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GENATLAS PHENOTYPE
last update : 15/10/2008
Symbol TALL
Location 5q35.1
Name T-cell acute lymphoblastic leukemia, TLX3 rearranged
Corresponding gene TLX3
Main clinical features leukemia
Genetic determination
Function/system disorder hematology
Type malignancy
Mechanism(s)
Gene mutationChromosome rearrangementEffectComments
  translocation   cryptic t(5;14)(q35;q32)with ectopic expression of TLX3 in 20p100 of pediatric T-ALL cases
  translocation   variant and alternative translocations:t(5;7)(q35;q21)with CDK6,and fusion of the BCL11B and RANBP17/TLX3 loci resulting from subtle ins/del
Remark(s) acquired somatic rearrangements ; multiple genetic abnormalities cooperate in the malignant trasformation of thymocytes (NOTCH1 mutations, p15/p16 deletions, NUP214-ABL1 amplifications, cryptic del5q35 and others)