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GENATLAS PHENOTYPE
last update : 05-11-2014
Symbol RAK
Location 15q21.3
Name Kitamura reticulate acropigmentation
Corresponding gene ADAM10
Main clinical features
  • reticulate, slightly depressed, sharply demarcated brown macules without hypopigmentation, affecting the dorsa of the hands and feet in the first or second decade of life
  • macules gradually darken and extend to the proximal regions of the extremities; progression of the eruptions stops in middle age, and the increased pigmentation is found on the flexor aspects of the wrists, neck, patella, and olecranon
  • characteristic skin lesions are reticulate, slightly depressed pigmented macules mainly affecting the dorsa of the hands and feet, which first appear before puberty and subsequently expand to the proximal limb and the trunk.
  • Genetic determination autosomal dominant
    Function/system disorder dermatology
    Type disease
    Remark(s)