| 1 | FAN1, HD
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| Genetic and Functional Analyses Point to FAN1 as the Source of Multiple Huntington Disease Modifier Effects
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| Kim KH, Hong EP, Shin JW, Chao MJ, Loupe J, Gillis T, Mysore JS, Holmans P, Jones L, Orth M, Monckton DG, Long JD, Kwak S, Lee R, Gusella JF, MacDonald ME, Lee JM.
|
| Am J Hum Genet. Jul 2;107(1):96-110. doi: 10.1016/j.ajhg.2020.05.012. Epub 2020 Jun 25. 2020
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| 2 | HD, HTT
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| A Comprehensive Haplotype-Targeting Strategy for Allele-Specific HTT Suppression in Huntington Disease.
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| Kay C, Collins JA, Caron NS, Agostinho LA, Findlay-Black H, Casal L, Sumathipala D, Dissanayake VHW, Cornejo-Olivas M, Baine F, Krause A, Greenberg JL, Paiva CLA, Squitieri F, Hayden MR.
|
| Am J Hum Genet 105(6):1112-1125. doi: 10.1016/j.ajhg.2019.10.011. Epub 2019 Nov 7.
2019
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| 3 | FAN1, HD, HTT
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| FAN1 modifies Huntington's disease progression by stabilizing the expanded HTT CAG repeat.
|
| Goold R, Flower M, Moss DH, Medway C, Wood-Kaczmar A, Andre R, Farshim P, Bates GP, Holmans P, Jones L, Tabrizi SJ.
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| Hum Mol Genet. Feb 15;28(4):650-661. doi: 10.1093/hmg/ddy375 2019
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| 4 | HD, HTT
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| Soluble N-terminal fragment of mutant Huntingtin protein impairs mitochondrial axonal transport in cultured hippocampal neurons.
|
| Tian J, Yan YP, Zhou R, Lou HF, Rong Y, Zhang BR.
|
| Neurosci Bull 30(1):74-80. doi: 10.1007/s12264-013-1393-0. Epub 2013 Dec 21.
2014
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| 5 | HD, HTT
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| HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation.
|
| Träger U, Andre R, Lahiri N, Magnusson-Lind A, Weiss A, Grueninger S, McKinnon C, Sirinathsinghji E, Kahlon S, Pfister EL, Moser R, Hummerich H, Antoniou M, Bates GP, Luthi-Carter R, Lowdell MW, Björkqvist M, Ostroff GR, Aronin N, Tabrizi SJ.
|
| Brain 137(Pt 3):819-33. doi: 10.1093/brain/awt355. Epub 2014 Jan 22.
2014
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| 6 | HD, HTT
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| A large scale Huntingtin protein interaction network implicates Rho GTPase signaling pathways in Huntington disease.
|
| Tourette C, Li B, Bell R, O'Hare S, Kaltenbach LS, Mooney SD, Hughes RE.
|
| J Biol Chem 289(10):6709-26. doi: 10.1074/jbc.M113.523696. Epub 2014 Jan 9.
2014
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| 7 | HD, HTT
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| A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.
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| Damiano M, Diguet E, Malgorn C, D'Aurelio M, Galvan L, Petit F, Benhaim L, Guillermier M, Houitte D, Dufour N, Hantraye P, Canals JM, Alberch J, Delzescaux T, Déglon N, Beal MF, Brouillet E.
|
| Hum Mol Genet 22(19):3869-82. doi: 10.1093/hmg/ddt242. Epub 2013 May 29.
2013
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| 8 | HD, HTT
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| Depletion of cognate charged transfer RNA causes translational frameshifting within the expanded CAG stretch in huntingtin.
|
| Girstmair H, Saffert P, Rode S, Czech A, Holland G, Bannert N, Ignatova Z.
|
| Cell Rep 3(1):148-59. doi: 10.1016/j.celrep.2012.12.019. Epub 2013 Jan 24.
2013
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| 9 | HD
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| Dysregulation of mitochondrial calcium signaling and superoxide flashes cause mitochondrial genomic DNA damage in Huntington disease.
|
| Wang JQ, Chen Q, Wang X, Wang QC, Wang Y, Cheng HP, Guo C, Sun Q, Chen Q, Tang TS.
|
| J Biol Chem 288(5):3070-84. doi: 10.1074/jbc.M112.407726. Epub 2012 Dec 17.
