Citations for
1RSPO2, TCF3
Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification.
Reis AH, Sokol SY.
Sci Rep. Jun 28;11(1):13433. doi: 10.1038/s41598-021-92824-6. 2021
2BCL11B, TCF3
Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network.
Longabaugh WJR, Zeng W, Zhang JA, Hosokawa H, Jansen CS, Li L, Romero-Wolf M, Liu P, Kueh HY, Mortazavi A, Rothenberg EV.
Proc Natl Acad Sci U S A 114(23):5800-5807. doi: 10.1073/pnas.1610617114. 2017
3NACC1, POU5F1, SOX2, TCF3
Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation.
Malleshaiah M, Padi M, Rué P, Quackenbush J, Martinez-Arias A, Gunawardena J.
Cell Rep 14(5):1181-94. doi: 10.1016/j.celrep.2015.12.101. 2016
4TCF3, TCF4
Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development.
Wöhner M, Tagoh H, Bilic I, Jaritz M, Poliakova DK, Fischer M, Busslinger M.
J Exp Med 213(7):1201-21. doi: 10.1084/jem.20152002. Epub 2016 Jun 3. 2016
5TCF3
Transcription factor 3 controls cell proliferation and migration in glioblastoma multiforme cell lines.
Li R, Li Y, Hu X, Lian H, Wang L, Fu H.
Biochem Cell Biol 94(3):247-55. doi: 10.1139/bcb-2015-0162. Epub 2016 Feb 22. 2016
6SPI1, TCF3
E2A Antagonizes PU.1 Activity through Inhibition of DNA Binding.
Rogers JH, Owens KS, Kurkewich J, Klopfenstein N, Iyer SR, Simon MC, Dahl R.
Biomed Res Int 2016:3983686. doi: 10.1155/2016/3983686. Epub 2016 Jan 28. 2016
7SMAD2, SMAD3, TCF3
E2a is necessary for Smad2/3-dependent transcription and the direct repression of lefty during gastrulation.
Wills AE, Baker JC.
Dev Cell 32(3):345-57. doi: 10.1016/j.devcel.2014.11.034. 2015
8TCF3, TCF4
A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.
Shah M, Rennoll SA, Raup-Konsavage WM, Yochum GS.
Cell Cycle 14(3):323-32. doi: 10.4161/15384101.2014.980643. 2015
9TCF3
Tcf3 expression marks both stem and progenitor cells in multiple epithelia.
Howard JM, Nuguid JM, Ngole D, Nguyen H.
Development 141(16):3143-52. doi: 10.1242/dev.106989. Epub 2014 Jul 18. 2014
10LCN2, TCF3
Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2.
Miao Q, Ku AT, Nishino Y, Howard JM, Rao AS, Shaver TM, Garcia GE, Le DN, Karlin KL, Westbrook TF, Poli V, Nguyen H.
Nat Commun 5:4088. doi: 10.1038/ncomms5088. 2014
11TCF3
Tcf3 represses Wnt-β-catenin signaling and maintains neural stem cell population during neocortical development.
Kuwahara A, Sakai H, Xu Y, Itoh Y, Hirabayashi Y, Gotoh Y.
PLoS One 9(5):e94408. doi: 10.1371/journal.pone.0094408. eCollection 2014. 2014
12ID2, IL10, TCF3
Id2 represses E2A-mediated activation of IL-10 expression in T cells.
Masson F, Ghisi M, Groom JR, Kallies A, Seillet C, Johnstone RW, Nutt SL, Belz GT.
Blood 123(22):3420-8. doi: 10.1182/blood-2014-03-561456. Epub 2014 Apr 10. 2014
13CXXC1, TCF3, YWHAG
Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3γ promoter and is sustained by E2A.
Mai T, Pone EJ, Li G, Lam TS, Moehlman J, Xu Z, Casali P.
J Immunol 191(4):1895-906. doi: 10.4049/jimmunol.1300922. Epub 2013 Jul 12. 2013
14TCF3
Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation.
Atlasi Y, Noori R, Gaspar C, Franken P, Sacchetti A, Rafati H, Mahmoudi T, Decraene C, Calin GA, Merrill BJ, Fodde R.
PLoS Genet 9(5):e1003424. doi: 10.1371/journal.pgen.1003424. Epub 2013 May 2. 2013
15ID2, TCF3
Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation.
Masson F, Minnich M, Olshansky M, Bilic I, Mount AM, Kallies A, Speed TP, Busslinger M, Nutt SL, Belz GT.
J Immunol 190(9):4585-94. doi: 10.4049/jimmunol.1300099. Epub 2013 Mar 27. 2013
16GATA3, TCF3
E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment.
Xu W, Carr T, Ramirez K, McGregor S, Sigvardsson M, Kee BL.
