| 1 | NCK1, NPHS1, WTIP
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| Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.
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| Keyvani Chahi A, Martin CE, Jones N.
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| J Biol Chem 291(24):12799-808. doi: 10.1074/jbc.M116.724245. Epub 2016 Mar 31.
2016
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| 2 | KIRREL2, NPHS1
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| Functions of the podocyte proteins nephrin and Neph3 and the transcriptional regulation of their genes.
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| Ristola M, Lehtonen S.
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| Clin Sci (Lond) 126(5):315-28. doi: 10.1042/CS20130258.
2014
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| 3 | FYN, NCK1, NPHS1
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| Direct regulation of nephrin tyrosine phosphorylation by Nck adaptor proteins.
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| New LA, Keyvani Chahi A, Jones N.
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| J Biol Chem 288(3):1500-10. doi: 10.1074/jbc.M112.439463. Epub 2012 Nov 27. 2013
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| 4 | CD2AP, NPHS1, SEPTIN7
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| Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.
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| Wasik AA, Polianskyte-Prause Z, Dong MQ, Shaw AS, Yates JR 3rd, Farquhar MG, Lehtonen S.
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| Mol Biol Cell 23(17):3370-9. doi: 10.1091/mbc.E11-12-1010. Epub 2012 Jul 18. 2012
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| 5 | NPHS1
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| Mutations in NPHS1 in a Chinese child with congenital nephrotic syndrome.
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| Yu ZH, Wang DJ, Meng DC, Huang J, Nie XJ.
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| Genet Mol Res 11(2):1460-4. doi: 10.4238/2012.May.18.6.
2012
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| 6 | NPHS1, ROBO2
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| Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.
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| Fan X, Li Q, Pisarek-Horowitz A, Rasouly HM, Wang X, Bonegio RG, Wang H, McLaughlin M, Mangos S, Kalluri R, Holzman LB, Drummond IA, Brown D, Salant DJ, Lu W.
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| Cell Rep 2(1):52-61. doi: 10.1016/j.celrep.2012.06.002. Epub 2012 Jul 12.
2012
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| 7 | NPHS1, SIRPA
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| SIRPα interacts with nephrin at the podocyte slit diaphragm.
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| Kajiho Y, Harita Y, Kurihara H, Horita S, Matsunaga A, Tsurumi H, Kanda S, Sugawara N, Miura K, Sekine T, Hattori S, Hattori M, Igarashi T.
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| FEBS J 279(17):3010-21. doi: 10.1111/j.1742-4658.2012.08682.x. Epub 2012 Jul 23.
2012
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| 8 | NPHS1, NPHS2, SRN1
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| A spectrum of novel NPHS1 and NPHS2 gene mutations in pediatric nephrotic syndrome patients from Pakistan.
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| Abid A, Khaliq S, Shahid S, Lanewala A, Mubarak M, Hashmi S, Kazi J, Masood T, Hafeez F, Naqvi SA, Rizvi SA, Mehdi SQ.
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| Gene Jul 10;502(2):133-7. doi: 10.1016/j.gene.2012.04.063. Epub 2012 Apr 28. 2012
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| 9 | KIRREL, KIRREL2, NPHS1
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| Trans-interaction of nephrin and Neph1/Neph3 induces cell adhesion that associates with decreased tyrosine phosphorylation of nephrin.
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| Heikkilä E, Ristola M, Havana M, Jones N, Holthöfer H, Lehtonen S.
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| Biochem J 435(3):619-28.
2011
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| 10 | KIRREL, MYO1C, NPHS1
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| Motor protein Myo1c is a podocyte protein that facilitates the transport of slit diaphragm protein Neph1 to the podocyte membrane.
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| Arif E, Wagner MC, Johnstone DB, Wong HN, George B, Pruthi PA, Lazzara MJ, Nihalani D.
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| Mol Cell Biol 31(10):2134-50. Epub 2011 Mar 14.
2011
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| 11 | NGFR, NPHS1
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| The podocyte protein nephrin is required for cardiac vessel formation.
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| Wagner N, Morrison H, Pagnotta S, Michiels JF, Schwab Y, Tryggvason K, Schedl A, Wagner KD.
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| Hum Mol Genet 20(11):2182-94. Epub 2011 Mar 14.