2013
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| 10 | HD, HTT
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| Structural features and domain organization of huntingtin fibrils.
|
| Bugg CW, Isas JM, Fischer T, Patterson PH, Langen R.
|
| J Biol Chem 287(38):31739-46. doi: 10.1074/jbc.M112.353839.
2012
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| 11 | HD, HTT
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| Meclizine is neuroprotective in models of Huntington's disease.
|
| Gohil VM, Offner N, Walker JA, Sheth SA, Fossale E, Gusella JF, MacDonald ME, Neri C, Mootha VK.
|
| Hum Mol Genet 20(2):294-300. Epub 2010 Oct 25.
2011
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| 12 | HD
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| ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease.
|
| Maher P, Dargusch R, Bodai L, Gerard PE, Purcell JM, Marsh JL.
|
| Hum Mol Genet 20(2):261-70. Epub 2010 Oct 15.
2011
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| 13 | FIS1, HD, HTT, MFN1, MFN2, OPA1, PPID, TOMM40
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| Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage.
|
| Shirendeb U, Reddy AP, Manczak M, Calkins MJ, Mao P, Tagle DA, Reddy PH.
|
| Hum Mol Genet 20(7):1438-55. Epub 2011 Jan 21.
2011
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| 14 | CDH2, HD
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| Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.
|
| Reis SA, Thompson MN, Lee JM, Fossale E, Kim HH, Liao JK, Moskowitz MA, Shaw SY, Dong L, Haggarty SJ, Macdonald ME, Seong IS.
|
| Hum Mol Genet 20(12):2344-55. Epub 2011 Mar 29.
2011
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| 15 | HD, HTT
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| Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions.
|
| Davranche A, Aviolat H, Zeder-Lutz G, Busso D, Altschuh D, Trottier Y, Klein FA.
|
| Hum Mol Genet 20(14):2795-806. Epub 2011 Apr 25.
2011
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| 16 | HD, HTT
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| Huntingtin facilitates polycomb repressive complex 2.
|
| Seong IS, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM, Wheeler VC, Walz T, Kingston RE, Gusella JF, Conlon RA, Macdonald ME.
|
| Hum Mol Genet 19(4):573-83. Epub 2009 Nov 23.PMID: 19933700 2010
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| 17 | AP1S1 CD4, HD, HTT
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| Expression analysis of novel striatal-enriched genes in Huntington disease.
|
| Mazarei G, Neal SJ, Becanovic K, Luthi-Carter R, Simpson EM, Leavitt BR.
|
| Hum Mol Genet 19(4):609-22. Epub 2009 Nov 23.PMID: 19934114 2010
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| 18 | ARNT2, HD, POU3F2, SIM1
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| Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction.
|
| Yamanaka T, Tosaki A, Miyazaki H, Kurosawa M, Furukawa Y, Yamada M, Nukina N.
|
| Hum Mol Genet 19(11):2099-112. Epub 2010 Feb 25.PMID: 20185558 2010
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| 19 | HD, PPARGC1A, TFAM
|
| Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease.
|
| Kim J, Moody JP, Edgerly CK, Bordiuk OL, Cormier K, Smith K, Beal MF, Ferrante RJ.
|
| Hum Mol Genet 19(20):3919-35. Epub 2010 Jul 21.
2010
|
| 20 | HD, HTT
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| Effects of overexpression of huntingtin proteins on mitochondrial integrity.
|
| Wang H, Lim PJ, Karbowski M, Monteiro MJ.
|
| Hum Mol Genet 18(4):737-52. Epub 2008 Nov 27.
2009
|
| 21 | HD, HTT
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| Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells.
|
| Ratovitski T, Gucek M, Jiang H, Chighladze E, Waldron E, D'Ambola J, Hou Z, Liang Y, Poirier MA, Hirschhorn RR, Graham R, Hayden MR, Cole RN, Ross CA.
|
| J Biol Chem 284(16):10855-67. Epub 2009 Feb 9.
2009
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| 22 | HD
|
| A patient with early onset Huntington disease and severe cerebellar atrophy.
|
| Sakazume S, Yoshinari S, Oguma E, Utsuno E, Ishii T, Narumi Y, Shiihara T, Ohashi H.
|
| Am J Med Genet A 149A(4):598-601.
2009
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| 23 | HD, HTT, NR1H3
|
| Wild-type but not mutant huntingtin modulates the transcriptional activity of liver X receptors.
|
| Futter M, Diekmann H, Schoenmakers E, Sadiq O, Chatterjee K, Rubinsztein DC.
|
| J Med Genet 46(7):438-46. Epub 2009 May 17.
