Symbol
| TALL
|
Location
| 5q35.1
|
Name
|
T-cell acute lymphoblastic leukemia, TLX3 rearranged |
Corresponding gene
|
TLX3
|
Main clinical features
|
leukemia |
Genetic determination
Function/system disorder
| hematology |
Type
| malignancy
| |
Gene mutation | Chromosome rearrangement | Effect | Comments |
|
---|
 
| translocation
|  
| cryptic t(5;14)(q35;q32)with ectopic expression of TLX3 in 20p100 of pediatric T-ALL cases
|  
| translocation
|  
| variant and alternative translocations:t(5;7)(q35;q21)with CDK6,and fusion of the BCL11B and RANBP17/TLX3 loci resulting from subtle ins/del
| |
Remark(s)
|
acquired somatic rearrangements ; multiple genetic abnormalities cooperate in the malignant trasformation of thymocytes (NOTCH1 mutations, p15/p16 deletions, NUP214-ABL1 amplifications, cryptic del5q35 and others) |