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GENATLAS PHENOTYPE

last update : 4/09/2006

Symbol	PSORS1
Location	6p21.3
HGNC id	9573
Name	familial psoriasis 1
Corresponding gene	PSORS1C1 , PSORS1C2 , HCP5
Main clinical features	in Caucasian and Chinese Hans population, characterized by red scaly patches affecting the scalp, elbows and knees associated with an increased incidence of arthritis
Genetic determination
Related entries	. other susceptibility loci: IL12B, IL23R, 1q24, CDKAL1(6q22), 21q22 are pleiotropic susceptibility loci for psoriasis, crohn disease and type II diabetes . RNF114 (20q13.13), distinct 5q31 variants contribute to Crohn disease and psoriasis risk
Function/system disorder	dermatology
Type	susceptibility factor

Remark(s)

major contributor, linked to HLA-B17 and HLA-C, interacting with PSORS4, the corneodesmosine gene CDSN may be implicated