| Symbol
| WT2
|
| Location
| 11p15.5
|
| HGNC id
| 12797
|
| Name
|
non-syndromic Wilms tumor |
| Corresponding gene
|
H19
|
| Main clinical features
|
sporadic WT without features of growth disorders |
| Genetic determination
| epigenetic |
| Prevalence
| in 3p100 of sporadic WT
|
| Function/system disorder
| kidney and urinary tract |
| Type
| malignancy
|
| Gene mutation | Chromosome rearrangement | Effect | Comments |
|
|---|
| imprinting defect
|
|
| constitutional 11p15 defects including H19 DMR epimutations, uniparental disomy 11p15 and H19 DMR imprinting center mutations (one microinsertion and one microdeletion),
| |
| Remark(s)
|
imprinted domain 1 anomalies |
| Genotype/Phenotype correlations
|
individuals with imprinted domain 2 anomalies do not have an increase of WT |