Blood 121(9):1534-42. doi: 10.1182/blood-2012-08-449447. Epub 2013 Jan 7. 2013
17TCF3
Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47.
Teachenor R, Beck K, Wright LY, Shen Z, Briggs SP, Murre C.
Mol Cell Biol. 32(9):1671-82. 2012
18EP300, TCF3
E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus.
Sakamoto S, Wakae K, Anzai Y, Murai K, Tamaki N, Miyazaki M, Miyazaki K, Romanow WJ, Ikawa T, Kitamura D, Yanagihara I, Minato N, Murre C, Agata Y.
J Immunol 188(11):5547-60. doi: 10.4049/jimmunol.1002346. Epub 2012 Apr 27. 2012
19CCND3, CDK6, TCF3
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM.
Nature 490(7418):116-20. doi: 10.1038/nature11378. Epub 2012 Aug 12. 2012
20ASCL1, DBH, HAND2, PHOX2B, TCF3
Interaction of Hand2 and E2a is important for transcription of Phox2b in sympathetic nervous system neuron differentiation.
Hashimoto Y, Tsutsumi M, Myojin R, Maruta K, Onoda F, Tashiro F, Ohtsu M, Murakami Y.
Biochem Biophys Res Commun 408(1):38-44. Epub 2011 Mar 29. 2011
21SNAI1, SNAI2, TCF3
Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis.
Lee K, Gjorevski N, Boghaert E, Radisky DC, Nelson CM.
EMBO J 30(13):2662-74. doi: 10.1038/emboj.2011.159. 2011
22TCF12, TCF3
HEB and E2A function as SMAD/FOXH1 cofactors.
Yoon SJ, Wills AE, Chuong E, Gupta R, Baker JC.
Genes Dev. 25(15):1654-61. 2011
23TCF3
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
Nie L, Zhao Y, Wu W, Yang YZ, Wang HC, Sun XH.
Cell Res. 21(5):754-69. 2011
24HESX1, TCF3
HESX1- and TCF3-mediated repression of Wnt/â-catenin targets is required for normal development of the anterior forebrain.
Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP.
Development 138(22):4931-42. doi: 10.1242/dev.066597. Epub 2011 Oct 17. 2011
25ELL2, TCF3
Transcriptional and epigenetic regulation of B cell development.
Santos P, Arumemi F, Park KS, Borghesi L, Milcarek C.
Immunol Res 50(2-3):105-12. doi: 10.1007/s12026-011-8225-y. Review. 2011
26HLF, TCF3, ZNF521
Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.
Yamasaki N, Miyazaki K, Nagamachi A, Koller R, Oda H, Miyazaki M, Sasaki T, Honda ZI, Wolff L, Inaba T, Honda H.
Oncogene 29(13):1963-75. Epub 2010 Jan 11. 2010
27COL2A1, SCX, SOX9, TCF3
Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription.
Furumatsu T, Shukunami C, Amemiya-Kudo M, Shimano H, Ozaki T.
Int J Biochem Cell Biol. 42(1):148-56. 2010
28RANBP17, TCF3, XPO7
Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12.
Lee JH, Zhou S, Smas CM.
J Cell Biochem 111(1):195-206. 2010
29CERS5, HMGB1, TCF3, TP53, TRIM28, ZNF346
Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.
Kijanka G, Hector S, Kay EW, Murray F, Cummins R, Murphy D, MacCraith BD, Prehn JH, Kenny D.
Gut 59(1):69-78. Epub . 2010
30TCF3
E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.
Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C.
Proc Natl Acad Sci U S A 106(6):1930-5. Epub 2009 Jan 30. 2009
31MAP3K10, NTRK2, TCF3
Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways.
Pedraza N, Rafel M, Navarro I, Encinas M, Aldea M, Gallego C.
J Biol Chem 284(47):32980-8. Epub 2009 Sep 28.PMID: 19801649 2009
32CASK, CDKN1A, TCF3
Human calcium/calmodulin-dependent serine protein kinase regulates the expression of p21 via the E2A transcription factor.
Sun R, Su Y, Zhao X, Qi J, Luo X, Yang Z, Yao Y, Luo X, Xia Z.
Biochem J 419(2):457-66. Erratum in: Biochem J. 2009 Jun 15;420(3):493. PMID: 19125693 2009
33LEF1, TCF3, TCF4
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.
Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E.
Nat Genet 41(10):1068-75. Epub 2009 Aug 30.PMID: 19718027 2009
34TCF3
Daxx inhibits muscle differentiation by repressing E2A-mediated transcription.
Gupta A, Hou R, Liu L, Hiroyasu S, Hadix JA, Huggins GS, Sibinga NE.
