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GENATLAS PHENOTYPE
last update : 23-03-2021
Symbol POF6
Location 2p13.3
Name premature ovarian failure, 6
Corresponding gene FIGLA
Main clinical features
  • secondary amenorrhea with elevated gonadotropins occurring before age 40
  • depletion of ova is usually the basis although an ovary no longer sensitive to gonadotropins can masquerade as true failure
  • Genetic determination autosomal dominant
    Function/system disorder endocrinology
    Type disease
    Remark(s)