| 1 | FUS, SNPH
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| Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations
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| Salam S, Tacconelli S, Smith BN, Mitchell JC, Glennon E, Nikolaou N, Houart C, Vance C.
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| Sci Rep. Jun 30;11(1):13613. doi: 10.1038/s41598-021-93189-6. 2021
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| 2 | ETM4, ETM5, FUS, TENM4
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| Genetics of essential tremor.
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| Tio M, Tan EK.
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| Parkinsonism Relat Disord. Jan;22 Suppl 1:S176-8. doi: 10.1016/j.parkreldis.2015.09.022. Epub 2015 Sep 14 2016
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| 3 | FUS, PSMD12, SFPQ, UBA1, VCP
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| Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways.
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| Wang T, Jiang X, Chen G, Xu J.
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| Neurobiol Aging 36(1):527-35. doi: 10.1016/j.neurobiolaging.2014.07.044.
2015
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| 4 | FUS, HSPD1
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| FUS Interacts with HSP60 to Promote Mitochondrial Damage.
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| Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, Cheng H, Li Y, Bigio EH, Mesulam M, Xu Q, Du S, Fushimi K, Zhu L, Wu JY.
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| PLoS Genet 11(9):e1005357. doi: 10.1371/journal.pgen.1005357. eCollection 2015 Sep.
2015
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| 5 | EWSR1, FUS
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| A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins.
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| Thomsen C, Grundevik P, Elias P, Ståhlberg A, Aman P.
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| FASEB J 27(12):4965-74. doi: 10.1096/fj.13-234435. Epub 2013 Aug 23.
2013
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| 6 | ALS6, FUS
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| ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN.
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| Groen EJ, Fumoto K, Blokhuis AM, Engelen-Lee J, Zhou Y, van den Heuvel DM, Koppers M, van Diggelen F, van Heest J, Demmers JA, Kirby J, Shaw PJ, Aronica E, Spliet WG, Veldink JH, van den Berg LH, Pasterkamp RJ.
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| Hum Mol Genet 22(18):3690-704. doi: 10.1093/hmg/ddt222. Epub 2013 May 15.
2013
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| 7 | ALS6, ATXN2, FUS
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| Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis.
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| Farg MA, Soo KY, Warraich ST, Sundaramoorthy V, Blair IP, Atkin JD.
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| Hum Mol Genet 22(4):717-28. doi: 10.1093/hmg/dds479. Epub 2012 Nov 19.
2013
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| 8 | ALS6, FUS, PRMT1
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| Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations.
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| Tradewell ML, Yu Z, Tibshirani M, Boulanger MC, Durham HD, Richard S.
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| Hum Mol Genet 21(1):136-49. Epub 2011 Sep 28.
2012
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| 9 | ETM4, FUS
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| Exome Sequencing Identifies FUS Mutations as a Cause of Essential Tremor.
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| Merner ND, Girard SL, Catoire H, Bourassa CV, Belzil VV, Rivière JB, Hince P, Levert A, Dionne-Laporte A, Spiegelman D, Noreau A, Diab S, Szuto A, Fournier H, Raelson J, Belouchi M, Panisset M, Cossette P, Dupré N, Bernard G, Chouinard S, Dion PA, Rouleau GA.
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| Am J Hum Genet 91(2):313-9. Epub 2012 Aug 2. 2012
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| 10 | FUS, MAPT
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| Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.
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| Orozco D, Tahirovic S, Rentzsch K, Schwenk BM, Haass C, Edbauer D.
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| EMBO Rep 13(8):759-64. doi: 10.1038/embor.2012.90. Epub 2012 Jun 19.
2012
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| 11 | FUS
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| TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements.
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| Tan AY, Riley TR, Coady T, Bussemaker HJ, Manley JL.
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| Proc Natl Acad Sci U S A 109(16):6030-5. doi: 10.1073/pnas.1203028109. Epub 2012 Mar 29.
2012
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| 12 | FUS, PLEC
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| Fused in sarcoma (FUS) interacts with the cytolinker protein plectin: implications for FUS subcellular localization and function.