J Cell Biochem. 107(3):438-47. 2009
35ATP1B1, TCF3
Regulation of the bHLH transcription factor E2A in epithelial cells by interaction with the Na/K-ATPase beta1 subunit.
Plotkin M, Pelger L.
Arch Biochem Biophys 480(1):68-74. Epub 2008 Aug 14.PMID: 18727914 2008
36EBF1,IKZF1,IKZF3,LEF1,PAX5,TCF3
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.
Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB, Su X, Pui CH, Relling MV, Evans WE, Shurtleff SA, Downing JR.
Nature 446(7137):758-64. 2007
37GATA3,GFI1B,TCF3
Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.
Wei X, Kee BL.
Blood 109(10):4406-14. Epub 2007 Feb 1. 2007
38TCF3
Molecular cytogenetic characterization of TCF3 (E2A)/19p13.3 rearrangements in B-cell precursor acute lymphoblastic leukemia.
Barber KE, Harrison CJ, Broadfield ZJ, Stewart AR, Wright SL, Martineau M, Strefford JC, Moorman AV.
Genes Chromosomes Cancer 46(5):478-86. 2007
39GFI1B, TCF3
Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas.
Xu W, Kee BL.
Blood 109(10):4406-14. Epub 2007 Feb 1. 2007
40PBX1, TCF3
Characterisation of genomic translocation breakpoints and identification of an alternative TCF3/PBX1 fusion transcript in t(1;19)(q23;p13)-positive acute lymphoblastic leukaemias.
Paulsson K, Jonson T, Ora I, Olofsson T, Panagopoulos I, Johansson B.
Br J Haematol 138(2):196-201. 2007
41TCF3
Overexpression of E2A proteins induces epithelial-mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis.
Slattery C, McMorrow T, Ryan MP.
FEBS Lett 580(17):4021-30. Epub 2006 Jun 23. 2006
42PBX1, TCF3
Critical role for a single leucine residue in leukemia induction by E2A-PBX1.
Bayly R, Murase T, Hyndman BD, Savage R, Nurmohamed S, Munro K, Casselman R, Smith SP, LeBrun DP.
Mol Cell Biol 26(17):6442-52. 2006
43NANOG, TCF3, TCF7L1
Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.
Pereira L, Yi F, Merrill BJ.
Mol Cell Biol 26(20):7479-91. Epub 2006 Aug 7. 2006
44TCF3
Genomic organization and characterization of the promoter for the E2A gene.
Hata K, Mizuguchi J.
Gene 325:53-61. 2004
45SNAI1, TWIST1, TCF3, CDKN1A
Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist.
Takahashi E, Funato N, Higashihori N, Hata Y, Gridley T, Nakamura M.
Biochem Biophys Res Commun 325(4):1136-44. 2004
46TCF3, CREBBP, HMCN1
E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells.
Bayly R, Chuen L, Currie RA, Hyndman BD, Casselman R, Blobel GA, LeBrun DP.
J Biol Chem 279(53):55362-71. Epub 2004 Oct 26. 2004
47TCF3
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.
Nie L, Xu M, Vladimirova A, Sun XH.
EMBO J 22(21):5780-92.PMID: 14592976 2003
48TCF12, TCF3
Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL.
Tremblay M, Herblot S, Lecuyer E, Hoang T.
J Biol Chem. 278(15):12680-7 2003
49GARNL1, TCF3
Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain.
Heng JI, Tan SS.
J Biol Chem 277(45):43152-9. Epub 2002 Aug 27. 2002
50HAND2, TCF3
The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer.
Dai YS, Cserjesi P.
J Biol Chem. 277(15):12604-12. 2002
51HLF, TCF3, TLE6
The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1.
Dang J, Inukai T, Kurosawa H, Goi K, Inaba T, Lenny NT, Downing JR, Stifani S, Look AT.
Mol Cell Biol 21(17):5935-45. 2001
52TCF3, MDFI
Inhibition of Tcf3 binding by I-mfa domain proteins.
Snider L, Thirlwell H, Miller JR, Moon RT, Groudine M, Tapscott SJ.
Mol Cell Biol 21(5):1866-73. 2001
53ACS3, TCF3, TWIST1
Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location.
El Ghouzzi V, Legeai-Mallet L, Aresta S, Benoist C, Munnich A, de Gunzburg J, Bonaventure J.
Hum Mol Genet 9(5):813-9. 2000
54TCF3
Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity.
Neufeld B, Grosse-Wilde A, Hoffmeyer A, Jordan BW, Chen P, Dinev D, Ludwig S, Rapp UR.
J Biol Chem. 275(27):20239-42. 2000
55TCF3
A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts.
Vitelli L, Condorelli G, Lulli V, Hoang T, Luchetti L, Croce CM, Peschle C.
