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GENATLAS PHENOTYPE
last update : 08-11-2017
Symbol PARK21
Location 3q22.1
Name Parkinson disease 21
Corresponding gene DNAJC13
Main clinical features
  • typical adult-onset Parkinson disease characterized by tremor, rigidity, bradykinesia, postural instability, and good response to levodopa treatment
  • postmortem examination of 3 affected individuals showed loss of dopaminergic neurons and Lewy bodies and Lewy neurites in the substantia nigra
  • Genetic determination autosomal dominant
    Related entries including also cases of essential tremor (PMID: 25118025)
    Function/system disorder neurology
    Type disease
    Remark(s)