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| Thomsen C, Udhane S, Runnberg R, Wiche G, Ståhlberg A, Aman P.
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| Exp Cell Res 318(5):653-61. doi: 10.1016/j.yexcr.2011.12.019. Epub 2012 Jan 4.
2012
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| 13 | ALS6, FUS, TNPO1
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| Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
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| Zhang ZC, Chook YM.
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| Proc Natl Acad Sci U S A 109(30):12017-21. doi: 10.1073/pnas.1207247109. Epub 2012 Jul 9.
2012
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| 14 | ETM4, FUS
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| Exome sequencing identifies FUS mutations as a cause of essential tremor.
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| Merner ND, Girard SL, Catoire H, Bourassa CV, Belzil VV, Rivière JB, Hince P, Levert A, Dionne-Laporte A, Spiegelman D, Noreau A, Diab S, Szuto A, Fournier H, Raelson J, Belouchi M, Panisset M, Cossette P, Dupré N, Bernard G, Chouinard S, Dion PA, Rouleau GA.
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| Am J Hum Genet. Aug 10;91(2):313-9. doi: 10.1016/j.ajhg.2012.07.002. Epub 2012 Aug 2. 2012
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| 15 | ALS6, FUS
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| Identification of a FUS splicing mutation in a large family with amyotrophic lateral sclerosis.
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| Belzil VV, St-Onge J, Daoud H, Desjarlais A, Bouchard JP, Dupré N, Camu W, Dion PA, Rouleau GA.
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| J Hum Genet 56(3):247-9. Epub 2010 Dec 16.
2011
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| 16 | EWSR1, FUS, TAF15
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| mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.
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| Spitzer JI, Ugras S, Runge S, Decarolis P, Antonescu C, Tuschl T, Singer S.
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| Genes Chromosomes Cancer 50(5):338-47. doi: 10.1002/gcc.20858. Epub 2011 Feb 22.
2011
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| 17 | ALS6, FUS
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| FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion.
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| Suzuki N, Aoki M, Warita H, Kato M, Mizuno H, Shimakura N, Akiyama T, Furuya H, Hokonohara T, Iwaki A, Togashi S, Konno H, Itoyama Y.
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| J Hum Genet 55(4):252-4. Epub 2010 Mar 12.
2010
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| 18 | ALS6, FUS
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| Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.
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| Corrado L, Del Bo R, Castellotti B, Ratti A, Cereda C, Penco S, Sorarù G, Carlomagno Y, Ghezzi S, Pensato V, Colombrita C, Gagliardi S, Cozzi L, Orsetti V, Mancuso M, Siciliano G, Mazzini L, Comi GP, Gellera C, Ceroni M, D'Alfonso S, Silani V.
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| J Med Genet 47(3):190-4. Epub 2009 Oct 26.PMID: 19861302 2010
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| 19 | FUS, TARDBP
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| TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration.
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| Lagier-Tourenne C, Polymenidou M, Cleveland DW.
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| Hum Mol Genet 19(R1):R46-64. Epub 2010 Apr 15. Review.PMID: 20400460 2010
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| 20 | ALS10, ALS6, FUS, TARDBP
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| ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.
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| Ling SC, Albuquerque CP, Han JS, Lagier-Tourenne C, Tokunaga S, Zhou H, Cleveland DW.
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| Proc Natl Acad Sci U S A 107(30):13318-23. Epub 2010 Jul 12.PMID: 20624952 2010
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| 21 | ALS1, ALS10, ALS6, ALS8, ALS9, ANG, FUS, SOD1, TARDBP, VAPB
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| SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations.
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| Millecamps S, Salachas F, Cazeneuve C, Gordon P, Bricka B, Camuzat A, Guillot-Noël L, Russaouen O, Bruneteau G, Pradat PF, Le Forestier N, Vandenberghe N, Danel-Brunaud V, Guy N, Thauvin-Robinet C, Lacomblez L, Couratier P, Hannequin D, Seilhean D, Le Ber I, Corcia P, Camu W, Brice A, Rouleau G, LeGuern E, Meininger V.
