| Main clinical features
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characterized by mildly impaired global development apparent from infancy, poor speech acquisition, hypotonia with early feeding difficulties, mildly delayed walking, and variable behavioral abnormalities, such as autistic features, hyperactivity, or attention deficits
coarse facial features, including prominent forehead, large ears, and wide mouth; also wide hands, thickened fingers, and cutaneous toe syndactyly, as well as joint hyperlaxity
ASD or behavior problems, non-ASD
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