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GENATLAS PHENOTYPE

last update : 17-04-2010

Symbol	MTS
Location	2p21
Name	Muir-Torre syndrome
Corresponding gene	MSH2 , TIMM8A
Main clinical features	non polyposis colorectal cancer with multiple cutaneous sebaceous neoplasms and genitourinary carcinoma, or keratoacanthomas characterized by the development of cancers in the colorectum and endometrium, and to a lesser extent, cancers of the stomach, urinary tract, ovaries, small bowel and brain
Genetic determination	autosomal dominant
Function/system disorder	digestive tract/gastrointestinal
Type	malignancy

Gene product

Name	yeast mutator gene homolog (MSH2)

Remark(s)