2011
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| 12 | NPHS1, PICK1, PRKCA
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| PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia.
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| Quack I, Woznowski M, Potthoff SA, Palmer R, Königshausen E, Sivritas S, Schiffer M, Stegbauer J, Vonend O, Rump LC, Sellin L.
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| J Biol Chem 286(15):12959-70. doi: 10.1074/jbc.M110.204024. Epub 2011 Feb 14.
2011
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| 13 | FLNA, INPPL1, NPHS, NPHS1, RAPH1
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| Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.
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| Venkatareddy M, Cook L, Abuarquob K, Verma R, Garg P.
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| PLoS One 6(12):e28710. doi: 10.1371/journal.pone.0028710. Epub 2011 Dec 14. 2011
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| 14 | KIRREL, KIRREL2, KIRREL3, NPHS1, XPR1
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| A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis.
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| Neumann-Haefelin E, Kramer-Zucker A, Slanchev K, Hartleben B, Noutsou F, Martin K, Wanner N, Ritter A, Gödel M, Pagel P, Fu X, Müller A, Baumeister R, Walz G, Huber TB.
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| Hum Mol Genet 19(12):2347-59. Epub 2010 Mar 16.PMID: 20233749 2010
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| 15 | KIRREL2, NPHS1
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| Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system.
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| Nishida K, Hoshino M, Kawaguchi Y, Murakami F.
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| J Biol Chem 285(1):373-80. Epub 2009 Nov 2.PMID: 19887377 2010
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| 16 | CD2AP, NPHS1, SH3KBP1
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| CIN85/RukL is a novel binding partner of nephrin and podocin and mediates slit diaphragm turnover in podocytes.
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| Tossidou I, Teng B, Drobot L, Meyer-Schwesinger C, Worthmann K, Haller H, Schiffer M.
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| J Biol Chem 285(33):25285-95. Epub 2010 May 10. 2010
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| 17 | KIRREL2, NPHS1, PTF1A
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| Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system.
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| Nishida K, Hoshino M, Kawaguchi Y, Murakami F.
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| J Biol Chem 285(1):373-80. doi: 10.1074/jbc.M109.060657. Epub 2009 Nov 2.
2010
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| 18 | NPHS1
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| Analysis of polymorphism in renin angiotensin system and other related genes in South Indian chronic kidney disease patients.
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| Anbazhagan K, Sampathkumar K, Ramakrishnan M, Gomathi P, Gomathi S, Selvam GS.
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| Clin Chim Acta 406(1-2):108-12. Epub 2009 Jun 9.
2009
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| 19 | NPHS1, NPHS2, SRN1
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| Clinical features and long-term outcome of nephrotic syndrome associated with heterozygous NPHS1 and NPHS2 mutations.
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| Caridi G, Gigante M, Ravani P, Trivelli A, Barbano G, Scolari F, Dagnino M, Murer L, Murtas C, Edefonti A, Allegri L, Amore A, Coppo R, Emma F, De Palo T, Penza R, Gesualdo L, Ghiggeri GM.
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| Clin J Am Soc Nephrol 4(6):1065-72. Epub 2009 Apr 30.
2009
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| 20 | NPHS1
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| A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion.
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| Sohn RL, Huang P, Kawahara G, Mitchell M, Guyon J, Kalluri R, Kunkel LM, Gussoni E.
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| Proc Natl Acad Sci U S A 106(23):9274-9. Epub 2009 May 22.
2009
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| 21 | NPHS1, NPHS2
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| Predisposition to relapsing nephrotic syndrome by a nephrin mutation that interferes with assembly of functioning microdomains.
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| Shono A, Tsukaguchi H, Kitamura A, Hiramoto R, Qin XS, Doi T, Iijima K.
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| Hum Mol Genet 18(16):2943-56. Epub 2009 May 14.PMID: 19443487 2009
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| 22 | KIRREL, NPHP1, NPHS1, PAED6B, PARD3, PARD6A
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| Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity.
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| Hartleben B, Schweizer H, Lübben P, Bartram MP, Möller CC, Herr R, Wei C, Neumann-Haefelin E, Schermer B, Zentgraf H, Kerjaschki D, Reiser J, Walz G, Benzing T, Huber TB.
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| J Biol Chem 283(34):23033-8. Epub 2008 Jun 18. 2008
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| 23 | NPHS1
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| Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome.