2009
|
| 24 | ADORA2A, HD
|
| A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.
|
| Dhaenens CM, Burnouf S, Simonin C, Van Brussel E, Duhamel A, Defebvre L, Duru C, Vuillaume I, Cazeneuve C, Charles P, Maison P, Debruxelles S, Verny C, Gervais H, Azulay JP, Tranchant C, Bachoud-Levi AC, Dürr A, Buée L, Krystkowiak P, Sablonnière B, Blum D; Huntington French Speaking Network.
|
| Neurobiol Dis 35(3):474-6. Epub 2009 Jul 8.PMID: 19591938 2009
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| 25 | ADORA2A, HD
|
| The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system.
|
| Chiang MC, Chen HM, Lai HL, Chen HW, Chou SY, Chen CM, Tsai FJ, Chern Y.
|
| Hum Mol Genet 18(16):2929-42. Epub 2009 May 14.PMID: 19443488 2009
|
| 26 | HD
|
| Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset.
|
| Swami M, Hendricks AE, Gillis T, Massood T, Mysore J, Myers RH, Wheeler VC.
|
| Hum Mol Genet 18(16):3039-47. Epub 2009 May 23.PMID: 19465745 2009
|
| 27 | HD, HTT
|
| Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion.
|
| Smith R, Bacos K, Fedele V, Soulet D, Walz HA, Obermüller S, Lindqvist A, Björkqvist M, Klein P, Onnerfjord P, Brundin P, Mulder H, Li JY.
|
| Hum Mol Genet 18(20):3942-54. Epub 2009 Jul 23.PMID: 19628478 2009
|
| 28 | HD, HPCA
|
| Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons.
|
| Rudinskiy N, Kaneko YA, Beesen AA, Gokce O, Régulier E, Déglon N, Luthi-Carter R.
|
| J Neurochem 111(2):460-72. Epub 2009 Aug 17.PMID: 19686238 2009
|
| 29 | BDNF, HD
|
| Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease.
|
| Zuccato C, Marullo M, Conforti P, MacDonald ME, Tartari M, Cattaneo E.
|
| Brain Pathol 18(2):225-38. Epub 2007 Dec 17.
2008
|
| 30 | HD, HTT
|
| Huntington's disease: genetics lends a hand.
|
| Palfi S, Jarraya B.
|
| Nature 453(7197):863-4. No abstract available. 2008
|
| 31 | AGO2, HD, HTT
|
| Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies.
|
| Savas JN, Makusky A, Ottosen S, Baillat D, Then F, Krainc D, Shiekhattar R, Markey SP, Tanese N.
|
| Proc Natl Acad Sci U S A 105(31):10820-5. Epub 2008 Jul 31. 2008
|
| 32 | HD
|
| Towards a transgenic model of Huntington's disease in a non-human primate.
|
| Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, Li XJ, Chan AW.
|
| Nature 453(7197):921-4. Epub 2008 May 18.
2008
|
| 33 | BDNF, HD, HTT
|
| Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons.
|
| Zala D, Colin E, Rangone H, Liot G, Humbert S, Saudou F.
|
| Hum Mol Genet 17(24):3837-46. Epub 2008 Sep 4. 2008
|
| 34 | HAP, HD
|
| Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease.
|
| Metzger S, Rong J, Nguyen HP, Cape A, Tomiuk J, Soehn AS, Propping P, Freudenberg-Hua Y, Freudenberg J, Tong L, Li SH, Li XJ, Riess O.
|
| Hum Mol Genet 17(8):1137-46. Epub 2008 Jan 11.PMID: 18192679 2008
|
| 35 | HD, HTT
|
| N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
|
| Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ.
|
| J Neurosci 28(11):2783-92.PMID: 18337408 2008
|
| 36 | HD, HTT
|
| Huntington's disease: from pathology and genetics to potential therapies.
|
| Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC.
|
| Biochem J 412(2):191-209. Review.PMID: 18466116 2008
|
| 37 | HD, HTT
|
| Global changes to the ubiquitin system in Huntington's disease.
|
| Bennett EJ, Shaler TA, Woodman B, Ryu KY, Zaitseva TS, Becker CH, Bates GP, Schulman H, Kopito RR.
|
| Nature 448(7154):704-8. 2007
|
| 38 | HD
|
| Factors associated with HD CAG repeat instability in Huntington disease.
|
| Wheeler VC, Persichetti F, McNeil SM, Mysore JS, Mysore SS, MacDonald ME, Myers RH, Gusella JF, Wexler NS; US-Venezuela Collaborative Research Group.
|
| J Med Genet 44(11):695-701. Epub 2007 Jul 27.
