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last update : 05-11-2011
Symbol SSS3
Location 14q12
Name Sick sinus syndrome 3
Corresponding gene MYH6
Main clinical features
  • characterized by pathological sinus bradycardia (slow heart rate), sinus arrest and/or chronotropic incompetence (attenuated heart rate response to exercise
  • symptoms are often intermittent and/or nonspecific and include dizziness, syncope, and heart failure; is the most common indication for permanent pacemaker implantation
  • Genetic determination
    Function/system disorder
    Type susceptibility factor
    Genotype/Phenotype correlations
  • c.2161C>T missense mutation in MYH6 resulting in p.Arg721Trp associates with SSS3 (PMID: 21378987))