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| Heeringa SF, Vlangos CN, Chernin G, Hinkes B, Gbadegesin R, Liu J, Hoskins BE, Ozaltin F, Hildebrandt F; Members of the APN Study Group.
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| Nephrol Dial Transplant 23(11):3527-33. Epub 2008 May 23.
2008
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| 24 | KCNMA1, NPHS1
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| Nephrin binds to the COOH terminus of a large-conductance Ca2+-activated K+ channel isoform and regulates its expression on the cell surface.
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| Kim EY, Choi KJ, Dryer SE.
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| Am J Physiol Renal Physiol 295(1):F235-46. Epub 2008 May 14.
2008
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| 25 | NPHS1
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| Transcriptional suppression of nephrin in podocytes by macrophages: roles of inflammatory cytokines and involvement of the PI3K/Akt pathway.
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| Takano Y, Yamauchi K, Hayakawa K, Hiramatsu N, Kasai A, Okamura M, Yokouchi M, Shitamura A, Yao J, Kitamura M.
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| FEBS Lett 581(3):421-6. Epub 2007 Jan 12. 2007
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| 26 | NPHS1
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| Nephrin--a unique structural and signaling protein of the kidney filter.
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| Patrakka J, Tryggvason K.
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| Trends Mol Med 13(9):396-403. Epub 2007 Sep 4. Review. 2007
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| 27 | NPHS1
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| Nephrin is critical for the action of insulin on human glomerular podocytes.
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| Coward RJ, Welsh GI, Koziell A, Hussain S, Lennon R, Ni L, Tavaré JM, Mathieson PW, Saleem MA.
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| Diabetes 56(4):1127-35.
2007
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| 28 | KIRREL, NPHS1
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| Neph1 cooperates with nephrin to transduce a signal that induces actin polymerization.
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| Garg P, Verma R, Nihalani D, Johnstone DB, Holzman LB.
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| Mol Cell Biol 27(24):8698-712. Epub 2007 Oct 8.PMID: 17923684 2007
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| 29 | NPHS1
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| beta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity.
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| Quack I, Rump LC, Gerke P, Walther I, Vinke T, Vonend O, Grunwald T, Sellin L.
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| Proc Natl Acad Sci U S A 103(38):14110-5. Epub 2006 Sep 12. 2006
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| 30 | ACTN4, CD2AP, NPHS1, NPHS2, SRN1, SRN4, WT1
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| Mutations in the Wilms' tumor 1 gene cause isolated steroid resistant nephrotic syndrome and occur in exons 8 and 9.
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| Mucha B, Ozaltin F, Hinkes BG, Hasselbacher K, Ruf RG, Schultheiss M, Hangan D, Hoskins BE, Everding AS, Bogdanovic R, Seeman T, Hoppe B, Hildebrandt F; Members of the APN Study Group.
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| Pediatr Res 59(2):325-31. 2006
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| 31 | ACTN4, NPHS1, NPHS2, CD2AP
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| The relationship among nephrin, podocin, CD2AP, and alpha-actinin might not be a true 'interaction' in podocyte.
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| Fan Q, Xing Y, Ding J, Guan N, Zhang J.
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| Kidney Int 69(7):1207-15. 2006
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| 32 | NPHS1, IQGAP1
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| Characterization of the interactions of the nephrin intracellular domain.
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| Liu XL, Kilpelainen P, Hellman U, Sun Y, Wartiovaara J, Morgunova E, Pikkarainen T, Yan K, Jonsson AP, Tryggvason K.
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| FEBS J 272(1):228-43. 2005
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| 33 | KIRREL3, KIRREL, NPHS1
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| NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases.
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| Gerke P, Sellin L, Kretz O, Petraschka D, Zentgraf H, Benzing T, Walz G.
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| J Am Soc Nephrol 16(6):1693-702. Epub 2005 Apr 20. 2005
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| 34 | NPHS1, PPARA
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| PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.
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| Ren S, Xin C, Beck KF, Saleem MA, Mathieson P, Pavenstadt H, Pfeilschifter J, Huwiler A.
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| Biochem Biophys Res Commun 338(4):1818-24. Epub 2005 Nov 2. 2005
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| 35 | NPHS1
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| Nephrin gene (NPHS1) in patients with minimal change nephrotic syndrome (MCNS).
