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GENATLAS PHENOTYPE
last update : 21/08/2006
Symbol MTC1
Location 10q11.21
Name familial and sporadic medullary thyroid carcinoma
Corresponding gene RET
Other symbol(s) FMTC, MTC
Main clinical features
  • cancer predisposion
  • inherited cancer syndrome that predispose to C-cell hyperplasia and MTC
    • Genetic determination autosomal dominant
    Related entries FPTC
    Function/system disorder endocrinology
    Type malignancy
    Gene product
    Name receptor tyrosine kinase with cadherin homology domain (RET)
    Mechanism(s)
    Gene mutationChromosome rearrangementEffectComments
    various types     germ-line mutations in the RET proto-oncogene, mainly in exons 10 and 11, but not only
    Remark(s) allelic disorder to MEN2A