Mol Cell Biol. 20(14):5330-42. 2000
56TCF3
Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription.
Thomas MK, Yao KM, Tenser MS, Wong GG, Habener JF.
Mol Cell Biol. 19(12):8492-504. 1999
57HLF, PBX1, TCF3, TFPT
Identification of a novel molecular partner of the E2A gene in childhood leukemia.
Brambillasca F, Mosna G, Colombo M, Rivolta A, Caslini C, Minuzzo M, Giudici G, Mizzi L, Biondi A, Privitera E.
Leukemia. 13(3):369-75. 1999
58TCF3
Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia.
Honda H, Inaba T, Suzuki T, Oda H, Ebihara Y, Tsuiji K, Nakahata T, Ishikawa T, Yazaki Y, Hirai H.
Blood. 93(9):2780-90. 1999
59TCF3
Characterization of the mUBC9-binding sites required for E2A protein degradation.
Huggins GS, Chin MT, Sibinga NE, Lee SL, Haber E, Lee ME.
J Biol Chem. 274(40):28690-6. 1999
60CSF3R, PBX1, TCF3
The gene encoding the granulocyte colony-stimulating factor receptor is a target for deregulation in pre-B ALL by the t(1;19)-specific oncoprotein E2A-Pbx1.
de Lau WB, Hurenkamp J, Berendes P, Touw IP, Clevers HC, van Dijk MA.
Oncogene 17 : 503-510. 1998
61CDKN2A, CDKN2B, HLF, TCF3
Different patterns of homozygous p16INK4A and P15INK4B deletions in childhood acute lymphoblastic leukemias containing distinct E2A translocations.
Maloney KW, et al.
Leukemia 12 : 1417-1421. 1998
62MSC, TCF3
Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes.
Massari ME, Rivera RR, Voland JR, Quong MW, Breit TM, van Dongen JJ, de Smit O, Murre C.
Mol Cell Biol. 18(6):3130-9. 1998
63TCF3
E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein.
Loveys DA, Streiff MB, Kato GJ.
Nucleic Acids Res. 24(14):2813-20. 1996
64TCF3
Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins.
Groisman R, Masutani H, Leibovitch MP, Robin P, Soudant I, Trouche D, Harel-Bellan A.
J Biol Chem. 271(9):5258-64. 1996
65TCF3, HLF
Two types of genomic rearrangements create alternative E2A-HLF fusion proteins in t(17;19)-ALL.
Hunger SP, et al.
Blood 83 : 2970-2977. 1994
66TCF3
Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.
Hsu HL, Wadman I, Baer R.
Proc Natl Acad Sci U S A. 91(8):3181-5. 1994
67TCF3
Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity.
Xia Y, Hwang LY, Cobb MH, Baer R.
Oncogene. 9(5):1437-46. 1994
68TCF3
The helix-loop-helix gene E2A is required for B cell formation.
Zhuang Y, Soriano P, Weintraub H.
Cell. 79(5):875-84. 1994
69TCF3
E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements.
Bain G, Maandag EC, Izon DJ, Amsen D, Kruisbeek AM, Weintraub BC, Krop I, Schlissel MS, Feeney AJ, van Roon M, et al.
Cell. 79(5):885-92. 1994
70PBX1, TCF3
New E2A/PBX1 fusion transcript in a patient with t(1;19)(q23;p13) acute lymphoblastic leukemia.
Numata SI, et al.
Leukemia 7 : 1441-1444. 1993
71TCF3
Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia.
Privitera E, et al.
Blood 79 : 1781-1788. 1992
72HLF, TCF3
Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.
Inaba T, et al.
Science 257 : 531-534. 1992
73TCF3, PBX1
Unexpected heterogeneity in E2A/PBX1 fusion messenger RNA detected by the polymerase chain reaction in pediatric patients with acute lymphoblastic leukemia.
Izraeli S, et al.
Blood 80 : 1413-1417. 1992
74TCF3
Analysis of the oligomerization of myogenin and E2A products in vivo using a two-hybrid assay system.
Chakraborty T, Martin JF, Olson EN.
J Biol Chem. 267(25):17498-501. 1992
75TCF3, PBX1
The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias.
Hunger SP, et al.
Blood 77 : 687-693. 1991
76PBX1, TCF3
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in Pre-B ALL.
Kamps MP, et al.
Cell 60 : 547-555. 1990
77TCF3, TCF4
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.
Henthorn P, Kiledjian M, Kadesch T.
Science 247(4941):467-70. 1990
78TCF3
The gene for enhancer binding proteins E12/E47 lies at the t(1;19) breakpoint in acute leukemias.
Mellentin JD, et al.
Science 246 : 379-382. 1989
79TCF3
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.
Murre C, et al.
Cell 56 : 777-783. 1989