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GENATLAS PHENOTYPE

last update : 27-12-2017

Symbol	PROTLS
Location	10q23.31
Name	Proteus-like syndrome
Other name(s)	SOLAMEN syndrome (Segmental overgrowth, Lipomatosis, Arteriovenous Malformation and Epidermal Nevus)
Corresponding gene	PTEN
Other symbol(s)	PROTS, SOLAMEN
Main clinical features	gigantism, partial, of hands and feet, nevi, hemihypertrophy, and macrocephaly
Genetic determination	autosomal dominant
Function/system disorder	osteo-articular
	connective tissue
Type	disease

Gene product

Name	phosphatase and tensin homolog

Remark(s)

grouped with its allelic disorders Bannayan-Zonana syndrome (BZS) and Cowden syndrome and classified as the PTEN hamartomas syndrome (PHTS)