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GENATLAS PHENOTYPE

last update : 05-11-2011

Symbol	SSS3
Location	14q12
Name	Sick sinus syndrome 3
Corresponding gene	MYH6
Main clinical features	characterized by pathological sinus bradycardia (slow heart rate), sinus arrest and/or chronotropic incompetence (attenuated heart rate response to exercise symptoms are often intermittent and/or nonspecific and include dizziness, syncope, and heart failure; is the most common indication for permanent pacemaker implantation
Genetic determination
Function/system disorder
Type	susceptibility factor

Remark(s)

Genotype/Phenotype correlations

c.2161C>T missense mutation in MYH6 resulting in p.Arg721Trp associates with SSS3 (PMID: 21378987))