2007
|
| 39 | HTT, HD
|
| Regional and cellular gene expression changes in human Huntington's disease brain.
|
| Hodges A, Strand AD, Aragaki AK, Kuhn A, Sengstag T, Hughes G, Elliston LA, Hartog C, Goldstein DR, Thu D, Hollingsworth ZR, Collin F, Synek B, Holmans PA, Young AB, Wexler NS, Delorenzi M, Kooperberg C, Augood SJ, Faull RL, Olson JM, Jones L, Luthi-Carter R.
|
| Hum Mol Genet 15(6):965-77. Epub 2006 Feb 8. 2006
|
| 40 | HTT, UBQLN1, HD
|
| Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin.
|
| Wang H, Lim PJ, Yin C, Rieckher M, Vogel BE, Monteiro MJ.
|
| Hum Mol Genet 15(6):1025-41. Epub 2006 Feb 6. 2006
|
| 41 | HTT, HD
|
| Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.
|
| Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, Warby SC, Doty CN, Roy S, Wellington CL, Leavitt BR, Raymond LA, Nicholson DW, Hayden MR.
|
| Cell 125(6):1179-91. 2006
|
| 42 | HCRT, HTT, HD
|
| Orexin loss in Huntington's disease.
|
| Petersen A, Gil J, Maat-Schieman ML, Bjorkqvist M, Tanila H, Araujo IM, Smith R, Popovic N, Wierup N, Norlen P, Li JY, Roos RA, Sundler F, Mulder H, Brundin P.
|
| Hum Mol Genet 14(1):39-47. Epub 2004 Nov 03. 2005
|
| 43 | HTT, TPR, HD
|
| Polyglutamine expansion of huntingtin impairs its nuclear export.
|
| Cornett J, Cao F, Wang CE, Ross CA, Bates GP, Li SH, Li XJ.
|
| Nat Genet 37(2):198-204. Epub 2005 Jan 16. 2005
|
| 44 | HTT, HD
|
| Inclusions to the rescue? Neuroprotective role for huntingtin inclusions in HD.
|
| Slow E.
|
| Clin Genet 67(3):228-9. No abstract available. 2005
|
| 45 | HTT, HD
|
| Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.
|
| Tang TS, Slow E, Lupu V, Stavrovskaya IG, Sugimori M, Llinas R, Kristal BS, Hayden MR, Bezprozvanny I.
|
| Proc Natl Acad Sci U S A 102(7):2602-7. Epub 2005 Feb 3. 2005
|
| 46 | HTT, HD
|
| HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism.
|
| Seong IS, Ivanova E, Lee JM, Choo YS, Fossale E, Anderson M, Gusella JF, Laramie JM, Myers RH, Lesort M, Macdonald ME.
|
| Hum Mol Genet 14(19):2871-80. Epub 2005 Aug 22. 2005
|
| 47 | HTT, HD
|
| Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease.
|
| Benn CL, Landles C, Li H, Strand AD, Woodman B, Sathasivam K, Li SH, Ghazi-Noori S, Hockly E, Faruque SM, Cha JH, Sharpe PT, Olson JM, Li XJ, Bates GP.
|
| Hum Mol Genet 14(20):3065-78. Epub 2005 Sep 23. 2005
|
| 48 | BDNF, HD
|
| Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.
|
| Canals JM, Pineda JR, Torres-Peraza JF, Bosch M, Martín-Ibañez R, Muñoz MT, Mengod G, Ernfors P, Alberch J.
|
| J Neurosci 24(35):7727-39.
