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References OMIM Gene GeneReviews HGMD HGNC
last update : 07-11-2016
Symbol PPKS2
Location 6p24.3
Name palmoplantar keratoderma (hyperkeratosis) striata
Corresponding gene DSP
Other symbol(s) PPK6
Main clinical features
  • characterized by a linear pattern of skin thickening on the palms and flexion aspect of the fingers
  • affected individuals developed palmoplantar thickening in the first or early second decade of life; most prominent in a linear pattern along the flexor aspects of the fingers and over pressure points on the soles
  • Genetic determination autosomal dominant
    Related entries PPKS1, PPKS3
    Function/system disorder connective tissue
    Type disease
    Gene product
    Name desmoplakin (DSP)