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| J Med Genet 47(8):554-60. Epub 2010 Jun 24.PMID: 20577002 2010
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| 22 | ALS6, FUS
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| ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import.
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| Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C.
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| EMBO J 29(16):2841-57. Epub 2010 Jul 6.PMID: 20606625 2010
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| 23 | FUS, HDAC6, TARDBP
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| Amyotrophic lateral sclerosis-associated proteins TDP-43 and FUS/TLS function in a common biochemical complex to co-regulate HDAC6 mRNA.
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| Kim SH, Shanware NP, Bowler MJ, Tibbetts RS.
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| J Biol Chem 285(44):34097-105. Epub 2010 Aug 18.
2010
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| 24 | ALS6, FUS
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| Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.
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| Bosco DA, Lemay N, Ko HK, Zhou H, Burke C, Kwiatkowski TJ Jr, Sapp P, McKenna-Yasek D, Brown RH Jr, Hayward LJ.
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| Hum Mol Genet 19(21):4160-75. Epub 2010 Aug 10.
2010
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| 25 | ALS6, FUS, TARDBP
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| Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
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| Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr.
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| Science 323(5918):1205-8. 2009
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| 26 | ALS6, FUS, TARDBP
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| Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
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| Vance C, Rogelj B, Hortobágyi T, De Vos KJ, Nishimura AL, Sreedharan J, Hu X, Smith B, Ruddy D, Wright P, Ganesalingam J, Williams KL, Tripathi V, Al-Saraj S, Al-Chalabi A, Leigh PN, Blair IP, Nicholson G, de Belleroche J, Gallo JM, Miller CC, Shaw CE.
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| Science 323(5918):1208-11. 2009
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| 27 | ALS6, FUS, TARDBP
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| Rethinking ALS: the FUS about TDP-43.
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| Lagier-Tourenne C, Cleveland DW.
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| Cell 136(6):1001-4. Review. 2009
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| 28 | DDIT3, FUS, NFKBIZ
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| The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
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| Göransson M, Andersson MK, Forni C, Ståhlberg A, Andersson C, Olofsson A, Mantovani R, Aman P.
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| Oncogene 28(2):270-8. Epub 2008 Oct 13.
2009
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| 29 | FUS
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| Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
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| Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr.
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| Science 323(5918):1205-8.
2009
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| 30 | FUS
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| RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells.
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| Doi H, Okamura K, Bauer PO, Furukawa Y, Shimizu H, Kurosawa M, Machida Y, Miyazaki H, Mitsui K, Kuroiwa Y, Nukina N.
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| J Biol Chem 283(10):6489-500. Epub 2007 Dec 31.
2008
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| 31 | DDX39, FUS, SARNP, THOC4
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| Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
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| Sugiura T, Sakurai K, Nagano Y.
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| Exp Cell Res 313(4):782-90. Epub 2006 Dec 5. 2007
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| 32 | FUS, CREB3L1, CREB3L2
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| Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene.
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| Mertens F, Fletcher CD, Antonescu CR, Coindre JM, Colecchia M, Domanski HA, Downs-Kelly E, Fisher C, Goldblum JR, Guillou L, Reid R, Rosai J, Sciot R, Mandahl N, Panagopoulos I.
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| Lab Invest 85(3):408-15. 2005
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| 33 | FUS, CREB3L2
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| The chimeric FUS/CREB3l2 gene is specific for low-grade fibromyxoid sarcoma.
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| Panagopoulos I, Storlazzi CT, Fletcher CD, Fletcher JA, Nascimento A, Domanski HA, Wejde J, Brosjo O, Rydholm A, Isaksson M, Mandahl N, Mertens F.
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| Genes Chromosomes Cancer 40(3):218-28. 2004
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| 34 | FUS, ERG
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| FUS/ERG gene fusions in Ewing's tumors.
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| Shing DC, McMullan DJ, Roberts P, Smith K, Chin SF, Nicholson J, Tillman RM, Ramani P, Cullinane C, Coleman N.
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| Cancer Res 63(15):4568-76. 2003
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| 35 | FUS
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| Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation.
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| Bertrand P, et al.