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| Lahdenkari AT, Kestila M, Holmberg C, Koskimies O, Jalanko H.
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| Kidney Int 65(5):1856-63. 2004
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| 36 | KIRREL, NPHS1
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| Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability.
|
| Liu G, Kaw B, Kurfis J, Rahmanuddin S, Kanwar YS, Chugh SS.
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| J Clin Invest 112(2):209-21. 2003
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| 37 | KIRREL, NPHS1
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| Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1.
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| Gerke P, Huber TB, Sellin L, Benzing T, Walz G.
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| J Am Soc Nephrol 14(4):918-26. 2003
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| 38 | NPHS1, NPHS2
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| Genotype/phenotype correlations of NPHS1 and NPHS2 mutations in nephrotic syndrome advocate a functional inter-relationship in glomerular filtration.
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| Koziell A, Grech V, Hussain S, Lee G, Lenkkeri U, Tryggvason K, Scambler P.
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| Hum Mol Genet 11(4):379-88. 2002
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| 39 | NPHS1
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| Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome.
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| Beltcheva O, Martin P, Lenkkeri U, Tryggvason K.
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| Hum Mutat 17(5):368-73. 2001
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| 40 | NPHS1
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| Defective nephrin trafficking caused by missense mutations in the NPHS1 gene: insight into the mechanisms of congenital nephrotic syndrome.
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| Liu L, Done SC, Khoshnoodi J, Bertorello A, Wartiovaara J, Berggren PO, Tryggvason K.
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| Hum Mol Genet 10(23):2637-44. 2001
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| 41 | NPHS1
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| Novel mutation in the nephrin gene of a Japanese patient with congenital nephrotic syndrome of the Finnish type.
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| Aya K, Tanaka H, Seino Y.
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| Kidney Int 57(2):401-4. 2000
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| 42 | NPHS1
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| Structure of the gene for congenital nephrotic syndrome of the Finnish type (NPHS1) and characterization of mutations.
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| Lenkkeri U, et al.
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| Am J Hum Genet 64 : 51-61. 1999
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| 43 | NPHS1
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| Altered gene expression and functions of mitochondria in human nephrotic syndrome.
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| Holthofer H, et al.
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| FASEB J 13(3):523-32. 1999
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| 44 | CD2AP, NPHS1
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| Congenital Nephrotic Syndrome in Mice Lacking CD2-Associated Protein.
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| Shih, N.-Y.; Li, J.; Karpitskii, V.; Nguyen, A.; Dustin, M. L.; Kanagawa, O.; Miner, J. H.; Shaw, A. S.
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| Science 286(5438):312-315 1999
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| 45 | NPHS1
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| Nephrin is specifically located at the slit diaphragm of glomerular podocytes.
|
| Ruotsalainen V, et al.
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| Proc Natl Acad Sci U S A 96(14):7962-7 1999
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| 46 | NPHS1
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| Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney.
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| Tryggvason K, Ruotsalainen V, Wartiovaara J.
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| Int J Dev Biol 43(5 Spec No):445-51. Review 1999
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| 47 | NPHS1
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| Elevated frequency and allelic heterogeneity of congenital nephrotic syndrome, Finnish type, in the old order Mennonites.
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| Bolk S, Puffenberger EG, Hudson J, Morton DH, Chakravarti A.
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| Am J Hum Genet 65(6):1785-90. No abstract available 1999
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| 48 | NPHS1
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| Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome.
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| KestilŠ M, et al.
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| Mol Cell 1 : 575-582. 1998
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| 49 | NPHS1
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| Assembly of a 1-Mb restriction-mapped cosmid contig spanning the candidate region for Finnish congenital nephrosis (NPHS1) in 19q13.1.
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| Olsen AS, et al.
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| Genomics 34 : 223-225. 1996
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| 50 | NPHS1
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| Fine mapping and haplotype analysis of the locus for congenital nephrotic syndrome on chromosome 19q13.1.
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| MŠnnikkš M, et al.
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| Am J Hum Genet 57 : 1377-1383. 1995
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| 51 | NPHS1
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| Congenital nephrotic syndrome of the finnish type maps to the long arm of chromosome 19.
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| KestilŠ M, et al.
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| Am J Hum Genet 54 : 757-764. 1994
|