2004
|
| 49 | HD, HTT
|
| Mechanisms of neuronal cell death in Huntington's disease.
|
| Sawa A, Tomoda T, Bae BI.
|
| Cytogenet Genome Res 100(1-4):287-95. 2003
|
| 50 | HD, HTT
|
| Huntington's disease: a synaptopathy?
|
| Li JY, Plomann M, Brundin P.
|
| Trends Mol Med 9(10):414-20. Review. 2003
|
| 51 | HD, HTT, IFT57
|
| Accomplices to neuronal death.
|
| Mattson MP.
|
| Nature 415(6870):377-9. No abstract available. 2002
|
| 52 | HD, HTT
|
| Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease.
|
| Zuccato C, Ciammola A, Rigamonti D, Leavitt BR, Goffredo D, Conti L, MacDonald ME, Friedlander RM, Silani V, Hayden MR, Timmusk T, Sipione S, Cattaneo E.
|
| Science 293(5529):493-8. 2001
|
| 53 | HD, HTT
|
| Motor disorder in Huntington's disease begins as a dysfunction in error feedback control.
|
| Smith MA, Brandt J, Shadmehr R.
|
| Nature 403(6769):544-9. 2000
|
| 54 | CREBBP, HD, HTT, TP53
|
| The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.
|
| Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H, Wanker EE, Bates GP, Housman DE, Thompson LM.
|
| Proc Natl Acad Sci U S A 97(12):6763-8. 2000
|
| 55 | HD, HTT
|
| Molecular aspects of Huntington's disease.
|
| Walling HW, et al.
|
| J Neurosci Res 54(3):301-8. Review. 1998
|
| 56 | CALM1, HD, HTT
|
| Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.
|
| Bao J, et al.
|
| Proc Natl Acad Sci U S A 93(10):5037-42. 1996
|
| 57 | HD, HTT
|
| Somatic mosaicism in sperm is associated with intergenerational (CAG)n changes in Huntington disease.
|
| Telenius H, et al.
|
| Hum Mol Genet 4 : 189-195. 1995
|
| 58 | HD, HTT
|
| Ancestral differences in the distribution of the delta2642 glutamic acid polymorphism is associated with varying CAG repeat lengths on normal chromosomes : insights into the genetic evolution of Huntington disease.
|
| Almqvist E, et al.
|
| Hum Mol Genet 4 : 207-214. 1995
|
| 59 | HD, HTT
|
| Haplotype analysis of the delta2642 and (CAG)n polymorphisms in the Huntington's disease (HD) gene provides an explanation for an apparent 'founder' HD haplotype.
|
| Rubinsztein DC, et al.
|
| Hum Mol Genet 4 : 203-206. 1995
|
| 60 | HD, HTT
|
| Somatic expansion of the (CAG)n repeat in Huntington disease brains.
|
| De Rooij KE, et al.
|
| Hum Genet 95 : 270-274. 1995
|
| 61 | ATXN1, HD, HTT, MJD
|
| Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias.
|
| Trottier Y, Lutz Y, Stevanin G, Imbert G, Devys D, Cancel G, Saudou F, Weber C, David G, Tora L, et al.
|
| Nature 378 : 403-406. 1995
|
| 62 | HD, HTT
|
| A worldwide study of the Huntington's disease mutation.
|
| Kremer B, et al.
|
| N Engl J Med 330 : 1401-1406. 1994
|
| 63 | HD, HTT
|
| A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.
|
| The Huntington's disease collaborative research Group.
|
| Cell 72 : 971-983. 1993
|
| 64 | HD, HTT
|
| Expansion of the (CAG)n repeat causing Huntington's disease in 352 patients of German origin.
|
| ZŸhlke C, et al.
|
| Hum Mol Genet 2 : 1467-1469. 1993
|
| 65 | HD, HTT
|
| De novo expansion of a (CAG)n repeat in sporadic Huntington's disease.
|
| Myers RH, et al.
|
| Nat Genet 5 : 168-173. 1993
|
| 66 | HD
|
| Dynamic mutation in Dutch Huntington's disease patients: increased paternal repeat instability extending to within the normal size range.
|
| De Rooij KE, De Koning Gans PA, Skraastad MI, Belfroid RD, Vegter-Van Der Vlis M, Roos RA, Bakker E, Van Ommen GJ, Den Dunnen JT, Losekoot M.
|
| J Med Genet 30(12):996-1002.
1993
|
| 67 | HD, HTT
|
| Characterization and localization of the Huntington disease gene product.
|
| Hoogeveen AT, Willemsen R, Meyer N, de Rooij KE, Roos RA, van Ommen GJ, Galjaard H.
|
| Hum Mol Genet 2(12):2069-73.
