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GENATLAS PHENOTYPE

last update : 23-12-2013

Symbol	NPHS3
Location	10q23.33
Name	childhood nephrotic syndrome 3
Corresponding gene	PLCE1
Main clinical features	nephrotic syndrome, steroid responsiveness severe form of isolated nephrotic syndrome with rapid progression to terminal renal failure, caused by a developmental rather than structural podocyte dysfunction and major cause of diffuse mesangial sclerosis also cases with focal segmental glomerulosclerosis (FSGS) and later nephrotic syndrome
Genetic determination	autosomal recessive
Function/system disorder	kidney and urinary tract
Type	disease

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