| Main clinical features
|
characterized by chronic accumulation of abnormal fibrillar material in the anterior segment of the eye, leading to numerous clinical complications apart from secondary glaucoma development
. disorder of the suspensory ligament, secondary glaucoma results from effects of exfoliated lens material ('capsular glaucoma')
. abnormalities in the zonules, ciliary body, iris, trabecular meshwork, and corneal endothelium, which could lead to significant clinical problems, including cataract surgery complications and glaucoma
. generalized disorder of the extracellular matrix, characterized by the pathological accumulation of abnormal fibrillar material in the anterior segment of the eye predisposing to glaucomatous optic neuropathy |