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| Oncogene 18(31):4515-21 1999
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| 36 | FUS
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| TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.
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| Perrotti D, et al.
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| EMBO J 17 : 4442-4455. 1998
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| 37 | FUS
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| Detection of TLS/FUS-CHOP fusion transcripts in myxoid and round cell liposarcomas by nested reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues.
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| Hisaoka M, et al.
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| Diagn Mol Pathol 7 : 96-101. 1998
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| 38 | FUS, TAF15
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| Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
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| Morohoshi F, Ootsuka Y, Arai K, Ichikawa H, Mitani S, Munakata N, Ohki M.
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| Gene 221(2):191-8. 1998
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| 39 | FUS, SFRS13A, SRSF2
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| Oncoptotein TLS interacts with serine-arginine ptoteins involved in RNA xplicing. involved in RNA splicing.
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| Yang L, Embree LJ, Tsai S, Hickstein DD.
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| J Biol Chem 273(43):27761-4. 1998
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| 40 | ERG, FUS, AMLT1
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| Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript.
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| Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, Kaneko Y, Sako M, Kobayashi Y, Tojou A, Miura I, Kakuda H, Funabiki T, Horibe K, Hamaguchi H, Akiyama Y, Bessho F, Yanagisawa M, Hayashi Y.
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| Blood 90(3):1192-9. 1997
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| 41 | DDIT3, ERG, EWSR1, FUS
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| Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia.
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| Panagopoulos I, Lassen C, Isaksson M, Mitelman F, Mandahl N, Aman P.
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| Oncogene 15(11):1357-62. 1997
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| 42 | EWSR1, FUS
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| Expression patterns of the human sarcoma-associated genes FUS and EWS and the genomic structure of FUS.
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| Aman P, et al.
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| Genomics 37 : 1-8. 1996
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| 43 | DDIT3, ERG, FUS
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| Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21).
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| Panagopoulos I, et al.
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| oncogene 11 : 1133-1137 1995
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| 44 | FUS
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| An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.
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| Ichikawa H, et al.
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| Cancer Res 54 : 2865-2868. 1994
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| 45 | FUS, ERG
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| TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domain.
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| Prasad DDK, et al.
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| Oncogene 9 : 3717-3729. 1994
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| 46 | FUS, ERG
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| Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22).
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| Panagopoulos I, et al.
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| Genes Chromosomes Cancer 11 : 256-262. 1994
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| 47 | FUS, DDIT3
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| Isolation of asomatic cell hybrid retaining the der(16)t(12;16)(q13;p11.2) from a myxoid liposarcoma cell line.
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| Schoenmakers HFPM, et al.
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| Cytogenet Cell Genet 62 : 159-161. 1993
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| 48 | DDIT3, FUS
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| Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
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| Crozat A, et al.
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| Nature 363 : 640-644. 1993
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| 49 | FUS, DDIT3
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| Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
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| Rabbitts TH, et al.
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| Nat Genet 4 : 175-180. 1993
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| 50 | FUS, DDIT3
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| Myxoid liposarcoma with t(12;16)(q13;p11) contains site-specific differences in methylation patterns surrounding a zinc-finger gene mapped to the breakpoint region on chromosome 12.
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| Paulien S, et al.
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| Cancer Res 50 : 7902-7907. 1990
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| 51 | FUS, DDIT3
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| Localization of the chromosomal breakpoints of the t(12;16) in liposarcoma to subbands 12q13.3 and 16p11.2.
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| Eneroth M, et al.
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| Cancer Genet Cytogenet 48 : 101-107. 1990
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| 52 | FUS, DDIT3
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| Translocation t(12;16) in a case of myxoid liposarcoma.
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| Smith S, et al.
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| Cancer Genet Cytogenet 26 : 185-186. 1987
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| 53 | FUS, DDIT3
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| Cytogenetic studies of adipose tissue tumors. II.Recurrent reciprocal translocation t(12;16)(q13;p11) in myxoid liposarcomas.
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| Turc-Carel C, et al.
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| Cancer Genet Cytogenet 23 : 291-299. 1986
|