VHL
|
| Long range restriction map of the von Hippel-Lindau gene region on human chromosome 3p.
|
| Szymanski SC, et al.
|
| Hum Genet 92 : 282-288. 1993
|
| 207 | VHL
|
| Taql and Pstl RFLPs in the von Hippel-Lindau disease gene (VHL).
|
| Richards FM, et al.
|
| Hum Mol Genet 2 : 1750. 1993
|
| 208 | VHL, TSG3B, DLEC1
|
| Three distinct regions involved in 3p deletion in human lung cancer.
|
| Hibi K, Takahashi T, Yamakawa K, Ueda R, Sekido Y, Ariyoshi Y, Suyama M, Takagi H, Nakamura Y, Takahashi T.
|
| Oncogene 7 : 445-449. 1992
|
| 209 | VHL
|
| cA479 (D3S719): a cosmid mapped telomeric of the von Hippel Lindau disease gene contains the D3S18 locus.
|
| Liu W, Vance J, Smith DI.
|
| Hum Mol Genet 1 : 201. 1992
|
| 210 | VHL
|
| VHL is located close to D3S601 in the interval between RAF1 and D3S18.
|
| Latif F, et al.
|
| Am J Hum Genet 51 : A63. 1992
|
| 211 | VHL
|
| Molecular cloning of the von Hippel-Lindau tumor suppressor gene region : isolation and analysis of cDNAs encoded in the region.
|
| Lerman MI, et al.
|
| Am J Hum Genet 51 : A63. 1992
|
| 212 | VHL
|
| Genetic mapping of dinucleotide repeat polymorphisms and von Hippel Lindau disease on chromosome 3p25-26.
|
| Vance JM, et al.
|
| Am J Hum Genet 51 : A203. 1992
|
| 213 | VHL
|
| Presymptomatic diagnosis of von Hippel-Lindau disease with flanking DNA markers.
|
| Maher ER, et al.
|
| J Med Genet 29 : 902-905. 1992
|
| 214 | VHL
|
| Clustering of features of von Hippel-Lindau syndrome : evidence for a complex genetic locus.
|
| Neumann HPH, et al.
|
| Lancet 337 : 1052-1054. 1991
|
| 215 | VHL
|
| Genetic flanking markers refine diagnostic criteria and provide insights into genetics of von Hippel Lindau disease.
|
| Seizinger BR, et al.
|
| Proc Natl Acad Sci U S A 88 : 2864-2868. 1991
|
| 216 | VHL
|
| von Hippel-Lindau (VHL) disease : distinct phenotypes suggest more than mutant allele at the VHL locus.
|
| Glenn GM, et al.
|
| Hum Genet 87 : 207-210. 1991
|
| 217 | VHL
|
| Mapping of the von Hippel-Lindau disease locus to a small region of chromosome 3p by genetic linkage analysis.
|
| Maher Er, et al.
|
| Genomics 10 : 957-960. 1991
|
| 218 | VHL, RAF1
|
| New RFLP markers around the von Hippel-Lindau disease (VHL) locus.
|
| Lerman M, et al.
|
| (HGM11) Cytogenet Cell Genet 58 : 1878. 1991
|
| 219 | VHL
|
| Genetic linkage analysis of von Hippel-Lindau disease.
|
| Maher ER, et al.
|
| (HGM11) Cytogenet Cell Genet 58 : 1879. 1991
|
| 220 | VHL
|
| Physical mapping the putative VHL-gene region.
|
| Szymanski S, et al.
|
| (HGM11) Cytogenet Cell Genet 58 : 1882. 1991
|
| 221 | VHL
|
| Cytogenetics of renal cell carcinomas associated with von Hippel-Lindau disease.
|
| Kovacs G, Emanuel A, Neumann HP, Kung HF.
|
| Genes Chromosomes Cancer 3 : 256-262. 1991
|
| 222 | PTC1, VHL
|
| Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.
|
| Herrmann MA, Hay ID, Bartelt DH Jr, Ritland SR, Dahl RJ, Grant CS, Jenkins RB.
|
| J Clin Invest 88 : 1596-1604. 1991
|
| 223 | VHL, TSG3B
|
| Allelic loss at chromosome 3p characterizes clear cell phenotype of renal cell carcinoma.
|
| Ogawa O, Kakehi Y, Ogawa K, Koshiba M, Sugiyama T, Yoshida O.
|
| Cancer Res 51 : 949-953. 1991
|
| 224 | VHL, TSG3B, DLEC1
|
| Histopathological, cytogenetic, and molecular characterization of renal cortical tumors.
|
| Presti JC Jr, Rao PH, Chen Q, Reuter VE, Li FP, Fair WR, Jhanwar SC.
|
| Cancer Res 51 : 1544-1552. 1991
|
| 225 | VHL
|
| Confirmation of linkage in von Hippel-Lindau disease.
|
| Vance JM, et al.
|
| Genomics 6 : 565-567. 1990
|
| 226 | VHL
|
| Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma.
|
| Maher ER, Yates JR, Ferguson-Smith MA.
|
| J Med Genet 27 : 311-314. 1990
|
| 227 | VHL
|
| A single recombination event between the von Hippel-Lindau disease (VHL) gene and D3S18 suggests a map location for the gene in the interval between RAF1 (3p25) and D3S18 (3p26) loci on human chromosome 3.
|
| Latif F, et al.
|
| Am J Hum Genet 47 : A11. 1990
|
| 228 | VHL
|
| Toward the isolation of the gene causing von Hippel-Lindau disease: identification of tightly linked flanking markers.
|
| Seizinger BR, et al.
|
| Am J Hum Genet 47 : A17. 1990
|
| 229 | VHL
|
| Localization of the von Hippel-Lindau disease gene to a small region of chromosome 3.
|
| Hosoe S, et al.
|
| Genomics 8 : 634-640. 1990
|
| 230 | VHL
|
| Mapping of von Hippel-Lindau disease to chromosome 3p confirmed by genetic linkage analysis.
|
| Maher ER, et al.
|
| J Neurol Sci 100 : 27-30. 1990
|
| 231 | VHL
|
| Linkage studies in von Hippel Lindau disease.
|
| Vance JM, et al.
|
| (HGM10) Cytogenet Cell Genet 51 : 1097. 1989
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| 232 | VHL, RCC1
|
| Loss of heterozygosity on 3p in a renal cell carcinoma in von Hippel-Lindau syndrome.
|
| Decker HJ, Gemmill RM, Neumann HP, Walter TA, Sandberg AA.
|
| Cancer Genet Cytogenet 39 : 289-293. 1989
|
| 233 | VHL, TSG3B, TSG17A
|
| Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.
|
| Weston A, Willey JC, Modali R, Sugimura H, McDowell EM, Resau J, Light B, Haugen A, Mann DL, Trump BF, et al.
|
| Proc Natl Acad Sci U S A 86 : 5099-5103. 1989
|
| 234 | VHL
|
| von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma.
|
| Seizinger BR, et al.
|
| Nature 332 : 268-269. 1988
|
| 235 | VHL
|
| Linkage studies of von Hippel-Lindau syndrome using multiple-locus hypervariable DNA probes.
|
| Wells RA, et al.
|
| (HGM9) Cytogenet Cell Genet 46 : 714. 1987
|