| Main clinical features
|
neurologic disorder characterized by onset of slowly progressive lower limb spasticity, optic atrophy, and peripheral neuropathy in the first decade
symptoms first appeared in the first decade, manifest as gait impairment associated with mild to moderate spasticity, hyperreflexia of the knee, and extensor plantar responses
also distal sensory impairment, with loss of ankle reflexes, distal leg atrophy, and pes cavus; funduscopic analysis showed optic atrophy and reduced visual acuity; brain imaging showed atrophy of the optic nerve |