1993
|
| 68 | HD, HTT
|
| Cloning of the Huntington disease region in yeast artificial chromosomes.
|
| Zuo J, et al.
|
| Hum Mol Genet 1 : 149-159. 1992
|
| 69 | HD, HTT
|
| Huntington disease : no evidence for locus heterogeneity.
|
| Conneally PM, Haines JL, Tanzi RE, Wexler NS, Penchaszadeh GK, Harper PS, Folstein SE, Cassiman JJ, Myers RH, Young AB, et al.
|
| Genomics 5 : 304-308. 1989
|
| 70 | HD, HTT
|
| Evidence from family studies that the gene causing Huntington disease is telomeric to D4S95 and D4S90.
|
| Robbins C, Theilmann J, Youngman S, Haines J, Altherr MJ, Harper PS, Payne C, Junker A, Wasmuth J, Hayden MR.
|
| Am J Hum Genet 44 : 422-425. 1989
|
| 71 | HD, HTT
|
| The Huntington disease locus is most likely within 325 kilobases of the chromosome 4p telomere.
|
| Doggett NA, et al.
|
| Proc Natl Acad Sci U S A 86 : 10011-10014. 1989
|
| 72 | HD, HTT
|
| The gene causing Huntington disease is telomeric to a variable number of tandem repeat (VNTR) polymorphism detected by D4S95 and a new DNA marker D4S90.
|
| Hayden MR, et al.
|
| Am J Hum Genet 43 : A86. 1988
|
| 73 | HD, HTT
|
| First-trimester prenatal diagnosis for Huntington's disease with DNA probes.
|
| Hayden MR, et al.
|
| Lancet I : 1284-1285. 1987
|
| 74 | HD, HTT
|
| Exclusion testing for Huntington's disease in pregnancy with a closely linked DNA marker.
|
| Quarrell OWJ, et al.
|
| Lancet I : 1281-1283. 1987
|
| 75 | D4S62, HD, HTT
|
| Localization of the Huntington's disease gene to a small segment of chromosome 4 flanked by D4S10 and the telomere.
|
| Gilliam TC, et al.
|
| Cell 50 : 565-571. 1987
|
| 76 | D4S10, HD, HTT
|
| Fine mapping of the Huntington disease linked to D4S10 locus by non-radioactive in situ hybridization.
|
| Landegent JE, et al.
|
| Hum Genet 73 : 354-357. 1986
|
| 77 | HD, HTT
|
| Huntington disease-linked restriction fragment length polymorphism localized within band p16.1 of chromosome 4 by in situ hybridization.
|
| Magenis RE, et al.
|
| Am J Hum Genet 39 : 383-391. 1986
|
| 78 | D4S10, HD, HTT
|
| Subregional assignment of the linked marker G8 (D4S10) for Huntington disease to chromosome 4p16.1-16.3.
|
| Wang HS, Greenberg CR, Hewitt J, Kalousek D, Hayden MR.
|
| Am J Hum Genet 39 : 392-396. 1986
|
| 79 | D4S10, HD, HTT
|
| Mapping of the DNA locus D4S10 and the linked Huntington's disease gene to 4p16-->p15.
|
| Zabel BU, et al.
|
| Cytogenet Cell Genet 42 : 187-190. 1986
|
| 80 | D4S10, HD, HTT
|
| Studies of a DNA marker (G8) genetically linked to Huntington disease in British families.
|
| Youngman S, et al.
|
| Hum Genet 73 : 333-339. 1986
|
| 81 | HD, HTT
|
| Huntington disease-linked (HD) restriction fragment polymorphismlocalized to band p16 of chromosome 4 by in situ hybridization.
|
| Magenis RE, et al.
|
| (HGM8) Cytogenet Cell Genet 40 : 685. 1985
|
| 82 | D4S10, HD, HTT
|
| Genetic linkage between the G8 locus (D4S10) and Huntington's diseasefamilies in Britain.
|
| Youngman S, et al.
|
| (HGM8) Cytogenet Cell Genet 40 : 786. 1985
|
| 83 | HD, HTT
|
| Huntington's disease: two families with differing clinical featuresshow linkage to the G8 probe.
|
| Folstein SE, et al.
|
| Science 229 : 776-779. 1985
|
| 84 | HD, HTT
|
| Linkage analysis of Huntington's disease using RFLPs.
|
| Gusella JF, et al.
|
| (HGM7) Cytogenet Cell Genet 37 : 484-485. 1984
|
| 85 | HD, HTT
|
| A polymorphic DNA marker genetically linked to Huntington's disease.
|
| Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE, Watkins PC, Ottina K, Wallace MR, Sakaguchi AY, et al.
|
| Nature 306(5940):234-8.
1983
|